公开(公告)号：US06228866B1

公开(公告)日：2001-05-08

申请号：US09524255

申请日：2000-03-13

申请人： Naoyuki Taniguchi ,  Kaoru Kobayashi ,  Masao Naka

发明人： Naoyuki Taniguchi ,  Kaoru Kobayashi ,  Masao Naka

IPC分类号： A61K31435

CPC分类号： C07D221/04 ,  C07D221/20

摘要： A compound represented by formula (I): wherein all symbols are defined in the specification, or an acid addition salt thereof or a hydrate thereof; a process for preparing the same; and a nitrogen monoxide synthase inhibitor comprising the same as an active ingredient.

摘要翻译： 由式（I）表示的化合物：其中所有符号在说明书中定义，或其酸加成盐或其水合物; 其制备方法; 和含有该活性成分的一氧化氮合酶抑制剂。

公开(公告)号：US5789605A

公开(公告)日：1998-08-04

申请号：US759817

申请日：1996-12-03

申请人： Amos B. Smith, III ,  Yuping Qiu ,  Michael Kaufman ,  Hirokaza Arimoto ,  David R. Jones ,  Kaoru Kobayashi

发明人： Amos B. Smith, III ,  Yuping Qiu ,  Michael Kaufman ,  Hirokaza Arimoto ,  David R. Jones ,  Kaoru Kobayashi

IPC分类号： C07D303/16 ,  A61K31/047 ,  A61K31/12 ,  A61K31/27 ,  A61K31/336 ,  A61K31/351 ,  A61K31/366 ,  A61K31/422 ,  A61K31/427 ,  A61K31/5355 ,  A61K31/7028 ,  A61P35/00 ,  A61P37/06 ,  C07C239/06 ,  C07D263/22 ,  C07D309/10 ,  C07D309/30 ,  C07D309/32 ,  C07D319/06 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07F7/18 ,  C07H23/00 ,  C07D407/06

CPC分类号： C07D413/12 ,  C07C239/06 ,  C07D263/22 ,  C07D309/30 ,  C07D319/06 ,  C07F7/1892

摘要： Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.

公开(公告)号：US5526136A

公开(公告)日：1996-06-11

申请号：US170030

申请日：1993-12-20

申请人： Hirofumi Hisikura ,  Ryo Hirayama ,  Kaoru Kobayashi

发明人： Hirofumi Hisikura ,  Ryo Hirayama ,  Kaoru Kobayashi

IPC分类号： H04N5/783 ,  H04N5/923 ,  H04N5/937 ,  H04N9/793 ,  H04N9/81 ,  H04N5/76 ,  H04N5/213 ,  H04N5/78

CPC分类号： H04N9/7936 ,  H04N5/923 ,  H04N5/937 ,  H04N9/81 ,  H04N5/783

摘要： An image is stably reproduced in a special reproduction mode of still, frame advance or slow motion mode without residual image and/or blur. A video signal reproducing apparatus operates to alternately repeat the steps of interrupting a de-emphasizing process at a time at which the de-emphasis process for one video image signal period is completed, holding a content of a frame memory constituting the de-emphasis circuit without refreshing the content and performing a de-emphasis process based the content of the memory during a subsequent video image signal period.

摘要翻译： 图像以静止，帧提前或慢动作模式的特殊再现模式被稳定再现，没有残留图像和/或模糊。 视频信号再现装置操作以交替重复在一个视频信号周期的去加重处理完成时中断去加重处理的步骤，保持构成去加重电路的帧存储器的内容 而不刷新内容并且在随后的视频图像信号周期期间基于存储器的内容执行去加重处理。

公开(公告)号：US5409815A

公开(公告)日：1995-04-25

申请号：US311556

申请日：1989-02-16

申请人： Yukimitsu Nakagawa ,  Naofumi Hayasuke ,  Atsushi Masaki ,  Yutaka Ishida ,  Kohji Murakami ,  Ken Okabayashi ,  Kiyoshi Tsutsui ,  Hitoshi Minamino ,  Kazuo Ikegaya ,  Kaoru Kobayashi ,  Haruhide Kawabe ,  Sadao Ueda

