公开(公告)号：US07361146B1

公开(公告)日：2008-04-22

申请号：US11416317

申请日：2006-05-01

申请人： Rupinder Bharmi ,  Gene A. Bornzin

发明人： Rupinder Bharmi ,  Gene A. Bornzin

IPC分类号： A61B5/02 ,  A61B5/04 ,  A61B5/08 ,  A61N1/00

CPC分类号： A61B5/0452 ,  A61B5/0031 ,  A61B5/02405 ,  A61B5/0472 ,  A61B5/08 ,  A61B5/0803 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/145 ,  A61B5/411 ,  A61B5/4818 ,  A61B2562/0219 ,  A61N1/3601 ,  A61N1/365 ,  A61N1/37

摘要： Techniques are provided for tracking patient respiration based upon intracardiac electrogram (IEGM) signals or other electrical cardiac signals. Briefly, respiration patterns are detected based upon cycle-to-cycle changes in morphological features associated with individual electrical events with the IEGM signals. For example, slight changes in the peak amplitudes of QRS-complexes, P-waves or T-waves are tracked to identify cyclical variations representative of patient respiration. Alternatively, the integrals of the morphological features of the individual events may be calculated for use in tracking respiration. In any case, once respiration patterns have been identified, episodes of abnormal respiration, such as apnea, hyperpnea, nocturnal asthma, or the like, may be detected and therapy automatically delivered. In particular, techniques for detecting abnormal respiration based on various respiratory parameters derived from the IEGM—such as respiration depth and respiration power—are described.

摘要翻译： 提供了基于心内电描记图（IEGM）信号或其他心电信号跟踪患者呼吸的技术。 简而言之，基于与具有IEGM信号的各个电气事件相关联的形态特征的周期到周期的变化来检测呼吸模式。 例如，跟踪QRS复合物，P波或T波的峰值振幅的轻微变化来识别代表患者呼吸的周期性变化。 或者，可以计算各个事件的形态特征的积分用于跟踪呼吸。 无论如何，一旦发现呼吸模式，可以检测出异常呼吸发作，如呼吸暂停，呼吸过度，夜间哮喘等，并且治疗自动递送。 特别地，描述了基于从IEGM得到的各种呼吸参数（例如呼吸深度和呼吸功率）来检测异常呼吸的技术。

公开(公告)号：US07359752B1

公开(公告)日：2008-04-15

申请号：US11181708

申请日：2005-07-13

申请人： Gene A. Bornzin ,  Mark W. Kroll

发明人： Gene A. Bornzin ,  Mark W. Kroll

IPC分类号： A61N1/00

CPC分类号： A61N1/372 ,  A61B50/30 ,  A61N1/37235 ,  A61N2001/37294 ,  G06F19/3481 ,  G16H40/63

摘要： A test assembly for an implantable medical device, which includes a patient simulator capable of providing signals to the implantable medical device that are representative of the patient's organ function to thereby test whether the implantable medical device is capable of detecting circumstances requiring the deliver of therapy. The patient simulator further includes a plurality of loads that can be selected to correspond to the loads actually seen by the implantable medical device when delivering therapy to the patient.

摘要翻译： 一种用于可植入医疗装置的测试组件，其包括能够向可植入医疗装置提供代表患者器官功能的信号的患者模拟器，从而测试可植入医疗装置是否能够检测需要递送治疗的情况。 患者模拟器还包括多个负载，其可以选择以对应于当向患者递送治疗时由可植入医疗装置实际看到的负载。

公开(公告)号：US07289848B1

公开(公告)日：2007-10-30

申请号：US10723027

申请日：2003-11-25

申请人： Gene A. Bornzin ,  Joseph J. Florio ,  Kerry Bradley

发明人： Gene A. Bornzin ,  Joseph J. Florio ,  Kerry Bradley

IPC分类号： A61N1/362 ,  A61B5/402

CPC分类号： A61N1/3702 ,  A61N1/368

摘要： An implantable cardiac stimulation system and method provides an external display of a heart activity signal sensed internally by an implantable cardiac stimulation device which has the appearance of a surface EKG. The heart activity signal is sensed by the implanted device and is processed by the device or the external display to have frequency characteristics resembling that of a surface EKG. The heart activity signal to be displayed takes the form of an intracardiac electrogram signal with a low frequency roll-on of no greater than 0.4 Hz and a high frequency cutoff of no less than 20 Hz. This provides a heart activity signal for display which has the appearance and most attributes of a surface EKG.

