公开(公告)号：US11169169B2

公开(公告)日：2021-11-09

申请号：US16434698

申请日：2019-06-07

Applicant: Roche Diagnostics Operations, Inc. ,  Hitachi High-Tech Corporation

Inventor： Kouhei Nonaka ,  Takamichi Mori ,  Yoichi Aruga ,  Yosuke Horie ,  Andrew McCaughey ,  Alexander Seiler

IPC: G01N35/10 ,  B01L3/02 ,  G01N35/00 ,  B01F11/00

Abstract: A method of washing an aspiration probe of an in-vitro diagnostic system is disclosed. The aspiration probe comprises an outer surface and an inner surface forming an inner space for receiving a fluid. The method comprises dipping the aspiration probe into a first wash fluid so that the outer surface is immersed at least in part into the first wash fluid, aspirating an amount of the first wash fluid into the inner space of the aspiration probe, propagating an ultrasonic vibration to the outer surface of the aspiration probe via the first wash fluid, and rinsing the outer surface and the inner surface of the aspiration probe with a second wash fluid. Further, an in-vitro diagnostic method and an in-vitro diagnostic system are disclosed.

公开(公告)号：US20210333291A1

公开(公告)日：2021-10-28

申请号：US17370180

申请日：2021-07-08

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Uwe KOBOLD ,  Andreas LEINENBACH ,  Indranil MITRA ,  Holger BUSSKAMP

IPC: G01N33/72 ,  G01N33/68

Abstract: The present invention refers to a method for determining intact glycated hemoglobin A (HbA1c) by mass spectrometry (MS), a kit and a diagnostic system adapted for performing the method.

公开(公告)号：US20210333290A1

公开(公告)日：2021-10-28

申请号：US17370170

申请日：2021-07-08

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Uwe KOBOLD ,  Andreas LEINENBACH ,  Indranil MITRA

IPC: G01N33/72 ,  G01N33/68

Abstract: The present invention refers to a method for determining peptide fragments of glycated hemoglobin A (HbA1c) molecules by mass spectrometry (MS), a reagent kit, and a clinical diagnostic system adapted for performing the method.

公开(公告)号：US11156610B2

公开(公告)日：2021-10-26

申请号：US15621280

申请日：2017-06-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Barbara Upmeier ,  Toralf Zarnt ,  Johannes Polz

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68

Abstract: Described is a method for determining an analyte in a sample suspected to contain the analyte, by a) contacting the sample with a first and a second capture compound for the analyte, wherein the first and second capture compounds are non-identical capture compounds, and the capture compounds compete in binding to the analyte; b) contacting the capture compounds contacted with the sample with a specifier, wherein the specifier competes in binding to the capture compounds with the analyte; c) determining the amount of complexes having the specifier and a capture compound; and d) determining the analyte in a sample based on the result of step c). Also disclosed is a method for improving the specificity of an indirect immunoassay for determining an analyte, as well as kits, devices, and uses related to the methods.

公开(公告)号：USD933828S1

公开(公告)日：2021-10-19

申请号：US29730658

申请日：2020-04-07

Applicant: Roche Diagnostics Operations, Inc

Designer： Johann Florian Wassermann ,  Roman Gebhard ,  Samuel Coendet

公开(公告)号：US11110464B2

公开(公告)日：2021-09-07

申请号：US16127869

申请日：2018-09-11

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Rudolf Durco ,  Marcel Kaeppeli

IPC: B01L9/06 ,  G01N35/04 ,  B65G47/86

Abstract: A sample container carrier, a laboratory sample distribution system comprising such a sample container carrier and a laboratory automation system comprising such a laboratory sample distribution system are presented.

公开(公告)号：US20210174943A1

公开(公告)日：2021-06-10

申请号：US17109554

申请日：2020-12-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Fernando Blanco

IPC: G16H40/20 ,  G06Q10/02 ,  G16H40/67 ,  G16H10/60 ,  G16H10/20 ,  G06Q30/02 ,  G06Q40/08 ,  G16H50/70 ,  G16H10/40 ,  G16H40/40 ,  G06Q50/04 ,  G06Q10/06 ,  G06F16/29 ,  G06F16/9537 ,  G06F3/0488 ,  G06F3/0482 ,  G01C21/36 ,  G01C21/00

Abstract: A method for tracking availability of a point-of-care (POC) device for a user is provided. The method comprises entering type(s) of test(s) needed by the user, providing a list of available POC devices to the user based on the type(s) of test(s) needed, based on the list of available POC devices, providing a map to the user showing locations of nearby POC devices with availability for the type(s) of test(s) needed; selecting one of the nearby POC devices by touching the location of the POC device on the map and booking that POC device for the type(s) of test(s) needed at a particular time slot, and communicating the booking to the selected POC device. The selected POC device then blocks that time slot.

公开(公告)号：US20210154684A1

公开(公告)日：2021-05-27

申请号：US16953868

申请日：2020-11-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Andreas Drechsler

IPC: B04B7/12 ,  B04B5/04

Abstract: A bucket insert for use in a centrifuge is disclosed. The bucket insert comprises an insert body, the insert body comprising a plurality of elongated receptacles for receiving elongated sample vessels. The bucket insert is configured for orienting the elongated sample vessels in a tilted orientation. In the tilted orientation, at least some of the elongated sample vessels are oriented in a non-parallel fashion.

公开(公告)号：US11016098B2

公开(公告)日：2021-05-25

申请号：US16158931

申请日：2018-10-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Uwe Kobold ,  Roland Thiele ,  Noah Weiss ,  Benjamin Tiemann

IPC: G01N33/68 ,  H01J49/00 ,  G01N33/58 ,  G01N33/96 ,  B01D59/44 ,  G01N30/72 ,  G01N1/28

Abstract: A method and an apparatus for determining a concentration of a target analyte in a sample of bodily fluid are disclosed. The method involves providing a sample of bodily fluid including the target analyte, providing an internal standard solution including a mixture of components having a plurality of isotopes of the target analyte, wherein a concentration of each isotope is unknown, adding the internal standard solution to the sample, analyzing the sample including the internal standard solution using a mass spectrometer, creating a sample function curve based on signal intensities, wherein the signal intensities define arbitrary units, transferring an analyte signal into a corresponding arbitrary analyte unit by means of the sample function curve, and transferring the arbitrary analyte unit into the concentration of a target analyte by means of a standardization function representing a curve of concentrations depending on the arbitrary units.

公开(公告)号：US20210146368A1

公开(公告)日：2021-05-20

申请号：US17095868

申请日：2020-11-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Rein ,  Benjamin Sauer

IPC: B01L3/00 ,  G01N21/88 ,  G01N21/90

Abstract: An apparatus for determining properties of a laboratory sample container is presented. The apparatus comprises a light source for emitting light to illuminate the laboratory sample container and a number of curved reflecting and/or scattering units. A respective curved reflecting and/or scattering unit comprises a curved shape and is adapted to reflect and/or scatter light of the light source to an outer surface of the laboratory sample container for illuminating the laboratory sample container. The apparatus also comprises a camera adapted to take an image of the laboratory sample container. The image comprises image data related to the laboratory sample container. The apparatus also comprises a control unit adapted to determine the properties of the laboratory sample container based on the image data related to the laboratory sample container.