公开(公告)号：US11407897B2

公开(公告)日：2022-08-09

申请号：US17107773

申请日：2020-11-30

Applicant: CYTIVA SWEDEN AB

Inventor： David Moore ,  Matthew Jeremiah Misner ,  Hongyi Zhou ,  Patrick McCloskey ,  Matthew Rainka

IPC: C08L81/06 ,  C08G75/20 ,  B01D71/68 ,  B01D71/80 ,  B01D71/82 ,  C08L71/00 ,  C08L101/00 ,  C08G65/40 ,  C08G81/00 ,  B01D69/08 ,  B01D67/00 ,  B01D61/24

Abstract: Multicomponent copolymers including two or more types of repeat units is presented. In one example, the multicomponent copolymer includes at least one repeat unit AC having a structure (I), at least one repeat unit DC having a structure (II), and at least one repeat unit BC having a structure (III) or (V). The multicomponent copolymer may be cross-linked via a cross-linking agent. A polymer blend including the multicomponent copolymer or a cross-linked copolymer and a second polymer is also provided. The multicomponent copolymer may be a random or a block copolymer. The structural units of the multicomponent copolymers provide improved, tunable properties, such as improved biocompatibility and hydrophilicity, protein fouling, and mechanical properties, to the copolymers and/or the membranes fabricated from the copolymers.

公开(公告)号：US20220163493A1

公开(公告)日：2022-05-26

申请号：US17602701

申请日：2020-04-16

Applicant: CYTIVA SWEDEN AB

Inventor： Jens Widehammar ,  Key Hyckenberg ,  Orjan Grelsson ,  Lars Mattsson ,  Kjell Karlsson

IPC: G01N30/86

Abstract: Disclosed is a chromatography system arranged to perform automated chromatography column efficiency testing for a specific column to determine efficiency parameters such as h and As and optionally to further provide guidance to the user with respect to column efficiency, the system having a controller arranged to automatically access data to enable the calculation of a column compression plate height, said data being derived from at least stored parameters of the specific column and the resin to be used in that column, thereby to calculate the efficiency of the column.

公开(公告)号：US11333641B2

公开(公告)日：2022-05-17

申请号：US16070846

申请日：2017-01-27

Applicant: Cytiva Sweden AB

Inventor： Stefan Dargy ,  Olle Bjernulf ,  Mats Lundkvist

IPC: G01N30/80 ,  G01N35/10 ,  G01N35/02 ,  G01N30/02 ,  G01N35/04

Abstract: Disclosed is a fraction collector for dispensing liquids into plural receptacles (P1,P2) arranged in a two dimensional array. The fraction collector comprises a table (22) for supporting said receptacles, and an arm supported above the table, in turn supporting a liquid dispenser (35), the fraction collector arm is rotatable about an arm axis (C) and the liquid dispenser is movable along the arm on a carriage 34 (FIG. 2). Thereby, the dispenser is low cost and is repositionable simply above the receptacles as a result of said rotation and as a result of said movement along the arm, without occupying too much laboratory bench space.

公开(公告)号：US11327020B2

公开(公告)日：2022-05-10

申请号：US17072760

申请日：2020-10-16

Applicant: FUJIFILM Corporation ,  CYTIVA SWEDEN AB

Inventor： Yasutake Tanaka ,  Akira Yamaguchi ,  Erik Bjerneld

IPC: G01N21/64 ,  H04N5/232 ,  H04N5/235 ,  H04N5/321

Abstract: An imaging system includes: an imaging unit that images a subject; and a control unit that enables the imaging unit to perform pre-imaging one or more times, and main imaging one or more times following the pre-imaging; the control unit has an image generating portion that generates a subject image based on one or more taken images in each of the pre-imaging and the main imaging, an interface portion that displays the subject image and accepts a user input for setting at least a region-of-interest, of the region-of-interest and a non-region-of-interest of the subject image, a region setting portion as defined herein, an SN ratio calculating portion as defined herein, and a total light exposure time calculating portion as defined herein; and the control unit enables the imaging unit to perform the main imaging based on the total light exposure time.

公开(公告)号：US11306293B2

公开(公告)日：2022-04-19

申请号：US16737390

申请日：2020-01-08

Applicant: Cytiva Sweden AB

Inventor： Ann-Christin Magnusson ,  Mats Lundgren ,  Eva Blanck ,  Christine Sund Lundstrom

IPC: A61K31/7088 ,  A61K35/18 ,  A61K38/17 ,  A61K39/00 ,  A61K39/385 ,  C12N7/00 ,  C12N5/071 ,  C12N9/88 ,  C12N15/86

Abstract: The present invention relates to a method for virus propagation. More closely the invention relates to a method for animal component free propagation and production of rotavirus (RV) using recombinant trypsin.

公开(公告)号：US11255851B2

公开(公告)日：2022-02-22

申请号：US15760754

申请日：2016-09-22

Applicant: CYTIVA SWEDEN AB

Inventor： Olof Karlsson

IPC: G01N33/557 ,  G01N33/543 ,  G01N21/41 ,  G01N21/552

Abstract: A system and method for evaluation of an interaction between an analyte in a fluid sample and a ligand immobilized on a sensor surface of a biosensor is provided. In one example, the system includes a plurality of needles, each being arranged to inject a fluid sample to one of sensor surfaces or detection spots. A plurality of fluid samples, each containing known concentrations of analyte, is provided. The plurality of fluid samples may be divided into at least two groups, each group having a number of fluid samples corresponding to the number of needles. The system and method is configured to perform the injections without intermediate regeneration or renewal of the immobilized ligand. Software for performing the steps of the method and a computer readable medium for storing the software are also provided.

