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403 条记录 (耗时 0.108 秒)

    Albumin fusion proteins
    113.
    发明授权
    Albumin fusion proteins 有权

    公开(公告)号：US07189690B2

    公开(公告)日：2007-03-13

    申请号：US10775180

    申请日：2004-02-11

    申请人： Craig A. Rosen ,  William A. Haseltine

    发明人： Craig A. Rosen ,  William A. Haseltine

    IPC分类号： C07K14/00

    CPC分类号： C07K14/76 ,  C07K14/4713 ,  C07K14/765 ,  C07K2319/00 ,  C12N15/62

    摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating or preventing diseases, disorders or conditions related to diabetes mellitus using albumin fusion proteins of the invention.

    Vascular endothelial growth factor 2 and methods of use
    114.
    发明授权
    Vascular endothelial growth factor 2 and methods of use 失效
    血管内皮生长因子2及其使用方法

    公开(公告)号：US07153827B1

    公开(公告)日：2006-12-26

    申请号：US09219442

    申请日：1998-12-23

    申请人： Jing-Shan Hu ,  Craig A. Rosen ,  Liang Cao

    发明人： Jing-Shan Hu ,  Craig A. Rosen ,  Liang Cao

    IPC分类号： A61K38/00 ,  A01N37/18 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/52 ,  C07K2319/00 ,  C12N2799/026

    摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.

    摘要翻译： 公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。

    Polynucleotides encoding human vascular endothelial growth factor 2
    115.
    发明授权
    Polynucleotides encoding human vascular endothelial growth factor 2 失效
    编码人血管内皮生长因子2的多核苷酸

    公开(公告)号：US07115392B2

    公开(公告)日：2006-10-03

    申请号：US10127551

    申请日：2002-04-23

    申请人： Craig A. Rosen ,  Jing-Shan Hu ,  Liang Cao

    发明人： Craig A. Rosen ,  Jing-Shan Hu ,  Liang Cao

    IPC分类号： C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C12N15/74 ,  C07H21/04

    CPC分类号： C07K14/52 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026

    摘要： Disclosed is a human VEGF2 polypeptide and DNA (RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.

    摘要翻译： 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还公开了使用这种多肽刺激伤口愈合和维持血管组织修复的方法。 还提供了使用拮抗剂抑制肿瘤生长，炎症和治疗糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。 还公开了用于检测VEGF2编码序列中的突变和来自宿主的样品中VEGF2蛋白浓度变化的诊断方法。

    Secreted protein HHTLF25 antibodies
    116.
    发明授权
    Secreted protein HHTLF25 antibodies 失效
    分泌蛋白HHTLF25抗体

    公开(公告)号：US07105644B2

    公开(公告)日：2006-09-12

    申请号：US09983802

    申请日：2001-10-25

    申请人： Craig A. Rosen ,  Steven M. Ruben ,  David W. LaFleur

    发明人： Craig A. Rosen ,  Steven M. Ruben ,  David W. LaFleur

    IPC分类号： C07K16/24 ,  C12N5/12 ,  G01N33/53

    CPC分类号： C12N9/00 ,  A61K38/00 ,  C07K14/47 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5041 ,  G01N33/5047 ,  G01N33/505 ,  G01N33/5058 ,  G01N33/68 ,  G01N33/6842 ,  G01N2500/00

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins. Disclosed embodiments of the invention also include antibodies that bind to secreted protein HHTLF25 and methods for making and using such antibodies.

    摘要翻译： 本发明涉及新型人分泌蛋白质和含有编码这种蛋白质的编码区基因的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。 本发明的公开的实施方案还包括结合分泌蛋白HHTLF25的抗体以及制备和使用该抗体的方法。

    Antibodies to breast specific gene 1
    117.
    发明授权
    Antibodies to breast specific gene 1 失效
    乳腺特异性基因的抗体1

    公开(公告)号：US07071309B2

    公开(公告)日：2006-07-04

    申请号：US10267849

    申请日：2002-10-10

    申请人： Hongjun Ji ,  Craig A. Rosen

    发明人： Hongjun Ji ,  Craig A. Rosen

    IPC分类号： C07K16/00

    CPC分类号： C12Q1/6886 ,  A61K39/00 ,  C07K14/47 ,  C12Q1/6809 ,  C12Q2600/156 ,  G01N33/57415 ,  G01N2500/04 ,  C12Q2539/113

    摘要： Human breast specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for breast cancer and as an agent to determine if breast cancer has metastasized. Also disclosed are antibodies specific to the breast specific gene polypeptides which may be used to target cancer cells and be used as part of a breast cancer vaccine. Methods of screening for antagonists for the polypeptide and therapeutic uses thereof are also disclosed.

    摘要翻译： 公开了人类乳腺特异性基因多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这样的多核苷酸或多肽作为乳腺癌的诊断标记物和用作确定乳腺癌是否转移的药剂的方法。 还公开了可用于靶向癌细胞并用作乳腺癌疫苗的一部分的乳腺特异性基因多肽特异性抗体。 还公开了筛选多肽的拮抗剂的方法及其治疗用途。

    Peptidoglycan recognition proteins
    119.
    发明授权
    Peptidoglycan recognition proteins 失效
    肽聚糖识别蛋白

    公开(公告)号：US07041802B2

    公开(公告)日：2006-05-09

    申请号：US10180454

    申请日：2002-06-27

    申请人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    发明人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    IPC分类号： C07K16/00 ,  C12P21/08 ,  C12N5/06 ,  G01N33/53

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A–B, FIGS. 2A–C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

    摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新的肽聚糖识别结合蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

    Antibodies to secreted protein HEMCM42
    120.
    发明授权
    Antibodies to secreted protein HEMCM42 有权
    抗体分泌蛋白HEMCM42

    公开(公告)号：US07001992B2

    公开(公告)日：2006-02-21

    申请号：US10062831

    申请日：2002-02-05

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Gregory A. Endress

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Gregory A. Endress

    IPC分类号： C07K16/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K16/00

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。