摘要:
An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.
摘要:
An Instant Messaging (IM) method and server are provided. The method includes: receiving instance login information sent by an IM client, wherein the instance login information at least includes login information of a user of the IM client and instance information of a terminal located by the IM client (101); authenticating identity of the user of the IM client, according to the login information in the instance login information (102); when the authenticating is passed, allocating an instance number for the IM client, according to the instance information in the instance login information, wherein the instance number is configured to uniquely identify the IM client (103). The server includes a receiving module (801), an authenticating module (802) and an allocating module (803). By adopting the method and server provided, multipoint login of one login account may be effectively achieved, and multiple aspects requirements of a user may be satisfied.
摘要:
Lister strain vaccinia viruses that are encode a modified A34R gene resulting in increased extracellular enveloped virus (EEV) form of the virus and/or increased resistance of the virus to neutralizing antibodies. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要:
The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
摘要:
A system and method are disclosed for automatically captioning an electronic demonstration using object properties captured from the operating system. In response to an action that is initiated by a demonstrator, the operating system is queried to obtain the property information for the target object to which the action is directed as well as the parent object of the target object. This property information is then used to generate explanatory captions that are displayed to a user or trainee during the playback of the electronic demonstration.
摘要:
Systems and methods for use in communication between a client and a server, via a networking device, are provided. The method may include sending a request to establish a data connection from the client to the server via the networking device, setting a data connection keep-alive interval for the data connection to a predetermined safe value, and sending a request to establish a test connection between the client and the server. The method may further include determining an efficient keep-alive interval for communication between the client and server via the networking device, using the test connection, setting the data connection keep-alive interval to the efficient keep-alive interval determined using the test connection, and uploading the efficient keep-alive interval from the client to the server in an efficient keep-alive interval notification message, for communication to other clients connected to the server.
摘要:
Described herein is a context-free protocol (i.e., the COFFEE protocol) for stimulating cooperation among selfish nodes. Various embodiments have the ability to transmit a packet over the path successfully without the dependency on the information of other packets' transmissions. It is assumed that every node in the network is rational, and therefore during the packet forwarding stage, if the intermediate nodes can not clearly tell whether the packet is destined to them or not, they do not simply drop the packet. Thus, in the COFFEE protocol, by introducing several techniques, for a packet received by a node, the node thinks the packet could potentially be destined to itself and forwards the packet to find out the answer. Detailed analysis and performance evaluations have been conducted to demonstrate the effectiveness of the COFFEE protocol.
摘要:
Systems, methods, and apparatus are described that employ specially designed interference patterns to build an in-band side channel without degrading the effective throughput of the main channel. A first device (100) includes a control component (130) that generates control information and an interference component (140) that transmits the control information (450) through emission of patterned interference data concurrently while other users are transmitting other data (420). A second device (300) receives the patterned interference data and the other data via a single antenna (350) and decodes the patterned interference data to extract the control data (450). The first device (100) transmits the other data (420) on a side channel (440) that resides in the same spectrum as the main channel (410) in which the other data (420) is emitted. The first device (100) encodes the interference patterns such that the control data (450) can be safely transmitted and extracted without effecting other data transmission. In one aspect, devices (100, 200, 300) can employ a dynamic cooperation multi-access channel (DC-MAC) protocol (1510) to schedule transmission of the other data (420) on the main channel (410), and to employ the side channel (440) for control and coordination.
摘要:
Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要:
Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.