公开(公告)号：US10270535B1

公开(公告)日：2019-04-23

申请号：US16234635

申请日：2018-12-28

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Yossef Ehrlichman ,  Ofer Amrani ,  Shlomo Ruschin

IPC: H03M1/00 ,  H04B10/516 ,  H04B10/50 ,  G02F1/225 ,  G02F7/00 ,  H04B10/556 ,  H04B10/54 ,  H04B10/2575 ,  H04B10/25 ,  H03M1/70 ,  G02F1/01 ,  G02F1/015 ,  G02F1/21

Abstract: A system for converting digital data into a modulated optical signal, comprises an electrically controllable device having M actuating electrodes. The device provides an optical signal that is modulated in response to binary voltages applied to the actuating electrodes. The system also comprises a digital-to-digital converter that provides a mapping of input data words to binary actuation vectors of M bits and supplies the binary actuation vectors as M bits of binary actuation voltages to the M actuating electrodes, where M is larger than the number of bits in each input data word. The digital-to-digital converter is enabled to map each digital input data word to a binary actuation vector by selecting a binary actuation vector from a subset of binary actuation vectors available to represent each of the input data words.

公开(公告)号：US10266579B2

公开(公告)日：2019-04-23

申请号：US15509842

申请日：2015-09-10

Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. ,  RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Genady Kostenich ,  Mor Oron-Herman ,  Arie Orenstein ,  Talia Shekhter Zahavi ,  Ehud Gazit ,  Yoseph Salitra ,  Ludmila Buzhansky

IPC: C07K14/655 ,  A61K38/08 ,  A61K38/12 ,  A61K47/62 ,  A61K47/69

Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.

公开(公告)号：US20190041472A1

公开(公告)日：2019-02-07

申请号：US16077497

申请日：2017-02-14

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Alexander GERBER ,  Gil MARKOVICH ,  Leah BEN GUR ,  Einat TIROSH

IPC: G01R33/07 ,  G01R33/09 ,  H01L43/06

Abstract: A magnetic field sensor system comprises an electrically conducting film of ferromagnetic nanoparticles printed directly on a supporting structure, and electrically conducting contacts coupled to the film for injecting an electric current into the film and measuring a voltage generated across said film responsive to said injected current in a direction that is generally perpendicular to the current direction in the plane of the film.

公开(公告)号：US20180372678A1

公开(公告)日：2018-12-27

申请号：US16060423

申请日：2016-12-08

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Fernando PATOLSKY ,  Vadim KRIVITSKY ,  Marina ZVERZHINETSKY

IPC: G01N27/414 ,  H01L23/532 ,  H01L29/06 ,  H01L51/00 ,  H01L51/05

Abstract: A method of detecting a presence and/or concentration of a marker, e.g., a marker, in a liquid, e.g., a liquid, is disclosed. The method comprises: contacting the liquid with a sensor having an immobilized affinity moiety interacting with the marker and being configured to generate a detectable signal responsively to the interaction. The method further comprises washing the liquid off the sensor, and detecting the presence and/or concentration of the marker based on a detectable signal received from the sensor within a time-window beginning a predetermined time period after a beginning time of the washing.

公开(公告)号：US20180372673A1

公开(公告)日：2018-12-27

申请号：US16008218

申请日：2018-06-14

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Fernando Patolsky ,  Vadim Krivitsky ,  Boris Filanovsky

IPC: G01N27/404 ,  G01N27/30 ,  G01N33/00

Abstract: A carbon electrode having a functional moiety that forms a charge-transfer complex with a nitro-containing compound covalently attached to a surface of the electrode, and a process of preparing such an electrode are provided. Also provided are sensing systems integrating the carbon electrode and methods utilizing same for electrochemical detection of nitro-containing compounds.

公开(公告)号：US20180370910A1

公开(公告)日：2018-12-27

申请号：US16062253

申请日：2016-12-19

Applicant: THOMAS JEFFERSON UNIVERSITY ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Nir Ben-Tal ,  Roger S. Armen ,  Laurence C. Eisenlohr ,  Jitendra Belani ,  Michael Miller ,  Inbar Fish ,  Ori Kalid

IPC: C07C311/16 ,  A61P31/16 ,  C07C311/29

Abstract: An effective therapeutic agent for the M2 channel comprising sulfonylamide or oxabicyclo structures effective for treating amantadine-resistant influenza A infections, and methods of treating amantadine-resistant influenza A infections through administration of the same.

公开(公告)号：US20180361023A1

公开(公告)日：2018-12-20

申请号：US16061675

申请日：2016-12-15

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Tal DVIR ,  Assaf SHAPIRA ,  Michal SHEVACH ,  Idan GAL

IPC: A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61K35/35

Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 μM in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.

公开(公告)号：US20180346882A1

公开(公告)日：2018-12-06

申请号：US16045784

申请日：2018-07-26

Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Benjamin Dekel ,  Orit Harari-Steinberg ,  Ella Buzhor

IPC: C12N5/071

CPC classification number: C12N5/0686 ,  C12N2500/90 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/33 ,  C12N2501/392 ,  C12N2533/40

Abstract: A method of generating a nephrospheroid is disclosed. The method comprises culturing human adult kidney cells in a culture medium under non-adherent conditions. Uses thereof and other renal cell populations are also disclosed.

公开(公告)号：US10088418B2

公开(公告)日：2018-10-02

申请号：US15329260

申请日：2015-09-02

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ori Cheshnovsky ,  Omer Tzang

IPC: G01J3/46 ,  G01N21/63 ,  G01N21/17 ,  G01N21/65 ,  G02B21/06

Abstract: A method of microscopy is disclosed. The method comprises directing a pulse of a pump optical beam to form an optical spot on a substance and measuring changes in a temperature-dependent or photo-excited property of the substance. The method further comprises analyzing the measured changes to distinguish between information pertaining to the property at a portion of the spot, and information pertaining to the property at other portions of the spot. A largest diameter of the portion of the spot is optionally and preferably less than a central wavelength of the pump optical beam.

公开(公告)号：US20180273911A1

公开(公告)日：2018-09-27

申请号：US15764691

申请日：2016-09-29

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  SYNVACCINE LTD.

Inventor： Tamir TULLER ,  Eli GOZ ,  Shimshi ATAR ,  Hadas ZUR

IPC: C12N7/00 ,  A61K39/12

CPC classification number: C12N7/00 ,  A61K35/76 ,  A61K39/12 ,  A61K2039/5254 ,  C12N2770/24121 ,  C12N2770/24162 ,  G16B99/00 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/391 ,  Y02A50/465

Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.