公开(公告)号：US20130184272A1

公开(公告)日：2013-07-18

申请号：US13823915

申请日：2011-09-16

申请人： Masahiro Oka ,  Yukio Yamada

发明人： Masahiro Oka ,  Yukio Yamada

IPC分类号： A61K31/4162 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/4709

CPC分类号： A61K31/4162 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/5377 ,  C07D495/04

摘要： The problem of the present invention is to provide a compound useful for the prophylaxis or treatment of diseases related to the control of the differentiation of muscle cell or adipocyte differentiation, such as diabetes, obesity, dyslipidemia, and having a superior efficacy.The present invention provides an agent for the prophylaxis or treatment of diabetes, obesity or dyslipidemia, containing a compound represented by the formula (I) wherein each symbol is as defined in the DESCRIPTION, or a salt thereof or a prodrug thereof.

摘要翻译： 本发明的问题在于提供一种可用于预防或治疗与控制肌肉细胞或脂肪细胞分化如糖尿病，肥胖，血脂异常并具有优异功效的分化有关的疾病的化合物。 本发明提供一种预防或治疗糖尿病，肥胖症或血脂异常的药剂，其含有由式（I）表示的化合物，其中每个符号如说明书中所定义，或其盐或其前药。

公开(公告)号：US20120055703A1

公开(公告)日：2012-03-08

申请号：US13242712

申请日：2011-09-23

申请人： Tomoyuki Ishimatsu ,  Yukio Yamada

发明人： Tomoyuki Ishimatsu ,  Yukio Yamada

IPC分类号： H05K1/09 ,  H05K3/10

CPC分类号： H05K3/361 ,  H05K3/28 ,  H05K3/323 ,  H05K2201/09154 ,  H05K2201/099 ,  Y10T29/49117 ,  Y10T29/49126 ,  Y10T29/4913 ,  Y10T29/49144 ,  Y10T29/49155

摘要： A method for producing a joined structure, containing: after placing an anisotropic conductive film in the predetermined manner, placing a wiring member containing a wiring plate formed thereon, where the wiring plate has a resist region in which the wiring plate is covered with a resist layer, and a second electrode region in which the wiring plate is not covered with the resist layer, so that the edge of the resist region at a boundary with the second electrode region comes above the chamfer part of the substrate; and heating and compressing the anisotropic conductive film from the side of the wiring member to melt and make the anisotropic conductive film flow into the side of the resist region to thereby cover the second electrode region with the anisotropic conductive film, so as to electrically connect the first electrode region and the second electrode region.

摘要翻译： 一种接合结构体的制造方法，其特征在于，具有：在以规定的方式配置各向异性导电膜之后，配置包含布线板的配线构件，所述布线构件具有在所述布线板被抗蚀剂覆盖的抗蚀剂区域 以及布线板未被抗蚀剂层覆盖的第二电极区域，使得与第二电极区域的边界处的抗蚀剂区域的边缘位于基板的倒角部分的上方; 并且从布线部件的侧面加热和压缩各向异性导电膜以熔化，使各向异性导电膜流入抗蚀剂区域的侧面，从而利用各向异性导电膜覆盖第二电极区域，从而将 第一电极区域和第二电极区域。

公开(公告)号：US20120017842A1

公开(公告)日：2012-01-26

申请号：US13146921

申请日：2010-02-01

申请人： Yukio Yamada ,  Hitoshi Shimizu ,  Takeshi Kimura

发明人： Yukio Yamada ,  Hitoshi Shimizu ,  Takeshi Kimura

IPC分类号： A01K1/03 ,  G01N21/01 ,  G01J3/44

CPC分类号： G01N21/01 ,  A01K1/0613 ,  A46D3/00 ,  A61B5/0071 ,  A61B5/0073 ,  A61B2503/40 ,  A61B2560/06 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/1787 ,  G01N2021/651

摘要： A measurement object holder that holds a measurement object in an optical measurement instrument, wherein the optical measurement instrument takes, as the measurement object, a living body in which isotropic scattering of light occurs inside and receives light emitted from the measurement object is disclosed. The measurement object holder includes a block that is formed in a predetermined outer shape by a material having optical properties in which the isotropic scattering of light occurs inside; and a cavity portion that is formed inside the block, that has an inner shape following the outer shape of the measurement object and in which the measurement object is accommodated.

