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221 条记录 (耗时 0.063 秒)

    Process for preparing difluoromethylpyrazolyl carboxylates
    92.
    发明申请
    Process for preparing difluoromethylpyrazolyl carboxylates 失效
    制备二氟甲基吡唑羧酸酯的方法

    公开(公告)号：US20100069646A1

    公开(公告)日：2010-03-18

    申请号：US12513003

    申请日：2007-11-02

    申请人： Martin Sukopp ,  Michael Rack ,  Sebastian Peer Smidt ,  Sandra Löhr ,  Michael Keil ,  Jochen Dietz ,  Joachim Rheinheimer ,  Thomas Grote ,  Thomas Zierke ,  Jan Klaas Lohmann

    发明人： Martin Sukopp ,  Michael Rack ,  Sebastian Peer Smidt ,  Sandra Löhr ,  Michael Keil ,  Jochen Dietz ,  Joachim Rheinheimer ,  Thomas Grote ,  Thomas Zierke ,  Jan Klaas Lohmann

    IPC分类号： C07D231/10 ,  C07F7/08

    CPC分类号： C07D231/14

    摘要： The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylates of the formula I in which R1 is C1-C8-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy-C1-C4-alkyl, etc.; and R2 is hydrogen, C1-C4-alkyl, benzyl or phenyl, wherein a) a compound of the general formula II in which X is fluorine, chlorine or bromine, R1 has one of the meanings given above and R4 is C1-C8-alkyl, C3-C8-cycloalkyl, C2-C8-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R3nSiCl(4-n) in which n is 1, 2 or 3 and the substituents R3 are independently of one another selected from the group consisting of C1-C8-alkyl and phenyl and with a metal selected from the metals of groups 1, 2, 3, 4 and 12 of the Periodic Table of the Elements having a redox potential of less than −0.7 V, based on a normal hydrogen electrode (at 25° C. and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula III R2HN—NH2   (III) in which R2 has one of the meanings given above.

    摘要翻译： 本发明涉及制备式Ⅰ的二氟甲基取代的吡唑-4-基羧酸酯的方法，其中R 1是C 1 -C 8烷基，C 3 -C 8环烷基，C 1 -C 4烷氧基-C 1 -C 4烷基等 。 并且R 2是氢，C 1 -C 4 - 烷基，苄基或苯基，其中a）通式II的化合物，其中X是氟，氯或溴，R 1具有上面给出的含义之一，R 4是C 1 -C 8 - 烷基，C 3 -C 8 - 环烷基，C 2 -C 8 - 烯基，苄基或苯基与通式R 3 n SiCl（4-n）的硅烷化合物反应，其中n为1,2或3，取代基R 3独立地为 选自由C 1 -C 8 - 烷基和苯基组成的组中的一种，以及选自元素周期表第1,2,3,4和12族金属的金属，其氧化还原电位小于-0.7 V，基于正常的氢电极（在25℃和101.325kPa）; 和b）将来自步骤a）的反应混合物与通式III的化合物R2HN-NH2（III）反应，其中R2具有上述含义之一。

    Method for Producing 5-Halo-2,4,6-Trifluoroisophthalic Acid
    97.
    发明申请
    Method for Producing 5-Halo-2,4,6-Trifluoroisophthalic Acid 审中-公开
    5-卤代-2,4,6-三氟间苯二甲酸的制备方法

    公开(公告)号：US20080146839A1

    公开(公告)日：2008-06-19

    申请号：US11908870

    申请日：2006-03-16

    申请人： Michael Rack ,  Sebastian Peer Smidt ,  Manuel Budich ,  Volker Maywald ,  Michael Keil ,  Bernd Wolf

    发明人： Michael Rack ,  Sebastian Peer Smidt ,  Manuel Budich ,  Volker Maywald ,  Michael Keil ,  Bernd Wolf

    IPC分类号： C07C63/70 ,  C07C25/13

    CPC分类号： C07C25/13 ,  C07C17/23 ,  C07C17/363 ,  C07C51/08 ,  C07C63/68

    摘要： The invention relates to a method for producing 5-halo-2,4,6-tifluoroisophthalic acid of formula (I), wherein X represents F, Cl, Br, or I, by hydrolysis of 5-halo-2,4,6-trifluoroisophthalodinitrile of formula (II). Said invention is characterised in that in a first step, isophthalodinitrile (II) or a solution containing isophthalodinitrile (II) is reacted with a concentrated sulphuric acid at room temperature in order to form a 5-halo-2,4,6-trifluoroisophthalodiamide of general formula (III), and is, subsequently, heated and in a second step, isophthalic acid (I) is produced after additional heating and addition of water.

    摘要翻译： 本发明涉及一种制备式（I）的5-卤代-2,4,6-三氟间苯二甲酸的方法，其中X代表F，Cl，Br或I，通过5-卤代-2,4,6 （II）的三氟间苯二腈。 本发明的特征在于，在第一步中，室温下将间苯二腈（II）或含有间苯二腈（II）的溶液与浓硫酸反应，以形成5-卤代-2,4,6-三氟间苯二甲酰胺， 通式（III），并且随后被加热，在第二步中，在另外加热和加入水之后产生间苯二甲酸（I）。

    Preparation of -4-thioalkybrobenzene derivatives
    99.
    发明授权
    Preparation of -4-thioalkybrobenzene derivatives 有权
    4-硫代烷基苯衍生物的制备

    公开(公告)号：US07301034B2

    公开(公告)日：2007-11-27

    申请号：US10332861

    申请日：2001-07-17

    申请人： Rene Lochtman ,  Michael Keil ,  Joachim Gebhardt ,  Michael Rack ,  Wolfgang von Deyn

    发明人： Rene Lochtman ,  Michael Keil ,  Joachim Gebhardt ,  Michael Rack ,  Wolfgang von Deyn

    IPC分类号： C07D261/04 ,  C07D261/08

    CPC分类号： C07D413/04 ,  C07C319/14 ,  C07D261/04 ,  C07C323/62

    摘要： A process for preparing 4-thioalkylbromobenzene derivatives of the formula I where: R1 is C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl, halogen, R2 is C1-C6-alkyl, C1-C6-alkoxy, C3-C8-cycloalkyl, C2-C6-alkenyl, cyano or a heterocyclic radical, R3 is C1-C6-alkyl, which comprises reacting a compound of the formula II, in which R1 and R2 are as defined above, with a dialkyl disulfide of the formula III R3—S—S—R3III in the presence of a nitrite and a catalyst in a suitable solvent is described.

    摘要翻译： 制备式I的4-硫代烷基溴苯衍生物的方法，其中：R 1是C 1 -C 6 - 烷基，C 1 -C 6 - C 1 -C 6 - 卤代烷基，C 1 -C 6 - 烷氧基，C 1 -C 6 - C 6 - 卤代烷氧基，C 3 -C 8 - 环烷基，卤素，R 2是C 1 -C 6烷基， C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，C 3 - C 8 - 环烷基，C 2 -C 6 - 烯基，氰基或杂环基，R 3是 C 1 -C 6 - C 6 - 烷基，其包括使式II化合物（其中R 1和R 2） / SUP>如上所定义，与式III的二烷基二硫化物<？in-line-formula description =“In-line Formulas”end =“lead”？> R 3 -SSR < 描述了在合适的溶剂中存在亚硝酸盐和催化剂的情况下，在实施例3中描述的“In-line-formula description =”In-Line Formulas“end =”tail“？>