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公开(公告)号:US4379920A
公开(公告)日:1983-04-12
申请号:US196525
申请日:1980-10-14
申请人: David Brown , Anthony F. Giles , Howard W. Cramer , H. Mary Noble , Louis J. Nisbet , Michael E. Bushell , Glenis Weare , Ian Y. Caldwell
发明人: David Brown , Anthony F. Giles , Howard W. Cramer , H. Mary Noble , Louis J. Nisbet , Michael E. Bushell , Glenis Weare , Ian Y. Caldwell
IPC分类号: C07D501/57 , C12P35/08 , A61K31/545
摘要: Cephamycin compounds of the formula (I) ##STR1## wherein R.sup.1 represents hydroxyl or sulphooxy and R.sup.2 represents sulphooxy together with derivatives thereof including salts, esters, N-protected derivatives and solvates thereof are disclosed. These compounds are of great value as intermediates in the preparation of other cephamycin compounds.The compounds of the invention may be isolated from fermentation broths of strains of the genus Streptomyces which produce the compounds and a new such strain is described. The isolation of the compounds may be achieved by a liquid/liquid or liquid/solid ion-exchange technique, and is preferably achieved by the formation of an ion-pair in a liquid/liquid technique.
摘要翻译: 公开了式(I)的头孢霉素化合物其中R 1表示羟基或磺酰氧基,R 2表示磺酰氧基及其衍生物,包括其盐,酯,N-保护的衍生物和溶剂合物。 这些化合物在制备其他头孢霉素化合物中作为中间体具有重要价值。 本发明的化合物可以从产生化合物的链霉菌属菌株的发酵液中分离出来,并且描述了一种新的这种菌株。 化合物的分离可以通过液体/液体/液体/固体离子交换技术来实现,并且优选通过在液体/液体技术中形成离子对来实现。
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公开(公告)号:US10919441B1
公开(公告)日:2021-02-16
申请号:US16601941
申请日:2019-10-15
申请人: Barrett Thompson , David Brown
发明人: Barrett Thompson , David Brown
摘要: A trailer marker system including side markers and a round marker is disclosed herein. The side markers are to extend along the side of a trailer or trailer vehicle. The side markers are elongated lights, while the round marker is a circular shaped light. The side markers and round marker illuminate the surroundings of a trailer vehicle for increased safety. Importantly, each of the side markers and rear marker include lights that face down towards the roadway. This results in road markings being illuminated as to allow a driver of the trailer vehicles to safely remain on the road. Additionally, the downward facing lights found in the side markers and the rear marker help to eliminate blind spots. Blind spots when making a turn or reversing the trailer are eliminated as they are illuminated in order to allow the driver to be safer when operating the trailer vehicle.
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公开(公告)号:US09813156B2
公开(公告)日:2017-11-07
申请号:US15033099
申请日:2014-10-30
申请人: TYCO ELECTRONICS UK LTD , TYCO ELECTRONICS CORPORATION , TYCO ELECTRONICS RAYCHEM BVBA , David Brown , David Mather , Robert Neil Shaddock , William Atley Weeks , Joris Franckx , Jan Jozef Julia Maria Erreygers
发明人: David Brown , David Mather , Robert Neil Shaddock , William Atley Weeks , Joris Franckx , Jan Jozef Julia Maria Erreygers
CPC分类号: H04B10/2504 , G02B6/3817 , H04B10/27 , H04B10/272 , H04Q11/0067
摘要: A hybrid service terminal for use in a passive fiber optic network comprises a plurality of optical fiber connectors, each coupled to a respective optical fiber for receiving downstream optical frames from an Optical Line Terminal (OLT); a plurality of hybrid fiber/copper connectors, each of the hybrid fiber/copper connectors coupled to a respective one of the plurality of optical fiber connectors; and a plurality of electrical connectors configured to receive electrical signals from a multi-line converter module over a respective one of a plurality of electrical conductors. One of the plurality of hybrid fiber/copper connectors is configured to provide the downstream optical frames to the multi-line converter module for conversion to the electrical signals. Each of the plurality of electrical connectors is coupled to a respective one of the plurality of hybrid fiber/copper connectors for providing the electrical signals over a respective metallic drop cable coupled to a respective network terminal at a corresponding customer premise.