摘要翻译： 本发明公开了一种将测量对象保持在光学测量仪器中的测量对象保持器，其中所述光学测量仪器作为所述测量对象，将生物体作为测量对象的内部发生光的各向同性散射并接收从测量对象发射的光。 测量对象保持器包括通过具有光学特性的材料形成为预定的外部形状的块，其中发生光的各向同性散射; 以及形成在所述块内的空腔部，所述空腔部具有与所述测量对象的外部形状相邻并且容纳所述测量对象的内部形状。

公开(公告)号：US20110271906A1

公开(公告)日：2011-11-10

申请号：US13145949

申请日：2010-04-12

申请人： Yukio Yamada

发明人： Yukio Yamada

IPC分类号： B05B5/04 ,  B05B5/03

CPC分类号： B05B5/0535 ,  B05B3/1064 ,  B05B5/0403 ,  B05B5/0407 ,  B05B5/0426 ,  B05B5/0533 ,  B05B5/057 ,  B05B15/50

摘要： A rotary atomizing head is mounted on a fore end side of a motor. A shaping air ring having a plurality of air outlet holes at fixed intervals is provided on a rear side of the rotary atomizing head. Outer surfaces of the air motor and outer surfaces of the shaping air ring are enshrouded over the entire circumference by a cover member formed of an electrically insulating material. An external electrode assembly is provided radially outwardly of the cover member. An annular projecting portion which projects forward is provided on the shaping air ring over the entire circumference. The air outlet holes are open in a fore distal end of this annular projecting portion. As a result, a corona discharge can be generated by allowing an electric field to be concentrated at the fore distal end of the annular protecting portion.

摘要翻译： 旋转雾化头安装在电动机的前端侧。 在旋转雾化头的后侧设有具有固定间隔的多个排气孔的整形空气环。 气动马达的外表面和成形气环的外表面通过由电绝缘材料形成的盖构件在整个圆周上被遮蔽。 外部电极组件设置在盖构件的径向外侧。 在整个圆周上的成形用空气环上设置有向前方突出的环状的突出部。 排气孔在该环状突出部的前端部开口。 结果，可以通过允许电场集中在环形保护部分的前远端处来产生电晕放电。

公开(公告)号：US20100282865A1

公开(公告)日：2010-11-11

申请号：US12811127

申请日：2009-05-21

申请人： Yukio Yamada

发明人： Yukio Yamada

IPC分类号： B05B15/06

CPC分类号： B05B3/1042 ,  B05B3/1064 ,  B05B5/0407 ,  F16D1/076 ,  F16D1/108

摘要： A rotation restricting mechanism is provided between a mounting shaft section of a rotational shaft and a mounting tube section of a rotary atomizing head. The rotation restricting mechanism includes a male spline member provided on the outer peripheral side of the mounting shaft section, and a female spline member provided on the inner peripheral side of the mounting tube section. By meshing engagement of the male spline member with the female spline member, the rotation restricting mechanism restricts rotational displacements of the rotary atomizing head relative to the rotational shaft.

摘要翻译： 旋转限制机构设置在旋转轴的安装轴部和旋转雾化头的安装管部之间。 旋转限制机构包括设置在安装轴部的外周侧的阳花键部件和设置在安装管部的内周侧的内花键部件。 通过将阳花键构件与雌花键构件啮合，旋转限制机构限制旋转雾化头相对于旋转轴的旋转位移。

公开(公告)号：US20100206225A1

公开(公告)日：2010-08-19

申请号：US12676460

申请日：2008-10-09

申请人： Yukio Yamada

发明人： Yukio Yamada

IPC分类号： B05B5/04

CPC分类号： B05B5/0535 ,  B05B5/0407 ,  B05B5/0426

摘要： An atomizer (2) with a rotary atomizing head (4) is mounted on the front side of a housing member (6) in which an air motor (3) is accommodated. A primary external electrode (8) is located around the outer peripheral side of the housing member (6) in such a way as to encircle the housing member (6). A secondary external electrode (10) is located on the front side of the housing member (6), in a position closer to the rotary atomizing head (4) than the primary external electrode (8). A first high voltage (V1) in the form of a direct-current voltage is supplied to the primary external electrode (8) from a first high voltage generator (11). On the other hand, a second high voltage (V2), in the form of a pulsating voltage (V2p) consisting of a series of intermittent pulses in a range lower than the first high voltage (V1), is supplied to the secondary external electrode (10) from a second high voltage generator (12).

