摘要:
Compounds of the formula (I): as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.
摘要:
The invention is concerned with novel vinylogous acid derivatives of formula I: wherein A and R1 to R5 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are useful as chymase inhibitors.
摘要:
The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to Farnesoid-X-receptors (FXR) and can be used to treat diseases which are modulated by FXR agonists such as diabetes and dyslipidemia.
摘要:
The invention relates to a solid oxide fuel cell stack having individual cells arranged above one another, which are each arranged, if required, with contact layers between a top shell and a bottom shell gas-tightly connected with the top shell in the edge region, as well as having gas distributor structures in each case between the top shell of a first individual cell and of the bottom shell of the adjacent individual cell, so that, by way of these gas distributor structures and openings provided in the top shell as well as the bottom shell in the region within the edges, one gas transfer respectively can take place to the facing side of the individual cell. Each individual cell consisting of a substrate with an anode layer, a solid electrolyte layer and a cathode layer applied thereto, and a stress equalizing layer provided with openings and having a thermal expansion behavior essentially identical in the operating temperature range of the fuel cell to that of the solid electrolyte layer being applied to the side of the substrate situated opposite the electrode layers and the electrolyte layer. Preferably, the top shell and the bottom shell and/or the gas distributor structures applied to them in each case are identical parts which are built into the stack while being mutually rotated by 180°.
摘要:
The invention relates to compounds of formula (I): and pharmaceutically acceptable salts and pharmaceutically acceptable esters thereof, wherein R1, R2, R3, R4, R5, R6, A, m, n and p are defined as in claim 1. These compounds can be used as pharmaceutical compositions for the treatment of, for example, diabetes.
摘要翻译:本发明涉及式(I)的化合物及其药学上可接受的盐和药学上可接受的酯,其中R 1,R 2,R 3, R 4,R 5,R 6,A,m,n和p如权利要求1中所定义。这些化合物可以是 用作用于治疗例如糖尿病的药物组合物。
摘要:
This invention relates to compounds of the formula wherein one of R5, R6 and R7 is and X1, X2, Y1 to Y4, R1 to R13 and m and n are defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要:
Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R7 have the significances given in the description and claims can be used in the form of pharmaceutical compositions.
摘要:
A housing arrangement can be connected to a flywheel for rotation in common around an axis of rotation, and a pressure element is connected to the housing arrangement for rotation in common around the axis of rotation but is able to shift in the axial direction. A release spring arrangement includes at least one spring element which acts on the pressure element and is supported against the flywheel after the housing arrangement has been attached to the flywheel. Each spring element is held in place on the pressure element by means of a fastening element.