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公开(公告)号：US5023379A
公开(公告)日：1991-06-11
申请号：US492018
申请日：1990-03-12
IPC分类号： C07B61/00 , B01J23/00 , B01J23/40 , B01J23/44 , B01J25/00 , B01J25/02 , C07C20060101 , C07C67/00 , C07C209/26 , C07C213/00 , C07C213/02 , C07C215/06 , C07C215/10 , C07C215/12 , C07C249/02
CPC分类号： C07C215/10 , C07C213/02 , C07C249/02
摘要： A process for the production of hydroxyamines of the formula IR.sup.1 --CH(OH)--CH(NHR.sup.3)--R.sup.2 (I)whereinR.sup.1 and R.sup.2 independently of one another are H or CH.sub.2 OH andR.sup.3 is H, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -hydroxyalkyl comprising reacting an oxo compound with an amine and reducing the resultant ketimine with a reducing agent.
摘要翻译： 制备式I的基团的方法R1-CH（OH）-CH（NHR3）-R2（Ⅰ）其中R1和R2彼此独立地是H或CH2OH，R3是H，C1-C4烷基或 包括将氧代化合物与胺反应并用还原剂还原所得的酮亚胺的C 1 -C 4 - 羟烷基。
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公开(公告)号：US1946079A
公开(公告)日：1934-02-06
申请号：US43793730
申请日：1930-03-21
申请人： DU PONT
发明人： GEORGES KERN JEAN , SALA CHARLES J
IPC分类号： C07C215/10 , C07C305/06
CPC分类号： C07C215/10 , C07C305/06 , Y10S516/05
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公开(公告)号：US1799821A
公开(公告)日：1931-04-07
申请号：US21071427
申请日：1927-08-04
申请人： DU PONT
发明人： GEORGES KERN JEAN , SALA CHARLES J
IPC分类号： C07C215/10 , C07C305/06
CPC分类号： C07C215/10 , C07C305/06
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94.发明公开公开(公告)号：US20230265059A1
公开(公告)日：2023-08-24
申请号：US18004064
申请日：2021-07-03
发明人： Venkatragavan RAMASAMY , Balaiah ERUGU , Ajay Madhukar SINGAVARAPU , Vinayagam NALLAPPAN , Saravanan SIVAPRAGASAM , Vijayakumar KURAPATI , Silambarasan RAMAN
IPC分类号： C07D263/57 , C07C231/12 , C07C215/10
CPC分类号： C07D263/57 , C07C231/12 , C07C215/10 , C07B2200/13
摘要： The present disclosure relates to novel solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole of Formula (I) and it pharmaceutically acceptable salts thereof.
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95.发明申请公开(公告)号：US20190210956A1
公开(公告)日：2019-07-11
申请号：US16353607
申请日：2019-03-14
发明人： Matthew Hilfiger , B. Raghava Reddy
IPC分类号： C07C213/00 , C07B41/02 , C09K8/36 , C07C215/10
CPC分类号： C07C213/00 , C07B41/02 , C07C215/10 , C07C215/14 , C09K8/36
摘要： N-hydroxyalkylated polyamines, methods of making N-hydroxyalkylated polyamines, and drilling fluids containing N-hydroxyalkylated polyamines are provided, in which the N-hydroxyalkylated polyamine includes Formula (I): where R1 and R2 are independently a —C or —CH group; R3 is an aliphatic hydrocarbyl; R4 and R5 are independently acyclic hydrocarbyls, or R1, R2, R4, and R5 are covalently connected to form a cyclic hydrocarbyl; and R6, R7, R8, and R9 are independently acyclic hydrocarbyls or acyclic heterohydrocarbyls.
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公开(公告)号：US20180305311A1
公开(公告)日：2018-10-25
申请号：US15962498
申请日：2018-04-25
IPC分类号： C07D207/333 , C07C215/40 , A61K38/26 , C07D295/027 , A61K31/4985 , C07C215/10 , C07C217/60 , C07C211/51 , C07D233/58 , A61K31/4015 , C07C211/11 , C07C215/12 , C07C211/30 , C07C229/26 , A61K31/40 , A61K31/155 , C07C211/27 , A61K31/64 , A61K31/505 , C07C211/35 , A61K45/06 , C07C279/14
CPC分类号： C07D207/333 , A61K31/155 , A61K31/40 , A61K31/4015 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K45/06 , A61K2300/00 , C07C211/11 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/51 , C07C215/10 , C07C215/12 , C07C215/40 , C07C217/60 , C07C229/26 , C07C279/14 , C07C2601/14 , C07D233/58 , C07D295/027
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of these novel salts and use thereof.