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公开(公告)号:US09592197B2
公开(公告)日:2017-03-14
申请号:US11012267
申请日:2004-12-16
申请人: Viswanathan Srinivasan , Juan Carlos Menendez , Venkatesh Balasubramanian , Somphet Peter Suphasawud , Ralph Brown , David Brown
发明人: Viswanathan Srinivasan , Juan Carlos Menendez , Venkatesh Balasubramanian , Somphet Peter Suphasawud , Ralph Brown , David Brown
IPC分类号: A61K9/20 , A61K9/10 , A61K9/24 , A61K31/485 , A61K45/06
CPC分类号: A61K9/10 , A61K9/209 , A61K31/485 , A61K45/06 , A61K2300/00
摘要: A pharmaceutical dosage form which comprises diphenhydramine and/or a pharmaceutically acceptable salt thereof and at least one second drug. The dosage form provides a plasma concentration within the therapeutic range of the at least one second drug over a period which is coextensive with a substantial part of the period over which the dosage form provides a plasma concentration within the therapeutic range of diphenhydramine or salt thereof. This Abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.
摘要翻译: 包含苯海拉明和/或其药学上可接受的盐和至少一种第二种药物的药物剂型。 所述剂型在与所述剂型在苯海拉明或其盐的治疗范围内提供血药浓度的相当长的一段时间内共同延长的时期内提供至少一种第二药物的治疗范围内的血浆浓度。 本摘要既不旨在限定本说明书中公开的发明,也不旨在以任何方式限制本发明的范围。
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公开(公告)号:US20170065779A1
公开(公告)日:2017-03-09
申请号:US15119128
申请日:2015-02-20
申请人: David Brown
发明人: David Brown
CPC分类号: A61M15/0098 , A61M11/02 , A61M15/0003 , A61M15/003 , A61M15/0031 , A61M2202/064 , A61M2206/10 , A61M2209/06 , B05B11/062 , A61M2202/0007
摘要: The present invention discloses a method and device for dispersing powders and, in particular, to a method of dispersing inhaling powders in which a powder is positioned in a passage wherein the passage has one or more exits, one or more inlets and one or more obstructions to block the movement or to contain the powder within the device before use, whereupon a breaching pressure differential between the one or more exits and the one or more inlets of the passage is applied to breach the one or more obstructions so as to generate a flow through the passage which fully or partially aerosolizes the powder by means of the generated flow thus releasing a fully or partially aerosolized powder from the device.
摘要翻译: 本发明公开了一种分散粉末的方法和装置,特别是一种分散吸入粉末的方法,其中粉末定位在通道中,其中通道具有一个或多个出口,一个或多个入口和一个或多个障碍物 以阻止运动或在使用之前将粉末容纳在装置内,由此施加一个或多个出口与通道的一个或多个入口之间的破裂压力差以破坏一个或多个障碍物,从而产生流动 通过通过所述通道,其通过产生的流完全或部分地雾化粉末,从而从装置释放完全或部分雾化的粉末。
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公开(公告)号:US09388996B2
公开(公告)日:2016-07-12
申请号:US14261137
申请日:2014-04-24
申请人: Isaac Ray , David Brown , Igor Beyder
发明人: Isaac Ray , David Brown , Igor Beyder
CPC分类号: F24F9/00 , B03C3/16 , B03C3/41 , B03C2201/10 , Y02A50/2357
摘要: An improved HVAC system is provided for the delivery of a temperature controlled air supply via one or more air curtains provided at windows, doors and walls. The air curtains create a double layer of insulation over the surface of a window, door or wall. The invention provides for the use of the temperature controlled air flow from the air curtain to directly affect the interior room temperature. The invention provides an improved system for continuous cleaning the recycled air through the use of a wet electrostatic precipitator in the HVAC air flow, as well as providing a higher speed mode for the air curtain to prevent the inflow of particles and contaminants from outside of the building, when windows or doors are open. The invention may be installed on existing construction, or incorporated as part of new construction.
