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91.发明申请公开(公告)号：US20110243925A1
公开(公告)日：2011-10-06
申请号：US11911222
申请日：2006-04-13
Applicant: Niko Bausch , Heinz-Herbert Fiebig , André Korrat , Martina Maurer , Thomas Metz , Julia Schüler
Inventor： Niko Bausch , Heinz-Herbert Fiebig , André Korrat , Martina Maurer , Thomas Metz , Julia Schüler
IPC: A61K39/395 , C40B40/08 , C12Q1/68 , A61P35/00
CPC classification number: C12Q1/6809 , C12Q1/68 , C12Q1/6837 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G06F19/20
Abstract: The present invention relates to a method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound, the use thereof, a microarray wherein the nucleotide sequences attached to the substrate consist of nucleotide sequences corresponding to the predictive genes of said gene expression profile, and a diagnostic kit containing said microarray.
Abstract translation: 本发明涉及一种用于提供基因表达谱的方法，该基因表达谱预测各个肿瘤对药学上有效的化合物的特异性应答，其用途，微阵列，其中与底物连接的核苷酸序列由对应于 所述基因表达谱的预测基因和含有所述微阵列的诊断试剂盒。
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92.发明申请公开(公告)号：US20110237454A1
公开(公告)日：2011-09-29
申请号：US13034051
申请日：2011-02-24
Applicant: Woong Yang Park , Ae Kyung Park , Chang Nim Im , Sook Ik Jeon
Inventor： Woong Yang Park , Ae Kyung Park , Chang Nim Im , Sook Ik Jeon
IPC: C40B30/04 , C07H21/04 , C07K16/00 , C40B40/06 , C40B40/10 , C40B40/08 , C12Q1/68 , G01N33/50 , G01N33/53
CPC classification number: G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N2800/40 , Y10T436/143333
Abstract: Disclosed are a composition for the diagnosis of exposure to electromagnetic radiation, comprising an agent capable of measuring the expression level of the diagnostic marker, a diagnosis kit comprising the same, a method for detecting the diagnostic marker, and a method for the diagnosis of exposure to electromagnetic radiation. The diagnostic markers are very useful for monitoring and diagnosing exposure to electromagnetic fields, and can be used as instruments by which physiological mechanisms incurred upon electromagnetic radiation exposure are examined.
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93.发明申请MARKER FOR DIAGNOSIS OF EXPOSURE TO ELECTROMAGNETIC RADIATION AND DIAGNOSTIC KIT COMPRISING THE SAME 审中-公开用于诊断接触电磁辐射的标记和包含其的诊断试剂盒公开(公告)号：US20110237453A1
公开(公告)日：2011-09-29
申请号：US13033813
申请日：2011-02-24
Applicant: Woong Yang Park , Ae Kyung Park , Chang Nim Im , Sook Ik Jeon
Inventor： Woong Yang Park , Ae Kyung Park , Chang Nim Im , Sook Ik Jeon
IPC: C40B30/04 , C07H21/04 , C07K16/00 , C40B40/06 , C40B40/10 , C40B40/08 , C12Q1/68 , G01N33/50 , G01N33/53
CPC classification number: C12Q1/6883 , C12Q2600/158 , G01N2800/40 , Y10T436/143333
Abstract: Disclosed are a composition for the diagnosis of exposure to electromagnetic radiation, comprising an agent capable of measuring the expression level of the diagnostic marker, a diagnosis kit comprising the same, a method for detecting the diagnostic marker, and a method for the diagnosis of exposure to electromagnetic radiation. The diagnostic markers are very useful for monitoring and diagnosing exposure to electromagnetic fields, and can be used as instruments by which physiological mechanisms incurred upon electromagnetic radiation exposure are examined.
