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    FLOW DISTRIBUTION AND COLLECTION FEATURES FOR ENSURING SCALABLE UNIFORM FLOW IN A CHROMATOGRAPHY OR MEMBRANE SEPARATION DEVICE
    121.
    发明申请
    FLOW DISTRIBUTION AND COLLECTION FEATURES FOR ENSURING SCALABLE UNIFORM FLOW IN A CHROMATOGRAPHY OR MEMBRANE SEPARATION DEVICE 有权

    公开(公告)号：US20210039015A1

    公开(公告)日：2021-02-11

    申请号：US16987845

    申请日：2020-08-07

    Applicant: McMaster University

    Inventor： Raja Ghosh ,  Paul Gatt ,  Umatheny Umatheva ,  Guoqiang Che

    IPC: B01D15/22 ,  B01D15/14

    Abstract: A chromatography device for removing a solute from a fluid is described herein. The device includes a first plate having an inlet, a first primary channel fluidly coupled to the inlet and a first set of secondary channels fluidly coupled to the first primary channel. The device also includes a middle frame housing chromatographic media and a second plate having an outlet, a second primary channel fluidly coupled to the outlet and a first set of secondary channels fluidly coupled to the second primary channel. The first set of secondary channels directs the fluid in a direction that is transverse to a direction of flow of the fluid through the chromatographic media and the second set of secondary channels directs the fluid to the outlet in a direction that is transverse to the direction of flow of the fluid through the chromatographic media.

    ULTRA SOFT CUTTING TOOL COATINGS AND COATING METHOD
    127.
    发明申请
    ULTRA SOFT CUTTING TOOL COATINGS AND COATING METHOD 审中-公开

    公开(公告)号：US20190314900A1

    公开(公告)日：2019-10-17

    申请号：US16383157

    申请日：2019-04-12

    Applicant: McMaster University

    Inventor： Maryam Aramesh ,  Saharnaz Montazeri ,  Stephen Velduis

    IPC: B23B27/14

    Abstract: A cutting tool, comprising a substrate having a cutting surface and a coating adhered to the cutting surface in a solid state, wherein the coating includes a soft metal and is capable of melting and functioning as an in-situ liquid lubricant when the cutting tool is applied in a machining operation. Also, a method of applying a coating to a cutting tool, comprising receiving a premachining workpiece, the premachining workpiece formed of a coating material including a soft metal; and machining the premachining workpiece with the cutting tool such that a layer of the coating material adheres to a cutting surface of the cutting tool in a solid state.

    Allosteric activators for treatment of phenylketonuria
    128.
    发明授权
    Allosteric activators for treatment of phenylketonuria 有权

    公开(公告)号：US10426751B2

    公开(公告)日：2019-10-01

    申请号：US15542225

    申请日：2016-01-08

    Applicant: MCMASTER UNIVERSITY

    Inventor： Philip Britz-McKibbin

    IPC: A61K31/215 ,  A61K31/192 ,  C12Q1/26

    Abstract: A method of restoring activity in phenylalanine hydroxylase is provided. The method comprises exposing the phenylalanine hydroxylase to shikimic acid, a functionally equivalent analog thereof, a pharmaceutically acceptable salt of shikimic acid or analog thereof, or combinations thereof. A method of screening for allosteric activators for a target enzyme is also provided comprising the steps of: denaturing the target enzyme with a first chaotropic agent to yield denatured enzyme, incubating the denatured enzyme with a candidate compound under denaturing conditions to allow enzyme refolding, and assaying enzyme activity in the presence of enzyme substrate and a candidate compound; and if enzyme activity of the denatured enzyme was restored in step i) by at least about 10% of residual enzyme activity, denaturing the target enzyme with a second chaotropic agent to yield denatured enzyme, incubating the denatured enzyme with the candidate compound under non-denaturing conditions to allow enzyme refolding, and assaying enzyme activity in the presence of enzyme substrate and the candidate compound, wherein an increase in enzyme activity of at least about 10% of residual enzyme activity indicates that the candidate compound is an allosteric activator of the target enzyme.

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