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    Selective posttranslational modification of phage-displayed polypeptides
    92.
    发明申请
    Selective posttranslational modification of phage-displayed polypeptides 有权
    噬菌体展示多肽的选择性翻译后修饰

    公开(公告)号：US20070178448A1

    公开(公告)日：2007-08-02

    申请号：US11580223

    申请日：2006-10-11

    Applicant: Meng-Lin Tsao ,  Feng Tian ,  Peter Schultz

    Inventor： Meng-Lin Tsao ,  Feng Tian ,  Peter Schultz

    IPC: C12Q1/70 ,  C12N7/01

    CPC classification number: C12P21/02 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/50 ,  C12N7/00 ,  C12N9/93 ,  C12N15/1037 ,  C12N15/67 ,  C12N2795/14122

    Abstract: The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such as p-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2] cycloaddition reactions and Staudinger modifications.

    Abstract translation: 本发明涉及噬菌体展示多肽的翻译后修饰。 这些显示的多肽包含至少一个非天然氨基酸，例如芳基叠氮氨基酸如对叠氮基-L-苯丙氨酸或炔基 - 氨基酸如对 - 炔丙氧基苯丙氨酸，其被并入噬菌体展示的融合物 通过使用包含合适的正交氨酰-tRNA合成酶和合适的正交tRNA物质的体内正交翻译系统，在选定位置上的多肽。 这些非天然氨基酸有利地提供翻译后修饰的靶标，例如叠氮炔 - 炔[3 + 2]环加成反应和施陶丁格修饰。

    Method of and system for stabilization of sensors
    93.
    发明申请
    Method of and system for stabilization of sensors 审中-公开
    传感器稳定方法和系统

    公开(公告)号：US20070173712A1

    公开(公告)日：2007-07-26

    申请号：US11322977

    申请日：2005-12-30

    Applicant: Rajiv Shah ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

    Inventor： Rajiv Shah ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

    IPC: A61B5/05 ,  G01D18/00 ,  A61B5/00

    Abstract: A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry cases a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulator voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

    Abstract translation: 血糖感测系统包括传感器和传感器电子设备。 传感器包括多个电极。 传感器电子设备包括稳定电路。 稳定电路将第一时间帧施加到电极中的一个施加第一电压，并且将第二电压施加到第二时间框架中的一个电极。 稳定电路重复施加第一电压和第二电压以继续阳极 - 阴极循环。 传感器电子设备可以包括电源，调节器和电压施加装置，其中电压施加装置从调节器接收调节器电压，在第一时间帧向电极施加第一电压，并将第二电压施加到 第二时间段的电极。

    Site-specific incorporation of redox active amino acids into proteins
    96.
    发明申请
    Site-specific incorporation of redox active amino acids into proteins 有权
    将氧化还原活性氨基酸的位点特异性掺入蛋白质

    公开(公告)号：US20070009990A1

    公开(公告)日：2007-01-11

    申请号：US10575991

    申请日：2004-10-13

    Applicant: Lital Alfonta ,  Peter Schultz ,  Zhiwen Zhang

    Inventor： Lital Alfonta ,  Peter Schultz ,  Zhiwen Zhang

    IPC: C12N9/16 ,  C07H21/04 ,  C12P21/06 ,  C12N1/21 ,  C12N15/74

    CPC classification number: C12N9/93 ,  C12P21/02

    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.

    Abstract translation: 提供了将氧化还原活性氨基酸掺入蛋白质的蛋白质生物合成机理组分的组成和方法，其中包括正交tRNA，正交氨酰-tRNA合成酶和tRNA /合成酶正交对。 还提供了用于鉴定这些正交对的方法以及使用这些正交对产生具有氧化还原活性氨基酸的蛋白质的方法。

    Interior weld and improved sling
    98.
    发明申请
    Interior weld and improved sling 审中-公开
    内部焊缝和改进吊索

    公开(公告)号：US20060125305A1

    公开(公告)日：2006-06-15

    申请号：US11346681

    申请日：2006-02-03

    Applicant: Richard Schultz ,  Peter Schultz

    Inventor： Richard Schultz ,  Peter Schultz

    IPC: A47C7/02

    CPC classification number: A47C7/282 ,  A47C31/023 ,  Y10T24/2164

    Abstract: An interior weld for furniture having a tubular member is disclosed. The weld has a first tubular member and a second tubular member. The first tubular member is adapted to receive the tubular second member. An edge of the tubular second member contacts an inner surface of the first tubular member. A weld is formed on the inner surface of the first tubular member at the contact point where the second tubular member contacts the first tubular member. There is a weld at that contact point which immovably attaches the second member to the first member.

