公开(公告)号：US1811663A

公开(公告)日：1931-06-23

申请号：US26961328

申请日：1928-04-12

Applicant: HERCULES POWDER CO LTD

Inventor： BOYD NEWTON C

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C06B25/12 ,  C07C203/06

公开(公告)号：US20230167047A1

公开(公告)日：2023-06-01

申请号：US17920327

申请日：2021-04-21

Applicant: DSM IP ASSETS B.V.

Inventor： Peter Hans RIEBEL ,  Angela WILDERMANN

IPC: C07C201/02 ,  C07C67/08

CPC classification number: C07C201/02 ,  C07C67/08

Abstract: The invention relates to a safe and efficient process for the for the acylation of an α,ω-alkanediol, which can be used in the manufacture of ω-nitrooxy-C3-10alkane-1-ols. The process is safer to operators and allows to obtain advantageous yields on industrial scale.

公开(公告)号：US10703707B2

公开(公告)日：2020-07-07

申请号：US16413322

申请日：2019-05-15

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Chih-Lung Chin ,  Shih-Hsien Liu ,  Wan-Chi Chen ,  Kung-Lung Cheng

IPC: C07C201/02 ,  B01J19/00 ,  C07D493/04

Abstract: A method for preparing a nitrate ester is provided. The method includes providing a first solution including a compound (which has at least one hydroxyl group) and a carboxylic acid having 2-5 carbon atoms; providing a second solution including nitric acid, acetic anhydride, and acetic acid; and transferring the first solution and the second solution to a microreactor, obtaining a nitrate ester after a residence time. In particular, the ratio of the weight of nitric acid to the total volume of the acetic anhydride and acetic acid is 1:1 to 1:3.5. The ratio of the molar amount of nitric acid to the hydroxyl group equivalent of the compound is from 1:1 to 15:1.

公开(公告)号：US20160200663A1

公开(公告)日：2016-07-14

申请号：US14912387

申请日：2014-06-25

Applicant: JOSEF MEISSNER GMBH & CO. KG

Inventor： Jurgen POHLMANN ,  Heinrich HERMANN ,  Mirko HANDEL ,  Jurgen GEBAUER

IPC: C07C201/02 ,  B01D11/04 ,  B01J19/18

CPC classification number: C07C201/02 ,  B01D11/0473 ,  B01J19/1812 ,  C07C203/04

Abstract: The invention relates to a method and to a device for removing contaminants arising during the production of aliphatic or alicyclic nitric acid esters, in particular for removing contaminants from nitrated crude nitric acid esters, which nitrated crude nitric acid esters arise during the nitration of monovalent or multivalent aliphatic or alicyclic alcohols capable of nitration, after the separation of the final nitrating acid, and to a production system for nitrating monovalent or multivalent aliphatic alcohols capable of nitration with subsequent purification of the nitrated nitric acid esters.

Abstract translation: 本发明涉及一种用于去除在制备脂族或脂环族硝酸酯期间产生的污染物的方法和装置，特别是用于从硝化的粗硝酸酯中除去污染物，硝酸化的硝酸酯在硝化单价或 在最终的硝酸分离后能够进行硝化的多价脂肪族或脂环族醇，以及能够硝化硝酸硝酸酯的能够进行硝化的一价或多价脂肪族醇的生产体系​​。

公开(公告)号：US09365488B2

公开(公告)日：2016-06-14

申请号：US14374031

申请日：2012-12-21

Applicant: SHANDONG LIBAODE CHEMICAL CO., LTD.

