公开(公告)号：US20120029261A1

公开(公告)日：2012-02-02

申请号：US13253595

申请日：2011-10-05

申请人： Mark E. Deem ,  Hanson Gifford

发明人： Mark E. Deem ,  Hanson Gifford

IPC分类号： A61M37/00 ,  A61M11/00 ,  A61M5/00 ,  A61M25/10 ,  A61M25/00 ,  A61N1/30

CPC分类号： A61M37/00 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00434 ,  A61B2018/1861 ,  A61K9/0021 ,  A61K9/0078 ,  A61K38/164 ,  A61K38/168 ,  A61K38/4893 ,  A61K41/00 ,  A61K41/0028 ,  A61K41/0047 ,  A61M37/0092 ,  A61M2210/1035 ,  A61N1/08 ,  A61N1/303 ,  A61N1/327 ,  A61N5/10 ,  A61N7/00 ,  A61N2007/003 ,  C12Y304/24069 ,  Y02A50/471 ,  A61K2300/00

摘要： Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

摘要翻译： 提供了用于施用神经毒素片段的方法和装置，例如肉毒杆菌毒素（BoNT）的活性轻链（LC），如血清型A，B，C，D，E，F或G肉毒毒素之一 通过靶向细胞膜的透化以使肉毒杆菌神经毒素轻链（BoNT-LC）分子穿过目标细胞膜转移到在哺乳动物系统中产生治疗反应的细胞溶质中。 所述方法和装置包括使用基于导管的递送系统，非侵入性递送系统和透皮递送系统。

公开(公告)号：US08038671B2

公开(公告)日：2011-10-18

申请号：US11464755

申请日：2006-08-15

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/14

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of patent foramen ovale (PFO) provide for applying energy to tissues adjacent the PFO with a catheter device to substantially close the PFO acutely. Apparatus generally includes a catheter device having at least one energy transmission member at or near its distal end configured to apply energy to PFO tissues to acutely, substantially close the PFO. Applied energy may be monoploar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like. Some embodiments of a catheter device further include one or more tissue apposition members near the distal end for helping bring PFO tissues together, such as a PFO covering member, a vacuum applying member and/or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

摘要翻译： 用于治疗卵圆孔卵泡（PFO）的方法和装置提供用导管装置向邻近PFO的组织施加能量，以基本上封闭PFO。 装置通常包括导管装置，其具有在其远端处或其近端处的至少一个能量传递构件，其被配置为向PFO组织施加能量以急剧，基本上关闭PFO。 应用能量可以是单极或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热等。 导管装置的一些实施例还包括靠近远端的一个或多个组织定位构件，用于帮助使PFO组织在一起，例如PFO覆盖构件，真空施加构件等。 通过基于本发明的基于能量的方法的PFO闭合可以有助于预防中风，治疗偏头痛，并且可能治疗或预防其它医疗状况。

公开(公告)号：US20070203549A1

公开(公告)日：2007-08-30

申请号：US11363867

申请日：2006-02-27

申请人： Denise Demarais ,  Benjamin Clark ,  Nicolas Zadno ,  Erik Thai ,  Hanson Gifford

发明人： Denise Demarais ,  Benjamin Clark ,  Nicolas Zadno ,  Erik Thai ,  Hanson Gifford

IPC分类号： A61N1/32

CPC分类号： A61B18/1477 ,  A61B18/1206 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00613 ,  A61B2018/126 ,  A61M5/14 ,  A61M37/00 ,  A61N1/05 ,  A61N1/0514 ,  A61N1/0551 ,  A61N1/321 ,  A61N1/327 ,  A61N1/36007

摘要： Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, the ITEV PEF system comprises an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers. With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly. The methods and apparatus of the present invention may, for example, be used to modulate one or more target neural fibers that contribute to renal function.

