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111.发明申请公开(公告)号：US20170286612A1
公开(公告)日：2017-10-05
申请号：US15621420
申请日：2017-06-13
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Daniel Almonacid , Jessica Richman
CPC classification number: G16H40/67 , G06F19/3418 , G16B35/00 , G16B40/00 , G16B50/00 , G16B50/50 , G16C20/60 , G16H20/00 , G16H50/20 , G16H50/50 , Y02A90/26
Abstract: A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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112.发明申请公开(公告)号：US20170277848A1
公开(公告)日：2017-09-28
申请号：US15621445
申请日：2017-06-13
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Daniel Almonacid , Jessica Richman
CPC classification number: G16H40/67 , G06F19/3418 , G16B35/00 , G16B40/00 , G16B50/00 , G16B50/50 , G16C20/60 , G16H20/00 , G16H50/20 , G16H50/50 , Y02A90/26
Abstract: A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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公开(公告)号：US20170270272A1
公开(公告)日：2017-09-21
申请号：US15606975
申请日：2017-05-26
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Jessica Richman , Daniel Almonacid
CPC classification number: G16H40/67 , C12Q1/68 , C12Q1/6883 , C12Q1/689 , C12Q2600/118 , G06F19/30 , G06F19/3418 , G16B5/00 , G16B50/00 , G16B99/00 , G16H20/10 , G16H50/20 , G16H50/50 , Y02A90/26
Abstract: A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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公开(公告)号：US09663831B2
公开(公告)日：2017-05-30
申请号：US14593424
申请日：2015-01-09
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Jessica Richman
CPC classification number: C12Q1/689 , C12Q1/6869 , C12Q1/6888 , G06F19/22
Abstract: A method and system for analyzing a microbiome of an individual, comprising: providing a sampling kit to the individual at a location remote from the sample processing network, the sampling kit including a sample container having a lysing component and a sample preservation component and configured to receive a sample from a collection site of the individual; receiving the sample container with the sample from the collection site of the individual; generating a microbiome sequence dataset based upon sequencing nucleic acid content of a microorganism portion of the sample; identifying a set of microorganisms represented in the microorganism portion based upon performance of a mapping operation on portions of the microbiome sequence dataset; generating an analysis based upon a set of features related to the microorganism portion; and transmitting information derived from the analysis to the individual.
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公开(公告)号：US20170053061A1
公开(公告)日：2017-02-23
申请号：US15240919
申请日：2016-08-18
Applicant: uBiome, Inc.
Inventor： Daniel Almonacid , Zachary Apte , Jessica Richman
CPC classification number: G16B25/00 , C12Q1/6806 , C12Q1/6844 , G01N35/0099 , G01N2035/00881 , G16B30/00 , G16B35/00 , G16C20/60 , G16C99/00 , C12Q2537/143 , C12Q2537/165
Abstract: A method and system for selection of a primer set for a set of target sequences includes: identifying candidate fragments upon performance of a comparison operation with the set of target sequences; identifying a forward subset of unique forward candidates and a reverse subset of unique reverse candidates; reducing the forward subset and the reverse subset based on a filtering operation; performing an in silico search operation with the reduced forward subset and the reduced reverse subset; generating a set of candidate degenerate primers based on the in silico search operation and a base mismatch criterion; generating a reduced set of candidate degenerate primers upon filtering the set of candidate degenerate primers according to the set of primer criteria; and selecting forward primer subsets that amplify the set of target sequences and identifying a reverse primer subset for each of the forward primer subsets with an in silico PCR operation.
