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公开(公告)号：US20120158116A1
公开(公告)日：2012-06-21
申请号：US12969134
申请日：2010-12-15
CPC分类号： A61F2/958 , A61F2/915 , A61F2/962 , A61F2002/91575 , A61F2002/9522 , A61F2002/9583 , A61L31/02 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/416 , Y10T29/49826 , Y10T29/49888 , Y10T29/49913
摘要： A balloon disposed near a distal end of the catheter tubing and moving between deflated and inflated states, and proximal and distal stent retention bands concentrically arranged around respective proximal and distal end portions of the balloon. The proximal stent retention band has a distal end located within 2 mm of the proximal end of a stent coaxially received by the balloon and the distal stent retention band has a largest diameter within 2 mm of the distal end of the stent received by the balloon.
摘要翻译： 设置在导管管的远端附近并在放气和膨胀状态之间移动的气囊，以及同心地布置在气囊的相应近端部分和远端部分的近端和远端支架保持带。 近端支架保持带的远端位于由球囊同轴接收的支架的近端的2mm内，并且远侧支架保持带具有由球囊接收的支架远端的2mm内的最大直径。
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公开(公告)号：US08080052B2
公开(公告)日：2011-12-20
申请号：US10185250
申请日：2002-06-28
申请人： Robert Burgermeister , David C. Majercak , David R. Fischell , Hikmat Hojeibane , Robert E. Fischell
发明人： Robert Burgermeister , David C. Majercak , David R. Fischell , Hikmat Hojeibane , Robert E. Fischell
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2230/0013
摘要： The present invention envisions an improved flexible connecting link used in conjunction with in-phase and half-phase circumferential sets of strut members. By increasing the total length and diagonality of the undulating connecting links, the present invention is a stent that provides increased flexibility during delivery and enhanced conformability to the shape of a curved artery when the stent is deployed into a curved vessel such as a tortuous coronary artery.
摘要翻译： 本发明设想了一种改进的柔性连接链节，其与支柱构件的同相和半相周向组合一起使用。 通过增加起伏的连接链节的总长度和对角线，本发明是一种支架，其在输送期间提供增加的灵活性，并且当支架部署到诸如曲折冠状动脉的弯曲容器时对弯曲动脉的形状具有增强的适应性 。
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公开(公告)号：US08024028B2
公开(公告)日：2011-09-20
申请号：US12379627
申请日：2009-02-26
IPC分类号： A61B5/04
CPC分类号： A61N1/37235 , A61B5/0031 , A61B5/0452 , A61B5/0472 , A61B5/413 , A61N1/025 , A61N1/37247
摘要： Disclosed is a “tracker system” that includes implanted electrical leads which are part of an implanted cardiotracker plus external equipment that includes external alarm means and a physician's programmer. The tracker system is designed to monitor the degradation of a patient's cardiovascular condition from one or more causes. These causes include the rejection of a transplanted heart and/or the progression of a stenosis in a coronary artery. As one or more stenoses in a coronary artery become progressively more narrow thereby causing reduced blood flow to the heart muscle coronary circulation, the tracker system can alert the patient by either or both internal and/or external alarm means to take the appropriate medical action. The physician's programmer can be used to display histograms of key heart signal parameters that are indicative of the patient's cardiovascular condition.
摘要翻译： 公开了一种“跟踪器系统”，其包括植入的电引线，其是植入式心脏病治疗仪的一部分以及包括外部警报装置和医师程序员的外部设备。 跟踪器系统被设计成从一个或多个原因监测患者的心血管疾病的恶化。 这些原因包括移植心脏的排斥和/或冠状动脉狭窄进展。 由于冠状动脉中的一个或多个狭窄变得越来越窄，从而导致血液流向心脏肌肉冠状动脉循环的减少，所以跟踪器系统可以通过内部和/或外部报警装置中的一个或两个来警告患者以采取适当的医疗行动。 医师的程序员可用于显示指示患者心血管疾病的关键心脏信号参数的直方图。
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公开(公告)号：US06936065B2
公开(公告)日：2005-08-30
申请号：US10158714
申请日：2002-05-30
CPC分类号： A61F2/95 , A61F2/958 , A61M2025/0186 , A61M2025/1004
摘要： The present invention is a stent delivery system that uses short section of guidewire fixedly attached to the distal section of a balloon angioplasty catheter onto which a stent is co-axially mounted. By not having a guidewire that slides through the balloon of the balloon angioplasty catheter, the deflated balloon on which the stent is mounted can have a reduced diameter. Therefore, the outer diameter of the pre-deployed stent mounted onto that balloon is also minimized. This provides a smaller profile, i.e., a smaller outer diameter, for the stent. The time to perform a stent delivery procedure is reduced; a separate guidewire does not have to be placed prior to using the stent delivery system to place the stent at the site of a stenosis. Another embodiment of the present invention has a core wire that extends for nearly the entire length of the stent delivery system, the guidewire having different levels of stiffness for different portions of the core wire's length.