摘要翻译： 提供了通过血管外途径进行脉冲电场神经调节的方法和装置，例如，以实现不可逆的电穿孔或电融合，坏死和/或诱导细胞凋亡，基因表达的改变，细胞因子上调的变化以及目标中的其他条件 神经纤维。 在一些实施方案中，ITEV PEF系统包括具有一个或多个电极的血管内导管，其配置用于穿过患者血管的壁进行血管外放置，使其与目标神经纤维接近。 随着电极在PEF递送之前从血管内位置传递到血管外位置，可以相对于血管内PEF减少施加的电压或通过电极传递并且达到所需神经调节所必需的能量的大小 系统具有仅位于血管内的一个或多个电极。 本发明的方法和装置可以例如用于调节一种或多种有助于肾功能的靶神经纤维。

公开(公告)号：US20060058775A1

公开(公告)日：2006-03-16

申请号：US11120335

申请日：2005-05-03

申请人： John Stevens ,  William Peters ,  Wesley Sterman ,  Hanson Gifford

发明人： John Stevens ,  William Peters ,  Wesley Sterman ,  Hanson Gifford

IPC分类号： A61M31/00

CPC分类号： A61B17/3421 ,  A61B17/320783 ,  A61B2017/00243 ,  A61B2017/22067 ,  A61B2090/3784 ,  A61F2/958 ,  A61M25/0032 ,  A61M25/10 ,  A61M2025/0681 ,  A61M2025/1052

摘要： A system for inducing cardioplegic arrest and performing an endovascular procedure within the heart or blood vessels of a patient. An endoaortic partitioning catheter has an inflatable balloon which occludes the ascending aorta when inflated. Cardioplegic fluid may be infused through a lumen of the endoaortic partitioning catheter to stop the heart while the patient's circulatory system is supported on cardiopulmonary bypass. One or more endovascular devices are introduced through an internal lumen of the endoaortic partitioning catheter to perform a diagnostic or therapeutic endovascular procedure within the heart or blood vessels of the patient. Surgical procedures such as coronary artery bypass surgery or heart valve replacement may be performed in conjunction with the endovascular procedure while the heart is stopped. Embodiments of the system are described for performing: fiberoptic angioscopy of structures within the heart and its blood vessels, valvuloplasty for correction of valvular stenosis in the aortic or mitral valve of the heart, angioplasty for therapeutic dilatation of coronary artery stenoses, coronary stenting for dilatation and stenting of coronary artery stenoses, atherectomy or endarterectomy for removal of atheromatous material from within coronary artery stenoses, intravascular ultrasonic imaging for observation of structures and diagnosis of disease conditions within the heart and its associated blood vessels, fiberoptic laser angioplasty for removal of atheromatous material from within coronary artery stenoses, transmyocardial revascularization using a side-firing fiberoptic laser catheter from within the chambers of the heart, and electrophysiological mapping and ablation for diagnosing and treating electrophysiological conditions of the heart.

公开(公告)号：US08852181B2

公开(公告)日：2014-10-07

申请号：US11855787

申请日：2007-09-14

申请人： William Malecki ,  Dan Francis ,  Kenneth Home ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Home ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/14 ,  A61B17/00 ,  A61B17/34 ,  A61B19/00 ,  A61B17/30 ,  A61B18/00

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of anatomic defects in human tissues, such as patent foramen ovale (PFO), atrial or ventricular septal defects, left atrial appendage, patent ductus arteriosis, blood vessel wall defects and certain electrophysiological defects, involve positioning a distal end of an elongate catheter device at the site of the anatomic defect, engaging tissues at the site of the anatomic defect to bring the tissues together, and applying energy to the tissues with the catheter device to substantially close the anatomic defect acutely. Apparatus generally includes an elongate catheter having a proximal end and a distal end, a vacuum application member coupled with the distal end for engaging tissues at the site of the anatomic defect and applying vacuum to the tissues to bring them together, and at least one energy transmission member coupled with the vacuum application member for applying energy to tissues at the site of the anatomic defect to substantially close the defect acutely.

