-
111.发明公开公开(公告)号：US20230310333A1
公开(公告)日：2023-10-05
申请号：US18043594
申请日：2021-08-23
Inventor： Weiping ZHU , Yun FU , Yufang XU , Xuhong QIAN
CPC classification number: A61K9/5115 , A61K38/28 , A61K9/0021
Abstract: A mesoporous silica nanoparticle controlled release system, a preparation method thereof and an application thereof, and specifically provides a mesoporous silica nanomaterial that can be used for controlled release is disclosed. The mesoporous silica nanomaterial that can be used for controlled release comprises a mesoporous silica nanoparticle functionalized by means of a polyhydroxy compound and a nanoparticle plugging agent functionalized by means of a phenylboronic acid compound. When substrate concentration is relatively low, the nanomaterial achieves “zero early release”; when substrate concentration is relatively high, mesoporous pores blocked by the plugging agent are opened and active ingredients are released. The nanomaterial can be loaded into microneedles and microneedle array patches used to treat diabetes or to control blood sugar levels in patients.
-
公开(公告)号：US20230296617A1
公开(公告)日：2023-09-21
申请号：US17904503
申请日：2021-02-09
Inventor： Yi Yang , Yuzheng Zhao , Chenxia Zhang , Li Huang , Yejun Zou , Xie Li , Shuning Liu
CPC classification number: G01N33/6812 , G01N33/582 , C12N15/63
Abstract: Disclosed is a tryptophan optical probe, a preparation method therefor and the use thereof. Disclosed is an optical probe, comprising a tryptophan-sensitive polypeptide or a functional variant thereof and an optically active polypeptide or a functional variant thereof, wherein the optically active polypeptide or the functional variant thereof is located in the sequence of the tryptophan-sensitive polypeptide or the functional variant thereof. Furthermore, disclosed are a method for preparing the above-mentioned probe and the use thereof in the detection of tryptophan.
-
公开(公告)号：US20230296616A1
公开(公告)日：2023-09-21
申请号：US17904498
申请日：2021-02-09
IPC: G01N33/68 , G01N33/533 , C07K14/00
CPC classification number: G01N33/6812 , G01N33/533 , C07K14/001
Abstract: Provided is an arginine fluorescent probe, comprising a polypeptide B that responds to arginine and a fluorescent protein A that expresses arginine; the fluorescent protein A is inserted into the polypeptide B, B is divided into an upper structural part and a lower structural part, B1 and B2, and a probe structure represented by the formula B1-A-B2 is formed; optimized mutants are likewise obtained by truncation and site-directed mutagenesis at different positions, and specific binding of the polypeptide B and arginine leads to a change in the fluorescence signal of the fluorescent protein A; and the polypeptide B is an arginine binding protein or a mutant thereof. The arginine fluorescent probe provided by the present invention has a relatively small protein molecular weight, is easy to express, experiences large dynamic changes in fluorescence, has good specificity, can be expressed, by means of genetic manipulation, in different subcellular organelles of cells, and can be used for the high-throughput, quantitative detection of arginine inside and outside of cells.
-
公开(公告)号：US20230133910A1
公开(公告)日：2023-05-04
申请号：US17907055
申请日：2021-03-29
Inventor： Yi YANG , Xianjun CHEN , Xin XIE , Ni SU
IPC: C12Q1/6876 , C12Q1/6816
Abstract: The present disclosure relates to an aptamer nucleic acid molecule, a complex containing the aptamer and fluorophore small molecules, a method for detecting intrecellular or extracellular RNA, DNA or other target molecules, as well as a kit containing the aptamer. The aptamer of the present disclosure can specifically bind to fluorophore small molecules, and can significantly improve their fluorescence intensity under light excitation at suitable wavelength.
-
公开(公告)号：US20230097553A1
公开(公告)日：2023-03-30
申请号：US17904587
申请日：2021-02-09
Inventor： Honglin LI , Ke XU , Zhenjiang ZHAO
IPC: A61K31/42 , A61K31/277 , A61P31/18 , A61P31/16
Abstract: An application of a compound represented by formula I or a pharmaceutically acceptable salt thereof in the preparation of a drug for treating RNA virus infection.
