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124 条记录 (耗时 0.051 秒)

    Nucleic acid molecules encoding cytostatin II
    91.
    发明授权
    Nucleic acid molecules encoding cytostatin II 失效
    编码细胞抑素II的核酸分子

    公开(公告)号：US06329169B1

    公开(公告)日：2001-12-11

    申请号：US09043646

    申请日：1998-09-09

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

    IPC分类号： C12P2102

    CPC分类号： G01N33/57415 ,  A61K38/00 ,  C07K14/475

    摘要： The invention relates to cytostatin II growth modulatory peptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications which are related, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及细胞抑制素II生长调节肽，编码多肽的多核苷酸，特别是通过表达多核苷酸产生多肽的方法，多肽的激动剂和拮抗剂。 本发明还涉及利用这些多核苷酸，多肽，激动剂和拮抗剂用于部分与研究，诊断和临床领域有关的应用的方法。

    Pancreas-derived plasminogen activator inhibitor
    92.
    发明授权
    Pancreas-derived plasminogen activator inhibitor 失效
    胰腺来源的纤溶酶原激活物抑制剂

    公开(公告)号：US06303338B1

    公开(公告)日：2001-10-16

    申请号：US09026408

    申请日：1998-02-19

    申请人： Jian Ni ,  Reiner L. Gentz ,  Steven M. Ruben ,  Y. Eric Shi

    发明人： Jian Ni ,  Reiner L. Gentz ,  Steven M. Ruben ,  Y. Eric Shi

    IPC分类号： C07N2100

    CPC分类号： C07K14/81 ,  A61K38/00 ,  A61K48/00 ,  C07K14/8132 ,  C07K2319/00 ,  Y02A50/463

    摘要： The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions, including breast cancer, and diagnostic methods for detecting pathologic disorders.

    摘要翻译： 本发明涉及纤溶酶原激活物抑制剂蛋白家族的新成员。 特别地，提供编码胰腺衍生的纤溶酶原激活物抑制蛋白的分离的核酸分子。 还提供了胰腺来源的纤溶酶原激活物抑制剂多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于治疗生理和病理疾病状况的方法，包括乳腺癌，以及用于检测病理障碍的诊断方法。

    Antibodies to human cystatin E
    93.
    发明授权
    Antibodies to human cystatin E 有权
    人类半胱氨酸蛋白酶抑制剂E的抗体

    公开(公告)号：US06300477B1

    公开(公告)日：2001-10-09

    申请号：US09241376

    申请日：1999-02-02

    申请人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    IPC分类号： C07K1618

    CPC分类号： C07K14/8139 ,  A61K38/00

    摘要： Disclosed are antibodies and antibody fragments that bind to novel human CysE polypeptides. Also provided are methods for producing the antibodies. Also disclosed are methods for utilizing such antibodies and antibody fragments for the purification and analysis of CysE polypeptides, as well as the diagnosis and treatment of CysE polypeptide associated diseases.

    摘要翻译： 公开了结合新的人CysE多肽的抗体和抗体片段。 还提供了用于产生抗体的方法。 还公开了利用这些抗体和抗体片段来纯化和分析CysE多肽的方法，以及CysE多肽相关疾病的诊断和治疗。

    CD44-like protein and nucleic acids
    94.
    发明授权
    CD44-like protein and nucleic acids 失效
    CD44样蛋白和核酸

    公开(公告)号：US5942417A

    公开(公告)日：1999-08-24

    申请号：US892880

    申请日：1997-07-15

    申请人： Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

    发明人： Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N15/74 ,  C12N15/79 ,  C12N15/00 ,  C07H21/04 ,  C07K1/00

    CPC分类号： C07K14/70585 ,  A61K38/00 ,  C12N2799/026

    摘要： The present invention concerns a novel CD44-like protein receptor. In particular, isolated nucleic acid molecules are provided encoding the CD44-like protein. CD44-like polypeptides are also provided, as are screening methods for identifying agonists and antagonists capable of enhancing or inhibiting CD44-like protein-mediated signaling. The invention further concerns therapeutic methods for treating diseases associated with processes mediated by CD44-like protein signaling.

    摘要翻译： 本发明涉及一种新型的CD44样蛋白受体。 特别地，提供编码CD44样蛋白质的分离的核酸分子。 还提供CD44样多肽，以及用于鉴定能够增强或抑制CD44样蛋白介导的信号传导的激动剂和拮抗剂的筛选方法。 本发明还涉及用于治疗与由CD44样蛋白信号传导介导的过程相关的疾病的治疗方法。

    Human cystatin F
    95.
    发明授权
    Human cystatin F 失效
    人类半胱氨酸蛋白酶抑制剂F

    公开(公告)号：US5919658A

    公开(公告)日：1999-07-06

    申请号：US832535

    申请日：1997-04-03

    申请人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

    发明人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

    IPC分类号： A61K38/00 ,  C07K14/81 ,  C12P21/06 ,  C07H21/04 ,  C12N5/00 ,  C12N15/00

    CPC分类号： C07K14/8139 ,  A61K38/00 ,  C07K2319/00

    摘要： The invention relates to cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及半胱氨酸蛋白酶抑制剂F多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

    Use of an antibody that binds human tumor necrosis factor receptor-like 2
    98.
    发明授权
    Use of an antibody that binds human tumor necrosis factor receptor-like 2 有权
    使用结合人类肿瘤坏死因子受体的抗体2

    公开(公告)号：US07824675B2

    公开(公告)日：2010-11-02

    申请号：US12241203

    申请日：2008-09-30

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    IPC分类号： A61K39/00 ,  A61K39/395

    CPC分类号： C07K16/2878 ,  C07K2317/73 ,  C07K2319/30

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。