Abstract translation: 公开了用于诊断暴露于电磁辐射的组合物，其包括能够测量诊断标记物的表达水平的试剂，包含该诊断标记物的诊断试剂盒，用于检测诊断标记物的方法和用于诊断暴露的方法 到电磁辐射。 诊断标记对于监测和诊断电磁场的暴露非常有用，可用作检查电磁辐射暴露时产生的生理机制的仪器。
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公开(公告)号：US20110207628A1
公开(公告)日：2011-08-25
申请号：US13062860
申请日：2009-06-09
Applicant: Wei Li , Xiaoyu Jiang , Nora Blanca Caberoy
Inventor： Wei Li , Xiaoyu Jiang , Nora Blanca Caberoy
CPC classification number: C12N15/1037 , C07K2319/20 , C07K2319/50
Abstract: A dual display phage system for the identification of protein interaction networks and therapeutic targets.
Abstract translation: 用于鉴定蛋白质相互作用网络和治疗靶标的双重显示噬菌体系统。
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95.发明申请METHODS AND SYSTEMS FOR NUCLEIC ACID SEQUENCING VALIDATION, CALIBRATION AND NORMALIZATION 有权用于核酸序列确认，校准和正常化的方法和系统公开(公告)号：US20110207624A1
公开(公告)日：2011-08-25
申请号：US13030818
申请日：2011-02-18
Applicant: Min-Yi Shen , Douglas Greiner
Inventor： Min-Yi Shen , Douglas Greiner
CPC classification number: C12Q1/6874 , B01J2219/005 , C12Q2533/107 , C12Q2535/122 , G01N2201/1242 , G06F19/22 , C12Q2563/149 , C12Q2545/101
Abstract: A system for performing quality control for nucleic acid sample sequencing is disclosed. The system comprises a set of solid supports, each solid support having attached thereto a plurality of nucleic acid sequences, wherein the set comprises plural groups of solid supports and each group contains solid supports having the same nucleic acid sequences attached thereto. The nucleic acid sequences of each group differ from each other. The nucleic acid sequences are synthetically derived, and the nucleic acids sequences are designed such that the nucleic acid sequences produce a predefined pattern of detectable signals during a sequencing run. A method of preparing a quality control for performing nucleic acid sample sequencing, a method of validating a nucleic acid sequencing instrument during a nucleic acid sequencing experiment, and a method of processing nucleic acid sequencing data during a nucleic acid sequencing experiment are also disclosed.
Abstract translation: 公开了一种用于进行核酸样品测序的质量控制的系统。 该系统包含一组固体支持物，每个固体支持物附着有多个核酸序列，其中该组包含多组固体支持物，并且每组含有与其相连的相同核酸序列的固体支持物。 各组的核酸序列彼此不同。 核酸序列是合成衍生的，并且设计核酸序列使得核酸序列在测序运行期间产生可检测信号的预定模式。 还公开了制备用于进行核酸样品测序的质量控制的方法，在核酸测序实验期间验证核酸测序仪的方法，以及在核酸测序实验期间处理核酸测序数据的方法。
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Patent Agency Ranking
96.发明申请公开(公告)号：US20110201525A1
公开(公告)日：2011-08-18
申请号：US13093518
申请日：2011-04-25
Applicant: Jennifer Jones
Inventor： Jennifer Jones
CPC classification number: C12N15/1068 , C07K14/415 , C12N9/16 , C12N15/1044
Abstract: Libraries of nucleic acids encoding chimeric binding polypeptides based on plant scaffold polypeptide sequences. Also described are methods for generating the libraries.
Abstract translation: 基于植物支架多肽序列编码嵌合结合多肽的核酸的文库。 还描述了用于生成库的方法。
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公开(公告)号：US20110177976A1
公开(公告)日：2011-07-21
申请号：US13002137
申请日：2009-06-30
Applicant: Jeffrey I. Gordon , Peter Turnbaugh
Inventor： Jeffrey I. Gordon , Peter Turnbaugh
CPC classification number: G01N33/56911 , A23V2002/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , A23V2200/332
Abstract: Methods of modulating body fat or weight loss are presented Nucleic acid and protein microarrays that comprise biomolecules associated with an obese host microbiome or a lean host microbiome are utilized for analysis.