摘要翻译： 本发明是一种支架输送系统，其使用固定连接到气囊血管成形术导管的远侧部分的导线短段，支架同轴安装在该支架上。 通过不具有穿过球囊血管成形术导管的球囊的导丝，其上安装支架的放气球可具有减小的直径。 因此，安装在该球囊上的预先展开的支架的外径也被最小化。 这为支架提供了更小的外形，即较小的外径。 执行支架递送程序的时间减少; 在使用支架输送系统将支架置于狭窄部位之前，不必放置单独的导丝。 本发明的另一个实施例具有延伸到支架输送系统的整个长度的芯线，该导丝对于芯线长度的不同部分具有不同的刚度水平。
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95.发明授权System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes 有权用空间分离的检测和刺激电极控制癫痫发作的系统和方法公开(公告)号：US06597954B1
公开(公告)日：2003-07-22
申请号：US09724805
申请日：2000-11-28
IPC分类号： A61N136
CPC分类号： A61N1/0529 , A61B5/0002 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61M5/14276 , A61N1/0534 , A61N1/36064 , A61N1/36082 , G06F19/00
摘要： A system and method for controlling epilepsy and other neurological disorders by providing electrical stimulation to a patient's brain in response to detected neurological conditions. An implantable device includes a stimulation subsystem coupled to a stimulation electrode to provide responsive electrical brain stimulation in response to an event detected via an on-board processor's analysis of data received from a detection subsystem coupled to a detection electrode located in a different portion of the patient's brain.
摘要翻译： 一种通过响应于检测到的神经病症向患者的大脑提供电刺激来控制癫痫和其他神经障碍的系统和方法。 可植入装置包括耦合到刺激电极的刺激子系统，以响应于经由车载处理器对从耦合到位于所述第二部分的不同部分的检测电极的检测子系统接收的数据的分析而检测的事件来响应电脑刺激 病人的大脑
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公开(公告)号：US06459936B2
公开(公告)日：2002-10-01
申请号：US09932175
申请日：2001-08-17
IPC分类号： A61N118
CPC分类号： A61N1/36135 , A61N1/36017 , A61N1/36025 , A61N1/36064 , A61N1/36067 , A61N1/36075 , A61N1/37252
摘要： Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning means in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient. Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.
摘要翻译： 公开了一种用于治疗某些神经系统疾病如癫痫，偏头痛和帕金森病的多重电极闭环应答系统。 脑电极将放置在靠近脑部或脑组织深处。 当出现诸如癫痫发作的神经系统事件时，来自电极的EEG信号由控制模块中的信号调节装置处理，该控制模块可以放置在患者的头皮之下，患者的胸部内，或者位于病人的外部。 然后，控制模块中的神经事件检测装置将产生用于停止神经系统事件的响应。 响应可以是对脑电极或位于病人身体远端的电极的电信号。 该反应也可以是药物的释放或者诸如声音，光或机械振动或电刺激皮肤的感觉输入的应用。 对神经系统事件的反应可以来自患者内部或外部的装置。 该系统还具有在检测神经系统事件之前和之后发生的EEG相关信号的多通道记录的能力。 通过外部设备对系统的许多不同操作参数的可编程性提供了适应性，用于治疗表现不同症状的患者，并且对系统产生的反应有不同的反应。
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公开(公告)号：US06360122B1
公开(公告)日：2002-03-19
申请号：US09628977
申请日：2000-08-02
IPC分类号： A61B504
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/6814 , A61N1/36025 , A61N1/3605 , A61N1/36082 , A61N1/37211 , G06F19/00
摘要： Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient. Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.
