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    Small particle formation
    91.
    发明授权
    Small particle formation 失效
    小粒子形成

    公开(公告)号：US5780062A

    公开(公告)日：1998-07-14

    申请号：US553460

    申请日：1995-11-27

    Applicant: Sylvan Frank ,  Jan-Erik Lofroth ,  Levon Bostanian

    Inventor： Sylvan Frank ,  Jan-Erik Lofroth ,  Levon Bostanian

    IPC: A61K9/14 ,  A61K9/16 ,  B01J13/10

    CPC classification number: A61K9/1617 ,  A61K9/1635 ,  A61K9/1694 ,  B01J13/10

    Abstract: The present invention is concerned with the formation of small particles of organic compounds by precipitating said organic compounds in an aqueous medium containing polymer/amphiphile complexes. The process is preferably used to prepare a readily soluble pharmaceutically active compound.

    Abstract translation: PCT No.PCT / SE95 / 01302 Sec。 371日期：1996年11月27日 102（e）日期1996年11月27日PCT提交1995年11月3日PCT公布。 公开号WO96 / 14833 日期1996年5月23日本发明涉及通过在含有聚合物/两亲物络合物的水性介质中沉淀所述有机化合物而形成小颗粒有机化合物。 该方法优选用于制备容易溶解的药物活性化合物。

    Microcoacervation of propellant ingredients
    94.
    发明授权
    Microcoacervation of propellant ingredients 失效
    推进剂成分的微凝聚

    公开(公告)号：US5281286A

    公开(公告)日：1994-01-25

    申请号：US865540

    申请日：1992-04-09

    Applicant: David C. Sayles

    Inventor： David C. Sayles

    IPC: B01J13/10 ,  C06B23/00 ,  C06B45/18 ,  C06B45/00 ,  A61J5/00 ,  C06B21/00

    CPC classification number: C06B45/18 ,  B01J13/10 ,  C06B23/007

    Abstract: The coacervation of ferrocene and ferrocene derivative is carried out in aater-soluble polyol, coacervation mixture at a reaction temperature from about 40.degree. C. to about 55.degree. C. The coacervation mixture is comprised of about 70 to about 80 parts of a 1:1 ratio of water and a water soluble polyol selected from glycol, a glycerol, and an erythritol, a urea derivative selected from melamine and triazine, and an aldehyde or ketone selected from the water soluble aldehydes or ketones consisting of methanal, ethanal, propanal, propanone, and 2-butanone. Micro-droplets of the ferrocene derivative, 2,2-bis(ethylferrocenyl)propane, are formed by vigorous agitation of the coacervation mixture containing the ferrocene derivative. A polymeric coating on the outer surface of the micro-droplets produces a coacervate which is separated from the coacervation mixture. The coacervate polymeric coating of about 10 percent by weight enables the coated ferrocene derivative to be mixed in a solid propellant composition without rupturing and to achieve improved stability and compatibility as compared to liquid ferrocene and liquid ferrocene derivatives.

    Abstract translation: 二茂铁和二茂铁衍生物的凝聚在约40℃至约55℃的反应温度下在水溶性多元醇，凝聚混合物中进行。凝聚混合物由约70至约80份的1 ：1比例的水和选自二醇，甘油和赤藓糖醇的水溶性多元醇，选自三聚氰胺和三嗪的脲衍生物，以及选自由甲醛，乙醛，丙醛组成的水溶性醛或酮的醛或酮 ，丙酮和2-丁酮。 通过剧烈搅拌含有二茂铁衍生物的凝聚混合物形成二茂铁衍生物，2,2-双（乙基二茂铁基）丙烷的微滴。 在微滴的外表面上的聚合物涂层产生与凝聚混合物分离的凝聚层。 约10重量％的凝聚聚合物涂层使得涂覆的二茂铁衍生物能够在固体推进剂组合物中混合而不破裂，并且与液态二茂铁和液体二茂铁衍生物相比可获得改善的稳定性和相容性。

    Microencapsulated flavoring agents and methods for preparing same
    95.
    发明授权
    Microencapsulated flavoring agents and methods for preparing same 失效
    微胶囊调味剂及其制备方法

    公开(公告)号：US5266335A

    公开(公告)日：1993-11-30

    申请号：US942097

    申请日：1992-09-08

    Applicant: Subraman R. Cherukuri ,  Krishna P. Raman ,  Gul Mansukhani

    Inventor： Subraman R. Cherukuri ,  Krishna P. Raman ,  Gul Mansukhani

    IPC: A23G4/00 ,  A23G4/08 ,  A23G4/20 ,  A23L27/00 ,  B01J13/10 ,  A23G3/30

    CPC classification number: A23G4/20 ,  A23G4/08 ,  A23L27/72 ,  B01J13/10 ,  A23V2002/00