摘要翻译： 具有旋转雾化头（4）的雾化器（2）安装在容纳有气动马达（3）的壳体（6）的前侧。 主外部电极（8）以包围壳体（6）的方式围绕壳体构件（6）的外周侧定位。 第二外部电极（10）位于壳体部件（6）的前侧，位于比第一外部电极（8）更靠近旋转雾化头（4）的位置。 直流电压形式的第一高电压（V1）从第一高电压发生器（11）提供给初级外部电极（8）。 另一方面，由低于第一高电压（V1）的一系列间歇脉冲构成的脉动电压（V2p）形式的第二高电压（V2）被提供给二次外部电极 （10）从第二高压发生器（12）。

公开(公告)号：US07661610B2

公开(公告)日：2010-02-16

申请号：US11916499

申请日：2006-05-31

申请人： Yukio Yamada

发明人： Yukio Yamada

IPC分类号： B05B5/025 ,  B05B5/04 ,  B05B3/10 ,  B05C5/00

CPC分类号： B05B5/0533 ,  B05B5/04 ,  B05B5/0415 ,  B05B5/0426 ,  B05B15/50

摘要： An atomizer including an air motor and a rotary atomizing head, mounted in a front side of a housing member, while a high voltage generator applying a high voltage to paint through the air motor is mounted in a rear side of the housing member. A cover member is fitted on the housing member to cover an outer surface of the housing member. Opposite axial ends of the cover member are fitted on and attached to opposite axial ends of the housing member so as to leave an annular gap space between the cover member and the housing member. The annular gap space keeps almost entire radially confront areas of the cover member and the housing member, preventing high voltage electrostatic charges on the outer surfaces of the cover member from leaking through the housing member.

摘要翻译： 包括安装在壳体构件的前侧的空气马达和旋转雾化头的雾化器安装在壳体构件的后侧，同时通过空气马达施加高电压来涂漆的高压发生器。 盖构件安装在壳体构件上以覆盖壳体构件的外表面。 盖构件的相对的轴向端部装配并且附接到壳体构件的相对的轴向端部，以便在盖构件和壳体构件之间留下环形间隙空间。 环形间隙保持盖构件和壳体构件的几乎整个径向对向的区域，防止盖构件的外表面上的高压静电电荷泄漏通过壳体构件。

公开(公告)号：US07553454B2

公开(公告)日：2009-06-30

申请号：US11751793

申请日：2007-05-22

申请人： Yukio Yamada ,  Naoto Kakuta ,  Taisuke Hirono

发明人： Yukio Yamada ,  Naoto Kakuta ,  Taisuke Hirono

IPC分类号： B01L3/00 ,  B01L3/02 ,  B81B1/00

CPC分类号： B01L3/502776 ,  B01L2200/0636 ,  B01L2200/143 ,  B01L2300/0816 ,  B01L2400/0487 ,  B01L2400/0622

摘要： Buffer solution and blood are streamed in a channel of a micro chip so as to form layers. Aggregation inducing agent for aggregating platelets in blood is coated at a wall face on a buffer solution streaming side. If streaming amount of blood is increased in this state, a layer width of blood can be increased, and detail analysis between the aggregation inducing agent and the platelets is possible thereby. Even if it is necessary to take an image or a moving image for comparison between a pre-aggregation state and an aggregation state, it is sufficient to take only a portion where the aggregation inducing agent is coated, that is, a reaction portion. Then, a device can be made cheaper without two cameras or a moving mechanism for the camera or a micro chip.