Inventor： Deliang Xu ,  Hengtao Mao

IPC: C07C201/02 ,  C07C203/04 ,  C07C203/08

CPC classification number: C07C201/02 ,  C07C203/04

Abstract: The present invention provides a method for producing alkyl nitrate. The centrifugal extraction equipment acts as the esterification separator; a mixed acid solution containing sulfuric acid and nitric acid enters from the heavy phase inlet of the centrifugal extraction equipment; alkyl alcohol enters from the light phase inlet of the centrifugal extraction equipment; the feeding molar ratio of alkyl alcohol and nitric acid equals to 1:1.0-3.0; esterification reaction occurs with the mixed acid and alkyl alcohol at a temperature of 10˜60° C. under the rotating speed of 800-2000 r/min; under the action of centrifugal force, the generated coarse ester as a light phase and the spent acid as a heavy phase are separated; coarse ester as a light phase is discharged through the light-phase outlet of the centrifugal extractor; the spent acid as a heavy phase is discharged through the heavy-phase outlet of the centrifugal extractor; after alkali washing and water washing conventionally, coarse ester is dehydrated for drying and purified, then the refining products of alkyl nitrate is obtained. In the method of the present invention, esterification reaction, the separation of reaction products and the spent acid are finished in the same reactor simultaneously, which reduces the contact time of reaction products with the spent acid greatly, avoids the side reaction effectively, and ensures the safety of esterification process.

Abstract translation: 本发明提供硝酸烷基酯的制造方法。 离心萃取设备作为酯化分离器; 含有硫酸和硝酸的混合酸溶液从离心萃取设备的重相入口进入; 烷基醇从离心萃取设备的轻相进口进入; 烷基醇和硝酸的进料摩尔比等于1：1.0-3.0; 在混合酸和烷基醇的温度为10〜60℃，以800〜2000r / min的转速进行酯化反应; 在离心力作用下，生成的粗酯为轻质相，废酸为重相分离; 粗酯作为轻相通过离心萃取器的光相出口排出; 作为重相的废酸通过离心萃取器的重相出口排出; 在碱洗和水洗常规之后，将粗酯脱水干燥和纯化，得到硝酸烷基酯的精制产物。 在本发明的方法中，酯化反应，反应产物和废酸的分离同时在同一反应器中完成，这大大降低了反应产物与废酸的接触时间，有效避免了副反应，确保了 酯化过程的安全性。

公开(公告)号：US20120226068A1

公开(公告)日：2012-09-06

申请号：US13368601

申请日：2012-02-08

Applicant: Hao-Cheng Yang ,  Chia-Chung Tsai ,  Chi-Hsiang Yao

Inventor： Hao-Cheng Yang ,  Chia-Chung Tsai ,  Chi-Hsiang Yao

IPC: C07C201/02 ,  C07C69/734

CPC classification number: C07C65/24 ,  C07C203/04

Abstract: The present invention provides a novel anhydride derivative of 2-(S)-(6-methoxy-2-naphtyl)-propanoic acid for preparing nitrooxyalkyl esters of 2-(S)-(6-methoxy-2-naphtyl)-propanoic acid with high purity to meet requirements of the industry.

Abstract translation: 本发明提供2-（S） - （6-甲氧基-2-萘基） - 丙酸的新型酸酐衍生物，用于制备2-（S） - （6-甲氧基-2-萘基） - 丙酸 以高纯度满足行业要求。

公开(公告)号：US20110034720A1

公开(公告)日：2011-02-10

申请号：US12808829

申请日：2008-12-19

Applicant: Sascha Braune ,  Stefan Steinhofer ,  Peter Poechlauer ,  Rafael Wilhelmus E.G. Reintjens ,  Nicole Theodora W. Linssen ,  Mehul Thathagar

Inventor： Sascha Braune ,  Stefan Steinhofer ,  Peter Poechlauer ,  Rafael Wilhelmus E.G. Reintjens ,  Nicole Theodora W. Linssen ,  Mehul Thathagar

IPC: C07C201/02

CPC classification number: B01J19/0093 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00966 ,  B01J2219/00984 ,  C07C201/02 ,  C07C203/04

Abstract: A process for the continuous production of a compound of Formula (II), HO—R1—ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO—R1—OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.

