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公开(公告)号：US11027273B2
公开(公告)日：2021-06-08
申请号：US15555002
申请日：2016-03-01
Inventor： Xiujun Li , Sanjay Timilsina
IPC: B01L3/00 , G01N33/543 , G01N33/558
Abstract: Certain embodiments are directed to a paper hybrid microfluidic microplate. In certain aspects, the hybrid microfluidic microplate is a low-cost, sensitive, and fast diagnostic apparatus for detecting pathogens, diagnosing disease and other bio-applications, especially for low-resource settings.
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公开(公告)号：US20210156729A1
公开(公告)日：2021-05-27
申请号：US17097889
申请日：2020-11-13
Inventor： Constantine Tarawneh , Stephen Crown
Abstract: Described herein is a load sensor for a railcar that includes one or more strain gauges and one or more temperature sensors. The load sensor has a size and configuration that allows the load sensor to be embedded in a bearing adapter under the polymer steering pad of the railcar.
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公开(公告)号：US11013818B2
公开(公告)日：2021-05-25
申请号：US16114187
申请日：2018-08-27
Inventor： Jinming Gao , Gang Huang , Tian Zhao , Xinpeng Ma , Yiguang Wang , Yang Li , Baran D. Sumer
IPC: A61K49/00 , C09B69/10 , G01N33/84 , G01N33/58 , G01N21/64 , C08F8/42 , C08F8/34 , C08F8/32 , C08F8/30
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20210148825A1
公开(公告)日：2021-05-20
申请号：US17135679
申请日：2020-12-28
Inventor： Reto P. Fiolka
Abstract: This disclosure includes an imaging system that is configured to image in parallel multiple focal planes in a sample uniquely onto its corresponding detector while simultaneously reducing blur on adjacent image planes. For example, the focal planes can be staggered such that fluorescence detected by a detector for one of the focal planes is not detected, or is detected with significantly reduced intensity, by a detector for another focal plane. This enables the imaging system to increase the volumetric image acquisition rate without requiring a stronger fluorescence signal. Additionally or alternatively, the imaging system may be operated at a slower volumetric image acquisition rate (e.g., that of a conventional microscope) while providing longer exposure times with lower excitation power. This may reduce or delay photo-bleaching (e.g., a photochemical alteration of the dye that causes it to no longer be able to fluoresce), thereby extending the useful life of the sample.
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公开(公告)号：US20210146969A1
公开(公告)日：2021-05-20
申请号：US17097450
申请日：2020-11-13
Inventor： Constantine Tarawneh , Robert Jones , Anthony Villarreal , Harry Siegel
Abstract: Described herein is an electrically and thermally conductive thermoplastic polyurethane. The conductive thermoplastic polyurethane is formed in an injection-molded process from vapor grown carbon nanofibers and a modified form of thermoplastic polyurethane (TPU). The polymer pad encompassing the injection-molded insert may be used to replace an existing railcar adapter pad.
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Patent Agency Ranking
106.发明申请公开(公告)号：US20210139934A1
公开(公告)日：2021-05-13
申请号：US17092240
申请日：2020-11-07
Inventor： Steven J. GRAY , Frances C. SHAFFO
Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SLC6A1 loss and/or misfunction. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a GAT1 polypeptide.
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公开(公告)号：US10995056B2
公开(公告)日：2021-05-04
申请号：US16316692
申请日：2017-07-11
Inventor： John R. Falck , Mahesh P. Paudyal , László Kürti
IPC: C08F4/64 , C08F4/60 , C08F10/00 , C08F4/619 , C08F110/02 , C07C209/02 , C07D211/02 , C07C213/02 , C07J41/00 , C07C227/06 , C07D489/02 , C07D215/06 , C07D215/20 , C07D215/18 , C07D215/12 , C07D265/36 , C07D209/08 , C07D223/16 , C07D207/06 , C07D209/58 , C07D203/10 , C07C209/00 , C07C303/30 , C07D211/12 , C07D209/96 , C07J1/00
Abstract: In some aspects, the present disclosure provides methods of aminating an aromatic compound comprising reacting an aminating agent with an aromatic compound in the presence of a rhodium catalyst. In some embodiments, the methods may comprise aminating an aromatic compound which contains multiple different functional groups. The methods described herein may also be used to create bicyclic system comprising reacting an intramolecular aminating agent with an aromatic ring to obtain a second ring containing a nitrogen atom. In another aspect, the methods described herein may also be used to create a cyclic aliphatic cyclic/poly cyclic amine system comprising a reacting an intramolecular aminating agent by insertion into a C(sp3)-H bond.
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公开(公告)号：US20210124977A1
公开(公告)日：2021-04-29
申请号：US17048817
申请日：2019-04-18
Inventor： Karen PANETTA , Shreyas KAMATH KALASA MOHANDAS , Sos AGAIAN
Abstract: The present disclosure includes systems and methods for multimedia image analytic including automated binarization, segmentation, and enhancement using bio-inspired based visual morphology schemes. The present disclosure further includes systems and methods for biometric multimedia content authentication using extracted geometric features and one or more of the binarization, segmentation, and enhancement methods.
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公开(公告)号：US20210115424A1
公开(公告)日：2021-04-22
申请号：US17052116
申请日：2019-05-01
Applicant: The Regents of the University of California , The Board of Regents of The University of Texas System
Inventor： Robert T. Clubb , Brendan Rayhan Amer , Janine Y. Fu , Scott McConnell , Hung Ton-That , Chungyu Chang
Abstract: Covalently cross-linked pilus polymers displayed on the cell surface of Gram-positive bacteria are assembled by class C sortase enzymes. These pilus-specific transpeptidases located on the bacterial membrane catalyze a two-step protein ligation reaction—first, cleaving the LPXTG motif of one pilin protomer to form an acyl-enzyme intermediate, and second, joining the terminal threonine to the nucleophilic lysine residue residing within the pilin motif of another pilin protomer. Informed by the high-resolution crystal structures of corynebacterial pilus-specific sortase (SrtA) and by developing structural variants of the sortase enzyme whose catalytic pocket has been unmasked by activating mutations, we have developed new reagents capable of forming isopeptide bonds in vitro. The reagents disclosed herein can catalyze ligation of isolated SpaA domains in vitro provide a facile and versatile new platform for protein engineering and bio-conjugation that has major implications for biotechnology.
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公开(公告)号：US20210113402A1
公开(公告)日：2021-04-22
申请号：US16606627
申请日：2018-04-20
Inventor： Muthu WIJESUNDARA , Wei Carrigan
Abstract: Pressure modulating soft actuator array devices and related systems and methods. One example of the present systems comprises: a device having a body that defines a plurality of cavities; a pressure source configured to be in fluid communication with the plurality of cavities; a plurality of sensors configured to capture data indicative of pressure within the plurality of cavities; and one or more controllers configured to actuate the pressure source to move fluid toward and/or away from one or more of the plurality of cavities in response to data captured by the plurality of sensors; wherein the device is configured to be disposed between a user and a surface on which the user is seated upon.
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