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154 条记录 (耗时 0.076 秒)

    Protease-activated receptor PAR4 (ZCHEMR2)
    116.
    发明授权
    Protease-activated receptor PAR4 (ZCHEMR2) 失效

    公开(公告)号：US07084253B2

    公开(公告)日：2006-08-01

    申请号：US10187049

    申请日：2002-06-28

    申请人： Wenfeng Xu ,  Scott R. Presnell ,  David P. Yee ,  Donald C. Foster

    发明人： Wenfeng Xu ,  Scott R. Presnell ,  David P. Yee ,  Donald C. Foster

    IPC分类号： C07K14/705

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease cleavage of PAR4 exposes a PAR4 extracellular amino terminal portion that serves as a ligand for the PAR4 receptor. PAR4 may be used as a target in drug screening, and further used to identify proteinaceous or non-proteinaceous PAR4 agonists and antagonists. The present invention also includes antibodies to the PAR4 polypeptides.

    Polynucleotides for mammalian secreted protein, Z1055G2P
    118.
    发明授权
    Polynucleotides for mammalian secreted protein, Z1055G2P 失效
    哺乳动物分泌蛋白多核苷酸，Z1055G2P

    公开(公告)号：US06822082B2

    公开(公告)日：2004-11-23

    申请号：US09893737

    申请日：2001-06-28

    申请人： Paul O. Sheppard ,  Scott R. Presnell

    发明人： Paul O. Sheppard ,  Scott R. Presnell

    IPC分类号： C07H2100

    CPC分类号： C07K14/52 ,  C07K14/47 ,  C07K2319/00

    摘要： The present invention provides to polynucleotides and secreted proteins encoded by the polynucleotides. The proteins include a variety of fusion proteins, including fusions comprising a signal peptide selected from the group consisting of signal peptides shown in SEQ ID NO:M, wherein M is an even integer from 2 to 328, operably linked to a second polypeptide. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.

    摘要翻译： 本发明提供了由多核苷酸编码的多核苷酸和分泌的蛋白质。 蛋白质包括多种融合蛋白，包括融合物，其包含选自SEQ ID NO：M所示的信号肽的信号肽，其中M为2至328的偶数整数，可操作地连接到第二多肽。 本发明还提供了利用多肽的多核苷酸，多肽和拮抗剂的治疗和诊断方法。

    Cytokine receptor zalpha11
    120.
    发明授权
    Cytokine receptor zalpha11 有权
    细胞因子受体zalpha11

    公开(公告)号：US06576744B1

    公开(公告)日：2003-06-10

    申请号：US09404641

    申请日：1999-09-23

    申请人： Scott R. Presnell ,  Darrell C. Conklin ,  Julia E. Novak ,  Angela K. Hammond

    发明人： Scott R. Presnell ,  Darrell C. Conklin ,  Julia E. Novak ,  Angela K. Hammond

    IPC分类号： C07K1452

    CPC分类号： C07H21/04 ,  C07K14/715 ,  C07K16/1232 ,  C07K16/2866 ,  C07K2317/32 ,  C07K2319/00

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。