公开(公告)号：US07674416B2

公开(公告)日：2010-03-09

申请号：US11020826

申请日：2004-12-22

Applicant: James Hong ,  Rahul Bhagat ,  Syed Hossainy ,  Santosh Prabhu ,  K. T. Venkateswara Rao ,  Ashok Shah ,  Srinivasan Sridharan

Inventor： James Hong ,  Rahul Bhagat ,  Syed Hossainy ,  Santosh Prabhu ,  K. T. Venkateswara Rao ,  Ashok Shah ,  Srinivasan Sridharan

IPC: B32B38/08

CPC classification number: A61F2/915 ,  A61F2/07 ,  A61F2/91 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61L31/10 ,  A61L31/16 ,  Y10S623/901

Abstract: A hybrid stent is formed which exhibits both high flexibility and high radial strength. The expandable hybrid stent for implantation in a body lumen, such as a coronary artery, consists of radially expandable cylindrical rings generally aligned on a common longitudinal axis and interconnected by one or more links. In one embodiment, a dip-coated covered stent is formed by encapsulating cylindrical rings within a polymer material. In other embodiments, at least some of the rings and links are formed of a polymer material which provides longitudinal and flexural flexibility to the stent. These polymer rings and links are alternated with metallic rings and links in various configurations to attain sufficient column strength along with the requisite flexibility in holding open the target site within the body lumen. Alternatively, a laminated, linkless hybrid stent is formed by encapsulating cylindrical rings within a polymer tube.

Abstract translation: 形成具有高柔性和高径向强度的混合支架。 用于植入体腔（例如冠状动脉）中的可扩张混合支架由径向可扩展的圆柱形环构成，其通常在公共纵向轴线上对齐并且由一个或多个连杆相互连接。 在一个实施例中，通过将圆柱形环封装在聚合物材料内而形成浸涂的覆盖支架。 在其它实施例中，至少一些环和链节由聚合物材料形成，该聚合物材料向支架提供纵向和弯曲的柔性。 这些聚合物环和链环与金属环和各种结构的链接交替，以获得足够的柱强度以及在体腔内保持打开靶部位所需的灵活性。 或者，通过在聚合物管内封装圆柱形环来形成层压的无环式混合支架。

公开(公告)号：US07638156B1

公开(公告)日：2009-12-29

申请号：US11312149

申请日：2005-12-19

Applicant: Syed F. A. Hossainy ,  Gordon Stewart ,  Srinivasan Sridharan ,  Arkady Kokish ,  Klaus Kleine ,  Benjamyn Serna ,  Bjorn G. Svensson

Inventor： Syed F. A. Hossainy ,  Gordon Stewart ,  Srinivasan Sridharan ,  Arkady Kokish ,  Klaus Kleine ,  Benjamyn Serna ,  Bjorn G. Svensson

IPC: A61L33/00

CPC classification number: B05D1/32 ,  B05B12/20 ,  B05B13/0442 ,  B05D1/02 ,  Y10T428/13

Abstract: Masking apparatus and methods of masking a medical article, such as stent, for selective application of a coating composition on the article are disclosed.

Abstract translation: 公开了掩模设备和掩蔽诸如支架之类的医疗用品的选择性施用涂料组合物的方法。

公开(公告)号：US20090232700A1

公开(公告)日：2009-09-17

申请号：US12464488

申请日：2009-05-12

Applicant: Javier Alarcon ,  Kristin Weidemaier ,  David M. Kurisko ,  Srinivasan Sridharan

Inventor： Javier Alarcon ,  Kristin Weidemaier ,  David M. Kurisko ,  Srinivasan Sridharan

IPC: A61L2/08

CPC classification number: A61L2/082 ,  A61B5/1486 ,  A61L2/0011 ,  A61L2/0035 ,  A61L2/0094 ,  A61L2/022 ,  A61L2/081 ,  A61L2/087 ,  A61L2/10 ,  A61L2/206 ,  A61L2/208

Abstract: The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and separately sterilizing this partial assemblage and the binding reagent. The sterilized binding reagent and the sterilized partial assemblage are then aseptically assembled to produce the sterilized biosensor. Other embodiments of the methods described herein comprise assembling substantially all of the components of the biosensor, including the binding reagent, and sterilizing the assembled biosensor to produce a sterilized biosensor.

Abstract translation: 本发明涉及制造无菌生物传感器的方法，其中生物传感器包括至少一种包含至少一个非蛋白质结合结构域的结合试剂。 本文描述的方法的某些实施方案包括部分组装除了结合试剂之外的生物传感器的组分，并且对该部分组合物和结合试剂进行单独灭菌。 灭菌的结合试剂和灭菌的部分组合物然后无菌组装以产生无菌生物传感器。 本文描述的方法的其它实施方案包括组装生物传感器的基本上所有组分，包括结合试剂，并对组装的生物传感器进行灭菌以产生无菌生物传感器。

公开(公告)号：US20080113081A1

公开(公告)日：2008-05-15

申请号：US12018122

申请日：2008-01-22

Applicant: Syed Hossainy ,  Srinivasan Sridharan

Inventor： Syed Hossainy ,  Srinivasan Sridharan

IPC: B05D5/00

CPC classification number: A61M25/1029 ,  A61M2025/1031 ,  A61M2025/105

Abstract: Methods for modifying a balloon of a catheter assembly are disclosed.