摘要翻译： 可植入心脏刺激系统和方法提供外部显示心脏活动信号，该心脏活动信号由具有表面EKG外观的可植入心脏刺激装置内部感测。 心脏活动信号由植入装置感测，并被装置或外部显示器处理以具有类似于表面EKG的频率特性。 要显示的心脏活动信号采取心内电图信号的形式，具有不大于0.4Hz的低频滚动和不小于20Hz的高频截止。 这提供了用于显示的心脏活动信号，其具有表面EKG的外观和大多数属性。

公开(公告)号：US07233827B1

公开(公告)日：2007-06-19

申请号：US10865124

申请日：2004-06-09

申请人： Gene A. Bornzin ,  Joseph J. Florio ,  Laurence S. Sloman ,  Brian M. Mann ,  Jason A. Sholder

发明人： Gene A. Bornzin ,  Joseph J. Florio ,  Laurence S. Sloman ,  Brian M. Mann ,  Jason A. Sholder

IPC分类号： A61N1/365

CPC分类号： A61N1/3686 ,  A61N1/36185 ,  A61N1/371

摘要： An implantable cardiac stimulation device applies pacing stimulation pulses to a heart and senses evoked responses to the pacing stimulation pulses. A pulse generator applies the stimulation pacing pulses to the heart in accordance with a pacing configuration. A sensor control selects an evoked response sensing electrode configuration from among a plurality of evoked response sensing electrode configurations in response to the pacing configuration. A sensor is then programmed to sense the evoked responses with the selected evoked response sensing electrode configuration. In accordance with a preferred embodiment, signal-to-noise ratios obtained with the various electrode configurations are used to select a best electrode configuration for sensing evoked responses.

摘要翻译： 可植入心脏刺激装置将起搏刺激脉冲应用于心脏并感测对起搏刺激脉冲的诱发反应。 脉冲发生器根据起搏配置将刺激起搏脉冲施加到心脏。 传感器控制器响应于起搏配置从多个诱发响应感测电极配置中选择诱发响应感测电极配置。 然后将传感器编程为用所选择的诱发响应感测电极配置感测诱发的反应。 根据优选实施例，使用用各种电极配置获得的信噪比用于选择用于感测诱发响应的最佳电极配置。

公开(公告)号：US07225023B1

公开(公告)日：2007-05-29

申请号：US10032793

申请日：2001-10-25

申请人： Euljoon Park ,  Gene A. Bornzin ,  Junyu Mai

发明人： Euljoon Park ,  Gene A. Bornzin ,  Junyu Mai

IPC分类号： A61N1/365

CPC分类号： A61N1/36542

摘要： A system and method are provided for compensating for the drop in blood pressure upon standing. Upon transition from prolonged sitting, lying down, or standing position, the pacemaker abruptly increasing its pacing rate upon postural transition. This pacing rate is triggered when a patient stands after a prolonged reclined or supine/prone position.

摘要翻译： 提供了一种用于补偿静置时血压下降的系统和方法。 从长时间的坐姿，躺下或站姿转移时，起搏器在姿势转换时突然增加起搏速度。 当患者在长时间倾斜或仰卧/俯卧位后立即触发起搏速率。

公开(公告)号：US07212862B2

公开(公告)日：2007-05-01

申请号：US10247137

申请日：2002-09-18

申请人： Euljoon Park ,  Steve Koh ,  Gene A. Bornzin

发明人： Euljoon Park ,  Steve Koh ,  Gene A. Bornzin

IPC分类号： A61N1/365

CPC分类号： A61N1/36585 ,  A61N1/3601 ,  A61N1/36542 ,  A61N1/36557

摘要： An implantable cardiac stimulation device comprises a physiologic sensor and one or more pulse generators. The physiologic sensor is capable of sensing a physiologic parameter. The pulse generators can generate cardiac pacing pulses with a timing based on the physiologic parameter. The timed cardiac pacing pulses can prevent a sleep apnea condition. In one example, a cardiac stimulation device has a physiologic sensor and can be configured to pace a patient's heart according to a rest mode of operation. The cardiac stimulation device uses measurements from the physiologic sensor to prevent and treat sleep apnea using a revised rest mode of operation. The revised rest mode operates under a presumption that sleep apnea is primary to a reduced heart rate, rather than secondary, so that pacing at a rate higher than the natural cardiac rate during sleep will prevent sleep apnea.

摘要翻译： 植入式心脏刺激装置包括生理传感器和一个或多个脉冲发生器。 生理传感器能感测生理参数。 脉冲发生器可以产生基于生理参数的定时的心脏起搏脉冲。 定时的心脏起搏脉冲可以防止睡眠呼吸暂停状态。 在一个示例中，心脏刺激装置具有生理传感器，并且可以被配置为根据休息的操作模式来对患者的心脏进行加速。 心脏刺激装置使用来自生理传感器的测量来使用修改的休息模式来预防和治疗睡眠呼吸暂停。 修改后的休息模式的作用是假设睡眠呼吸暂停是降低心率而不是继发性睡眠呼吸暂停的原因，因此在睡眠期间以高于自然心率的速率起搏将防止睡眠呼吸暂停。