摘要翻译： 公开了一种用于治疗某些神经系统疾病如癫痫，偏头痛和帕金森病的多重电极闭环应答系统。 脑电极将放置在靠近脑部或脑组织深处。 当出现诸如发作癫痫发作的神经系统事件时，来自电极的EEG信号通过控制模块中的信号调节进行处理，所述控制模块可以放置在患者的头皮之下，患者的胸部内，或位于患者的外部。 然后，控制模块中的神经事件检测装置将产生用于停止神经系统事件的响应。 响应可以是对脑电极或位于病人身体远端的电极的电信号。 该反应也可以是药物的释放或者诸如声音，光或机械振动或电刺激皮肤的感觉输入的应用。 对神经系统事件的反应可以来自患者内部或外部的装置。 该系统还具有在检测神经系统事件之前和之后发生的EEG相关信号的多通道记录的能力。 通过外部设备对系统的许多不同操作参数的可编程性提供了适应性，用于治疗表现不同症状的患者，并且对系统产生的反应有不同的反应。
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公开(公告)号：US06354299B1
公开(公告)日：2002-03-12
申请号：US09609086
申请日：2000-06-30
IPC分类号： A61B1900
CPC分类号： A61N1/37217 , A61N1/36025 , A61N1/36082 , A61N1/36135
摘要： An implantable device incorporating an acoustic transducer allows information and alerts to be communicated from the device to a patient. Sounds, including but not limited to buzzes, tones, sequences of tones, combinations of tones, complex sounds, and segments of reproduced or simulated human speech, are transmitted from an intracranially implanted portion of the device via bone conduction to the patient's ears, particularly the inner ears. In the disclosed embodiment, the acoustic transducer is used in cooperation with an implantable closed-loop system for the treatment of certain neurological disorders such as epilepsy, migraine headaches and Parkinson's disease, to warn the patient of an imminent seizure or other episode, to provide information to the patient on the state of the implantable apparatus, and to provide reminders and other information to the patient.
摘要翻译： 结合声学换能器的可植入装置允许将信息和警报从装置传送到患者。 特别是通过骨传导从设备的颅内植入部分发送声音，包括但不限于嗡嗡声，音调，音调序列，音调的组合，复合声音和再现或模拟人类语言的段 内耳。 在所公开的实施例中，声换能器与用于治疗某些神经障碍如癫痫，偏头痛和帕金森病的可植入闭环系统配合使用，以警告患者即将发作或其他发作，以提供 向患者提供关于植入式装置的状态的信息，并向患者提供提醒和其他信息。
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公开(公告)号：US06350226B1
公开(公告)日：2002-02-26
申请号：US09637999
申请日：2000-08-15
IPC分类号： A61N500
CPC分类号： A61N5/1029
摘要： Disclosed is a novel wound dressing which applies ionizing radiation to the surface of the wound as soon after the wound is created as is possible. Optimally, the radiation has a range which extends to the bottom surface of the skin but not significantly beyond that depth. An example of a radioactive source that can apply this type of radiation dosing is a beta particle emitting radioisotope such as phosphorous-32 which has a range of approximately 3.5 mm for 90% of the electrons that it emits. Even very small amounts of phosphorous-32 can provide a sufficiently high level of irradiation to significantly diminish scar tissue formation. The radioactive bandage would typically be an elongated flexible structure which can be applied along a wound or surgical incision. Typically, the radioactive bandage would extend for approximately 1 to 5 mm beyond the cut in all directions. The radioactive bandage would include a shield structure which surrounds the thin, elongated radioactive portion thus disallowing stray radiation outward from the patient's skin. A radiation dose applied to the top of the incision of between 500 and 2000 cGy can substantially reduce scar tissue formation for most patients.
摘要翻译： 公开了一种新颖的伤口敷料，其可以在伤口创建之后尽可能快地向伤口的表面施加电离辐射。 最佳地，辐射具有延伸到皮肤底部表面但不超过该深度的范围。 可以应用这种辐射剂量的放射源的一个例子是发射放射性同位素的β粒子，例如磷32，其发射的电子的90％具有大约3.5mm的范围。 甚至非常少量的磷32可以提供足够高的照射水平以显着减少瘢痕组织形成。 放射性绷带通常是可以沿着伤口或手术切口施用的细长柔性结构。 通常，放射性绷带将在所有方向上延伸超过切口约1至5毫米。 放射性绷带将包括围绕细长的放射性部分的屏蔽结构，从而不允许从患者皮肤向外的杂散辐射。 施加到切口顶部的辐射剂量在500和2000cGy之间可以大大减少大多数患者的瘢痕组织形成。
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100.发明授权Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes 有权用于EEG监测和电刺激与多个电极的集成系统公开(公告)号：US06230049B1
公开(公告)日：2001-05-08
申请号：US09373676
申请日：1999-08-13
IPC分类号： A61B0500
CPC分类号： A61B5/4094 , A61B5/0002 , A61B5/0476 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： The disclosed invention is an integrated system for EEG monitoring and electrical stimulation from a multiplicity of scalp or intracranial implanted electrodes. The system integrates EEG monitoring and brain stimulation, supports remote electrode selection for stimulation and provides a wireless connection between the patient's brain electrodes and the EEG analysis workstation used to collect EEG data, analyze EEG signals and control system functionality.
摘要翻译： 所公开的发明是用于从多个头皮或颅内植入电极进行脑电监测和电刺激的集成系统。 该系统集成了EEG监测和脑刺激，支持远程电极选择进行刺激，并提供患者脑电极与用于收集EEG数据的EEG分析工作站之间的无线连接，分析脑电信号和控制系统功能。
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