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1.发明申请MANUFACTURE, METHOD AND USE OF DRUG-ELUTING MEDICAL DEVICES FOR PERMANENTLY KEEPING BLOOD VESSELS OPEN 审中-公开用于永久维持血液容器的药物设备的制造，方法和用途开放公开(公告)号：US20130005758A1
公开(公告)日：2013-01-03
申请号：US13529857
申请日：2012-06-21
IPC分类号： A61K31/439 , B05D5/00 , A61P31/10 , A61P37/08 , A61P29/00
CPC分类号： A61L29/16 , A61F2/95 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/80 , A61M25/1029 , A61M2025/1031 , A61M2025/1075
摘要： The invention relates to stents and catheter balloons having optimized coatings for eluting rapamycin as well as methods for manufacturing these coatings.
摘要翻译： 本发明涉及具有用于洗脱雷帕霉素的优化涂层的支架和导管球囊以及制造这些涂层的方法。
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2.发明申请公开(公告)号：US20120316496A1
公开(公告)日：2012-12-13
申请号：US13500875
申请日：2010-10-16
申请人： Michael Hoffmann , Erika Hoffmann , Roland Horres
发明人： Michael Hoffmann , Erika Hoffmann , Roland Horres
IPC分类号： A61M25/10
CPC分类号： A61L29/085 , A61L29/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2300/802
摘要： The present invention is related to dilatable medical products having short-term contact with the organism, as e.g. balloon catheters coated with at least one layer of at least one antiproliferative, immunosuppressive, anti-angiogenic, anti-inflammatory, fungicidal and/or anti-thrombotic agent and a transport mediator or a mixture of transport mediators, methods for coating of these coated dilatable medical products and the use of compositions for this coating.
摘要翻译： 本发明涉及与生物短期接触的可扩张医疗产品，例如， 涂覆有至少一层至少一种抗增殖，免疫抑制，抗血管生成，抗炎，杀真菌和/或抗血栓形成剂的运送介质或运输介质的混合物的球囊导管，这些涂覆的可扩张的 医疗产品和用于该涂层的组合物。
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公开(公告)号：US11185614B2
公开(公告)日：2021-11-30
申请号：US13700175
申请日：2011-05-27
申请人： Erika Hoffmann , Michael Hoffmann , Roland Horres
发明人： Erika Hoffmann , Michael Hoffmann , Roland Horres
IPC分类号： A61L29/16 , A61L29/08 , A61K31/337 , A61K31/436
摘要： The present invention relates to balloon catheters with or without crimped stent, whose surface is coated with at least one antirestenotic agent and at least one transport promoting molecular dispersant, as well as a method for the preparation of these medical devices.
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公开(公告)号：US09522219B2
公开(公告)日：2016-12-20
申请号：US14238876
申请日：2012-08-15
申请人： Michael Stekker , Norbert Hort , Frank Feyerabend , Erika Hoffmann , Michael Hoffmann , Roland Horres
发明人： Michael Stekker , Norbert Hort , Frank Feyerabend , Erika Hoffmann , Michael Hoffmann , Roland Horres
IPC分类号： A61L27/58 , A61L31/02 , A61L31/14 , C22C23/06 , C22F1/00 , C22C1/02 , A61F2/82 , A61K31/337 , A61K31/439 , C22F1/06
CPC分类号： A61L27/58 , A61F2/82 , A61K31/337 , A61K31/439 , A61L31/022 , A61L31/148 , C22C1/02 , C22C23/06 , C22F1/006 , C22F1/06 , C25F3/18
摘要： The present invention is directed to stents made of a magnesium alloy degradable under physiological conditions and an outer polymeric coating. Herein, the stents according to the invention can be additionally coated with at least one anti-inflammatory, antiproliferative, antiangiogenic, antirestenotic and/or antithrombogenic active agent.
摘要翻译： 本发明涉及由在生理条件下可降解的镁合金和外部聚合物涂层制成的支架。 本文中，根据本发明的支架可另外涂覆有至少一种抗炎，抗增殖，抗血管生成，抗再狭窄和/或抗血栓形成的活性剂。
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5.发明申请MEDICAL PRODUCT FOR TREATING STENOSIS OF BODY PASSAGES AND FOR PREVENTING THREATENING RESTENOSIS 有权用于治疗身体通行障碍和预防止痛药物的医疗产品公开(公告)号：US20100179475A1
公开(公告)日：2010-07-15
申请号：US12521863
申请日：2008-01-21
申请人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
发明人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
CPC分类号： A61M25/1029 , A61L29/16 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M2025/0057 , A61M2025/1031 , A61M2025/1088
摘要： A method for coating catheter balloons with a defined amount of a pharmacologically active agent, uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon.
摘要翻译： 使用具有确定量的药理活性剂涂覆导管球囊的方法，使用具有体积测量装置的涂覆装置，用于通过分配装置将可测量量的涂布溶液特异性地释放到导管气囊的表面上。
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6.发明授权Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis 有权用于治疗身体通道狭窄并防止威胁性再狭窄的气囊导管公开(公告)号：US09192697B2
公开(公告)日：2015-11-24
申请号：US13023594
申请日：2011-02-09
申请人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
发明人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
CPC分类号： A61L29/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/80 , A61M25/1029 , A61M2025/1031 , A61M2025/1075
摘要： The present invention is directed to a method for coating catheter balloons with a defined amount of a pharmacologically active agent, wherein the coating method uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon.
