公开(公告)号：US08323657B2

公开(公告)日：2012-12-04

申请号：US12312232

申请日：2007-10-02

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： C07K5/00

CPC分类号： C07K14/4748 ,  A61K39/0011 ,  A61K2039/5158 ,  A61K2039/57 ,  C07K16/30 ,  C07K2317/34

摘要： This invention provides a new tumor antigen having an epitope that induces a Th1 cell (a CD4-positive T cell specific to MAGE-A4), and a method ot application thereof.

摘要翻译： 本发明提供具有诱导Th1细胞（MAGE-A4特异性的CD4阳性T细胞）表位的新型肿瘤抗原及其应用方法。

公开(公告)号：US20120121616A1

公开(公告)日：2012-05-17

申请号：US13126612

申请日：2010-08-03

申请人： Takashi Nishimura ,  Tsutomu Kano

发明人： Takashi Nishimura ,  Tsutomu Kano

IPC分类号： A61K39/00 ,  A61P35/00 ,  A61P37/02 ,  A61P31/00

CPC分类号： A61K36/287 ,  A61K2236/37

摘要： Disclosed is a novel use of superheated stream-treated material. Disclosed is an immune balance-regulating agent comprising a superheated steam-treated product of crown daisy (Chrysanthemum coronarium). This immune balance-regulating agent, which comprises, as the active ingredient, a superheated stream-treated product of crown daisy that has been used as a food for a long time, is a composition having a very high safety and exerting an effect of controlling and normalizing the immune balance of a living organism. The present invention has been completed based on the finding that the superheated steam-treated product of crown daisy has anti-infective and antitumor activities based on type-1 immune stimulating effect and, moreover, shows an effect of ameliorating allergic diseases, which are caused by excessive type 2 immune responses, by controlling immune balance.

摘要翻译： 公开了过热流处理材料的新用途。 公开了一种免疫平衡调节剂，其包含冠状菊花（菊花菊）的过热蒸汽处理产物。 该免疫平衡调节剂是作为有效成分的长时间用作食品的冠状雏菊的过热流处理物，是具有非常高的安全性并发挥控制作用的组合物 并使生物体的免疫平衡正常化。 基于以下发现，完成了本发明：冠状雏菊的过热蒸汽处理产品基于1型免疫刺激作用具有抗感染和抗肿瘤活性，此外，显示出改善过敏性疾病的作用， 通过过度的2型免疫反应，通过控制免疫平衡。

公开(公告)号：US08029418B2

公开(公告)日：2011-10-04

申请号：US13055678

申请日：2009-06-04

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： A63B22/02

CPC分类号： A63B22/0235 ,  A63B22/0023 ,  A63B2210/06 ,  A63B2230/06 ,  A63B2230/75

摘要： A partially-inlaid treadmill system includes a running deck, a wide belt assembled on two parallel rollers to slide over the running deck, side handrails, a panel for controlling and monitoring the treadmill system, a partition that separates a first part of the treadmill system positioned for access to the user from a second part of the treadmill system that includes mechanisms and electro-electronics for driving the belt, incline devices, belt lubrication, ventilation and regulating devices, an emergency control lever, a drawer, a plurality of directional ventilation openings, and an aisle provided on the same side of the partition as the second part of the treadmill for accessing components of the second part of the treadmill system.

摘要翻译： 部分镶嵌的跑步机系统包括行驶甲板，组装在两个平行辊上的宽带，以便在行驶甲板上滑动，侧扶手，用于控制和监测跑步机系统的面板，分隔第一部分跑步机系统 定位用于从跑步机系统的第二部分接近用户，该第二部分包括用于驱动皮带，倾斜装置，皮带润滑，通风和调节装置的机构和电子电器，应急控制杆，抽屉，多个定向通气 开口和通道，其设置在与跑步机的第二部分在隔板的同一侧上，用于进入跑步机系统的第二部分的部件。

