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    AUTOMATED PRODUCT ENGAGER, TRANSPORTER AND PATTERENED DEPOSITOR SYSTEM
    102.
    发明申请
    AUTOMATED PRODUCT ENGAGER, TRANSPORTER AND PATTERENED DEPOSITOR SYSTEM 有权
    自动产品助推器，运输机和图形存放系统

    公开(公告)号：US20130152511A1

    公开(公告)日：2013-06-20

    申请号：US13810620

    申请日：2011-08-09

    Applicant: Stephen Derby ,  John McFadden ,  David Brown ,  Eugene Eckert

    Inventor： Stephen Derby ,  John McFadden ,  David Brown ,  Eugene Eckert

    IPC: B65B3/00

    CPC classification number: B65B3/00 ,  B65B5/105 ,  B65B35/246 ,  B65B61/28 ,  B65B2220/18 ,  B65G15/44 ,  B65G47/5118 ,  B65G47/52

    Abstract: The system (30) includes a product engager (32), a transporter (34) and a patterned depositor (36) for engaging products (38) and transporting the products (38) from the product engager (32) to the patterned depositor (36), such as between a product bagging machine (56) that forms and fills a bag (24), a conveyor that transports the bags as the products (38) and delivers them to a case packing machine as the patterned depositor (36). The product engager (32) and the patterned depositor (36) include first and second drivers (46, 48) and the transporter (34) includes an adjustable-length buffer (50) to compensate for any temporary difference between a first product delivery rate of the product engager (32) and a rate of movement of the products (38) passing from the product engager (32) along the transporter (34) to the patterned depositor (36).

    Abstract translation: 系统（30）包括产品收集器（32），运送器（34）和图案化存放器（36），用于接合产品（38）并将产品（38）从产品收集器（32）运送到图案化存放器 36），例如在形成并填充袋（24）的产品包装机（56）之间，作为产品（38）运输袋并将其作为图案化存放器（36）输送到包装机的输送机， 。 产品收集器（32）和图案化存储器（36）包括第一和第二驱动器（46,48），并且运输器（34）包括可调节长度的缓冲器（50），以补偿第一产品传送速率 （32）的产品（38）的运动速率以及从产品接合器（32）沿着运送器（34）传送到图案化存放器（36）的运动速率。

    Bifurcate arbiter
    104.
    发明授权
    Bifurcate arbiter 有权
    分叉仲裁者

    公开(公告)号：US08402181B2

    公开(公告)日：2013-03-19

    申请号：US12046590

    申请日：2008-03-12

    Applicant: David Brown

    Inventor： David Brown

    IPC: G06F3/00 ,  G06F15/173 ,  H04Q11/00

    CPC classification number: H04L49/90 ,  H04L47/50 ,  H04L47/58 ,  H04L47/6225 ,  H04L49/901

    Abstract: An arbiter for a space switch comprising a two buffers, a media access controller having data outputs coupled to the two buffers, and two control outputs coupled to respective buffers for buffering input data at a clock rate one-half that of the input data and a switch fabric connected to the two buffers for matching buffer data throughput with switch data throughput, the arbiter comprising first and second schedulers, each scheduler includes a plurality of inputs for connection to the two buffers for receiving requests, a plurality of outputs for granting requests and a plurality of inter connections to each of the plurality of schedulers for informing them of grants and logic for logically grouping input ports associated with a bifurcate input port, logically grouping output ports associated with a bifurcate output port, establishing round robin pointers for each of two alternate clock ticks for tracking next allowable requests and on one clock tick allowing connection requests from input ports to output ports and accepting a connection request in dependence upon the grouping of the input and output ports and the round robin pointer. The arbiter can be generalized to an n-furcated switch having n-furcated ports where n is an integer greater than or equal to two.