公开(公告)号：US20220033750A1

公开(公告)日：2022-02-03

申请号：US17296726

申请日：2019-12-10

Applicant: Cytiva Sweden AB

Inventor： Andreas Lundin ,  Bjorn Olovsson ,  Klaus Gebauer ,  Tim Francois ,  Kerstin Erickson

IPC: C12M1/00 ,  C12M1/34

Abstract: A flow distribution device for bioprocess systems, comprising: a flow distribution manifold (12; 112) comprising: at least four fluid connection conduits (14), wherein each fluid connection conduit (14) comprises a first end (18) for fluid connection and an opposite second end (20), and wherein at least three of the fluid connection conduits comprise a membrane (19a) and a valve seat (19b), which membrane (19a) can be put in at least two different positions in relation to the valve seat (19b) for allowing or preventing fluid flow between the first end (18) and the second end (20) of the fluid connection conduit (14); and a central common compartment (30) to which the second ends (20) of each of the fluid connection conduits (14) are connected, whereby the first ends (18) of each of the fluid connection conduits (14) can be in fluid communication with the central common compartment (30) and wherein the fluid connection conduits (14) are entering the central common compartment (30) from at least three different directions; wherein said flow distribution device (10) further comprises at least three membrane actuation members (41) which are provided in connection with one membrane (19a) of the flow distribution manifold (12; 112) each, wherein each of said membrane actuation members (41) is configured for actuating the membrane (19a) to be in at least two different positions in relation to the valve seat (19b), wherein a first position of the membrane (19a) allows flow between the first end (18) and the second end (20) of the fluid connection conduit (14) and a second position of the membrane (19a) prevents flow between the first end (18) and the second end (20) of the fluid connection conduit (14).

公开(公告)号：US20220032301A1

公开(公告)日：2022-02-03

申请号：US17277046

申请日：2019-09-27

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer ,  Markus Pitkanen

IPC: B01L3/00

Abstract: The present disclosure relates to a biological fluid processing system and method. The system comprises a fluid processing device comprising at least one fluid path, a pump for providing a pressure in the at least one fluid path, a valve arranged along said fluid path and a first actuator arranged to control the valve to assume a desired opening state of said fluid path. The biological fluid processing system comprises further a processing interface comprising a pump drive for driving the pump of the fluid processing device, and a processing control element comprising a pump control system arranged to control at least the pump drive and a valve control system arranged to control the first actuator. The system is modular. The fluid processing device is comprised in a fluid processing device module having a predetermined fluid processing device configuration. The processing interfaces have a predetermined processing interface configuration. The processing control element is arranged to receive information relating to the predetermined processing interface configuration of the processing interface module and/or the predetermined fluid processing device configuration of the fluid processing device module and control the at least one pump drive and/or the valve based on the received information relating to the predetermined fluid processing device configuration and the predetermined processing interface configuration.

公开(公告)号：US20220018817A1

公开(公告)日：2022-01-20

申请号：US17294710

申请日：2019-12-04

Applicant: Cytiva Sweden AB

Inventor： Daniel Salomonsson ,  Mats Lundkvist

IPC: G01N30/60 ,  B01D15/22 ,  B01D15/20

Abstract: Disclosed is a chromatographic separation column assembly (100) comprising a column cylinder (120) having a cylinder wall (126) including an inner wall surface (124) partially defining a column volume (50), and a column component (110/130) insertable into to the cylinder (120), wherein at least an edge region (113/133) of the column component is intended to be in contact or adjacent a part of the inner wall surface (124) in use, the edge region and the contacting or adjacent part of inner wall surface each being formed from a compatible heat fusible material or materials, and wherein at least the cylinder wall in the area of the contacting or adjacent part of the inner wall is formed from a material which allows transmission of the light energy needed to cause said fusing of the adapter plate edge region to the inner wall surface.

公开(公告)号：US20220001350A1

公开(公告)日：2022-01-06

申请号：US17381588

申请日：2021-07-21

Applicant: Cytiva Sweden AB

Inventor： Johan Rosenquist ,  Daria Donati ,  Mia Margareta Elisabet Bennemo

IPC: B01J19/00 ,  B01J4/00 ,  B01J19/24

Abstract: The present disclosure relates to a volume tailorable manufacturing system for quality assured manufacturing of biosafety level classified biopharmaceutical products and a method for tailoring a production volume capability of a manufacturing system.
The volume tailorable manufacturing system comprises one or more multi-product suites and a control facility configured to control a unidirectional flow in a circulation system of the one or more multi-product suites. The circulation system is configured to interconnect the one or more multi-product suites and comprises separated supply and return systems. The supply system comprising at least one inlet, the return system comprising at least one outlet that is paired with the inlet and provided at a spatially predetermined position from the inlet, and each inlet/outlet pair comprises a seal when not connected to an adjacent multi-product suite.