公开(公告)号：US09808575B2

公开(公告)日：2017-11-07

申请号：US14123072

申请日：2012-06-04

Applicant: Martin John McLoughlin ,  Darrell P. Morgan ,  Michael James David Heald ,  Kevin Richard Lozeau ,  Agnete Enga ,  Heather Martin ,  Eric Freitag ,  Daniel Formosa ,  Michael Schumann ,  Brian Lipford ,  Jake Cowperthwaite ,  Alex Flamm ,  Keith Lipford ,  Ilario Melzi

Inventor： Martin John McLoughlin ,  Darrell P. Morgan ,  Michael James David Heald ,  Kevin Richard Lozeau ,  Agnete Enga ,  Heather Martin ,  Eric Freitag ,  Daniel Formosa ,  Michael Schumann ,  Brian Lipford ,  Jake Cowperthwaite ,  Alex Flamm ,  Keith Lipford ,  Ilario Melzi

IPC: A61M37/00 ,  A61M5/145 ,  A61M5/20 ,  A61M5/32 ,  A61M5/158 ,  A61M5/172 ,  A61M5/50 ,  A61M5/315 ,  A61M5/31

CPC classification number: A61M5/14546 ,  A61M5/1452 ,  A61M5/158 ,  A61M5/172 ,  A61M5/20 ,  A61M5/3129 ,  A61M5/3134 ,  A61M5/3137 ,  A61M5/31511 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/3213 ,  A61M5/326 ,  A61M5/5086 ,  A61M2005/206 ,  A61M2005/3139 ,  A61M2005/3152 ,  A61M2005/3215 ,  A61M2202/04 ,  A61M2205/27 ,  A61M2205/276 ,  A61M2205/33 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/583 ,  A61M2205/584 ,  A61M2205/586 ,  A61M2205/8206 ,  F04C2270/0421

Abstract: There is provided a cassette unit that is suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit has a housing defining a cassette unit housing cavity and a needle projection aperture. The cassette unit housing cavity is arranged for receipt of a syringe that is suitable for use in the injected delivery of drug to a patient. The cassette unit includes a removable cap that fits over and thereby, acts such as to close off, the needle projection aperture; and connecting to the removable cap, a needle cover defining a needle sheath for sheathing of the needle tip of the syringe. The removable cap is provided with a finger-grip feature that is sized and shaped for gripping by the finger of a user to allow for removal of the removable cap and needle cover from the cassette unit housing.

公开(公告)号：US09789254B2

公开(公告)日：2017-10-17

申请号：US15113254

申请日：2015-01-22

Applicant: UCB BIOPHARMA SPRL

Inventor： Martin John McLoughlin ,  Michael James David Heald ,  Brian David Barney

IPC: A61M5/24 ,  A61M5/20

CPC classification number: A61M5/20 ,  A61M5/24 ,  A61M2005/2418 ,  A61M2005/244 ,  A61M2005/2481 ,  A61M2205/52 ,  A61M2205/584 ,  A61M2205/6054

Abstract: Provided is a cassette unit suitable for use with an auto-injector having a drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity, which is in receipt of a syringe, a rearward entrance to said cavity and a forward needle projection aperture. The cassette unit also comprises in capping relationship with the rearward entrance of the cassette unit housing, a cassette unit end-cap, said cassette unit end-cap defining a drive rod-receiving opening for receipt of a drive rod for providing forward axial drive to said plunger; a biasing element defining a biasing relationship between the cassette unit end-cap and an end flange of the syringe barrel, thereby urging the syringe forwards in relation to the cassette unit end-cap; and a damping element defining a damping relationship between the cassette unit end-cap and the flange of the syringe, thereby acting to damp rearward movement of the syringe relative to the cassette unit end-cap.