    Abstract translation: 一种用于空间切换器的仲裁器，包括两个缓冲器，具有耦合到两个缓冲器的数据输出的介质访问控制器以及耦合到相应缓冲器的两个控制输出，用于以输入数据的一半的时钟速率缓冲输入数据，以及 交换结构连接到两个缓冲器，用于与缓冲器数据吞吐量匹配，具有切换数据吞吐量，仲裁器包括第一和第二调度器，每个调度器包括用于连接到两个缓冲器的多个输入用于接收请求，多个输出用于授予请求， 与所述多个调度器中的每一个的多个内部连接，用于向所述多个调度器中的每个调度器通知用于逻辑地分组与双向输入端口相关联的输入端口的授权和逻辑，用于逻辑地分组与分支输出端口相关联的输出端口，为两个调度器中的每一个建立循环指针 用于跟踪下一个允许的请求的备用时钟滴答和允许连接请求的一个时钟刻度 输入端口到输出端口，并根据输入和输出端口和循环指针的分组接受连接请求。 仲裁器可以推广到具有n分叉端口的n分叉交换机，其中n是大于或等于2的整数。

    SYNTHETIC MIMICS OF MIR-34
    107.
    发明申请
    SYNTHETIC MIMICS OF MIR-34 失效
    MIR-34的合成纤维

    公开(公告)号：US20120288933A1

    公开(公告)日：2012-11-15

    申请号：US13365676

    申请日：2012-02-03

    Applicant: KEVIN KELNAR ,  David Brown

    Inventor： KEVIN KELNAR ,  David Brown

    IPC: C07H21/02 ,  C12N5/07

    CPC classification number: C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  C12N2310/141 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/3521

    Abstract: Embodiments concern methods and compositions involving miR-34 mimics, including miR-34a and miR-34c mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34a sequence and a complementary passenger strand. In additional embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34c sequence and a complementary passenger strand.

    Abstract translation: 实施方案涉及涉及miR-34模拟物的方法和组合物，包括miR-34a和miR-34c模拟物。 在一些实施方案中，存在具有经修饰的核苷酸的双链RNA分子，其具有miR-34a序列和补体乘客链的活性链。 在另外的实施方案中，存在具有经修饰的核苷酸的双链RNA分子，其具有与miR-34c序列和补体乘客链的活性链。

    METHODS AND COMPOSITIONS FOR REDUCING TARGET GENE EXPRESSION USING COCKTAILS OF siRNAS OR CONSTRUCTS EXPRESSING siRNAS
    110.
    发明申请
    METHODS AND COMPOSITIONS FOR REDUCING TARGET GENE EXPRESSION USING COCKTAILS OF siRNAS OR CONSTRUCTS EXPRESSING siRNAS 审中-公开
    使用siRNAs或表达siRNAs的构建体来减少靶基因表达的方法和组合物

    公开(公告)号：US20120122217A1

    公开(公告)日：2012-05-17

    申请号：US13360148

    申请日：2012-01-27

    Applicant: David Brown ,  Lance P. Ford ,  Rich Jarvis

    Inventor： David Brown ,  Lance P. Ford ,  Rich Jarvis

    IPC: C12N5/02

    CPC classification number: C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2330/31

    Abstract: The present invention concerns methods and compositions involving the production or generation of siRNA mixtures or pools capable of triggering RNA-mediated interference (RNAi) in a cell. Compositions of the invention include kits that include reagents for producing or generating siRNA pools. The present invention further concerns methods using polypeptides with RNase III activity for generating siRNA mixtures or pools that effect RNAi, including the generation of a number of RNA molecules to the same target gene.

    Abstract translation: 本发明涉及涉及产生或产生能够触发细胞中的RNA介导的干扰（RNAi）的siRNA混合物或池的方法和组合物。 本发明的组合物包括包含用于产生或产生siRNA池的试剂的试剂盒。 本发明进一步涉及使用具有RNase III活性的多肽产生影响RNAi的siRNA混合物或池的方法，包括向同一靶基因产生多个RNA分子。

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