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公开(公告)号：US07485700B2
公开(公告)日：2009-02-03
申请号：US11548056
申请日：2006-10-10
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。
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公开(公告)号：US07479542B2
公开(公告)日：2009-01-20
申请号：US11549760
申请日：2006-10-16
申请人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
发明人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
摘要翻译： 已经通过在编码成熟蛋白的多核苷酸序列中突变一个或多个半胱氨酸残基来产生IL-28A，IL-28B和IL-29的均质制剂。 可以显示半胱氨酸突变蛋白与其同源受体结合或表现出生物活性。 所示的一种生物活性是抗病毒活性。
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公开(公告)号：US20080032334A1
公开(公告)日：2008-02-07
申请号：US11539103
申请日：2006-10-05
IPC分类号： C12P21/06
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
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公开(公告)号：US07323446B2
公开(公告)日：2008-01-29
申请号：US11550246
申请日：2006-10-17
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基52-179或SEQ ID NO：2的残基258-370至少70％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US07294613B2
公开(公告)日：2007-11-13
申请号：US10091166
申请日：2002-03-05
CPC分类号： C07K14/4723 , A61K38/00 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the β-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
摘要翻译： 本发明涉及zamp1的多核苷酸和多肽分子，其是β-防御素家族的新成员。 多肽和编码它们的多核苷酸表现出抗微生物活性，并可用于微生物感染的研究或治疗。 本发明还包括针对zamp1多肽的抗体。
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公开(公告)号：US07241870B2
公开(公告)日：2007-07-10
申请号：US10928539
申请日：2004-08-27
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。
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公开(公告)号：US07183391B2
公开(公告)日：2007-02-27
申请号：US11082148
申请日：2005-03-16
申请人： Paul O. Sheppard , Brian A. Fox
发明人： Paul O. Sheppard , Brian A. Fox
CPC分类号： C07K14/8114 , A61K38/00
摘要： We claim the proteinase inhibitors comprising a Kunitz domain, wherein the Kunitz domain comprises amino acid residues 57–107 of SEQ ID NO: 2. We also claim a fusion protein comprising said Kunitz domain. In addition, we claim a method of inhibiting protease degradation or protease activity in a composition which contains plasma proteins and proteases. The proteinase inhibitors is used as components of cell culture media in cell culture process, and as inhibitors of protease-mediated degradation of plasma proteins in protein purification.
摘要翻译： 我们要求包含Kunitz结构域的蛋白酶抑制剂，其中Kunitz结构域包含SEQ ID NO：2的氨基酸残基57-107。我们还要求包含所述Kunitz结构域的融合蛋白。 此外，我们提出了在含有血浆蛋白和蛋白酶的组合物中抑制蛋白酶降解或蛋白酶活性的方法。 蛋白酶抑制剂在细胞培养过程中用作细胞培养基的组分，并且作为蛋白质介导的蛋白质纯化中血浆蛋白质降解的抑制剂。
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公开(公告)号：US07081519B1
公开(公告)日：2006-07-25
申请号：US09658677
申请日：2000-09-08
申请人： Paul O. Sheppard
发明人： Paul O. Sheppard
IPC分类号： C07K16/00
CPC分类号： C12N9/6472
摘要： Antibodies that specifically bind to novel serine protease polypeptides are disclosed. The polypeptides are selected from the group consisting of a polypeptide as shown in SEQ ID NO:2 from residue 1 through residue 373, a polypeptide as shown in SEQ ID NO:15 from residue 1 through residue 373, and a polypeptide as shown in SEQ ID NO:18 from residue 1 through residue 364.
摘要翻译： 公开了特异性结合新的丝氨酸蛋白酶多肽的抗体。 多肽选自SEQ ID NO：2所示的多肽，从残基1至残基373，如SEQ ID NO：15所示的多肽，残基1至残基373，多肽如SEQ ID NO： 来自残基1至残基364的SEQ ID NO：18。
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公开(公告)号：US06573363B1
公开(公告)日：2003-06-03
申请号：US09250124
申请日：1999-02-12
申请人： Paul O. Sheppard , Si Lok
发明人： Paul O. Sheppard , Si Lok
IPC分类号： C07K100
摘要： The present invention relates to polynucleotide and polypeptide molecules for zsig51, a novel member of the cystine knot family of polypeptides. The polypeptides comprise a sequence of amino acid residues that is at least 80% identical in amino acid sequence to residues 1 through 106 of SEQ ID NO:2. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.
摘要翻译： 本发明涉及用于zsig51的多核苷酸和多肽分子，多肽的胱氨酸结系家族的新成员。 多肽包含氨基酸序列与SEQ ID NO：2的残基1至106具有至少80％同一性的氨基酸残基序列。 本发明还提供了利用多肽的多核苷酸，多肽和拮抗剂的治疗和诊断方法。
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公开(公告)号：US06528050B1
公开(公告)日：2003-03-04
申请号：US09706968
申请日：2000-11-06
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： A61K4500
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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