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    SYRINGE SAFETY ASSEMBLY
    112.
    发明申请
    SYRINGE SAFETY ASSEMBLY 审中-公开
    灌肠安全装置

    公开(公告)号：US20150174340A1

    公开(公告)日：2015-06-25

    申请号：US14584145

    申请日：2014-12-29

    Applicant: UCB Pharma S.A.

    Inventor： Anthony Torris ,  Alistair Bramley ,  Daniel Formosa ,  Eric Freitag

    IPC: A61M5/32 ,  A61M5/315 ,  A61M5/31 ,  A61M5/50

    CPC classification number: A61M5/3232 ,  A61M5/3134 ,  A61M5/3137 ,  A61M5/31573 ,  A61M5/3204 ,  A61M5/321 ,  A61M5/326 ,  A61M5/34 ,  A61M5/5066 ,  A61M2005/3264 ,  A61M2005/3289 ,  A61M2207/00 ,  Y10T29/49826

    Abstract: Systems, devices, and methods are provided for providing safe syringe assemblies for injections. The syringe assemblies include a shielding mechanism that covers a syringe needle after an injection is delivered, thereby reducing the risk of a subsequent accidental stab from the needle. The shielding mechanism has a pre-injection configuration in which the needle extends beyond the housing and a post-injection configuration in which at least one component of the syringe assembly covers the needle. In some implementations, the syringe assembly includes a lock that inhibits the assembly from returning to the pre-injection configuration once an injection is delivered. The syringe assemblies may also include a bevel orientation mechanism that allows a user to align a needle bevel to accurately insert a needle for injection.

    Abstract translation: 提供了系统，装置和方法，用于为注射提供安全的注射器组件。 注射器组件包括在输注之后覆盖注射器针头的屏蔽机构，从而降低随后从针头偶然刺伤的风险。 屏蔽机构具有预注射构造，其中针延伸超过壳体和后注射构造，其中注射器组件的至少一个部件覆盖针。 在一些实施方案中，注射器组件包括一旦一旦注射被输送就禁止组件返回到预注射构型的锁。 注射器组件还可以包括斜面定向机构，其允许使用者对准针斜面以精确地插入用于注射的针。

    BACTERIAL HOST STRAIN COMPRISING A MUTANT SPR GENE AND HAVING REDUCED TSP ACTIVITY
    116.
    发明申请
    BACTERIAL HOST STRAIN COMPRISING A MUTANT SPR GENE AND HAVING REDUCED TSP ACTIVITY 有权
    含有突变体SPR基因并具有降低的TSP活性的细菌宿主菌株

    公开(公告)号：US20150132828A1

    公开(公告)日：2015-05-14

    申请号：US14600089

    申请日：2015-01-20

    Applicant: UCB PHARMA, S.A.

    Inventor： MARK ELLIS ,  DAVID PAUL HUMPHREYS

    IPC: C12N9/04

    CPC classification number: C12N9/0006 ,  C07K14/245 ,  C12N9/52 ,  C12N15/70 ,  C12Y101/01

    Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell.

    Abstract translation: 本发明提供了一种重组革兰氏阴性细菌细胞，其包含编码具有在一个或多个选自D133，H145，H157，N31，R62，I70，Q73，C94，S95，V98的氨基酸的突变的spr蛋白的突变型spr基因 ，Q99，R100，L108，Y115，V135，L136，G140，R144和G147，并且其中与野生型细胞相比，细胞具有降低的Tsp蛋白活性。

    Method for Producing Protein
    118.
    发明申请
    Method for Producing Protein 有权
    生产蛋白质的方法

    公开(公告)号：US20150025128A1

    公开(公告)日：2015-01-22

    申请号：US14451975

    申请日：2014-08-05

    Applicant: UCB PHARMA S.A.

    Inventor： Katharine Lacy Cain ,  Shirley Jane Peters ,  Paul Edward Stephens

    IPC: C12P21/00

    CPC classification number: C12P21/00 ,  C07K14/47 ,  C07K16/00 ,  C07K16/18 ,  C07K16/40 ,  C12N9/0004 ,  C12P21/02 ,  Y02P20/52

    Abstract: The present invention relates to a recombinant host cell, wherein the cell is modified to increase the expression levels of Ero1 and XBP1 relative to the expression levels of Ero1 and XBP1 in an unmodified cell. The present invention also relates to a method of producing a recombinant protein of interest comprising expressing the recombinant protein of interest in the recombinant host cell.

    Abstract translation: 本发明涉及重组宿主细胞，其中修饰细胞以相对于未修饰的细胞中Ero1和XBP1的表达水平增加Ero1和XBP1的表达水平。 本发明还涉及生产重组蛋白质的方法，包括在重组宿主细胞中表达重组蛋白质。

    BIOMARKERS FOR EPILEPSY
    119.
    发明申请
    BIOMARKERS FOR EPILEPSY 审中-公开
    生物标记为EPILEPSY

    公开(公告)号：US20140315737A1

    公开(公告)日：2014-10-23

    申请号：US14256309

    申请日：2014-04-18

    Applicant: UCB PHARMA, S.A.

    Inventor： CARLOS CARA TERRIBAS ,  JUAN RAMON GONZALEZ RUIZ ,  ANTONIO MARTINEZ MARTINEZ ,  ESTIBALIZ OLANO MARTIN ,  LAUREANO SIMON BUELA

    IPC: C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

    Abstract: The present invention relates to a group of epilepsy biomarkers comprising (i) SNP rs2740574; (ii) SNP rs1799735; (iii) SNP rs1695; (iv) SNP rs6280; and the locus of the human glutathione S-transferase theta-1 (GSTT1) gene. The invention particularly relates to this group of biomarkers as marker for protection against drug-resistant epilepsy. The group of biomarkers may additionally comprise at least one clinical marker selected from the group comprising (i) a focal seizure with secondary generalization; (ii) age at confirmed diagnosis of epilepsy; (iii) atrophy of hippocampus or medial temporal sclerosis; and (iv) the presence of a brain tumor. The present invention further relates to a method for detecting protection against drug-resistant epilepsy in a subject, a method for monitoring epilepsy therapy, a method of identifying an individual as eligible for an aggressive epilepsy therapy, a composition for detecting protection against drug-resistant epilepsy in a subject, a corresponding kit and a microarray for the analysis of protection against drug-resistant epilepsy.

    Abstract translation: 本发明涉及一组癫痫生物标志物，其包含（i）SNP rs2740574; （ii）SNP rs1799735; （iii）SNP rs1695; （iv）SNP rs6280; 和人谷胱甘肽S-转移酶θ-1（GSTT1）基因的位点。 本发明特别涉及这组生物标志物作为防止耐药性癫痫的标记物。 该组生物标志物可以另外包含至少一种选自以下的临床标志物：（i）具有次级泛化的局灶性发作; （ii）确诊癫痫的年龄; （iii）海马萎缩或内侧颞硬化; 和（iv）脑肿瘤的存在。 本发明还涉及用于检测受试者耐药性癫痫的保护方法，用于监测癫痫治疗的方法，鉴定个体是否符合侵略性癫痫治疗的方法，用于检测耐药性的组合物 受试者中的癫痫，相应的试剂盒和用于分析耐药性癫痫的保护的微阵列。

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