摘要翻译： 用于治疗人体组织中解剖缺陷的方法和装置，例如卵圆孔（PFO），心房或室间隔缺损，左心耳，动脉导管未闭，血管壁缺陷和某些电生理缺陷，涉及定位远端 在解剖缺损部位处的细长导管装置，将解剖缺损部位的组织接合在一起，并将组织用导管装置施加能量以急剧地闭合解剖缺损。 装置通常包括具有近端和远端的细长导管，与远端连接的真空施加构件，用于接合解剖缺损部位处的组织，并向组织施加真空以将它们组合在一起，以及至少一种能量 传输构件与真空施加构件联接，用于向解剖缺陷位置处的组织施加能量以急剧地闭合缺陷。

公开(公告)号：US08465485B2

公开(公告)日：2013-06-18

申请号：US13234908

申请日：2011-09-16

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B18/1445 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods, devices and systems for treating patent foramen ovale (PFO) involve advancing a catheter device to a position in a heart for treating a PFO, bringing tissues adjacent the PFO at least partially together, and applying energy to the tissues to substantially close the PFO acutely. Catheter devices generally include an elongate catheter body, at least one tissue apposition member at or near the distal end for bringing the tissues together, and at least one energy transmission member at or near the distal end for applying energy to the tissues. In some embodiments, the tissue apposition member(s) also act as the energy transmission member(s). Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like.

摘要翻译： 用于治疗卵孔卵泡（PFO）的方法，装置和系统涉及将导管装置推进到心脏中的位置以治疗PFO，使与PFO相邻的组织至少部分地在一起，并且向组织施加能量以基本上封闭PFO 急剧地 导管装置通常包括细长导管主体，位于或靠近远端的至少一个组织定位构件，用于将组织带到一起，以及在远端处或附近的至少一个能量传递构件，用于向组织施加能量。 在一些实施例中，组织安置构件也用作能量传递构件。 施加的能量可以是单极性或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热等。

公开(公告)号：US08338164B2

公开(公告)日：2012-12-25

申请号：US13253595

申请日：2011-10-05

申请人： Mark E. Deem ,  Hanson Gifford

发明人： Mark E. Deem ,  Hanson Gifford

IPC分类号： C12M1/00 ,  G01N33/53

CPC分类号： A61M37/00 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00434 ,  A61B2018/1861 ,  A61K9/0021 ,  A61K9/0078 ,  A61K38/164 ,  A61K38/168 ,  A61K38/4893 ,  A61K41/00 ,  A61K41/0028 ,  A61K41/0047 ,  A61M37/0092 ,  A61M2210/1035 ,  A61N1/08 ,  A61N1/303 ,  A61N1/327 ,  A61N5/10 ,  A61N7/00 ,  A61N2007/003 ,  C12Y304/24069 ,  Y02A50/471 ,  A61K2300/00

摘要： Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

摘要翻译： 提供了用于施用神经毒素片段的方法和装置，例如肉毒杆菌毒素（BoNT）的活性轻链（LC），如血清型A，B，C，D，E，F或G肉毒毒素之一 通过靶向细胞膜的透化以使肉毒杆菌神经毒素轻链（BoNT-LC）分子穿过目标细胞膜转移到在哺乳动物系统中产生治疗反应的细胞溶质中。 所述方法和装置包括使用基于导管的递送系统，非侵入性递送系统和透皮递送系统。

公开(公告)号：US08105817B2

公开(公告)日：2012-01-31

申请号：US12636477

申请日：2009-12-11

申请人： Mark E. Deem ,  Hanson Gifford

发明人： Mark E. Deem ,  Hanson Gifford

IPC分类号： C12M1/00

CPC分类号： A61M31/00 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00765 ,  A61K9/0043 ,  A61K38/4886 ,  A61K38/4893 ,  A61M25/007 ,  A61M25/0084 ,  A61M25/10 ,  A61M29/00 ,  A61M29/02 ,  A61M35/00 ,  A61M2025/0008 ,  A61M2025/0057 ,  A61M2025/0096 ,  A61M2025/105 ,  A61M2210/0618 ,  A61N1/05 ,  A61N1/0546 ,  A61N1/0568 ,  A61N1/327 ,  A61N7/00 ,  A61N7/022 ,  C12Y304/24069 ,  Y02A50/471

摘要： Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.