公开(公告)号：US20110124466A1

公开(公告)日：2011-05-26

申请号：US13055678

申请日：2009-06-04

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： A63B22/02

CPC分类号： A63B22/0235 ,  A63B22/0023 ,  A63B2210/06 ,  A63B2230/06 ,  A63B2230/75

摘要： A partially-inlaid treadmill system includes a running deck, a wide belt assembled on two parallel rollers to slide over the running deck, side handrails, a panel for controlling and monitoring the treadmill system, a partition that separates a first part of the treadmill system positioned for access to the user from a second part of the treadmill system that includes mechanisms and electro-electronics for driving the belt, incline devices, belt lubrication, ventilation and regulating devices, an emergency control lever, a drawer, a plurality of directional ventilation openings, and an aisle provided on the same side of the partition as the second part of the treadmill for accessing components of the second part of the treadmill system.

摘要翻译： 部分镶嵌的跑步机系统包括行驶甲板，组装在两个平行辊上的宽带，以便在行驶甲板上滑动，侧扶手，用于控制和监测跑步机系统的面板，分隔第一部分跑步机系统 定位用于从跑步机系统的第二部分接近用户，该第二部分包括用于驱动皮带，倾斜装置，皮带润滑，通风和调节装置的机构和电子电器，应急控制杆，抽屉，多个定向通气 开口和通道，其设置在与跑步机的第二部分在隔板的同一侧上，用于进入跑步机系统的第二部分的部件。

公开(公告)号：US20110027303A1

公开(公告)日：2011-02-03

申请号：US12935761

申请日：2009-03-31

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： A61K39/00 ,  C07K7/08 ,  C07K14/00 ,  C12N15/12 ,  C12N15/63 ,  C07K16/18 ,  C12N5/0783 ,  A61K35/12 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4747 ,  C07K14/4748 ,  C12N5/0636 ,  C12N2501/998

摘要： The object aims to provide: a novel tumor antigen; a novel therapeutic agent useful in a method for treating a malignant neoplasm by utilizing the tumor antigen; and a tumor antigen which can be used as the therapeutic agent. Thus, disclosed are: a novel tumor antigen which has an epitope capable of inducing a Th1 cell which is a CD4-positive T cell specific to Survivin; and use of the tumor antigen. Specifically disclosed is a polypeptide which comprises an amino acid sequence depicted in SEQ ID NO:17 or the like and has an activity to cause the production of a cytokine by a Th cell that is a cell specific to Survivin. The peptide can induce a Th cell that is specific to Survivin and can cause the production of a cytokine by the Sur/Th cell when the peptide is incubated together with an antigen-presenting cell and a CD4-positive T cell.

摘要翻译： 目的是提供：一种新型肿瘤抗原; 可用于通过利用肿瘤抗原治疗恶性肿瘤的方法的新型治疗剂; 以及可用作治疗剂的肿瘤抗原。 因此，所公开的是：具有能够诱导作为对存活蛋白特异性的CD4阳性T细胞的Th1细胞的表位的新型肿瘤抗原; 并使用肿瘤抗原。 具体公开的是包含SEQ ID NO：17等所示的氨基酸序列的多肽，其具有通过作为Survivin特异性细胞的Th细胞产生细胞因子的活性。 当肽与抗原呈递细胞和CD4阳性T细胞一起孵育时，肽可以诱导存活蛋白特异性的Th细胞，并且可以通过Sur / Th细胞产生细胞因子。

公开(公告)号：US20100226095A1

公开(公告)日：2010-09-09

申请号：US12675549

申请日：2008-09-12

申请人： Kenji Mimura ,  Hideki Takigawa ,  Hiroki Shiota ,  Kazuhiro Tada ,  Takashi Nishimura ,  Hiromi Ito ,  Seiki Hiramatsu ,  Atsuko Fujino ,  Kei Yamamoto ,  Motoki Masaki