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公开(公告)号：US09957230B2
公开(公告)日：2018-05-01
申请号：US15594795
申请日：2017-05-15
IPC分类号： C07D207/333 , C07D233/58 , A61K31/155 , C07C279/14 , C07C229/26 , C07C217/60 , C07C215/40 , C07C215/12 , C07C215/10 , C07C211/51 , C07C211/35 , C07C211/30 , C07C211/27 , C07C211/11 , A61K45/06 , A61K38/26 , A61K31/64 , A61K31/505 , A61K31/4985 , A61K31/4015 , A61K31/40 , C07D295/027
CPC分类号： C07D207/333 , A61K31/155 , A61K31/40 , A61K31/4015 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K45/06 , A61K2300/00 , C07C211/11 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/51 , C07C215/10 , C07C215/12 , C07C215/40 , C07C217/60 , C07C229/26 , C07C279/14 , C07C2601/14 , C07D233/58 , C07D295/027
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (1a) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of: these novel salts and use thereof.
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公开(公告)号：US20180099991A1
公开(公告)日：2018-04-12
申请号：US15727856
申请日：2017-10-09
申请人： Lupin Limited
发明人： Palash Sanphui , Radhakrishna Bhikaji Shivdavkar , Rajesh Vyas , Nandu Baban Bhise , Girij Pal Singh
IPC分类号： C07J9/00 , C07C279/14 , C07C229/26 , C07C215/10 , C07C277/00 , C07C227/16 , C07C213/08
CPC分类号： C07J9/005 , C07B2200/13 , C07C213/08 , C07C215/10 , C07C227/16 , C07C229/26 , C07C277/00 , C07C279/14
摘要： The invention relates to salts of Obeticholic Acid, their amorphous and crystalline polymorphic form and processes for preparation thereof.
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公开(公告)号：US20180000849A1
公开(公告)日：2018-01-04
申请号：US15704100
申请日：2017-09-14
发明人： Yasutsugu UEDA , Timothy P. CONNOLLY , John F. KADOW , Nicholas A. MEANWELL , Tao WANG , Chung-Pin H. CHEN , Kap-Sun YEUNG , Zhongxing ZHANG , David Kenneth LEAHY , Shawn K. PACK , Nachimuthu SOUNDARARAJAN , Pierre SIRARD , Kathia LEVESQUE , Dominique THORAVAL
IPC分类号： A61K31/675 , C07F9/6558 , C07F9/655 , C07F9/572 , C07F9/06 , C07D471/04 , A61K45/06 , C07F9/6561 , A61K31/497
CPC分类号： A61K31/675 , A61K31/497 , A61K31/519 , A61K45/06 , C07C215/10 , C07D471/04 , C07F9/062 , C07F9/5728 , C07F9/65515 , C07F9/65586 , C07F9/6561
摘要： This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
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公开(公告)号：US20170335240A1
公开(公告)日：2017-11-23
申请号：US15520902
申请日：2015-10-21
发明人： Gaelle Della Noce
IPC分类号： C11D1/83 , C11D3/20 , C11D3/30 , C07C215/10
CPC分类号： C11D1/83 , C07C215/10 , C11D3/2041 , C11D3/2065 , C11D3/30
摘要： A laundry detergent composition comprising:(a) 4 to 25 wt % of a linear alkyl benzene sulfonate; (b) 25 to 55 wt % nonionic surfactant, (c) 2 to 10 wt % of an amine having formula (I) wherein R1 is C1-C4 alkyl or C1-C4 hydroxyalkyl; or formula (II) wherein R2 is C1-C4 alkyl and R3 is C2-C8 alkyl; or a combination thereof; and (d) 10 to 35 wt % C3-C6 polyhydroxy compounds.
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