发明人： Yukimitsu Nakagawa ,  Naofumi Hayasuke ,  Atsushi Masaki ,  Yutaka Ishida ,  Kohji Murakami ,  Ken Okabayashi ,  Kiyoshi Tsutsui ,  Hitoshi Minamino ,  Kazuo Ikegaya ,  Kaoru Kobayashi ,  Haruhide Kawabe ,  Sadao Ueda

IPC分类号： C12N15/09 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/705 ,  C07K14/765 ,  C07K19/00 ,  C12N1/16 ,  C12N15/62 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  C12P21/06 ,  C07H21/04

CPC分类号： C12N15/81 ,  C07K14/765 ,  C12N15/625 ,  C07K2319/02 ,  C07K2319/55 ,  C07K2319/61

摘要： Novel signal peptides capable of functioning in yeasts have the amino acid sequence:Met-A.sub.1 -A.sub.2 -X-B-C-D-E-Fwherein A.sub.1 is a peptide chain composed of 1-3 amino acids each selected from the group consisting of Arg, Ser, Lys and His, A.sub.2 is a peptide chain composed of 1-3 amino acids, X is a peptide chain composed of 8-10 hydrophobic amino acids, B is Pro or Ser, C is Gly or Pro, D Cys, Ala, Leu, Ser, Thr and Val, E is Trp or Gln and F is Ala or Gly. DNA sequences coding for these signal peptides can be used for the secretory expression of heterologous proteins in yeasts.

摘要翻译： 能够在酵母中起作用的新型信号肽具有氨基酸序列：Met-A1-A2-XBCDEF，其中A1是由1-3个氨基酸组成的肽链，每个氨基酸选自Arg，Ser，Lys和His，A2 是由1-3个氨基酸组成的肽链，X是由8-10个疏水性氨基酸组成的肽链，B是Pro或Ser，C是Gly或Pro，D Cys，Ala，Leu，Ser，Thr和Val ，E是Trp或Gln，F是Ala或Gly。 编码这些信号肽的DNA序列可用于酵母中异源蛋白质的分泌表达。

公开(公告)号：US5352849A

公开(公告)日：1994-10-04

申请号：US708480

申请日：1991-05-31

申请人： Kaoru Kobayashi

发明人： Kaoru Kobayashi

IPC分类号： G10H1/00 ,  G10H5/00 ,  G10H7/00 ,  G10H7/08 ,  G10H5/02

CPC分类号： G10H5/007 ,  G10H2250/451 ,  G10H2250/515 ,  G10H2250/521 ,  Y10S84/10

摘要： A musical tone synthesizing apparatus is designed to simulate a physical phenomenon of a non-electronic musical instrument providing a sound generating element and an activating element. Herein, the sound generating element has its specific resonance characteristic, while the activating element imparts an excitation vibration to the sound generating element. This apparatus contains a plurality of loop circuits each including at least one delay element, wherein these loop circuits are connected together such that a signal picked up from one loop circuit is introduced into another loop circuit. This signal circulating through each loop circuit is delayed by a delay time which is controlled by a predetermined parameter corresponding to a desirable musical tone to be generated. In addition, an excitation signal, corresponding to the excitation vibration, is applied to at least one of the loop circuits. Preferably, the non-electronic musical instrument is a piano, so that the sound generating element is a string and the activating element is a hammer which strikes the string. Further, number of the loop circuits is set corresponding to the number of strings to be provided with respect to each key of the piano.