发明人： Kenji Mimura ,  Hideki Takigawa ,  Hiroki Shiota ,  Kazuhiro Tada ,  Takashi Nishimura ,  Hiromi Ito ,  Seiki Hiramatsu ,  Atsuko Fujino ,  Kei Yamamoto ,  Motoki Masaki

IPC分类号： H05K7/20 ,  F28F7/00 ,  B21D53/02

CPC分类号： H01L23/3737 ,  F28F2013/006 ,  H01L23/4334 ,  H01L23/49568 ,  H01L23/49575 ,  H01L24/29 ,  H01L24/45 ,  H01L24/48 ,  H01L2224/2929 ,  H01L2224/29386 ,  H01L2224/29499 ,  H01L2224/32245 ,  H01L2224/451 ,  H01L2224/48091 ,  H01L2224/48137 ,  H01L2224/48247 ,  H01L2224/48257 ,  H01L2924/01019 ,  H01L2924/181 ,  Y10T29/4935 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2924/00012

摘要： Provided is a heat conductive sheet obtained by dispersing an inorganic filler in a thermosetting resin, in which the inorganic filler contains secondary aggregation particles formed by isotropically aggregating scaly boron nitride primary particles having an average length of 15 μm or less, and the inorganic filler contains more than 20 vol % of the secondary aggregation particles each having a particle diameter of 50 μm or more. The heat conductive sheet is advantageous in terms of productivity and cost and excellent in heat conductivity and electrical insulating properties.

摘要翻译： 提供了一种通过将无机填料分散在热固性树脂中而获得的导热片，其中无机填料含有通过各向同性地聚集平均长度为15μm以下的鳞片状氮化硼一次粒子形成的二次凝集粒子，无机填料含有 大于20体积％的二次聚集粒子各自具有50μm以上的粒径。 导热片在生产率和成本方面是有利的，并且导热性和电绝缘性能优异。

公开(公告)号：US20090147369A1

公开(公告)日：2009-06-11

申请号：US11914251

申请日：2006-05-12

申请人： Kazunori Matsushita ,  Takashi Nishimura ,  Noritaka Tadano ,  Yutaka Ito

发明人： Kazunori Matsushita ,  Takashi Nishimura ,  Noritaka Tadano ,  Yutaka Ito

IPC分类号： G02B27/14

CPC分类号： G02B27/095 ,  G02B27/0977 ,  G02B27/144 ,  G02B27/145

摘要： A laser marking device (1) includes a laser light source (24) that emits a laser beam, and a beam splitter (230) receiving the laser beam and allowing a part of the laser beam to be reflected thereat and a remaining part of the laser beam to be transmitted therethorogh. The beam splitter (230) has an unpolarized film (233a, 233b) into which the laser beam is entered to divide the laser beam into a plurality of laser beams that travels in different directions, at a predetermined rate regardless of change of a polarized characteristic of the laser beam.

摘要翻译： 激光打标装置（1）包括发射激光束的激光光源（24）和接收激光束并使一部分激光束在其上反射的分束器（230），其余部分 激光束被传送到那里。 分束器（230）具有非偏光膜（233a，233b），其中进入激光束以将激光束分成以不同方向行进的多个激光束，以预定的速率与偏振特性的变化无关 的激光束。

公开(公告)号：US07509747B2

公开(公告)日：2009-03-31

申请号：US11635568

申请日：2006-12-08

申请人： Junichi Sudou ,  Takashi Nishimura ,  Takashi Odashima

发明人： Junichi Sudou ,  Takashi Nishimura ,  Takashi Odashima

IPC分类号： G01C5/00

CPC分类号： G01C15/004 ,  Y10S33/21

摘要： A laser level includes: a covering; a stand on which the covering is mounted; a laser unit provided in a space surrounded by the covering and the stand; and a radiation window, provided in the covering, through which a laser beam emitted from the laser unit is radiated to an exterior of the covering. The laser level includes removal means which removes moisture in the space.