Abstract translation: 在二相溶剂系统中连续制备其中R 1为具有3至6个碳原子的直链烷基的式（II）化合物HO-R1-ONO2（Ⅱ）的方法，包括使 式（I）化合物，其中R 1如上定义的HO-R 1 -OH（I）与硝酸在第一溶剂存在下反应，其中将式（II）化合物连续萃取到第二溶剂中， 反应在混合微反应器中进行，该混合微反应器通过圆形截面直通微反应器提供至少1.3相同条件下功率损耗的功率损失，该反应器的内径等于混合微反应器的平均水力直径 长度等于混合微反应器的长度。

公开(公告)号：US20110034719A1

公开(公告)日：2011-02-10

申请号：US12910550

申请日：2010-10-22

Applicant: Aldo BELLI ,  Vincenzo CANNATA ,  Telly FONDUCA ,  Martin HEDBERG ,  Andreas WESTERMARK ,  Marco VILLA

Inventor： Aldo BELLI ,  Vincenzo CANNATA ,  Telly FONDUCA ,  Martin HEDBERG ,  Andreas WESTERMARK ,  Marco VILLA

IPC: C07C201/02

CPC classification number: C07C309/73 ,  A61K31/21 ,  C07C67/08 ,  C07C67/58 ,  C07C201/02 ,  C07C303/28 ,  C07C309/66 ,  C07C309/67 ,  C07C69/734 ,  C07C203/04

Abstract: The present invention relates to a new process for the preparation of the (S)-naproxen 4-nitrooxybutyl ester and to new intermediates obtained and used therein. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active compounds such as (S)-naproxen 4-nitrooxybutyl ester. The invention also relates to the use of (S)-naproxen 4-nitrooxybutyl ester prepared according to the process of the present invention for the manufacturing of a medicament for the treatment of pain.

Abstract translation: 本发明涉及制备（S） - 萘普生4-硝基氧丁基酯的新方法及其中获得和使用的新中间体。 本发明还涉及新中间体用于制备药学活性化合物如（S） - 萘普生4-硝基氧基丁基酯的用途。 本发明还涉及根据本发明的方法制备的（S） - 萘普生4-硝基氧基丁基酯在制备用于治疗疼痛的药物中的用途。

公开(公告)号：US20080293961A1

公开(公告)日：2008-11-27

申请号：US12166739

申请日：2008-07-02

Applicant: Tiziano Scubla ,  Nevio Francescutti ,  Fausto Gorassini ,  Graziano Castaldi

Inventor： Tiziano Scubla ,  Nevio Francescutti ,  Fausto Gorassini ,  Graziano Castaldi

IPC: C07C201/02

CPC classification number: C07C203/04 ,  C07C201/02

Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.

Abstract translation: 本文公开了通过溶剂选择性萃取从1,4-丁二醇和1,4-丁二醇纯化1,4-丁二醇单硝酸酯的方法。

公开(公告)号：US20070232840A1

公开(公告)日：2007-10-04

申请号：US11231142

申请日：2005-09-19

Applicant: Robert Fox

Inventor： Robert Fox

IPC: C07C201/02

CPC classification number: C07C201/08 ,  Y02P20/544 ,  C07C205/06

Abstract: A method for making an energetic material is described, and which includes the steps of providing a source of aqueous nitric acid having a concentration of less than about 95% by weight; mixing a surfactant with the source of the aqueous nitric acid so as to dehydrate the aqueous nitric acid to produce a source of nitronium ions; providing a carbon dioxide environment; providing a source of an organic material to be nitrated to the carbon dioxide environment; and controllably mixing the source of nitronium ions with the carbon dioxide environment to nitrate the organic material and produce a resulting energetic material.

Abstract translation: 描述了制备高能材料的方法，其包括以下步骤：提供浓度小于约95重量％的硝酸水溶液源; 将表面活性剂与硝酸水溶液混合，以使硝酸水溶液脱水以产生硝鎓离子源; 提供二氧化碳环境; 提供要对二氧化碳环境进行硝化的有机材料的来源; 并可控制地将硝酸根源与二氧化碳环境混合以使有机材料硝酸化并产生所得的能量材料。