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公开(公告)号：US20080021027A1
公开(公告)日：2008-01-24
申请号：US11821265
申请日：2007-06-22
申请人： Gregory Benson , Konrad Bleicher , Alexander Chucholowski , Henrietta Dehmlow , Uwe Grether , Bernd Kuhn , Rainer Martin , Eric Niesor , Narendra Panday , Hans Richter , Franz Schuler , Xavier Warot , Matthew Wright , Minmin Yang
发明人： Gregory Benson , Konrad Bleicher , Alexander Chucholowski , Henrietta Dehmlow , Uwe Grether , Bernd Kuhn , Rainer Martin , Eric Niesor , Narendra Panday , Hans Richter , Franz Schuler , Xavier Warot , Matthew Wright , Minmin Yang
IPC分类号： A61K31/4184 , A61K31/41 , A61K31/422 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/47 , A61K31/5377 , A61P1/16 , C07D211/12 , C07D215/20 , C07D235/26 , C07D257/04 , C07D261/12 , C07D285/06 , C07D401/04 , C07D413/10 , C07D413/14
CPC分类号： C07D235/18 , C07D235/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D413/04 , C07D417/06
摘要： The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to Farnesoid-X-receptors (FXR) and can be used to treat diseases which are modulated by FXR agonists such as diabetes and dyslipidemia.
摘要翻译： 本发明涉及式（I）的新的苯并咪唑衍生物，其中R 1至R 8如在说明书和权利要求书中所定义，以及生理上可接受的盐 及其酯。 这些化合物与法呢型-X受体（FXR）结合，可用于治疗由FXR激动剂如糖尿病和血脂异常调节的疾病。
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公开(公告)号：US07645785B2
公开(公告)日：2010-01-12
申请号：US11821265
申请日：2007-06-22
申请人： Gregory Martin Benson , Konrad Bleicher , Alexander Chucholowski , Henrietta Dehmlow , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Eric J. Niesor , Narendra Panday , Hans Richter , Franz Schuler , Xavier Marie Warot , Matthew Wright , Minmin Yang
发明人： Gregory Martin Benson , Konrad Bleicher , Alexander Chucholowski , Henrietta Dehmlow , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Eric J. Niesor , Narendra Panday , Hans Richter , Franz Schuler , Xavier Marie Warot , Matthew Wright , Minmin Yang
IPC分类号： A61K31/4184 , C07D235/04 , C07D235/18
CPC分类号： C07D235/18 , C07D235/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D413/04 , C07D417/06
摘要： The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to Farnesoid-X-receptors (FXR) and can be used to treat diseases which are modulated by FXR agonists such as diabetes and dyslipidemia.
摘要翻译： 本发明涉及式（I）的新的苯并咪唑衍生物，其中R 1至R 8如说明书和权利要求书中所定义，以及其生理上可接受的盐和酯。 这些化合物与法呢型-X受体（FXR）结合，可用于治疗由FXR激动剂如糖尿病和血脂异常调节的疾病。
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公开(公告)号：US06706751B2
公开(公告)日：2004-03-16
申请号：US10014959
申请日：2001-12-11
申请人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
发明人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
IPC分类号： A61P4300
CPC分类号： C07D215/20 , C07D209/08
摘要： The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及新的二氢吲哚和四氢喹啉衍生物及其药学上可接受的盐和/或其药学上可接受的酯。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，霉菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病，以及治疗和 /或预防糖耐量异常和糖尿病。
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公开(公告)号：US07102007B2
公开(公告)日：2006-09-05
申请号：US10648451
申请日：2003-08-26
申请人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
发明人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
IPC分类号： C07D215/02 , A61K31/47
CPC分类号： C07D215/20 , C07D209/08
摘要： The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：US20050020624A1
公开(公告)日：2005-01-27
申请号：US10648451
申请日：2003-08-26
申请人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
发明人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
IPC分类号： A61K31/404 , A61K31/4045 , A61K31/47 , A61K31/4709 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/14 , A61P17/00 , A61P31/10 , A61P35/00 , A61P43/00 , C07D209/08 , C07D215/20 , C07D215/58 , C07D409/06 , C07D209/42 , C07D215/38
CPC分类号： C07D215/20 , C07D209/08
摘要： The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及新的二氢吲哚和四氢喹啉衍生物及其药学上可接受的盐和/或其药学上可接受的酯。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病，以及治疗和 /或预防糖耐量异常和糖尿病。
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公开(公告)号：US07189756B2
公开(公告)日：2007-03-13
申请号：US10881427
申请日：2004-06-30
申请人： Johannes Aebi , Daniel Bur , Alexander Chucholowski , Henrietta Dehmlow , Eric Argirios Kitas , Ulrike Obst , Hans Peter Wessel
发明人： Johannes Aebi , Daniel Bur , Alexander Chucholowski , Henrietta Dehmlow , Eric Argirios Kitas , Ulrike Obst , Hans Peter Wessel
IPC分类号： A61K31/40 , C07D207/04
CPC分类号： C07D401/12 , C07D207/36 , C07D207/48 , C07D403/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , Y02P20/582
摘要： The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.