Abstract translation: 公开了用于修改导管组件的球囊的方法。

公开(公告)号：US20080053592A1

公开(公告)日：2008-03-06

申请号：US11468798

申请日：2006-08-31

Applicant: Chandrashekhar S. Khadilkar ,  Srinivasan Sridharan ,  Aziz S. Shaikh

Inventor： Chandrashekhar S. Khadilkar ,  Srinivasan Sridharan ,  Aziz S. Shaikh

IPC: C03B29/00

CPC classification number: C04B37/008 ,  C03C3/062 ,  C03C3/078 ,  C03C3/089 ,  C03C14/00 ,  C04B35/6264 ,  C04B35/632 ,  C04B37/028 ,  C04B2235/6567 ,  C04B2237/66 ,  C23C24/00 ,  C23C26/00 ,  H05K1/0306 ,  H05K1/053 ,  H05K3/4611 ,  H05K3/4629 ,  H05K2203/068 ,  Y10T428/2438 ,  Y10T428/31641

Abstract: A method of applying a ceramic coating to a substrate comprises laminating one or more layers of a green ceramic tape to a rigid substrate using a tackifying resin to adhere the tape to the substrate. Upon firing, the tackifying resin ensures near zero shrinkage of the tape in the XY plane without usage of elevated pressures or temperatures during lamination of green tape to the substrate. The thermal degradation completion temperature of the tackifying resin is lower than that of the resin binder used in the green tape.

Abstract translation: 将陶瓷涂层施加到基底的方法包括使用增粘树脂将一层或多层生坯陶瓷带层压到刚性基底上以将带粘附到基底上。 在烧制时，增粘树脂确保胶带在XY平面内接近零收缩，而不会在将生胶带层压到基材中时使用升高的压力或温度。 增粘树脂的热降解完成温度低于生胶带中使用的树脂粘合剂的热降解完成温度。

公开(公告)号：US20080041516A1

公开(公告)日：2008-02-21

申请号：US11923258

申请日：2007-10-24

Applicant: Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

Inventor： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

IPC: B29C53/60

CPC classification number: A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

Abstract: Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

Abstract translation: 实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。 导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。 输送导管可以具有附件腔，同轴或共线腔，支撑心轴或其远端处的闭塞装置。 此外，根据一些实施例，闭塞装置可以是具有内衬和不同材料外层的单一材料或复合球囊，高顺应性低压气球或限制颗粒通过但不限制的过滤装置 限制流体，如血液。 可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。

公开(公告)号：US20070138694A1

公开(公告)日：2007-06-21

申请号：US11680027

申请日：2007-02-28

Applicant: Srinivasan Sridharan

Inventor： Srinivasan Sridharan

IPC: B29C65/00

CPC classification number: A61M25/104 ,  A61M2025/1075

Abstract: An expandable medical device or component thereof including a tubular body formed of a wrapped sheet of porous polymeric material fused together, the tubular body having a fused seam at an angle relative to the longitudinal axis of the tubular body which changes along the length of the tubular body from a first angle to a second angle greater than the first angle. The sheet of porous polymeric material is wound and then fused together such that the winding angle is less in a first longitudinal section of the tubular body compared with the winding angle in a second longitudinal section of the tubular body, in order to provide the second section with greater resistance to expansion (i.e., lower compliance) than the first section.

Abstract translation: 一种可扩张的医疗装置或其部件，包括一个管状体，该管状体由一层多孔聚合物材料形成，该多孔聚合物材料熔合在一起，该管状体具有相对于该管状体的纵向轴线成一定角度的熔融接缝， 主体从第一角度到大于第一角度的第二角度。 多孔聚合物材料片被卷绕并熔合在一起，使得与管状体的第二纵向部分中的缠绕角度相比，在管状体的第一纵向部分中卷绕角度较小，以便提供第二部分 与第一部分相比，具有更大的抗膨胀性（即较低的柔顺性）。

公开(公告)号：US20070111196A1

公开(公告)日：2007-05-17

申请号：US11465857

申请日：2006-08-21

Applicant: Javier Alarcon ,  Kristin Weidemaier ,  David Kurisko ,  Srinivasan Sridharan

Inventor： Javier Alarcon ,  Kristin Weidemaier ,  David Kurisko ,  Srinivasan Sridharan

IPC: C12Q1/00

CPC classification number: A61L2/082 ,  A61B5/1486 ,  A61L2/0011 ,  A61L2/0035 ,  A61L2/0094 ,  A61L2/022 ,  A61L2/081 ,  A61L2/087 ,  A61L2/10 ,  A61L2/206 ,  A61L2/208

Abstract: The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and separately sterilizing this partial assemblage and the binding reagent. The sterilized binding reagent and the sterilized partial assemblage are then aseptically assembled to produce the sterilized biosensor. Other embodiments of the methods described herein comprise assembling substantially all of the components of the biosensor, including the binding reagent, and sterilizing the assembled biosensor to produce a sterilized biosensor.