公开(公告)号：US09764101B2

公开(公告)日：2017-09-19

申请号：US14418437

申请日：2013-07-29

Applicant: UCB Biopharma SPRL

Inventor： Martin John McLoughlin ,  Ilario Melzi ,  Stefan Verlaak

IPC: A61M5/32 ,  A61M5/50 ,  A61M5/00 ,  A61M5/31 ,  A61M5/20 ,  A61M5/315 ,  A61M5/24

CPC classification number: A61M5/5086 ,  A61M5/002 ,  A61M5/20 ,  A61M5/3134 ,  A61M5/31505 ,  A61M5/31515 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/3213 ,  A61M5/326 ,  A61M2005/2013 ,  A61M2005/206 ,  A61M2005/2477 ,  A61M2005/3139 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/583 ,  A61M2205/586 ,  A61M2205/8206

Abstract: There is provided a cassette unit suitable for use with an auto-injector. The cassette unit comprises a cassette unit housing and a removable cap that in a capping position fits over and thereby, acts to close off, a needle projection aperture of the housing. The cassette unit housing has one or more first engagement features arranged for reversibly engaging one or more second engagement features of the removable cap for reversible lock engagement of the removable cap to the housing; and a shuttle lock control defining one or more blocking elements for selectively blocking movement of said first engagement features relative to said second engagement features. The shuttle lock control is axially movable relative to the cassette unit housing between a first ‘cassette unused’ position; a second ‘cassette unlocked’ position; and after replacement of the removable cap, a third ‘cassette used’ position, locating intermediate the first and second positions.

公开(公告)号：US09669158B2

公开(公告)日：2017-06-06

申请号：US14123046

申请日：2012-06-04

Applicant: Martin John McLoughlin ,  Darrell P. Morgan ,  Kevin Richard Lozeau ,  Agnete Enga ,  Eric Freitag ,  Daniel Formosa ,  Brian Lipford ,  Jake Cowperthwaite ,  Alex Flamm ,  Conrad Laskowski

Inventor： Martin John McLoughlin ,  Darrell P. Morgan ,  Kevin Richard Lozeau ,  Agnete Enga ,  Eric Freitag ,  Daniel Formosa ,  Brian Lipford ,  Jake Cowperthwaite ,  Alex Flamm ,  Conrad Laskowski

IPC: A61M37/00 ,  A61M5/145 ,  A61M5/20 ,  A61M5/32 ,  A61M5/158 ,  A61M5/172 ,  A61M5/50 ,  A61M5/315 ,  A61M5/31

CPC classification number: A61M5/14546 ,  A61M5/1452 ,  A61M5/158 ,  A61M5/172 ,  A61M5/20 ,  A61M5/3129 ,  A61M5/3134 ,  A61M5/3137 ,  A61M5/31511 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/3213 ,  A61M5/326 ,  A61M5/5086 ,  A61M2005/206 ,  A61M2005/3139 ,  A61M2005/3152 ,  A61M2005/3215 ,  A61M2202/04 ,  A61M2205/27 ,  A61M2205/276 ,  A61M2205/33 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/583 ,  A61M2205/584 ,  A61M2205/586 ,  A61M2205/8206 ,  F04C2270/0421

Abstract: Provided is an auto-injector for a syringe suitable for the injected delivery of drug to a patient. The auto-injector comprises a cassette unit arranged for receipt of a syringe. The cassette unit and/or syringe is movable from a rest position, in which the syringe needle tip is within the drive unit housing to a use position, in which the needle tip protrudes from a needle delivery aperture thereof. The auto-injector comprises a drive unit arranged for docking receipt of the cassette unit at a docking position and a drive arrangement. The drive unit is arranged for initial receipt of the cassette unit at an intermediate pre-docking position and for subsequent transport of the cassette unit to the docking position. In embodiments, the drive unit is arranged such that transport of the cassette unit to the docking position is permitted only following verification of an identifier at the intermediate pre-docking position.

公开(公告)号：US09550737B2

公开(公告)日：2017-01-24

申请号：US14406848

申请日：2013-06-11

Applicant: UCB Biopharma SPRL

Inventor： Daniel Christopher Brookings ,  Mark Daniel Calmiano ,  Ellen Olivia Gallimore ,  Helen Tracey Horsley ,  Martin Clive Hutchings ,  James Andrew Johnson ,  Boris Kroeplien ,  Fabien Claude Lecomte ,  Martin Alexander Lowe ,  Timothy John Norman ,  John Robert Porter ,  Joanna Rachel Quincey ,  James Thomas Reuberson ,  Matthew Duncan Selby ,  Michael Alan Shaw ,  Zhaoning Zhu ,  Anne Marie Foley

IPC: C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D491/107 ,  C07D235/12 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  C07D405/06

