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公开(公告)号：US20100076544A1
公开(公告)日：2010-03-25
申请号：US12520976
申请日：2008-01-30
Applicant: Erika Hoffmann , Michael Hoffmann , Roland Horres
Inventor： Erika Hoffmann , Michael Hoffmann , Roland Horres
IPC: A61F2/82
CPC classification number: A61L31/022 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42
Abstract: The embodiments described herein are directed to biodegradable stents comprising an inner biodegradable metal scaffold and an outer polymeric coating. The biodegradable coating consists preferentially of biodegradable polymers and may additionally include at least one pharmacologically active substance such as an anti-inflammatory, cytostatic, cytotoxic, antiproliferative, anti-microtubuli, antiangiogenic, antirestenotic (anti-restenosis), antifungicide, antineoplastic, antimigrative, athrombogenic and/or antithrombogenic agent.
Abstract translation: 本文描述的实施例涉及包含内部可生物降解的金属支架和外部聚合物涂层的可生物降解支架。 可生物降解的涂层优选由可生物降解的聚合物组成，并且还可以包括至少一种药理活性物质，例如抗炎，细胞抑制，细胞毒性，抗增殖，抗微管，抗血管生成，抗再狭窄（抗再狭窄），抗真菌剂，抗肿瘤剂， 促血和/或抗血栓形成剂。
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公开(公告)号：US07676738B2
公开(公告)日：2010-03-09
申请号：US11224761
申请日：2005-09-13
Applicant: Michael Hoffmann , J. Craig Cleaveland
Inventor： Michael Hoffmann , J. Craig Cleaveland
CPC classification number: G06Q10/04 , G06Q10/067
Abstract: Software is disclosed that creates a way of controlling alterations to cell contents of a data flow network so they can easily be turned on and off as separate layers. These layers can then be grouped as scenarios. Scenarios allow different layers of formula changes to be easily added and removed from the model.
Abstract translation: 公开了一种软件，其创建了控制数据流网络的小区内容的改变的方式，使得它们可以容易地作为单独的层被打开和关闭。 然后可以将这些层分组为场景。 方案允许不同层次的公式更改从模型中轻松添加和删除。
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公开(公告)号：US20090169528A1
公开(公告)日：2009-07-02
申请号：US12392221
申请日：2009-02-25
Applicant: Allen Comer , Michael Hoffmann , Lynn-Allen Hoffmann
Inventor： Allen Comer , Michael Hoffmann , Lynn-Allen Hoffmann
CPC classification number: C07K14/52 , A61K35/12 , C07K14/515 , C12N5/0698 , C12N2501/165 , C12N2501/17 , C12N2502/094 , C12N2502/1323 , C12N2502/99
Abstract: The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1 or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
Abstract translation: 本发明涉及体外培养的皮肤组织，特别涉及包含编码血管生成生长因子的外源基因的培养的皮肤组织。 在一些实施方案中，角质形成细胞表达外源血管生成素-1或VEGF家族的成员，优选VEGF-A。 在特别优选的实施方案中，将角质细胞掺入培养的皮肤组织中。
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公开(公告)号：US20080199506A1
公开(公告)日：2008-08-21
申请号：US11913545
申请日：2006-05-03
Applicant: Roland Horres , Michael Hoffmann , Erika Hoffmann , Marita Linssen , Roger Caspers , Michaela Styrnik
Inventor： Roland Horres , Michael Hoffmann , Erika Hoffmann , Marita Linssen , Roger Caspers , Michaela Styrnik
CPC classification number: C09D5/14 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2420/02
Abstract: The present invention relates to methods for coating the entire surface of lattice-like or mesh-like endoprostheses, wherein the endoprostheses initially are being provided with a thin layer covering the material surface of the endoprosthesis and subsequently, the surface of the entire endoprosthesis is being coated, wherein said coating of the entire surface covers the struts as well as the interstices between the individual struts.
Abstract translation: 本发明涉及用于涂覆格子状或网状内假体的整个表面的方法，其中内假体最初设置有覆盖内假体的材料表面的薄层，随后整个内用假体的表面是 其中整个表面的所述涂层覆盖支柱以及各个支柱之间的间隙。
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公开(公告)号：US20060167778A1
公开(公告)日：2006-07-27
申请号：US11230256
申请日：2005-09-19
Applicant: Michael Hoffmann , J. Cleaveland
Inventor： Michael Hoffmann , J. Cleaveland
Abstract: Software technology is used to build and perform object-oriented financial modeling. A software framework creates highly reusable and layered business objects. Business objects organize financial information and save time through ease of use and a simple intuitive interface.
Abstract translation: 软件技术用于构建和执行面向对象的财务建模。 软件框架创建高度可重用和分层的业务对象。 业务对象组织财务信息，通过易用性节省时间和简单直观的界面。
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Patent Agency Ranking
公开(公告)号：US20060059417A1
公开(公告)日：2006-03-16
申请号：US11224761
申请日：2005-09-13
Applicant: Michael Hoffmann , J. Cleaveland
Inventor： Michael Hoffmann , J. Cleaveland
IPC: G06F17/00
CPC classification number: G06Q10/04 , G06Q10/067
Abstract: Software is disclosed that creates a way of controlling alterations to cell contents of a data flow network so they can easily be turned on and off as separate layers. These layers can then be grouped as scenarios. Scenarios allow different layers of formula changes to be easily added and removed from the model.