Abstract translation: 本发明涉及制造无菌生物传感器的方法，其中生物传感器包括至少一种包含至少一个非酶蛋白质结合结构域的结合试剂。 本文描述的方法的某些实施方案包括部分组装除了结合试剂之外的生物传感器的组分，并且对该部分组合物和结合试剂进行单独灭菌。 灭菌的结合试剂和灭菌的部分组合物然后无菌组装以产生无菌生物传感器。 本文描述的方法的其它实施方案包括组装生物传感器的基本上所有组分，包括结合试剂，并对组装的生物传感器进行灭菌以产生无菌生物传感器。

公开(公告)号：US20070108423A1

公开(公告)日：2007-05-17

申请号：US11609998

申请日：2006-12-13

Applicant: Orville Brown ,  Srinivasan Sridharan

Inventor： Orville Brown ,  Srinivasan Sridharan

IPC: H01B1/12

CPC classification number: C03C8/02 ,  C03C3/064 ,  C03C3/066 ,  C03C8/04 ,  C03C8/18 ,  C03C8/22 ,  C04B41/009 ,  C04B41/5127 ,  C04B41/88 ,  C04B2111/00844 ,  H01B1/22 ,  H05K1/092 ,  Y10T428/24909 ,  Y10T428/24926 ,  C04B35/10 ,  C04B41/4539 ,  C04B41/5022 ,  C04B41/5049

Abstract: Thick film conductive copper pastes that are lead-free and cadmium-free. The inventive copper pastes possess desirable characteristics, including good solderability, good wire bondability, a low firing temperature, and a wide temperature processing window, and provide excellent adhesion to a variety of substrates, including alumina and glass coated stainless steel substrates, as well as low resistivity, and a microstructure after firing that is dense and substantially free of pores.

Abstract translation: 厚膜导电铜浆，无铅，无镉。 本发明的铜浆具有所需的特性，包括良好的可焊性，良好的线焊接性，低的烧制温度和宽的温度加工窗口，并且对各种基材（包括氧化铝和玻璃涂层的不锈钢基材）以及对 低电阻率和烧结后的微观结构是致密的并且基本上没有孔。

公开(公告)号：US20070106258A1

公开(公告)日：2007-05-10

申请号：US11609143

申请日：2006-12-11

Applicant: Jessica Chiu ,  Gregory Chan ,  Hongzhi Bai ,  Nianjiong Bei ,  Mark Bly ,  Srinivasan Sridharan ,  Tom Hatten

Inventor： Jessica Chiu ,  Gregory Chan ,  Hongzhi Bai ,  Nianjiong Bei ,  Mark Bly ,  Srinivasan Sridharan ,  Tom Hatten

IPC: A61M31/00

CPC classification number: A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

Abstract: A delivery catheter that includes a flexible shaft having a proximal end and a distal end, the distal end having an outer diameter less than about 13 mm; a delivery lumen having a proximal end and a distal end, the delivery lumen within the flexible shaft, the delivery lumen having at least an outlet port or at least one side hole at the distal end of the delivery lumen, the delivery lumen having a cross-sectional area at least about 5 mm2; a pressure monitoring lumen having a proximal end and a distal end, the pressure monitoring lumen within the flexible shaft; a pressure port adjacent to and connected to the distal end of the pressure monitoring lumen; a balloon inflation lumen having a proximal end and a distal end, the balloon inflation lumen within the flexible shaft; a soft tip at the distal end of the flexible shaft; a balloon at the distal end of the flexible shaft, the balloon connected to the distal end of the balloon inflation lumen, the balloon includes at least one of the following materials, polyether block amide resin, polyetheramide, polyurethane, silicone, natural latex, or synthetic latex; wherein the balloon is adapted to inflate to a diameter range of about 4 to about 15 mm.

Abstract translation: 输送导管，其包括具有近端和远端的柔性轴，所述远端具有小于约13mm的外径; 输送腔，其具有近端和远端，所述输送腔在所述柔性轴内，所述输送腔至少具有出口端口或至少一个在所述输送腔的远端处的侧孔，所述输送腔具有交叉 至少约5毫米2的截面积; 具有近端和远端的压力监测管腔，所述柔性轴内的所述压力监测腔; 与所述压力监视管腔的远端相邻并连接的压力口; 具有近端和远端的球囊充气腔，所述气囊膨胀腔在所述柔性轴内; 在柔性轴的远端处的软尖端; 在柔性轴的远端处的气囊，气囊连接到球囊充气腔的远端，气囊包括以下材料中的至少一种：聚醚嵌段酰胺树脂，聚醚酰胺，聚氨酯，硅氧烷，天然胶乳或 合成胶乳 其中所述气囊适于膨胀至约4至约15mm的直径范围。