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121.发明授权公开(公告)号：US07055723B2
公开(公告)日：2006-06-06
申请号：US10399429
申请日：2001-10-29
Applicant: Nikolaus Ingenhoven , Agathe Hodac , Noa Schmid
Inventor： Nikolaus Ingenhoven , Agathe Hodac , Noa Schmid
IPC: B67D3/00
CPC classification number: G01N35/1016 , B01J2219/00378 , B01L3/021 , B01L3/022 , B01L3/0268 , B01L3/5021 , B01L99/00 , B01L2400/025 , B01L2400/0439 , B01L2400/0478 , C40B60/14 , G01F25/0092 , G01N35/1065 , G01N2035/1006 , G01N2035/103 , G01N2035/1034 , G01N2035/1039 , G01N2035/1041
Abstract: The invention relates to a device (1) for dispensing or aspirating/dispensing liquid samples, including a pump (2) and a micro-ejection device (3), the micro-ejection device (3) having a pulse generator (4) with a chamber (5). The pulse generator (4) is used to produce pressure waves in the liquid in order to cause the samples of a liquid to be dispensed. The micro-ejection device (3) also comprises an end piece (6) and a liquid line (7) which connects the pulse generator (4) to the end piece (6) the pulse generator comprises a micro-actuator (10) which is configured to function in the same direction as that in which the pressure wave leaves the chamber (5). The inventive devices are characterised in that the chamber (5), in the area of the end facing away from the end piece (6), or the corresponding connecting element (14) has a narrowed section (16) which restricts any expansion of the pressure waves in the direction of the pump (2). The invention also relates to systems with multiple devices of this type.
Abstract translation: 本发明涉及一种用于分配或抽吸/分配液体样品的装置（1），包括泵（2）和微型喷射装置（3），所述微型喷射装置（3）具有脉冲发生器（4） 一个室（5）。 脉冲发生器（4）用于在液体中产生压力波，以便分配液体样品。 微型喷射装置（3）还包括将脉冲发生器（4）连接到端部件（6）的端部件（6）和液体管线（7），脉冲发生器包括微致动器（10） 构造成沿与压力波离开室（5）的方向相同的方向起作用。 本发明的装置的特征在于，在远离端件（6）的端部的区域中的腔室（5）或相应的连接元件（14）具有狭窄部分（16），其限制了 在泵（2）的方向上的压力波。 本发明还涉及具有这种类型的多个装置的系统。
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公开(公告)号：US20050244303A1
公开(公告)日：2005-11-03
申请号：US11056696
申请日：2005-02-11
Applicant: Nikolaus Ingenhoven , Noa Schmid , Stefano Fornito
Inventor： Nikolaus Ingenhoven , Noa Schmid , Stefano Fornito
CPC classification number: B01L3/022 , B01L3/021 , B01L3/0241 , B01L99/00 , B01L2400/025 , B01L2400/0439 , B01L2400/0478 , G01F25/0092 , G01N35/10 , G01N2035/1006 , G01N2035/103 , G01N2035/1039 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
Abstract: A device for aspirating and dispensing liquid samples comprising a pump that comprises a cylindrical chamber, a piston movable in this cylindrical chamber, and a piston drive that engages the piston. The device further comprises a tip connected to the cylindrical chamber with a line, and a channel system that discharges into the cylindrical chamber for flushing or rinsing the latter. The device is characterized in that the piston entirely seals this cylindrical chamber from the channel system, if the piston is positioned in the cylindrical chamber in such a way that a free piston end comes to rest between the channel system and the line. Preferably, the cylindrical chamber is located in a cylinder block, which comprises two parts that are separated by and enclosing an intermediate channel system. The channel system most preferably is implemented as a coherent cavity. According to a first embodiment, the cylindrical chamber is implemented as a sleeve that is inserted in a boring located in a cylinder block. According to a second embodiment, the cylindrical chamber is implemented as a boring located in a cylinder block. Furthermore, the invention also concerns systems with, for example, 384 or more such devices that are arranged in an array.