Abstract translation: 用于选择一组目标序列的引物组的方法和系统包括：在与所述靶序列集合执行比较操作时识别候选片段; 识别唯一前向候选的前向子集和唯一逆向候选的反向子集; 基于过滤操作减少前向子集和反向子集; 用减少的前向子集和减少的反向子集执行计算机搜索操作; 基于计算机搜索操作和基本不匹配标准生成一组候选简并引物; 在根据引物标准集过滤所述候选简并引物组后，产生一组降低的候选简并引物; 以及选择扩增靶序列集合的正向引物亚类，并使用计算机内PCR操作来识别每个正向引物子集的反向引物子集。
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Patent Agency Ranking
116.发明申请METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR NEUROLOGICAL HEALTH ISSUES 审中-公开微生物衍生诊断方法与系统及神经保健问题的治疗方法公开(公告)号：US20170039347A1
公开(公告)日：2017-02-09
申请号：US15294482
申请日：2016-10-14
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Daniel Almonacid , Jessica Richman , Siavosh Rezvan Belbahani
IPC: G06F19/00 , A61K35/742 , A61K45/06 , A61K35/744 , A61K35/745 , A61K35/741 , A61K35/747
CPC classification number: G16H20/40 , A61K35/741 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K45/06 , G06F19/3481 , G16B20/00 , G16B30/00 , G16B50/00 , G16H10/40 , G16H50/20 , G16H50/70 , Y02A90/26
Abstract: A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Abstract translation: 一种至少一种在至少一个受试者中表征，诊断和治疗神经性健康问题的方法，所述方法包括：从受试者群体接收一组生物样品; 为受试者群体生成微生物组合数据集和微生物群功能分集数据集中的至少一个; 基于从至少一个微生物组合数据集和微生物组合功能分集数据集提取的特征，产生神经健康问题的表征; 基于表征，产生配置以校正神经系统健康问题的治疗模型; 并且在与受试者相关联的输出装置处，基于表征和治疗模型促进对受试者的治疗。
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公开(公告)号：US20170002432A1
公开(公告)日：2017-01-05
申请号：US15198818
申请日：2016-06-30
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Jessica Richman , Daniel Almonacid
Abstract: An embodiment of a method for diagnostic testing includes: providing a sampling kit to a subject, the sampling kit including a sample container for reception of a sample from a collection site of the subject; receiving the sample from the subject; generating a microbiome sequence dataset based upon sequencing nucleic acid content of a microorganism portion of the sample; detecting a presence of a set of microbiome targets; generating a diagnostic analysis based on the detected set of microbiome targets; generating a therapy recommendation based on the set of microbiome targets; and promoting the therapy recommendation in coordination with presenting information derived from the diagnostic analysis.
Abstract translation: 用于诊断测试的方法的实施例包括：向受试者提供采样套件，所述采样套件包括用于从所述受试者的收集部位接收样品的样本容器; 从受试者接收样本; 基于样品的微生物部分的核酸含量测定产生微生物群序列数据集; 检测一组微生物靶标的存在; 基于检测到的一组微生物群目标产生诊断分析; 基于一组微生物靶标产生治疗推荐; 并与介绍从诊断分析中得出的信息配合推广治疗推荐。
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118.发明申请METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR AUTOIMMUNE SYSTEM CONDITIONS 审中-公开用于自动识别系统条件的微生物衍生诊断和治疗方法与系统公开(公告)号：US20160321416A1
公开(公告)日：2016-11-03
申请号：US15204707
申请日：2016-07-07
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Daniel Almondacid , Jessica Richman , Siavosh Rezvan Behbahani
CPC classification number: G16H50/20 , C12Q1/6883 , G06F19/00 , G06F19/14 , G06F19/18 , G06F19/28 , G06F19/3418 , G06F19/3456 , G06F19/3481 , Y02A90/26
Abstract: A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the autoimmune condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Abstract translation: 一种至少一种在至少一个受试者中表征，诊断和治疗自身免疫疾病的方法，所述方法包括：从受试者群体接收一组生物样品; 为受试者群体生成微生物组合数据集和微生物群功能分集数据集中的至少一个; 基于从至少一个微生物组合数据集和微生物组合功能分集数据集提取的特征产生自身免疫病症的表征; 基于表征，产生配置用于校正自身免疫状况的治疗模型; 并且在与受试者相关联的输出装置处，基于表征和治疗模型促进对受试者的治疗。
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119.发明申请公开(公告)号：US20160319358A1
公开(公告)日：2016-11-03
申请号：US15207930
申请日：2016-07-12
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Daniel Almonacid , Jessica Richman , Siavosh Rezvan Behbahani
IPC: C12Q1/68 , G06F19/14 , A61K35/741 , G06F19/28
Abstract: A method for at least one of characterizing, diagnosing, and treating an endocrine system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the endocrine system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the endocrine system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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120.发明申请METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR ENDOCRINE SYSTEM CONDITIONS 有权微生物衍生物诊断方法与系统及内分泌系统条件的治疗方法公开(公告)号：US20160232313A1
公开(公告)日：2016-08-11
申请号：US15098248
申请日：2016-04-13
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Daniel Almonacid , Jessica Richman , Siavosh Rezvan Behbahani
CPC classification number: G06F19/22 , C12Q1/689 , C12Q2600/106 , C12Q2600/112 , C12Q2600/16 , G06F19/00 , G06F19/12 , G06F19/24 , G06F19/28 , G06F19/3418 , G06F19/3456 , G16H50/20 , Y02A90/26
Abstract: A method for at least one of characterizing, diagnosing, and treating an endocrine system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the endocrine system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the endocrine system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Abstract translation: 一种至少一种在至少一个受试者中表征，诊断和治疗内分泌系统状况的方法，所述方法包括：从受试者群体接收聚集的一组生物样品; 为受试者群体生成微生物组合数据集和微生物群功能分集数据集中的至少一个; 基于从至少一个微生物组合数据集和微生物组合功能分集数据集提取的特征产生内分泌系统状况的表征; 基于表征，产生配置用于校正内分泌系统状况的治疗模型; 并且在与受试者相关联的输出装置处，基于表征和治疗模型促进对受试者的治疗。
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