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    SYNTHETIC MICROFLUIDIC SYSTEMS FOR TUMOR METASTASIS
    91.
    发明申请
    SYNTHETIC MICROFLUIDIC SYSTEMS FOR TUMOR METASTASIS 有权
    用于肿瘤分化的合成微流体系统

    公开(公告)号：US20140255971A1

    公开(公告)日：2014-09-11

    申请号：US14202511

    申请日：2014-03-10

    申请人： CFD Research Corporation

    发明人： Balabhaskar Prabhakarpandian ,  Kapil Pant

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5029 ,  B01L3/5027 ,  G01N33/5005 ,  G01N33/5011 ,  G01N33/5061 ,  G01N33/5088 ,  G01N33/86 ,  G01N2333/4703 ,  G01N2333/70525

    摘要： A method of assaying metastasis can include: providing a device of one of the embodiments; introducing the at least one cancer cell into the at least one internal chamber or at least one fluid channel; and studying metastasis of the at least one cancer cell. Optionally: introducing cancer cells into a first internal chamber; detecting escape of the cancer cell from the first internal chamber into the fluid channel; detecting migration of the cancer cell through the fluid channel; detecting adhesion of the cancer cell to a coating on the fluid channel; detecting invasion of the cancer cell into a second internal chamber from the fluid channel; or visualizing metastasis of the cancer cell with a visualization device.

    摘要翻译： 测定转移的方法可以包括：提供实施方案之一的装置; 将至少一个癌细胞引入所述至少一个内室或至少一个流体通道中; 并研究至少一种癌细胞的转移。 任选地：将癌细胞引入第一内室; 检测癌细胞从第一内室进入流体通道的逃逸; 检测癌细胞通过流体通道的迁移; 检测癌细胞与流体通道上的涂层的粘附; 检测来自流体通道的癌细胞侵入第二内室; 或用可视化装置可视化癌细胞的转移。

    BIOMARKERS FOR SEIZURES
    93.
    发明申请
    BIOMARKERS FOR SEIZURES 审中-公开
    生物标志物

    公开(公告)号：US20130331329A1

    公开(公告)日：2013-12-12

    申请号：US14001306

    申请日：2012-02-24

    申请人： John Robert Pollard ,  Peter B. Crino

    发明人： John Robert Pollard ,  Peter B. Crino

    IPC分类号： G01N33/543 ,  A61K38/17

    CPC分类号： G01N33/6896 ,  A61K38/1709 ,  G01N33/543 ,  G01N2333/521 ,  G01N2333/705 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2800/2857

    摘要： The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5 in the treatment of seizure, methods for assessing the effectiveness of a treatment of seizure, and diagnostic kits.

    摘要翻译： 该应用涉及癫痫发作和癫痫的标志物。 提供了多肽表达面板或阵列，其包含能够结合哺乳动物受试者的血浆或血清中的特异性多肽的一种或多种探针。 还提供检测癫痫发作的方法，预防癫痫发作的方法，使用sICAM-5治疗癫痫发作，评估癫痫发作的有效性的方法和诊断试剂盒。

    PRIMITIVE AND PROXIMAL HEPATIC STEM CELLS
    100.
    发明申请
    PRIMITIVE AND PROXIMAL HEPATIC STEM CELLS 有权
    主要和临床干细胞

    公开(公告)号：US20070099297A1

    公开(公告)日：2007-05-03

    申请号：US11609729

    申请日：2006-12-12

    申请人： Lola Reid ,  Nick Moss ,  Mark Furth ,  John Ludlow ,  Andrew Bruce

    发明人： Lola Reid ,  Nick Moss ,  Mark Furth ,  John Ludlow ,  Andrew Bruce

    IPC分类号： C12N5/08

    CPC分类号： C12N5/0672 ,  C12N2500/25 ,  C12N2500/36 ,  C12N2500/90 ,  C12N2501/11 ,  C12N2502/13 ,  G01N33/5005 ,  G01N33/68 ,  G01N2333/705 ,  G01N2333/70525 ,  G01N2333/70596

    摘要： Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor. Proximal hepatic stem cells may also be isolated by culturing colonies comprising a primitive hepatic stem cell under conditions which include a developmental factor. Resulting compositions may be used for treating liver disorders and for producing bioartificial organs.

    摘要翻译： 肝祖细胞包含两个人类肝干细胞，原始和近端肝干细胞，以及两个定型祖细胞群，一个为胆汁细胞，一个为肝细胞。 人原始肝干细胞是肝细胞群体的非常小的一部分，并且引起近端肝干细胞构成肝脏的大部分。 人近端肝干细胞产生胆汁和肝细胞定向的祖细胞。 原始和近端干细胞是人类肝脏的主要干细胞。 人原始肝干细胞可以通过人肝脏的免疫选择或在选择人原始肝干细胞的条件下培养人肝细胞来分离。 可以通过免疫选择或通过在包括发育因子的条件下培养人肝细胞来分离近端肝干细胞。 也可以通过在包括发育因子的条件下培养包含原始肝干细胞的菌落来分离近端肝干细胞。 所得组合物可用于治疗肝脏疾病和用于生产生物人造器官。