摘要翻译： 将毒素和毒素片段输送到患者的鼻腔的方法和系统提供毒素的释放和能量的释放，所述能量选择性地对靶细胞进行培养以增强毒素的摄取。 使用能量介导的递送对于缺乏细胞结合能力的轻链片段毒素是特别有利的。

公开(公告)号：US07922716B2

公开(公告)日：2011-04-12

申请号：US11049791

申请日：2005-02-02

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/14

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of anatomic defects in human tissues, such as patent foramen ovale (PFO), atrial or ventricular septal defects, left atrial appendage, patent ductus arteriosus, blood vessel wall defects and certain electrophysiological defects, involve positioning a distal end of an elongate catheter device at the site of the anatomic defect, engaging tissues at the site of the anatomic defect to bring the tissues together, and applying energy to the tissues with the catheter device to substantially close the anatomic defect acutely. Apparatus generally includes an elongate catheter having a proximal end and a distal end, a vacuum application member coupled with the distal end for engaging tissues at the site of the anatomic defect and applying vacuum to the tissues to bring them together, and at least one energy transmission member coupled with the vacuum application member for applying energy to tissues at the site of the anatomic defect to substantially close the defect acutely.

摘要翻译： 用于治疗人体组织中解剖缺陷的方法和装置，例如卵圆孔（PFO），心房或室间隔缺损，左心耳，动脉导管未闭，血管壁缺陷和某些电生理缺陷，涉及定位远端 在解剖缺损部位处的细长导管装置，将解剖缺损部位的组织接合在一起，并将组织用导管装置施加能量以急剧地闭合解剖缺损。 装置通常包括具有近端和远端的细长导管，与远端连接的真空施加构件，用于接合解剖缺损部位处的组织，并向组织施加真空以将它们组合在一起，以及至少一种能量 传输构件与真空施加构件联接，用于向解剖缺陷位置处的组织施加能量以急剧地闭合缺陷。

公开(公告)号：US20100003282A1

公开(公告)日：2010-01-07

申请号：US12559278

申请日：2009-09-14

申请人： Mark E. Deem ,  Hanson Gifford

发明人： Mark E. Deem ,  Hanson Gifford

IPC分类号： A61K39/00 ,  A61K39/08 ,  A61K39/05 ,  A61K39/02 ,  A61N1/30 ,  A61M37/00

CPC分类号： A61M37/00 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00434 ,  A61B2018/1861 ,  A61K9/0021 ,  A61K9/0078 ,  A61K38/164 ,  A61K38/168 ,  A61K38/4893 ,  A61K41/00 ,  A61K41/0028 ,  A61K41/0047 ,  A61M37/0092 ,  A61M2210/1035 ,  A61N1/08 ,  A61N1/303 ,  A61N1/327 ,  A61N5/10 ,  A61N7/00 ,  A61N2007/003 ,  C12Y304/24069 ,  Y02A50/471 ,  A61K2300/00

摘要： Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

摘要翻译： 提供了用于施用神经毒素片段的方法和装置，例如肉毒杆菌毒素（BoNT）的活性轻链（LC），如血清型A，B，C，D，E，F或G肉毒毒素之一 通过靶向细胞膜的透化以使肉毒杆菌神经毒素轻链（BoNT-LC）分子穿过目标细胞膜转移到在哺乳动物系统中产生治疗反应的细胞溶质中。 所述方法和装置包括使用基于导管的递送系统，非侵入性递送系统和透皮递送系统。