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247 条记录 (耗时 0.055 秒)

    Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production
    124.
    发明申请
    Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production 有权
    含有所述化合物的螺环杂环药物及其制备方法及其制备方法

    公开(公告)号：US20110046148A1

    公开(公告)日：2011-02-24

    申请号：US12865431

    申请日：2009-02-05

    申请人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    发明人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    IPC分类号： A61K31/499 ,  C07D403/12 ,  A61K31/517 ,  A61P37/08 ,  A61P29/00

    CPC分类号： C07D403/12

    摘要： The present invention relates to spirocyclic heterocycles of general formula (I) the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways, and the preparation thereof.

    摘要翻译： 本发明涉及通式（I）的互变异构体，其立体异构体，其混合物及其盐，特别是其与无机或有机酸的生理上可接受的盐的螺环杂环，其具有有价值的药理学性质，特别是对 由酪氨酸激酶介导的信号转导，其用于治疗疾病，特别是肿瘤疾病以及良性前列腺增生（BPH），肺和气道疾病的用途及其制备。

    Cyclic Inhibitors of 11Beta-Hydroxysteroid Dehydrogenase 1
    125.
    发明申请
    Cyclic Inhibitors of 11Beta-Hydroxysteroid Dehydrogenase 1 有权
    11β-羟基甾体脱氢酶的循环抑制剂1

    公开(公告)号：US20110009402A1

    公开(公告)日：2011-01-13

    申请号：US12741532

    申请日：2009-07-23

    申请人： Frank Himmelsbach

    发明人： Frank Himmelsbach

    IPC分类号： A61K31/5355 ,  C07D413/10 ,  A61P3/10

    CPC分类号： C07D413/10 ,  C07D413/14

    摘要： The invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.

    摘要翻译： 本发明涉及可用于治疗性治疗的式Ik，Im1，Im2，Im5，In1，In2，In5，Io1，Io2，Io5，Ip1，Ip3，其药学上可接受的盐及其药物组合物的新型化合物 与哺乳动物调节或抑制11＆amp; -HSD1相关的疾病。 本发明进一步涉及新化合物的药物组合物及其用于减少或控制细胞中皮质醇产生或抑制细胞中可的松转化为皮质醇的方法。

    Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof
    126.
    发明申请
    Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof 审中-公开
    双环杂环，含有这些化合物的药物组合物，其用途及其制备方法

    公开(公告)号：US20100234371A1

    公开(公告)日：2010-09-16

    申请号：US11996886

    申请日：2006-08-03

    申请人： Frank Himmelsbach ,  Birgit Jung

    发明人： Frank Himmelsbach ,  Birgit Jung

    IPC分类号： A61K31/5377 ,  C07D239/94 ,  A61K31/517 ,  C07D413/14 ,  A61P35/00

    CPC分类号： C07D401/12 ,  C07D239/94 ,  C07D403/12

    摘要： The invention relates to bicyclic heterocycles of general formula (I), in which Ra, Rb, Rc, Rd, Re and X are as defined in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, in particular, the physiologically-acceptable salts thereof with inorganic and organic acids with useful pharmacological properties, in particular, an inhibitory effect on signal transduction brought about by tyrosine kinases, the use thereof for the treatment of diseases, in particular of tumour diseases and benign prostatic hyperplasia (BPH), diseases of the lungs and airways and production thereof.

    摘要翻译： 本发明涉及通式（I）的双环杂环，其中Ra，Rb，Rc，Rd，Re和X如权利要求1所定义，互变异构体，立体异构体，其混合物和盐，特别是生理上可接受的 其与具有有用药理学性质的无机和有机酸的盐，特别是对由酪氨酸激酶引起的信号转导的抑制作用，其用于治疗疾病，特别是肿瘤疾病和良性前列腺增生症（BPH），疾病 的肺和气道及其生产。

    PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS
    130.
    发明申请
    PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS 审中-公开
    用于治疗呼吸道感染和胃肠疾病的药物组合物

    公开(公告)号：US20100099651A1

    公开(公告)日：2010-04-22

    申请号：US12446794

    申请日：2007-10-23

    申请人： Birgit Jung ,  Frank Himmelsbach ,  Gerald Pohl

    发明人： Birgit Jung ,  Frank Himmelsbach ,  Gerald Pohl

    IPC分类号： A61K31/517 ,  A61K31/5377 ,  A61K31/56 ,  A61P11/00

    CPC分类号： A61K9/0073 ,  A61K31/517 ,  A61K31/5375 ,  A61K31/55 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to novel pharmaceutical compositions comprising at least one EGFR kinase inhibitor and at least one additional active compound selected from beta-2 mimetics, steroids, PDE-IV inhibitors, p38 MAP kinase inhibitors, NK1 antagonists, anticholinergics and endothelin antagonists, processes for preparing the compositions and the use thereof as medicament in the treatment of respiratory or gastrointestinal complaints, as well as inflammatory diseases of the joints, the skin or the eyes.

    摘要翻译： 本发明涉及包含至少一种EGFR激酶抑制剂和至少一种选自β-2模拟物，类固醇，PDE-IV抑制剂，p38 MAP激酶抑制剂，NK1拮抗剂，抗胆碱能药和内皮素拮抗剂的其它活性化合物的新型药物组合物， 用于制备组合物及其用作治疗呼吸道或胃肠道疾病以及关节，皮肤或眼睛的炎性疾病的药物。