摘要翻译: 提供了一种改进的HVAC系统,用于通过设置在窗户,门和墙壁处的一个或多个气幕来传送温度控制的空气供应。 空气幕在窗户,门或墙壁的表面上形成双层绝缘。 本发明提供了使用来自气幕的温度控制的气流直接影响室内室温。 本发明提供了一种用于通过在HVAC空气流中使用湿式静电除尘器连续清洁再循环空气的改进系统,以及为气帘提供更高速度的模式,以防止颗粒和污染物从外部流入 当窗户或门打开时,建筑物。 本发明可以安装在现有的结构上,或作为新建筑的一部分。
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公开(公告)号:US09308164B2
公开(公告)日:2016-04-12
申请号:US10879506
申请日:2004-06-30
申请人: Viswanathan Srinivasan , Ralph Brown , David Brown , Himanshu Patel , Juan Carlos Menendez , Somphet Peter Suphasawud
发明人: Viswanathan Srinivasan , Ralph Brown , David Brown , Himanshu Patel , Juan Carlos Menendez , Somphet Peter Suphasawud
CPC分类号: A61K31/439 , A61K9/0095 , A61K9/209 , A61K31/46
摘要: A pharmaceutical dosage form which comprises two or more different hyoscyamine formulations, at least one of the formulations being an immediate release hyoscyamine formulation and at least one other one being a controlled release hyoscyamine formulation. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.
摘要翻译: 一种药物剂型,其包含两种或更多种不同的莨菪碱制剂,所述制剂中的至少一种是立即释放的莨菪碱制剂,并且至少一种其它制剂是受控释放的莨菪碱制剂。 该摘要既不旨在限定本说明书中公开的发明,也不旨在以任何方式限制本发明的范围。
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98.
公开(公告)号:US09211377B2
公开(公告)日:2015-12-15
申请号:US12846720
申请日:2010-07-29
申请人: Paul M. DiPerna , David Brown , Mike Rosinko , Dan Kincade , Michael Michaud , John Nadworny , Geoffrey A. Kruse , Thomas R. Ulrich
发明人: Paul M. DiPerna , David Brown , Mike Rosinko , Dan Kincade , Michael Michaud , John Nadworny , Geoffrey A. Kruse , Thomas R. Ulrich
IPC分类号: A61M5/142 , A61M5/14 , A61M5/315 , F04B53/14 , F16J15/32 , F16J15/56 , A61M5/168 , G06F3/0488
CPC分类号: A61M5/172 , A61M5/1413 , A61M5/14244 , A61M5/14248 , A61M5/16804 , A61M5/1723 , A61M5/31513 , A61M2005/14268 , A61M2205/3389 , A61M2205/50 , A61M2205/505 , A61M2205/52 , A61M2230/201 , A61M2230/63 , F04B43/113 , F04B53/143 , F16J15/32 , F16J15/56 , G06F3/0488 , G06F19/00 , G16H40/63
摘要: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.
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公开(公告)号:US08900627B2
公开(公告)日:2014-12-02
申请号:US12479747
申请日:2009-06-05
申请人: Lance Ford , David Brown , Andreas G. Bader
发明人: Lance Ford , David Brown , Andreas G. Bader
CPC分类号: A61K9/1075 , A61K9/0019 , A61K9/127 , A61K9/19 , A61K47/24 , A61K47/26 , A61K47/44 , A61K47/46
摘要: This application describes emulsion formulations containing neutral phospholipids for delivering RNAi, anti-miRNA, or aptamer agents in vivo. The application also relates to methods of making the formulations, and uses of the formulations as delivery agents.
摘要翻译: 本申请描述了含有用于在体内递送RNAi,抗miRNA或适体试剂的中性磷脂的乳剂制剂。 本申请还涉及制备制剂的方法和制剂作为递送剂的用途。
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公开(公告)号:US08735074B2
公开(公告)日:2014-05-27
申请号:US12870245
申请日:2010-08-27
申请人: Elizabeth Mambo , David Brown , Alex T. Adai , Tiffany Sanford , Stephanie Volz , Ashish Choudhary
发明人: Elizabeth Mambo , David Brown , Alex T. Adai , Tiffany Sanford , Stephanie Volz , Ashish Choudhary
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要: This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing lung disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as lung cancer.
摘要翻译: 该应用描述了可用作血清或血浆生物标志物的miRNA,用于表征患者的肺部疾病。 这些miRNA生物标志物可以单独使用或与其他标志物组合使用,用于诊断,预后或监测诸如肺癌的疾病。
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