-
Patent Agency Ranking
公开(公告)号：US20230086554A1
公开(公告)日：2023-03-23
申请号：US17630356
申请日：2021-04-28
Inventor： Shuai Gu , Lei Xing , Jianguo Yu
Abstract: The disclosure provides a precursor solution, a perovskite solar cell and a preparation method thereof. The solute of the precursor solution includes a metal halide, the solvent of the precursor solution is an organic solvent, and the precursor solution contains nanobubbles, which have a diameter not more than 1000 nm, and the zeta potential of the precursor solution does not exceed −20 mV. The method of preparing the precursor solution includes: (1) preparing an organic solvent containing nanobubbles; (2) dissolving a solute in the organic solvent containing nanobubbles. The precursor solution of the disclosure has a very low zeta potential, and the nanobubbles can exist stably in the organic solvent(s) for up to one month. When comparing with traditional methods for preparing the precursor solution of the perovskite cells, the method for preparing the precursor solution of the disclosure can effectively improve the stability, reproducibility and solubility of the metal halide in the organic solvent(s).
-
公开(公告)号：US20230056311A1
公开(公告)日：2023-02-23
申请号：US17611992
申请日：2020-05-15
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES
Inventor： Lixin ZHANG , Weishan WANG , Shanshan LI , Zilong LI , Gaoyi TAN , Jingyu ZHANG
Abstract: A method for improving the production of Streptomyces polyketide compounds is provided. The method greatly improves the capability of the Streptomyces polyketide compounds by strengthening a triacylglycerol decomposition pathway in Streptomyces during the stationary phase. A method for switching the primary metabolism of Streptomyces to the secondary metabolism, Streptomyces producing polyketide compounds, and use thereof are also provided.
-
公开(公告)号：US20220324067A1
公开(公告)日：2022-10-13
申请号：US17764136
申请日：2020-05-20
Inventor： Xiancheng ZHANG , Kaiming ZHANG , Shulei YAO , Shuang LIU , Feng CHENG , Shantung TU
IPC: B23P9/02
Abstract: Provided is a bilateral ultrasonic rolling processing track coordination method for a blade surface, the method comprising: step S1, performing layering processing on a blade to acquire a contour curve of “A”-shaped and “n”-shaped blade edges of a blade model at different heights; step S2: determining the endpoints of a blade processing track; and step S3: planning the thickness and the rotation angle of the blade, comprising: step S31, solving a main direction angle αmain of the contour curve; step S32, solving the thickness d of the blade; step S33, solving a rotation angle required by blade processing when the blade edge is “A”-shaped; and step S34, solving the rotation angle required by blade processing when the blade edge is “n”-shaped. According to the method, blade deformation generated by an ultrasonic rolling force is reduced, the processing efficiency is improved, and the blade processing precision is also improved.
-
公开(公告)号：US11345900B2
公开(公告)日：2022-05-31
申请号：US17294424
申请日：2019-11-26
Applicant: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: A monooxygenase having an amino acid sequence obtained by mutation of the amino acid sequence shown in SEQ ID NO:2 is disclosed. The use of the monooxygenase of the present invention in production of chiral sulfoxide-based drugs has advantages including mild reaction conditions, environmental friendliness, high yield, high optical purity of products, less peroxide products, and the like, and therefore the monooxygenase in the present invention has a good industrial application prospect in the production of proton pump inhibitors for the treatment of gastric ulcers.
-
公开(公告)号：US11306095B2
公开(公告)日：2022-04-19
申请号：US15577518
申请日：2016-05-30
Inventor： Honglin Li , Yufang Xu , Zhenjiang Zhao , Wei Zhou , Yuqiong Xu , Deheng Sun , Xia Wang , Zhuo Chen
IPC: C07D487/04 , A61P35/00 , A61P35/02 , A61K31/519 , C07D475/00
Abstract: The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR.
-
-
-
-
-
-
-
-
-
Search Results
232
records
(took 0.032 seconds)