摘要翻译： 激光水平包括：覆盖物; 安装盖的立场; 设置在被覆盖物和支架包围的空间中的激光单元; 以及设置在覆盖物中的辐射窗，激光单元发射的激光束通过该辐射窗辐射到覆盖物的外部。 激光水平包括去除空间中的水分的去除装置。

公开(公告)号：US07394771B2

公开(公告)日：2008-07-01

申请号：US10271585

申请日：2002-10-17

申请人： Daisuke Nakano ,  Kazuyuki Sumi ,  Takashi Nishimura ,  Yuji Ichikawa ,  Fumihiro Fukae

发明人： Daisuke Nakano ,  Kazuyuki Sumi ,  Takashi Nishimura ,  Yuji Ichikawa ,  Fumihiro Fukae

IPC分类号： H04L12/28 ,  H04B10/24

CPC分类号： H04B10/2503 ,  H04B10/0771 ,  H04B2210/075

摘要： In optical two-way communication using a single optical fiber, part of the light transmitted from an apparatus is received as stray light by the apparatus itself. This occasionally hampers accurate detection of disconnection from the partner apparatus and of the start of data communication by the partner apparatus after the establishment of connection. To overcome this, the timing with which an apparatus transmits a tone signal after the establishment of connection is compared with the timing with which the apparatus receives a tone signal from the partner apparatus, and the two apparatuses use different sets of data transmission properties (for example, different wavelengths) to accurately detect disconnection. Moreover, based on the properties of the received light and the characteristics of the receiving amplifier, repetition of the same code for longer than a predetermined period is detected to accurately detect disconnection. Furthermore, in response to a request for data communication after the establishment of connection, a tone signal having a different pattern from that used to establish connection is used to accurately detect the start of data communication.

摘要翻译： 在使用单个光纤的光学双向通信中，从设备发射的光的一部分被设备本身作为杂散光接收。 偶尔会妨碍对方设备断开连接的准确检测，以及对方设备建立连接后的数据通信开始。 为了克服这个原因，将在连接建立之后将设备发送音调信号的定时与设备从对方设备接收到音调信号的定时进行比较，并且两个设备使用不同的数据传输属性集（对于 例如，不同的波长）以精确地检测断开连接。 此外，基于接收光的特性和接收放大器的特性，检测出长于预定周期的相同代码的重复以精确地检测断开。 此外，响应于在建立连接之后的数据通信请求，使用具有与用于建立连接的模式不同的模式的音调信号来精确地检测数据通信的开始。

公开(公告)号：US20080149297A1

公开(公告)日：2008-06-26

申请号：US11795557

申请日：2006-02-01

申请人： Keiji Nakai ,  Tokumi Ikeda ,  Takahiro Hamada ,  Tsutomu Morikawa ,  Takashi Nishimura ,  Takuo Nakade

发明人： Keiji Nakai ,  Tokumi Ikeda ,  Takahiro Hamada ,  Tsutomu Morikawa ,  Takashi Nishimura ,  Takuo Nakade

IPC分类号： B22D11/00 ,  C22C18/02

CPC分类号： C23C2/00

摘要： The objective of the present invention is to provide a product that is superior in barrier properties (for example, zinc erosion resistance and anti-adhesive property), abrasion resistant property, surface hardening property, thermal stability and life-time prolonging property. The product, which is made in direct contact with molten metal containing zinc in a molten state, is characterized by including an iron-tungsten alloy coating that is applied to a part or the whole of the surface of the product that comes directly in contact with the molten metal.

摘要翻译： 本发明的目的是提供一种阻隔性（例如，耐锌侵蚀性和抗粘附性），耐磨损性，表面硬化性，热稳定性和使用寿命延长性优异的产品。 与熔融状态的含锌熔融金属直接接触的产品的特征在于包含铁 - 钨合金涂层，其被施加到直接接触的产品的部分或全部表面 熔融金属。