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    GASTRIC REFLUX RESISTANT DOSAGE FORMS
    94.
    发明申请
    GASTRIC REFLUX RESISTANT DOSAGE FORMS 有权
    胃肠反射耐药剂型

    公开(公告)号：US20100158958A1

    公开(公告)日：2010-06-24

    申请号：US12716593

    申请日：2010-03-03

    申请人： Nachiappan Chidambaram

    发明人： Nachiappan Chidambaram

    IPC分类号： A61K35/60 ,  A61K36/8962 ,  A61K36/48 ,  A61K31/25 ,  A61P3/02 ,  B29C39/02 ,  A61K47/42 ,  A61K9/00

    CPC分类号： A61K9/4825 ,  A61K9/4816 ,  A61K9/4833 ,  A61K35/60 ,  A61K47/10 ,  A61K47/36 ,  A61K47/42

    摘要： Gastric resistant film-forming compositions are described herein. The composition comprises a gastric resistant natural polymer, a film-forming natural polymer, and optionally a gelling agent. Suitable gastric resistant natural polymers include polysaccharides such as pectin and pectin-like polymers. The film-forming composition can be used to prepare soft or hard shell gelatin capsules which can encapsulate a liquid or semi-solid fill material or a solid tablet (Softlet®) comprising an active agent and one or more pharmaceutically acceptable excipients. Alternatively, the composition can be administered as a liquid with an active agent dissolved or dispersed in the composition. The compositions are not only gastric resistant but may also prevent gastric reflux associated with odor causing liquids, such as fish oil or garlic oil, encapsulated in a unit dosage form and esophageal irritation due to the reflux of irritant drugs delivered orally.

    摘要翻译： 本文描述了耐胃成膜组合物。 该组合物包含耐胃天然聚合物，成膜天然聚合物和任选的胶凝剂。 合适的耐胃天然聚合物包括多糖如果胶和果胶样聚合物。 成膜组合物可用于制备可包封液体或半固体填充材料的软壳或硬壳明胶胶囊或包含活性剂和一种或多种药学上可接受的赋形剂的固体片剂（Softlet）。 或者，组合物可以以溶解或分散在组合物中的活性剂作为液体施用。 组合物不仅具有抗胃肠道功能，而且还可以防止与气味引起的胃反流相关，所述气体引起的液体如鱼油或大蒜油以单位剂型形式包封，并且由于口服递送的刺激性药物的反流引起的食管刺激。

    Topical antimicrobial pharmaceutical compositions and methods
    99.
    发明授权
    Topical antimicrobial pharmaceutical compositions and methods 失效
    局部抗微生物药物组合物和方法

    公开(公告)号：US5208257A

    公开(公告)日：1993-05-04

    申请号：US902767

    申请日：1992-06-23

    申请人： Jon J. Kabara

    发明人： Jon J. Kabara

    IPC分类号： A01N37/12 ,  A61K31/20 ,  A61K31/23 ,  A61K31/25

    CPC分类号： A61K31/25 ,  A01N37/12 ,  A61K31/20 ,  A61K31/23

    摘要： The present invention discloses a topical antimicrobial and anti-parasite pharmaceutical composition and methods of using the same. The topical antimicrobial pharmaceutical composition includes a safe and effective amount of an ethoxylated or propoxylated glycerol fatty acid ester and a pharmaceutically acceptable carrier. Also disclosed is a topical antimicrobial pharmaceutical composition including a safe and effective amount of a tertiary mixture including, a glycerol fatty acid ester, a binary mixture of fatty acids including a first fatty acid antimicrobial agent selected from C.sub.6 to C.sub.18 fatty acids, and a second fatty acid antimicrobial agent selected from C.sub.6 to C.sub.18 fatty acids, and a pharmaceutically acceptable carrier. Further disclosed is a topical antimicrobial pharmaceutical composition including a safe and effective amount of an ethoxylated or propoxylated glycerol fatty acid ester, a binary fatty acid mixture including, a first fatty acid antimicrobial agent selected from C.sub.6 to C.sub.18 fatty acid and the second fatty acid antimicrobial agent selected from C.sub.6 to C.sub.18 fatty acids, where the second fatty acid is not the same as the first fatty acid, and a pharmaceutically acceptable carrier. Further disclosed is a method of treating and preventing microbial related skin conditions in humans or lower animals comprising topically applying, to the afflicted situs of a human of lower animal in need of such treatment, a safe and effective amount of the above composition.

    摘要翻译： 本发明公开了一种局部抗微生物剂和抗寄生虫药物组合物及其使用方法。 局部抗微生物药物组合物包括安全有效量的乙氧基化或丙氧基化甘油脂肪酸酯和药学上可接受的载体。 还公开了一种局部抗微生物药物组合物，其包括安全有效量的叔混合物，包括甘油脂肪酸酯，脂肪酸的二元混合物，包括选自C6至C18脂肪酸的第一种脂肪酸抗微生物剂和第二种 选自C6至C18脂肪酸的脂肪酸抗微生物剂和药学上可接受的载体。 还公开了一种局部抗微生物药物组合物，其包括安全有效量的乙氧基化或丙氧基化甘油脂肪酸酯，二元脂肪酸混合物，其包含选自C6至C18脂肪酸的第一种脂肪酸抗微生物剂和第二种脂肪酸抗微生物剂 选自C6至C18脂肪酸的试剂，其中第二脂肪酸与第一脂肪酸不同，和药学上可接受的载体。 还公开了一种治疗和预防人类或低等动物中微生物相关皮肤病症的方法，其包括向需要这种治疗的较低级动物的受影响的部位局部施用安全有效量的上述组合物。