摘要翻译： 音乐合成装置被设计为模拟提供声音产生元件和激活元件的非电子乐器的物理现象。 这里，发声元件具有其特定的共振特性，而激活元件向声音发生元件施加激励振动。 该装置包括多个环路电路，每个环路电路包括至少一个延迟元件，其中这些环路电路连接在一起，使得从一个环路电路拾取的信号被引入到另一个环路电路中。 通过每个环路循环的该信号被延迟延迟时间，该延迟时间由对应于要产生的期望音调的预定参数控制。 此外，对应于激励振动的激励信号被施加到至少一个回路电路。 优选地，非电子乐器是钢琴，使得声音产生元件是琴弦，激活元件是撞击弦的锤子。 此外，环路电路的数量对应于要提供的琴弦数量相对于钢琴的每个琴键。

公开(公告)号：US4945046A

公开(公告)日：1990-07-31

申请号：US57143

申请日：1987-06-03

申请人： Hajime Horii ,  Haruhide Kawabe ,  Hirofumi Arimura ,  Hiromichi Mukai ,  Kaoru Kobayashi ,  Muneo Tsujikawa ,  Masayuki Nishida ,  Tadakazu Suyama

发明人： Hajime Horii ,  Haruhide Kawabe ,  Hirofumi Arimura ,  Hiromichi Mukai ,  Kaoru Kobayashi ,  Muneo Tsujikawa ,  Masayuki Nishida ,  Tadakazu Suyama

IPC分类号： C07K14/02 ,  C12N15/81

CPC分类号： C07K14/005 ,  C12N15/81 ,  C12N2730/10122

摘要： A method of producing a heterologous protein in yeast is disclosed, which comprises transforming a yeast Saccharomyces cerevisiae with recombinant DNA comprising a promoter selected from the group consisting of a yeast promoter or a hybrid promoter derived from a yeast promoter, particularly a hybrid promoter containing the enhancer region of SV40 virus, and a gene coding for a heterologous protein such as HBsAg and Pre S-HBsAg, particularly full length Pre S-HBsAg culturing, the resulting transformed cells to express the gene coding the heterologous protein, and isolating the heterologous protein from the cultured medium. GAP-DH and PH05 promoters and miniaturized ones can be used as the yeast promoter. The expression of the full length Pre S-HBsAg is carried out in the same expression system as that for 2nd or 3rd Pre S-ABsAg.

摘要翻译： 公开了一种在酵母中产生异源蛋白质的方法，其包括用包含启动子的重组DNA转化酵母酿酒酵母，所述启动子选自酵母启动子或源自酵母启动子的杂合启动子，特别是含有 SV40病毒的增强子区和编码异源蛋白如HBsAg和Pre S-HBsAg的基因，特别是全长Pre S-HBsAg培养，所得转化细胞表达编码异源蛋白的基因，并分离异源蛋白 从培养基中。 GAP-DH和PH05启动子和小型化可用作酵母启动子。 全长前S-HBsAg的表达在与第2或第3前S-ABsAg相同的表达系统中进行。

公开(公告)号：US4721904A

公开(公告)日：1988-01-26

申请号：US810067

申请日：1985-12-17

申请人： Hidetoshi Ozaki ,  Kaoru Kobayashi

发明人： Hidetoshi Ozaki ,  Kaoru Kobayashi

IPC分类号： G01R25/00

CPC分类号： G01R25/00

摘要： A digital phase difference detecting circuit has a phase shifting circuit for shifting by +90.degree. or -90.degree. a phase of an input signal which has been sampled over a predetermined sampling period, a dividing circuit for dividing an output signal of the phase shifting circuit by the input signal, an operation circuit for performing an inverse trigonometric function operation on an output signal of the dividing circuit, and a subtracting circuit for obtaining the difference between an output signal of the operation circuit and a phase of a reference signal. The resulting output signal of the subtracting circuit indicates the phase difference between the reference signal and the input signal.

摘要翻译： 数字相位差检测电路具有移相电路，用于在预定采样周期内对输入信号的相位进行+ 90°或-90°的相移;分频电路，用于分频移相电路的输出信号 通过输入信号，对分割电路的输出信号进行反三角函数运算的运算电路，以及用于求出运算电路的输出信号与基准信号的相位之差的减法电路。 减法电路的结果输出信号表示参考信号与输入信号之间的相位差。