    Abstract: The present invention pertains to a microencapsulated flavoring agent in the form of a spheroidal microcapsule which comprises a core and a coating layer over the core, wherein the microcapsule comprises (A) a core present in an amount up to about 90%, by weight of the microcapsule, which comprises (a) a flavoring agent in an amount from about 20% to about 80%, by weight of the core, and (b) a resin in an amount from about 80% to about 20%, by weight of the core, and (B) a coating layer over the core which comprises in percentages by weight of the coating layer, (a) gelatin in an amount from about 45% to about 49%, (b) gum arabic in an amount from about 45% to about 49%, and (c) glutaraldehyde in an amount from about 2% to about 10%. The encapsulated flavoring agents may be used in a wide variety of ingestible compositions and chewing gum products. The present invention also pertains to methods for preparing the encapsulated flavoring agents and the ingestible compositions in which they may be employed.

    Abstract translation: 本发明涉及呈球形微胶囊形式的微胶囊化调味剂，其包含核心和核心上的包衣层，其中所述微胶囊包含（A）以高达约90重量％的量存在的核心， 所述微胶囊包含（a）所述核心重量的约20％至约80％的调味剂，和（b）约80％至约20％重量的树脂， 核心，和（B）芯上的涂层，其包含重量百分比的涂层，（a）约45％至约49％的明胶，（b）阿拉伯胶，其量为约 45％至约49％，和（c）约2％至约10％的戊二醛。 包封的调味剂可以用于多种可摄取组合物和口香糖产品中。 本发明还涉及制备包封的调味剂和可以使用它们的可摄入组合物的方法。

    Apparatus and method for making microcapsules
    97.
    发明授权
    Apparatus and method for making microcapsules 失效
    微胶囊制备装置及方法

    公开(公告)号：US4978483A

    公开(公告)日：1990-12-18

    申请号：US187982

    申请日：1988-04-29

    Applicant: Bruce K. Redding, Jr.

    Inventor： Bruce K. Redding, Jr.

    IPC: A61J3/07 ,  A61K9/50 ,  B01J13/04 ,  B01J13/10 ,  B01J13/20

    CPC classification number: A61J3/07 ,  A61K9/5089 ,  B01J13/04 ,  B01J13/10 ,  B01J13/20 ,  Y10S425/804

    Abstract: The invention is a process and apparatus for the manufacture of microcapsules. The microcapsules have a core which contains a liquid, gaseous, solid or multiple-phase material which is coated with an impermeable film. The microcapsules are formed by applying high pressure, for a short period of time, to a mixture of the core and shell material, and by gradually reducing the pressure, such as by passing the capsules through a baffled chamber. The invention also includes a method for adjusting the size of the microcapsules, and for adjusting the thickness of their shells. The microcapsules can be made with several shell layers, to increase their strength. They can also be made as multiple capsules, having two or more cores. The invention also includes a method and apparatus for making microcapsules in a continuous process. The present invention produces microcapsules in a small fraction of the time required by methods of the prior art.

    Abstract translation: 本发明是用于制造微胶囊的方法和装置。 微胶囊具有包含液体，气体，固体或多相材料的芯，其涂覆有不渗透膜。 通过将短时间的高压施加到芯和壳材料的混合物上，并且通过逐渐降低压力，例如通过将胶囊通过挡板室来形成微胶囊。 本发明还包括一种用于调整微胶囊尺寸并调节其壳体厚度的方法。 微胶囊可以制成几层壳层，以提高它们的强度。 它们也可以制成多个胶囊，具有两个或多个芯。 本发明还包括用于在连续过程中制备微胶囊的方法和装置。 本发明在现有技术方法所需时间的一小部分内产生微胶囊。

    Method of producing delayed release of sodium fluoride
    99.
    发明授权
    Method of producing delayed release of sodium fluoride 失效
    生产氟化钠延迟释放的方法

    公开(公告)号：US4220552A

    公开(公告)日：1980-09-02

    申请号：US912946

    申请日：1978-06-05

    Applicant: Charles J. Hitchcock

    Inventor： Charles J. Hitchcock

    IPC: A61K8/21 ,  A61K8/73 ,  A61K9/50 ,  A61K33/14 ,  A61Q11/00 ,  B01J13/02 ,  B01J13/10 ,  B44D1/02

    CPC classification number: A61Q11/00 ,  A61K33/14 ,  A61K8/21 ,  A61K8/731 ,  A61K9/5047 ,  B01J13/02 ,  B01J13/10 ,  Y10T428/2989