摘要翻译： 缓冲溶液和血液在微芯片的通道中流动以形成层。 用于聚集血液中血小板的聚集诱导剂在缓冲溶液流动侧的壁面上被涂覆。 如果在这种状态下血液流量增加，则可以增加血液层的宽度，从而能够进行聚集诱导剂与血小板的细节分析。 即使在预聚合状态和聚集状态之间需要拍摄图像或运动图像进行比较，只需要仅涂覆聚集诱导剂的部分即反应部分即可。 然后，如果没有两个相机或用于相机或微芯片的移动机构，则可以使设备更便宜。

公开(公告)号：US20090110361A1

公开(公告)日：2009-04-30

申请号：US12285118

申请日：2008-09-29

申请人： Yukio Yamada

发明人： Yukio Yamada

IPC分类号： G02B6/44

CPC分类号： G02B6/444 ,  G02B6/4471

摘要： An optical termination unit is provided for allowing an optical cable to be easily projected straight in any of five directions, including upward, downward, rightward, leftward, and rearward directions, thereby enhancing the efficiency of cable laying or the like. An end securing box 150 of the optical termination unit 100 includes a two-stage multi-tiered box structure separable to two bodies, the first stage including a clamp tray 120 and the second stage including a fusion tray 130 which is provided with a lid (lid 140) thereupon. An inlet Im (m=1, 2, 3, 4, 5) for introducing the end of a second optical cable to be embedded in a wall or a pillar is provided at each face of the enclosure. Holes H1 and H2 formed on the rear face 115 are provided for securing the end securing box 150 with a nylatch n. The end securing box 150 having a rectangular solid shape has multiple holes formed therein. This allows the end securing box 150 to be secured to a rear face 115 so as to be arbitrarily oriented on a right angle basis.

摘要翻译： 提供一种光学终端单元，用于允许光缆在包括向上，向下，向右，向左和向后方向的五个方向上的任何方向上容易地投影直线，从而提高电缆敷设等的效率。 光学终端单元100的端部固定盒150包括可分离到两个主体的两级多层盒结构，第一级包括夹具托盘120，第二级包括设置有盖的融合托盘130（ 盖140）。 在外壳的每个表面上设置用于引入待嵌入墙壁或支柱的第二光缆的端部的入口Im（m = 1,2,3,4,5）。 形成在后表面115上的孔H1和H2被设置用于将端部固定箱150固定在螺母n上。 具有矩形实心形状的端部固定盒150具有形成在其中的多个孔。 这使得端部固定盒150固定到后表面115，以便以直角为基础任意定向。

公开(公告)号：US20090026293A1

公开(公告)日：2009-01-29

申请号：US11908425

申请日：2006-05-31

申请人： Yukio Yamada ,  Tatsunori Imanishi

发明人： Yukio Yamada ,  Tatsunori Imanishi

IPC分类号： B05B5/00

CPC分类号： B05B5/0533 ,  B05B5/04 ,  B05B5/0415 ,  B05B5/0426 ,  B05B15/50

摘要： An atomizer (1) which is composed of an air motor (2) and a rotary atomizing head (3) is mounted in a front side of a housing member (9), outer surfaces (9A) of which are covered in a cover member (10). Further, a high voltage discharge electrode assembly (15) is provided around a front side of the housing member (9), with outer periphery of the cover member (10) circumvented by a blade ring (17) of the high voltage discharge electrode assembly (15). An edge portion (19) in the shape of a thin blade is provided at a projected rear end of the blade ring (17). Thus, electric field is concentrated at the edge portion (19) to induce a corona discharge on and around entire blade ring (17).

摘要翻译： 由空气马达（2）和旋转雾化头（3）组成的雾化器（1）安装在壳体（9）的前侧，其外表面（9A）被覆盖在盖构件 （10）。 此外，高压放电电极组件（15）围绕外壳构件（9）的前侧设置，盖构件（10）的外周由高压放电电极组件的叶片环（17）围绕 （15）。 在叶片环（17）的突出的后端设置有薄叶片形状的边缘部分（19）。 因此，电场集中在边缘部分（19）处，以在整个叶片环（17）上和周围引起电晕放电。