摘要翻译： 本发明涉及一种用限定量的药理活性剂涂覆导管球囊的方法，其中所述涂覆方法使用具有体积测量装置的涂覆装置，用于通过分配装置释放可测量量的涂布溶液 特别是在导管气囊的表面上。
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公开(公告)号：US08784862B2
公开(公告)日：2014-07-22
申请号：US12827710
申请日：2010-06-30
申请人： Roland Horres , Marita Katharina Linssen , Michael Hoffmann , Erika Hoffmann , Donate DiBiase , Volker Faust
发明人： Roland Horres , Marita Katharina Linssen , Michael Hoffmann , Erika Hoffmann , Donate DiBiase , Volker Faust
IPC分类号： A61F2/82 , A61K31/337 , A61K31/436 , A61K9/00 , A61P29/00 , A61L31/10 , C08L5/10 , A61L33/08 , A61L31/16 , A61K31/722 , A61K31/727 , A61K31/095 , A61K31/045 , A61K31/075 , A61K31/11 , A61K31/12 , A61K31/28 , A61K31/33 , A61K31/21 , A61K31/13
CPC分类号： A61L31/10 , A61K31/045 , A61K31/075 , A61K31/095 , A61K31/11 , A61K31/12 , A61K31/13 , A61K31/21 , A61K31/28 , A61K31/33 , A61K31/722 , A61K31/727 , A61L31/16 , A61L33/08 , C08B37/0075 , C08L5/10 , C09D105/08 , Y02A50/475
摘要： The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.
摘要翻译： 本发明涉及寡糖和多糖以及这些寡糖和/或多糖的用途，其含有糖单元N-酰基葡糖胺或N-酰基半乳糖胺用于生产血液相容性表面，以及用所述低聚糖表面的血液相容性涂布方法 和/或多糖，其模拟肝素，硫酸乙酰肝素和壳聚糖的常见生物合成前体物质。 本发明进一步描述了制备所述寡糖和/或多糖的方法，并公开了使用血液混合涂覆表面的各种可能性。 本发明特别涉及所述寡糖和/或多糖在具有至少一种根据本发明的沉积的血液相容性包衣的支架上的用途，其包含抗增生性，抗炎和/或抗血栓形成活性剂，用于制备所述支架的方法以及 使用所述支架预防再狭窄。
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8.发明申请MANUFACTURE, METHOD AND USE OF DRUG-ELUTING MEDICAL DEVICES FOR PERMANENTLY KEEPING BLOOD VESSELS OPEN 审中-公开用于永久维持血液容器的药物设备的制造，方法和用途公开(公告)号：US20110301697A1
公开(公告)日：2011-12-08
申请号：US13161161
申请日：2011-06-15
IPC分类号： A61F2/82 , A61P37/06 , A61P35/00 , A61K31/436
CPC分类号： A61L29/16 , A61F2/95 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/80 , A61M25/1029 , A61M2025/1031 , A61M2025/1075
摘要： The invention relates to stents and catheter balloons having optimized coatings for eluting rapamycin as well as methods for manufacturing these coatings.
摘要翻译： 本发明涉及具有用于洗脱雷帕霉素的优化涂层的支架和导管球囊以及制造这些涂层的方法。
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9.发明申请公开(公告)号：US20050176678A1
公开(公告)日：2005-08-11
申请号：US10513982
申请日：2003-04-15
申请人： Roland Horres , Marita Linssen , Michael Hoffmann , Erika Hoffmann , Donato Di Baise , Volker Faust
发明人： Roland Horres , Marita Linssen , Michael Hoffmann , Erika Hoffmann , Donato Di Baise , Volker Faust
IPC分类号： A61L27/00 , A61K31/165 , A61K31/337 , A61K31/366 , A61K31/436 , A61K31/727 , A61K31/728 , A61K45/00 , A61L31/00 , A61L31/10 , A61L31/16 , A61L33/00 , A61L33/08 , A61L33/10 , A61P3/06 , A61P7/02 , A61P19/06 , A61P35/00 , A61P37/06 , C08B37/00 , C08B37/08 , C08B37/10 , C09D105/08
CPC分类号： A61L31/10 , A61K31/045 , A61K31/075 , A61K31/095 , A61K31/11 , A61K31/12 , A61K31/13 , A61K31/21 , A61K31/28 , A61K31/33 , A61K31/722 , A61K31/727 , A61L31/16 , A61L33/08 , C08B37/0075 , C08L5/10 , C09D105/08 , Y02A50/475
摘要： The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.
摘要翻译： 本发明涉及寡糖和多糖以及这些寡糖和/或多糖的用途，其含有糖单元N-酰基葡糖胺或N-酰基半乳糖胺用于生产血液相容性表面，以及用所述低聚糖表面的血液相容性涂布方法 和/或多糖，其模拟肝素，硫酸乙酰肝素和壳聚糖的常见生物合成前体物质。 本发明进一步描述了制备所述寡糖和/或多糖的方法，并公开了使用血液混合涂覆表面的各种可能性。 本发明特别涉及所述寡糖和/或多糖在具有至少一种根据本发明的沉积的血液相容性包衣的支架上的用途，其包含抗增生性，抗炎和/或抗血栓形成活性剂，用于制备所述支架的方法以及 使用所述支架预防再狭窄。
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公开(公告)号：US09968573B2
公开(公告)日：2018-05-15
申请号：US14002223
申请日：2012-02-14
IPC分类号： A61K31/197 , A61L27/54 , A61L29/16 , A61L31/16 , A61K31/7036 , B05D1/02
CPC分类号： A61K31/197 , A61K31/7036 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/406 , A61L2420/02 , B05D1/02
摘要： The present invention relates to an endoprosthesis with a drug coating comprising or consisting of at least one antibiotic agent and at least one further substance having the following general
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