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338 条记录 (耗时 0.067 秒)

    PKIB and NAALADL2 for Target Genes of Prostate Cancer Therapy and Diagnosis
    91.
    发明申请
    PKIB and NAALADL2 for Target Genes of Prostate Cancer Therapy and Diagnosis 审中-公开
    PKIB和NAALADL2用于前列腺癌治疗和诊断的靶基因

    公开(公告)号：US20120022128A1

    公开(公告)日：2012-01-26

    申请号：US12674664

    申请日：2008-08-20

    申请人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

    发明人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

    IPC分类号： A61K31/713 ,  C12N15/63 ,  C12Q1/68 ,  A61P35/00 ,  C40B30/04 ,  C07K16/44 ,  C07K16/18 ,  G01N33/566 ,  C12N15/113 ,  G01N33/574

    CPC分类号： A61K31/70 ,  A61K48/00 ,  C07K14/47 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14

    摘要： The invention features methods for detecting prostate cancer, especially hormone-refractory prostate cancer (HRPC) or castration-resistant prostate cancer (CRPC), by detecting over-expression of PKIB or NAALADL2 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing prostate cancer including HRPC, based on the over-expression of PKIB or NAALADL2 in the prostate cancer, the cell proliferation function of PKIB or NAALADL2, the intracellular localization of PKIB or NAALADL2 or the interaction between PKIB and PKA-C. Also, provided are a method for treating prostate cancer by administering a double-stranded molecule against the PKIB or NAALADL2 gene. The invention also provides products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.

    摘要翻译： 本发明通过检测PKIB或NAALADL2的过表达来检测前列腺癌，特别是激素难治性前列腺癌（HRPC）或去势抗性前列腺癌（CRPC）的方法。 还公开了基于前列腺癌中PKIB或NAALADL2的过度表达，PKIB或NAALADL2的细胞增殖功能，PKIB或NAALADL2的细胞内定位或相互作用的鉴定，鉴定用于治疗和预防前列腺癌包括HRPC的化合物的方法 PKIB和PKA-C之间。 此外，提供了通过对PKIB或NAALADL2基因施用双链分子来治疗前列腺癌的方法。 本发明还提供了包括双链分子和编码它们的载体的产物，以及可用于所提供的方法中的包含分子或载体的组合物。

    ECT2 ONCOGENE AS A THERAPEUTIC TARGET AND PROGNOSTIC INDICATOR FOR LUNG AND ESOPHAGEAL CANCER
    94.
    发明申请
    ECT2 ONCOGENE AS A THERAPEUTIC TARGET AND PROGNOSTIC INDICATOR FOR LUNG AND ESOPHAGEAL CANCER 审中-公开
    ECT2 ONCOGENE作为肺癌和食管癌的治疗目标和预防指标

    公开(公告)号：US20110319280A1

    公开(公告)日：2011-12-29

    申请号：US13002977

    申请日：2009-07-16

    申请人： Yusuke Nakamura ,  Yataro Daigo ,  Akira Togashi

    发明人： Yusuke Nakamura ,  Yataro Daigo ,  Akira Togashi

    IPC分类号： C40B30/04 ,  G01N33/566 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57423 ,  G01N2800/50

    摘要： The invention features methods for detecting lung cancer or esophageal cancer, by detecting over-expression of ECT2 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing lung cancer or esophageal cancer, based on the over-expression of ECT2 in the lung cancer or esophageal cancer, the cell proliferation function of ECT2. Also, provided are a method for treating lung cancer or esophageal cancer by administering a double-stranded molecule against the ECT2 gene or an antibody against ECT2 protein. The invention also provides products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.