摘要翻译： 本发明涉及可用作金属蛋白酶抑制剂的吡咯烷衍生物。 锌蛋白酶，并且其有效治疗与血管收缩相关的疾病状态。
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公开(公告)号：US06858651B2
公开(公告)日：2005-02-22
申请号：US09925188
申请日：2001-08-09
申请人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
IPC分类号： C07D295/08 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/223 , A61K31/255 , A61K31/27 , A61K31/277 , A61K31/341 , A61K31/351 , A61K31/36 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/404 , A61K31/4164 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/5375 , A61K31/54 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/10 , A61P31/10 , A61P33/00 , A61P35/00 , C07C233/23 , C07C233/74 , C07C235/54 , C07C235/84 , C07C255/57 , C07C269/04 , C07C271/24 , C07C271/52 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C291/04 , C07C303/38 , C07C307/08 , C07C307/10 , C07C311/07 , C07C311/13 , C07C311/20 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/22 , C07D205/04 , C07D207/12 , C07D209/42 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/70 , C07D213/81 , C07D215/36 , C07D233/84 , C07D261/10 , C07D295/092 , C07D295/135 , C07D295/14 , C07D307/38 , C07D309/12 , C07D317/58 , C07D333/24 , C07D333/34 , C07D333/40 , A61K31/14 , C07C43/20
CPC分类号： C07D295/088 , C07C233/23 , C07C233/74 , C07C235/54 , C07C235/84 , C07C255/57 , C07C271/52 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C291/04 , C07C307/08 , C07C307/10 , C07C311/07 , C07C311/13 , C07C311/20 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/22 , C07C2601/02 , C07C2601/14 , C07D295/135
摘要： The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病的氨基环己醇衍生物 ，以及治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US06790860B2
公开(公告)日：2004-09-14
申请号：US10373622
申请日：2003-02-25
申请人： Johannes Aebi , Daniel Bur , Alexander Chucholowski , Henrietta Dehmlow , Eric Argirios Kitas , Ulrike Obst , Hans Peter Wessel
发明人： Johannes Aebi , Daniel Bur , Alexander Chucholowski , Henrietta Dehmlow , Eric Argirios Kitas , Ulrike Obst , Hans Peter Wessel
IPC分类号： C07D20704
CPC分类号： C07D401/12 , C07D207/36 , C07D207/48 , C07D403/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , Y02P20/582
摘要： The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.
摘要翻译： 本发明涉及可用作金属蛋白酶抑制剂的吡咯烷衍生物。 锌蛋白酶，并且其有效治疗与血管收缩相关的疾病状态。
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公开(公告)号：US06683201B2
公开(公告)日：2004-01-27
申请号：US09906214
申请日：2001-07-16
申请人： Jean Ackermann , Johannes Aebi , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller
IPC分类号： C07C22900
CPC分类号： C07D213/75 , C07C233/29 , C07C233/75 , C07C235/56 , C07C235/84 , C07C255/57 , C07C271/28 , C07C271/58 , C07C275/34 , C07C275/38 , C07C307/10 , C07C311/13 , C07C311/21 , C07C311/29 , C07C323/44 , C07C335/18 , C07C335/22 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/18 , C07D207/14 , C07D207/20 , C07D209/42 , C07D211/22 , C07D211/42 , C07D211/46 , C07D211/70 , C07D213/81 , C07D213/82 , C07D215/36 , C07D239/42 , C07D261/10 , C07D295/088 , C07D307/14 , C07D307/52 , C07D317/58 , C07D319/18 , C07D333/24 , C07D333/34 , C07D333/38
摘要： The present invention relates to compounds of formula (I) wherein U, Y, V, W, L, X, A1, A2, A3, A4, A5 and A6 are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasite infections, gallstones, tumors and/or hyperproliferative disorders, and/or treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及式（I）化合物，其中U，Y，V，W，L，X，A 1，A 2，A 3，A 4，A 5和A <6>如说明书和权利要求及其药学上可接受的盐和/或其药学上可接受的酯所定义。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶相关的疾病，例如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，寄生虫感染，胆结石，肿瘤和/或过度增殖性疾病， 和/或治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US07335687B2
公开(公告)日：2008-02-26
申请号：US11014374
申请日：2004-12-15
申请人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
IPC分类号： A61K31/14 , C07C205/00
CPC分类号： C07D295/088 , C07C233/23 , C07C233/74 , C07C235/54 , C07C235/84 , C07C255/57 , C07C271/52 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C291/04 , C07C307/08 , C07C307/10 , C07C311/07 , C07C311/13 , C07C311/20 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/22 , C07C2601/02 , C07C2601/14 , C07D295/135
摘要： The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病的氨基环己醇衍生物 ，以及治疗和/或预防糖耐量异常和糖尿病。
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