公开(公告)号：US07155282B1

公开(公告)日：2006-12-26

申请号：US10719307

申请日：2003-11-21

申请人： Xiaoyi Min ,  Gene A. Bornzin ,  Jeffery D. Snell

发明人： Xiaoyi Min ,  Gene A. Bornzin ,  Jeffery D. Snell

IPC分类号： A61N1/362

CPC分类号： A61N1/3704 ,  A61B5/0452 ,  A61B5/0456

摘要： A threshold sensing control for use in an implantable cardiac stimulation device controls the sensing of cardiac activity during a current cardiac cycle of a heart while avoiding sensing a T wave. The system includes a sensing circuit that senses cardiac activity of the heart during a cardiac cycle preceding the current cardiac cycle, a detector that measures selected T wave and R wave characteristics of the cardiac activity and a control circuit that varies the sensing threshold based upon the measured selected R wave and T wave characteristics. The sensing threshold control may be implemented for both intrinsic and paced beats.

摘要翻译： 用于可植入心脏刺激装置的阈值感测控制器控制在心脏的当前心动周期期间对心脏活动的感测，同时避免感测T波。 该系统包括感测电路，该感测电路在当前心动周期之前的心动周期期间感测心脏的心脏活动，测量心脏活动的所选T波和R波特征的检测器以及基于 测量选定的R波和T波特性。 感测阈值控制可以针对内部节奏和节奏节拍实现。

公开(公告)号：US07149584B1

公开(公告)日：2006-12-12

申请号：US10328642

申请日：2002-12-23

申请人： Steve Koh ,  Mark W. Kroll ,  Euljoon Park ,  Gene A. Bornzin

发明人： Steve Koh ,  Mark W. Kroll ,  Euljoon Park ,  Gene A. Bornzin

IPC分类号： A61N1/00

CPC分类号： A61N1/37252 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/37235

摘要： Time-varying spatial signals are detected by accelerometers mounted within the patient. The signals, representative of the actual 3-D trajectory of the patient, are compared with information representative of expected trajectories retrieved from memory to identify a current patient posture, which may be either a dynamic posture such as walking or running or a change in posture such as rising from a seated position to a standing position. In this manner, a change in posture of the patient is identified based upon a full 3-D trajectory, rather than merely the orientation of the patient at the beginning and the end of the change in posture. In an example described herein, the implantable device stores information representative of expected 3-D trajectories in the form of pre-calculated comparison matrices derived from orthonormal kernels employing Laguerre functions or Lagrange functions. A technique is also described for use by an external programmer for pre-calculating comparison matrices so as to reduce the processing burden within the implanted device during posture detection.

公开(公告)号：US07133721B1

公开(公告)日：2006-11-07

申请号：US10868493

申请日：2004-06-14

申请人： Gene A. Bornzin ,  Peter Boileau

发明人： Gene A. Bornzin ,  Peter Boileau

IPC分类号： A61N1/365

CPC分类号： A61N1/3621 ,  A61N1/365

摘要： An exemplary method includes providing an overdrive pacing rate, based at least in part on the overdrive pacing rate, determining an incidence limit for incidence of intrinsic atrial activity events, determining an incidence of intrinsic atrial activity events, comparing the incidence of intrinsic atrial activity events to the incidence limit and, based at least on the comparing, deciding whether to adjust the overdrive pacing rate. According to this exemplary method, the incidence limit is optionally a function of overdrive pacing rate. Another exemplary method includes determining a dwell limit wherein the dwell limit is optionally a function of overdrive pacing rate. Other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 一种示例性方法包括至少部分地基于超速起搏速率提供超速起搏速率，确定固有心房活动事件的发生率的发生率，确定固有心房活动事件的发生率，比较固有心房活动事件的发生率 至于发病限度，至少基于比较，决定是否调整超速起搏率。 根据该示例性方法，入射限制可选地是超速起搏速率的函数。 另一示例性方法包括确定停留极限，其中停留极限可选地是超速起搏速率的函数。 还公开了其它示例性方法，装置，系统等。

公开(公告)号：US07133719B1

公开(公告)日：2006-11-07

申请号：US10868331

申请日：2004-06-14

申请人： Gene A. Bornzin ,  Peter Boileau

发明人： Gene A. Bornzin ,  Peter Boileau

IPC分类号： A61N1/36

CPC分类号： A61N1/3622 ,  A61N1/365

摘要： An exemplary method includes providing an overdrive pacing rate, based at least in part on the overdrive pacing rate, determining an incidence limit for incidence of intrinsic atrial activity events, determining an incidence of intrinsic atrial activity events, comparing the incidence of intrinsic atrial activity events to the incidence limit and, based at least on the comparing, deciding whether to adjust the overdrive pacing rate. According to this exemplary method, the incidence limit is optionally a function of overdrive pacing rate. Another exemplary method includes determining a dwell limit wherein the dwell limit is optionally a function of overdrive pacing rate. Other exemplary methods, devices, systems, etc., are also disclosed.