    Abstract: A process of pretreating a lower alkyl cellulose, such as ethyl cellulose, which is to be used in microencapsulation of sodium fluoride for dental purposes. This process comprises dispersing a predetermined quantity of lower alkyl cellulose in an aqueous mineral acid, such as HCl, and stirring and aqueous washing of the cellulose such that the pH of the product is adjusted to 6.0 or less. This product is later dissolved in a BTX (benzene, toluene, xylene) solvent such as toluene. Sodium fluoride is added and process steps such as baffle stirring and drying are utilized to produce microencapsulation of the sodium fluoride with the lower alkyl cellulose. The process produces an encapsulating material of optimum sodium content and gives release time in water of 2.3-7.0 hours for the sodium fluoride.

    Abstract translation: 预处理低级烷基纤维素（如乙基纤维素）的方法，该方法用于牙科用氟化钠的微囊化。 该方法包括将预定量的低级烷基纤维素分散在无机酸水溶液如HCl中，并搅拌和水洗纤维素，使产物的pH调节至6.0以下。 该产物随后溶于BTX（苯，甲苯，二甲苯）溶剂如甲苯中。 加入氟化钠，并利用诸如挡板搅拌和干燥的工艺步骤来生产氟化钠与低级烷基纤维素的微囊化。 该方法产生最佳钠含量的封装材料，并为氟化钠在水中的释放时间为2.3-7.0小时。

    Process for microencapsulating hydrophobic oil droplets and product of said process
    100.
    发明授权
    Process for microencapsulating hydrophobic oil droplets and product of said process 失效
    疏水油泥浆微生物处理工艺及其工艺

    公开(公告)号：US3847832A

    公开(公告)日：1974-11-12

    申请号：US14890271

    申请日：1971-06-01

    Applicant: FUJI PHOTO FILM CO LTD

    Inventor： MATSUKAWA H ,  SAEKI K

    IPC: A61K9/50 ,  B01J13/10 ,  B44D1/44 ,  B01J13/02

    CPC classification number: B01J13/10 ,  A61K9/50 ,  Y10T428/249997 ,  Y10T428/2984 ,  Y10T428/2987

    Abstract: WHEREIN R1 AND R2 EACH REPRESENT A MEMBER SELECTED FROM THE GROUP CONSISTING OF A HYDROGEN ATOM AND AN ALKYL GROUP HAVING FROM 1 TO 18 CARBON ATOMS; X REPRESENTS A MEMBER SELECTED FROM THE GROUP CONSISTING OF A HYDROGEN ATOM AND AN ALKALI METAL; AND N REPRESENTS A DEGREE OF POLYMERIZATION RANGING FROM 1 TO 12, SAID CONDENSATION PRODUCT BEING EMPLOYED IN AN AMOUNT BETWEEN 1/200 AND 1/30 OF THE TOTAL AMOUNT OF SAID NYDROPHILIC COLLOID MATERIALS.

    R1,R2,(X-O3S-),(R1,R2,(X-O3S-)-NAPHTHALYL-CH2)N-NAPTHALENE

    1. IN A PROCESS OF MICROENCAPSULATING HYDROPHOBIC OIL DROPLETS BY COMPLEX COACERVATION COMPRISING THE STEPS OF PROVIDING AN OIL-IN-WATER EMULSION OF HYDROPHOBIC OIL DROPLETS AN AQUEOUS SOLUTION OF AT LEAST TWO HYDROPHILIC COLLOID MATERIALS HAVING OPPOSITE ELECTRIC CHARGES, AT LEAST ONE OF THE COLLOIDS BEING GELLABLE, CAUSING COACERVATION OF THE COLLOID MATERIALS BY DILUTING THE EMULSION WITH WATER AND/OR ADJUSTING ITS PH, GELLING THE ENCAPSULATING COMPLEX COLLOID MATERIAL BY COOLING AND PREHARDENING THE GELLED MATERIAL PRIOR TO HARDENING BY ADJUSTING THE PH OF THE SYSTEM TO THE ALKALI SIDE BY INTRODUCING THEREIN AN ALKALI AGENT AND A HARDENING AGENT. THE IMPROVEMENT WHICH COMPRISES ADDING A CONDENSATION PRODUUCT OF A NAPHTHALENESULFONIC ACID AND FORMALDEHYDE TO SAID HYDROPHILIC COLLOID MATERIALS AT A STAGE BEFORE SAID PREHARDENING STEP, SAID CONDENSATION PRODUCT OF SAID NAPHTHALENESULFONIC ACID AND FORMALDEHYDE HAVING THE FOLLOWING STRUCTURAL FORMULA:

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