CPC classification number: C07D235/12 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/06 ,  C07D491/107

Abstract: A series of benzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract translation: 因此，作为人TNFα活性的有效调节剂的一系列苯并咪唑衍生物有益于治疗和/或预防各种人类疾病，包括自身免疫和炎性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。

公开(公告)号：US09475820B2

公开(公告)日：2016-10-25

申请号：US14414299

申请日：2013-07-05

Applicant: UCB Biopharma SPRL

Inventor： Jonathan Mark Bentley ,  Daniel Christopher Brookings ,  Julien Alistair Brown ,  Thomas Paul Cain ,  Laura Jane Gleave ,  Alexander Heifetz ,  Victoria Elizabeth Jackson ,  Craig Johnstone ,  Deborah Leigh ,  James Madden ,  John Robert Porter ,  Matthew Duncan Selby ,  Zhaoning Zhu

IPC: A61K31/4985 ,  C07D241/36 ,  C07D491/107 ,  C07D487/04 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5513 ,  C07D451/02 ,  C07D471/08

CPC classification number: C07D491/107 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5513 ,  C07D451/02 ,  C07D471/08 ,  C07D487/04

Abstract: A series of imidazo[1,2-a]pyrazine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. The imidazo[1,2-a]pyrazine derivatives of the disclosure are of general formula

公开(公告)号：US09394361B2

公开(公告)日：2016-07-19

申请号：US14186074

申请日：2014-02-21

Applicant: UCB PHARMA S.A.

Inventor： Neil Gozzard ,  Alastair David Griffiths Lawson ,  Daniel John Lightwood ,  Roger Thomas Palframan ,  Bryan John Smith ,  Kerry Louise Tyson

IPC: C12N15/63 ,  A61K39/395 ,  C07K16/26 ,  C07K16/24 ,  C12N5/07 ,  C12P21/02 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K9/0078 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/544 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing antibody molecules.

Abstract translation: 本发明涉及对人IL-13的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途和产生抗体分子的方法。

公开(公告)号：US09249232B2

公开(公告)日：2016-02-02

申请号：US12307051

申请日：2007-06-26

Applicant: Ralph Adams ,  Alastair David Griffiths Lawson ,  Andrew George Popplewell ,  Kerry Louise Tyson

Inventor： Ralph Adams ,  Alastair David Griffiths Lawson ,  Andrew George Popplewell ,  Kerry Louise Tyson

IPC: C40B30/04 ,  C07K16/00 ,  C07K16/46

CPC classification number: C07K16/464 ,  C07K16/465 ,  C07K2317/24 ,  C07K2317/92

Abstract: The present invention relates to improved methods for the selection of appropriate human acceptor framework regions for non-human (donor) antibodies and methods for obtaining humanized antibodies of high affinity using such acceptor frameworks.

Abstract translation: 本发明涉及用于选择非人（供体）抗体的合适的人受体框架区的改进方法和使用这种受体框架获得高亲和力的人源化抗体的方法。

公开(公告)号：US09034600B2

公开(公告)日：2015-05-19

申请号：US14074880

申请日：2013-11-08

Applicant: UCB PHARMA S.A.

Inventor： Ralph Adams ,  Terence Seward Baker ,  Alastair David Griffiths Lawson

IPC: C12N15/09 ,  C07K16/24

CPC classification number: C07K16/244 ,  C07K2317/33 ,  C07K2317/92

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Abstract translation: 本发明涉及对IL-17A和IL-17F的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途和产生所述抗体分子的方法。

公开(公告)号：US11492396B2

公开(公告)日：2022-11-08

申请号：US15771310

申请日：2016-10-26

Applicant: UCB BIOPHARMA SPRL

Inventor： Sophie Glatt ,  Lucian Ionescu ,  Margaret Jones ,  Ruth Oliver ,  Stevan Graham Shaw ,  Foteini Strimenopoulou ,  Venkata Pavan Kumar Vajjah

IPC: A61K39/395 ,  C07K16/24 ,  A61P17/06 ,  A61P19/02 ,  A61K39/00

Abstract: The invention relates to therapeutic uses of antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F in the treatment of dermatological and rheumatological diseases, such as psoriasis, psoriatic arthritis and axial spondyloarthritis.