Abstract translation: 公开了一种软件，其创建了控制数据流网络的小区内容的改变的方式，使得它们可以容易地作为单独的层被打开和关闭。 然后可以将这些层分组为场景。 方案允许不同层次的公式更改从模型中轻松添加和删除。
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公开(公告)号：US06974697B2
公开(公告)日：2005-12-13
申请号：US10087346
申请日：2002-03-01
Applicant: Allen Comer , Lynn Allen-Hoffmann , Michael Hoffmann
Inventor： Allen Comer , Lynn Allen-Hoffmann , Michael Hoffmann
CPC classification number: C12N5/0698 , C12N2500/36 , C12N2500/38 , C12N2500/90 , C12N2501/01 , C12N2501/11 , C12N2501/13 , C12N2501/385 , C12N2501/39 , C12N2501/60 , C12N2502/094 , C12N2502/1323 , C12N2510/00 , C12N2533/54
Abstract: The present invention relates to in vitro cultured skin substitutes, and in particular to in vitro cultured skin substitutes that have improved barrier function. In some embodiments, improved barrier function is a result of improved culture conditions, while in other embodiments, improved barrier function results from genetic modification of keratinocytes. Improved culture conditions to improve barrier function include organotypic culture in the presence of linoleic acid and/or linoleic acid at about 75% humidity. Suitable genetic modifications for improving barrier function includes transfection with a DNA construct capable of expressing GKLF.
Abstract translation: 本发明涉及体外培养的皮肤替代物，特别涉及具有改善的屏障功能的体外培养的皮肤代用品。 在一些实施方案中，改进的屏障功能是改善的培养条件的结果，而在其它实施方案中，角质形成细胞的遗传修饰改善的屏障功能结果。 提高屏障功能的改善的培养条件包括在约75％湿度下亚油酸和/或亚油酸存在下的器官培养。 用于改善屏障功能的合适的遗传修饰包括用能够表达GKLF的DNA构建体的转染。
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公开(公告)号：US20050174108A1
公开(公告)日：2005-08-11
申请号：US11100071
申请日：2005-04-05
Applicant: Martin Kurz , Gerd Eckel , Roland Holder , Hansjuergen Eberle , Roland Springer , Michael Hoffmann , Walter Roth
Inventor： Martin Kurz , Gerd Eckel , Roland Holder , Hansjuergen Eberle , Roland Springer , Michael Hoffmann , Walter Roth
CPC classification number: G01D11/245 , G01D5/485 , G01D11/30
Abstract: A position transducer device is provided for detecting the position of a position transmitter. The position transducer device comprises a housing extending in a longitudinal direction and a measuring sensor arranged in the housing and extending parallel to the longitudinal direction. The position transmitter is coupled to the measuring sensor in a non-contacting manner. The outer surface of the housing is designed such that it can be enclosed at least partially by a fixing receiving means for fixing the housing to an application. The housing can be rotated relative to the position transmitter in the fixing receiving means in order to enable adjustment of the distance between the measuring sensor and the position transducer.
Abstract translation: 提供了一种位置传感器装置，用于检测位置传感器的位置。 位置传感器装置包括沿纵向方向延伸的壳体和布置在壳体中并且平行于纵向方向延伸的测量传感器。 位置传感器以非接触的方式联接到测量传感器。 壳体的外表面被设计成使得其可以至少部分地由用于将壳体固定到应用的固定接收装置封闭。 壳体可以相对于定影接收装置中的位置传感器旋转，以便能够调整测量传感器和位置传感器之间的距离。
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公开(公告)号：US06903544B2
公开(公告)日：2005-06-07
申请号：US10180110
申请日：2002-06-27
Applicant: Martin Kurz , Gerd Eckel , Roland Holder , Hansjuergen Eberle , Roland Springer , Michael Hoffmann , Walter Roth
Inventor： Martin Kurz , Gerd Eckel , Roland Holder , Hansjuergen Eberle , Roland Springer , Michael Hoffmann , Walter Roth
CPC classification number: G01D11/245 , G01D5/485 , G01D11/30
Abstract: In order to provide a position transducer device for detecting the position of a position transmitter, comprising a housing extending in a longitudinal direction and a measuring sensor arranged in the housing and extending parallel to the longitudinal direction, the position transmitter being coupled to this measuring sensor without contact, which is variable in its use for a user it is suggested that an outer surface of the housing be designed such that it can be enclosed at least partially by a fixing receiving means for fixing it to an application and that the housing can be rotated in the fixing receiving means.
Abstract translation: 为了提供一种位置传感器装置，用于检测位置传感器的位置，包括沿纵向延伸的壳体和布置在壳体中并且平行于纵向方向延伸的测量传感器，位置传感器耦合到该测量传感器 没有接触，其对于用户的使用是不同的，建议外壳的外表面被设计成使得其可以至少部分地被固定接收装置封闭以将其固定到应用上，并且壳体可以是 在定影接收装置中旋转。
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公开(公告)号：US20050060028A1
公开(公告)日：2005-03-17
申请号：US10493157
申请日：2002-10-15
Applicant: Roland Horres , Michael Hoffmann , Erika Hoffman , Donato Di Biase , Volker Faust
Inventor： Roland Horres , Michael Hoffmann , Erika Hoffman , Donato Di Biase , Volker Faust
CPC classification number: A61L31/16 , A61L31/10 , A61L33/0011 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2420/08
Abstract: The invention relates to stents with at least one hemocompatible coating which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.
Abstract translation: 本发明涉及具有至少一种含有抗增殖性，抗炎和/或抗血栓形成活性剂的血液相容性涂层的支架，用于制备所述支架的方法以及所述支架用于预防再狭窄的用途。
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