    摘要翻译： 本发明特征在于检测肺癌或食管癌的方法，通过检测ECT2与正常器官的过表达。 还公开了基于ECT2在肺癌或食管癌中的过表达，ECT2的细胞增殖功能，鉴定用于治疗和预防肺癌或食管癌的化合物的方法。 此外，提供了通过对ECT2基因施用双链分子或针对ECT2蛋白的抗体来治疗肺癌或食管癌的方法。 本发明还提供了包括双链分子和编码它们的载体的产物，以及可用于所提供的方法中的包含分子或载体的组合物。

    SHIFT CONTROL APPARATUS OF AUTOMATIC TRANSMISSION
    98.
    发明申请
    SHIFT CONTROL APPARATUS OF AUTOMATIC TRANSMISSION 有权
    自动变速箱换档控制装置

    公开(公告)号：US20110224878A1

    公开(公告)日：2011-09-15

    申请号：US13020847

    申请日：2011-02-04

    申请人： Yusuke Nakamura ,  Hiroyuki Sato

    发明人： Yusuke Nakamura ,  Hiroyuki Sato

    IPC分类号： F16H59/68

    CPC分类号： F16H61/66259 ,  F16H59/20 ,  F16H2061/0227

    摘要： There is provided a shift control apparatus of an automatic transmission in a vehicle including a constant speed traveling apparatus, which has a detecting device detecting a surrounding situation of the vehicle and operates according to the detected situation, and an automatic transmission capable of steplessly changing a transmission ratio, the shift control apparatus controlling the automatic transmission according to a shift map for changing the transmission ratio according to a traveling state. The shift control apparatus includes a plurality of shift maps, and a switching and selecting unit selecting and switching to one of the shift maps based on a shift-down request signal or a requested acceleration, which is outputted by a constant speed traveling control device of the constant speed traveling apparatus, according to the situation detected by the detecting device.

    摘要翻译： 本发明提供一种车辆中的自动变速器的变速控制装置，其包括：恒速行驶装置，其具有检测车辆的周围状况的检测装置，并根据检测到的情况进行动作;以及自动变速器，其能够无级变更 传动比，变速控制装置根据行驶状态根据用于改变传动比的换档图来控制自动变速器。 变速控制装置包括多个位移图，以及切换选择单元，基于由减速请求信号或所请求的加速度来选择和切换到其中一个换档图，所述减速请求信号或所请求的加速度由恒速行驶控制装置输出 恒速行驶装置，根据检测装置检测到的情况。

    Photographing apparatus and method, and program
    100.
    发明授权
    Photographing apparatus and method, and program 有权
    摄影装置及方法，程序

    公开(公告)号：US07899322B2

    公开(公告)日：2011-03-01

    申请号：US12554388

    申请日：2009-09-04

    申请人： Tomonori Masuno ,  Shinichiro Gomi ,  Masaru Suzuki ,  Yusuke Nakamura

    发明人： Tomonori Masuno ,  Shinichiro Gomi ,  Masaru Suzuki ,  Yusuke Nakamura

    IPC分类号： G03B13/10 ,  G03D13/00

    CPC分类号： H04N5/232 ,  G03B41/00 ,  H04N1/00183 ,  H04N5/23222 ,  H04N5/23293 ,  H04N2101/00

    摘要： A photographing apparatus includes the following elements. A photographing unit photographs an object. A position detecting unit detects the position of the photographing apparatus. A direction detecting unit detects the direction of the photographing apparatus when the object is photographed. An angle-of-view detecting unit detects the angle of view of the photographed image. A recommended-composition information obtaining unit obtains recommended-composition information including a recommended angle of view of the image photographed at the detected position and a recommended direction. An angle-of-view comparing unit compares the detected angle of view with the recommended angle of view. An angle-of-view adjusting unit adjusts the angle of view in accordance with the result of the comparison. A direction comparing unit compares the detected direction with the recommended direction. A presenting unit presents, in accordance with the result of the comparison, direction-change instruction information for instructing the direction of the photographing apparatus to be changed.

    摘要翻译： 摄影装置包括以下元件。 拍摄单元拍摄物体。 位置检测单元检测拍摄设备的位置。 方向检测单元在拍摄对象时检测拍摄装置的方向。 视角检测单元检测拍摄图像的视角。 推荐构图信息获取单元获取包括在检测位置拍摄的图像和推荐方向的推荐视角的推荐构图信息。 视角比较单元将检测到的视角与推荐的视角进行比较。 视角调整单元根据比较结果来调节视角。 方向比较单元将检测到的方向与推荐方向进行比较。 呈现单元根据比较结果呈现用于指示要改变拍摄设备的方向的方向改变指示信息。