公开(公告)号：US4633332A

公开(公告)日：1986-12-30

申请号：US567977

申请日：1984-01-04

申请人： Seiji Higurashi ,  Atsushi Miyashita ,  Kaoru Kobayashi

发明人： Seiji Higurashi ,  Atsushi Miyashita ,  Kaoru Kobayashi

IPC分类号： G11B5/02 ,  G11B5/008 ,  G11B5/53 ,  H04N5/7826 ,  H04N9/79 ,  H04N9/802 ,  H04N5/783

CPC分类号： G11B5/00878 ,  G11B5/0086 ,  G11B5/534 ,  H04N5/78263 ,  H04N9/7921 ,  H04N9/802

摘要： A multi-mode recording and playback system for VTR records audio signals and video signals and plays them back from audio tracks and video tracks on a magnetic tape by means of a plurality of rotating audio and video heads. A rotating drum around which a magnetic tape is wound carries therewith first to fourth rotary video heads and first and second rotary audio heads in predetermined relations with respect to angle and vertical level. In a desired mode, the audio heads write (read) audio signals in audio tracks, and the video heads write (read) video signals in video tracks, such that the centers of the audio and video tracks substantially coincide with each other.

摘要翻译： 用于VTR的多模式记录和重放系统记录音频信号和视频信号，并通过多个旋转音频和视频磁头从磁带上的音轨和视频轨道中回放它们。 卷绕磁带的旋转磁鼓以相对于角度和垂直度的预定关系携带第一到第四旋转视频磁头和第一和第二旋转音频磁头。 在期望的模式中，音频头在音频轨道中写入（读取）音频信号，并且视频头在视频轨道中写入（读取）视频信号，使得音频和视频轨道的中心基本上彼此重合。

公开(公告)号：US08692626B2

公开(公告)日：2014-04-08

申请号：US13568129

申请日：2012-08-07

申请人： Kaoru Kobayashi

发明人： Kaoru Kobayashi

IPC分类号： H03B5/30

CPC分类号： H03L1/02

摘要： An oscillation device for reducing memory capacity includes a frequency difference detecting unit and a compensation value obtaining unit. When oscillation frequencies of the first and second oscillation circuits are respectively f1 and f2, and oscillation frequencies of the first and second oscillation circuits at a reference temperature are respectively f1r and f2r, the frequency difference detecting unit determines a difference corresponding value x corresponding to a difference value between a value corresponding to a difference between f1 and f1r, and a value corresponding to a difference between f2 and f2r. The compensation value obtaining unit obtains a frequency compensation value of f1 resulting from ambient temperature different from reference temperature based on the difference corresponding value x, and calculates the frequency compensation value of f1 by calculating nth-order polynomial for X being a value corresponding to x/k, where k is a divide coefficient specific to a device.

摘要翻译： 用于降低存储容量的振荡装置包括频率差检测单元和补偿值获取单元。 当第一和第二振荡电路的振荡频率分别为f1和f2，第一和第二振荡电路在参考温度下的振荡频率分别为f1r和f2r时，频差检测单元确定对应于 在与f1和f1r之间的差对应的值之间的差值以及与f2和f2r之间的差对应的值。 补偿值获取单元基于差值对应值x从与参考温度不同的环境温度获得f1的频率补偿值，并且通过计算X的频率补偿值，计算对应于x的值的n阶多项式 / k，其中k是特定于设备的分频系数。

公开(公告)号：US08207223B2

公开(公告)日：2012-06-26

申请号：US12549136

申请日：2009-08-27

申请人： Toru Maruyama ,  Kaoru Kobayashi ,  Tohru Kambe ,  Takayuki Maruyama ,  Hideyuki Yoshida ,  Akio Nishiura ,  Nobutaka Abe

发明人： Toru Maruyama ,  Kaoru Kobayashi ,  Tohru Kambe ,  Takayuki Maruyama ,  Hideyuki Yoshida ,  Akio Nishiura ,  Nobutaka Abe

IPC分类号： A01N37/08 ,  A01N53/00 ,  A61K31/215 ,  A61K31/19 ,  A61K31/557

CPC分类号： C07C405/0033 ,  A61K9/0019 ,  A61K9/1647 ,  A61K9/19 ,  A61K9/2054 ,  A61K31/4015 ,  A61K31/41 ,  A61K31/5575 ,  A61K31/559

摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).

摘要翻译： 用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。 包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症 骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。