Abstract translation: 提供调节体脂肪或体重减轻的方法使用包含与肥胖宿主微生物组织或贫血宿主微生物组合物相关的生物分子的核酸和蛋白质微阵列进行分析。
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公开(公告)号：US20110158997A1
公开(公告)日：2011-06-30
申请号：US12936981
申请日：2009-04-08
Applicant: Nicola Mason
Inventor： Nicola Mason
IPC: A61K39/395 , C12P19/34 , C40B40/08 , C40B30/04 , C07H21/00 , C07K16/00 , C12N5/09 , G01N33/574 , C12Q1/70 , A61P35/00 , A61P35/04 , A61P31/12 , A61P31/20 , A61P29/00 , A61P31/04 , A61P31/10 , A61P33/00 , A61P37/04
CPC classification number: C07K16/005 , A61K2039/505 , C07K16/3053 , C07K2317/20 , C07K2317/622
Abstract: The invention is generally directed to antibody variable domains or antibodies, libraries of antibody variable domains or antibodies, methods of making said antibodies and libraries, and methods of treatment comprising administering the generated antibody variable domains or antibodies. Specifically, the invention is directed to novel primer nucleotide sequences that are used to amplify all rearranged sequences of canine variable heavy (VH) and variable light (VL) immunoglobulin chains that have been used in naturally occurring antibody responses. These novel sequences contain canine framework regions and complementarity determining regions which may be used to canine-ize antibodies. Further, these sequences are useful for the identification and targeting of viral and bacterial pathogens, and tumor-associated antigens.
Abstract translation: 本发明一般涉及抗体可变结构域或抗体，抗体可变结构域或抗体的文库，制备所述抗体和文库的方法，以及治疗方法，包括施用产生的抗体可变结构域或抗体。 具体地，本发明涉及用于扩增已经用于天然存在的抗体应答的犬可变重（VH）和可变轻（VL）免疫球蛋白链的所有重排序列的新型引物核苷酸序列。 这些新颖的序列含有犬骨架区和互补决定区，可用于犬抗人抗体。 此外，这些序列可用于鉴定和靶向病毒和细菌病原体以及肿瘤相关抗原。
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99.发明授权公开(公告)号：US07951753B2
公开(公告)日：2011-05-31
申请号：US11706847
申请日：2007-02-13
Applicant: Jennifer Jones
Inventor： Jennifer Jones
CPC classification number: C12N15/1068 , C07K14/415 , C12N9/16 , C12N15/1044
Abstract: Libraries of nucleic acids encoding chimeric binding polypeptides based on plant scaffold polypeptide sequences. Also described are methods for generating the libraries.
Abstract translation: 基于植物支架多肽序列编码嵌合结合多肽的核酸的文库。 还描述了用于生成库的方法。
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公开(公告)号：US20110113498A1
公开(公告)日：2011-05-12
申请号：US12992765
申请日：2009-05-15
Applicant: Christoph H. Westphal , Marc Donath , Peter Elliott , Michael Jirousek , Jill Milne
Inventor： Christoph H. Westphal , Marc Donath , Peter Elliott , Michael Jirousek , Jill Milne
CPC classification number: C07K14/4702 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
Abstract: Provided herein are Sirt1 polymorphic variants having a substitution at amino acid residue 107 or nucleotide 373. In certain embodiments, the Sirt1 polypeptide variants have a L107P substitution and the nucleic acid variants have a T373C substitution. Genetic and/or biochemical testing may be performed to identify whether a patient carries one of the disclosed polymorphic variants. Based on the polymorphic variant the patient carries, a medical practitioner may administer an appropriate therapy, such as a sirtuin activator.
Abstract translation: 本文提供了在氨基酸残基107或核苷酸373处具有取代的Sirt1多态变体。在某些实施方案中，Sirt1多肽变体具有L107P取代，并且核酸变体具有T373C取代。 可以进行遗传和/或生化测试以鉴定患者是否携带所公开的多态变体之一。 基于患者携带的多态变体，医师可以施用适当的治疗，例如沉默调节蛋白激活剂。
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