    Abstract translation: 公开了一种具有管状构件的家具的内部焊缝。 焊缝具有第一管状构件和第二管状构件。 第一管状构件适于容纳管状第二构件。 管状第二构件的边缘接触第一管状构件的内表面。 在第二管状构件与第一管状构件接触的接触点处，在第一管状构件的内表面上形成焊缝。 在该接触点处具有不可移动地将第二构件附接到第一构件的焊缝。

    Methods for the synthesis of substituted purines
    99.
    发明申请
    Methods for the synthesis of substituted purines 审中-公开
    合成取代嘌呤的方法

    公开(公告)号：US20060009642A1

    公开(公告)日：2006-01-12

    申请号：US11223429

    申请日：2005-09-09

    Applicant: Sheng Ding ,  Qiang Ding ,  Nathanael Gray ,  Peter Schultz

    Inventor： Sheng Ding ,  Qiang Ding ,  Nathanael Gray ,  Peter Schultz

    IPC: C07D473/24 ,  C07D473/16

    CPC classification number: C07D473/16 ,  C07D473/06 ,  C07D473/18

    Abstract: The invention provides general methods for preparing 2,9-, 2,6,9-, O6-aryl- and O6-alkyl-substituted purines in a combinatorial and traceless fashion. The methods involve, in some embodiments, Mitsunobu alkylation of 2-fluoro-6-phenylsulfenylpurine at N9 with alcohols in solution, followed by C2-capture of the purine core with a resin-bound amine and subsequent oxidation and displacement of the C6 sulfonyl group with amines and anilines.

    Abstract translation: 本发明提供了一种制备组合中的2,9-，2,6,9-六-O-芳基和O-6 - 烷基取代的嘌呤的一般方法， 无痕的时尚。 在一些实施方案中，所述方法涉及N9上的2-氟-6-苯基亚磺酰基嘌呤在溶液中的醇的Mitsunobu烷基化，随后用树脂结合的胺C2-捕获嘌呤核心，随后氧化和置换C6磺酰基 与胺和苯胺。

    Separation of propylene oxide from a mixture comprising propylene oxide and methanol
    100.
    发明申请
    Separation of propylene oxide from a mixture comprising propylene oxide and methanol 审中-公开
    从包含环氧丙烷和甲醇的混合物中分离环氧丙烷

    公开(公告)号：US20060006054A1

    公开(公告)日：2006-01-12

    申请号：US10884967

    申请日：2004-07-07

    Applicant: Hans-Georg Gobbel ,  Henning Schultz ,  Peter Schultz ,  Renate Patrascu ,  Malte Schultz ,  Meinolf Weidenbach

    Inventor： Hans-Georg Gobbel ,  Henning Schultz ,  Peter Schultz ,  Renate Patrascu ,  Malte Schultz ,  Meinolf Weidenbach

    IPC: B01D3/34 ,  C07C27/26

    CPC classification number: C07D301/32 ,  C07D301/12

    Abstract: A method of separating propylene oxide from a mixture (M) comprising propylene oxide and methanol, said method comprising (i) introducing said mixture (M) into an extractive distillation column; (ii) additionally introducing an extracting solvent into said extractive distillation column; (iii) distilling propylene oxide overhead from said extractive distillation column as top stream; (iv) withdrawing a bottoms stream from said extractive distillation column; (v) compressing the top stream obtained overhead in (iii) by means of at least one compressor to give a compressed vapor.

    Abstract translation: 一种从包含环氧丙烷和甲醇的混合物（M）中分离环氧丙烷的方法，所述方法包括（i）将所述混合物（M）引入萃取蒸馏塔中; （ii）另外将萃取溶剂引入所述​​萃取蒸馏塔中; （iii）从所述萃取蒸馏塔顶部馏出环氧丙烷作为顶部流; （iv）从所述萃取蒸馏塔中取出塔底物​​流; （v）通过至少一个压缩机压缩在（iii）中获得的塔顶馏出物的顶部流以产生压缩蒸汽。

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