Abstract translation: 用于抽吸和分配液体样品的装置，包括包括圆柱形腔室的泵，可在该圆柱形腔室中移动的活塞以及与活塞接合的活塞驱动器。 该装置还包括连接到具有管线的圆柱形腔室的尖端，以及排出到圆柱形室中用于冲洗或冲洗其的通道系统。 该装置的特征在于，如果活塞以这样的方式定位在柱形腔室中，则活塞将该圆柱形腔室与通道系统完全密封，使得自由活塞端部在通道系统和管线之间搁置。 优选地，圆柱形腔室位于气缸体中，该气缸体包括由中间通道系统分隔并包围中间通道系统的两个部件。 通道系统最优选地被实现为相干腔。 根据第一实施例，圆柱形腔室被实施为插入位于气缸体中的钻孔中的套筒。 根据第二实施例，圆柱形室被实现为位于气缸体中的钻孔。 此外，本发明还涉及具有例如384个或更多个以阵列排列的这种装置的系统。
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公开(公告)号：US06848633B2
公开(公告)日：2005-02-01
申请号：US10132607
申请日：2002-04-25
Applicant: Daniel Ryser
Inventor： Daniel Ryser
CPC classification number: B01L3/0268 , B05B7/066 , B05B7/10 , B05B7/12 , G01N1/38
Abstract: In an aspirating and dispensing/spraying device, a holder is screwed onto a tube, connected to a liquid supply line, in such a way that it is displaceable along the tube by rotation. The tube is surrounded at a distance by a coaxial sleeve, which is solidly anchored in the holder, having a discharge opening on its front end, which is conically narrowed, whose edge surrounds the front end of the tube, which carries a outlet opening, separated by a narrow annular gap from the tube. The sleeve carries a connecting piece laterally, to which a pressurized gas supply line is connected and which discharges eccentrically into the space between the sleeve and the tube, so that pressurized gas flowing in receives angular momentum. When the gas flows out of the annular gap, it mixes intensively with the liquid coming out of the outlet opening and forms a discharge cone made of a fine, symmetrical aerosol with the liquid. This aspirating and dispensing/spraying device is simultaneously implemented as a pipette for aspirating liquids through the outlet opening of the tube's front end, said tube carrying a sensor near said outlet opening for detecting a liquid surface during pipetting.
Abstract translation: 在抽吸和分配/喷涂装置中，将保持器拧到连接到液体供应管线的管上，使得其可以通过旋转沿着管移动。 该管被一个同轴的套管围绕，该同轴套被牢固地锚定在保持器中，其前端具有一个锥形变窄的排出口，其边缘围绕管的前端，该前端具有出口， 由与管子的窄的环形间隙隔开。 套筒横向地承载连接件，加压气体供应管线连接到该连接件上，并且偏心地排放到套筒和管之间的空间中，使得流入的加压气体接收角动量。 当气体从环形间隙流出时，它与从出口开口出来的液体密集地混合，并形成一个由液体制成的精细对称气溶胶的排出锥体。 该抽吸和分配/喷涂装置同时被实施为用于通过管前端的出口吸出液体的移液管，所述管在靠近所述出口开口处附着传感器，用于在移液期间检测液体表面。
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公开(公告)号：US12220694B2
公开(公告)日：2025-02-11
申请号：US17122470
申请日：2020-12-15
Applicant: TECAN TRADING AG
Inventor： Michael Keller , Thomas Geiges
IPC: B01L3/02
Abstract: Pipetting device for pipetting a liquid driven by a gaseous working medium, the pipetting device having at least one pipette connector adapted to attach a pipette at a connection opening at least one pressurizing and/or suctioning pressure source, a gas flow connection between said connection opening and at least one pressure source, a flow restriction defining at least a section of said gas flow connection, a first sensor configured to measure a quantity indicative of the temperature of the flow restriction. The invention is further directed to a gas flow connection element for a pipetting device and to a method of pipetting a liquid volume.
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公开(公告)号：USD1044028S1
公开(公告)日：2024-09-24
申请号：US29805775
申请日：2021-08-30
Applicant: Tecan Trading AG
Designer： Claudio Bohli
Abstract: FIG. 1 is a perspective view of a pipetting tip showing my new design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a left-side view thereof;
FIG. 5 is a right-side view thereof;
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.
The broken lines depict portions of the pipetting tip that form no part of the claimed design.
The dot-dash broken lines depict the boundaries of the claim and form no part thereof.-
Patent Agency Ranking
公开(公告)号：US20240207837A1
公开(公告)日：2024-06-27
申请号：US18390556
申请日：2023-12-20
Applicant: TECAN TRADING AG
Inventor： Philipp OTT , Adrian SAGER , Luca FREI
CPC classification number: B01L3/0275 , G01N35/10 , B01L2200/025 , B01L2200/026 , B01L2300/0681 , G01N2035/103
Abstract: A pipette tip adapter (1) is detachably connectable between a pipetting device (10) and a pipette tip (15). The pipette tip adapter has a body (2) with an interior compartment (7) for holding a liquid (18), a recess (3) entering into a part of the body (2) for detachably receiving a connector (11) of the pipetting device (10) and having a first opening (5) pneumatically connected with the interior compartment (7). The pipette tip adapter (1) further has a tube section (4) projecting from the pipette tip adapter (1) detachably securable with a pipette tip (15) and having a second opening (6) hydraulically connected with the interior compartment (7). The pipette tip adapter (1) may be used in an automated pipetting system (100). An automated pipetting system (100) having a pipette tip adapter (1) for preparing liquid reactions is also disclosed.
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公开(公告)号：US20240198345A1
公开(公告)日：2024-06-20
申请号：US18591107
申请日：2024-02-29
Applicant: TECAN TRADING AG
Inventor： Manfred LANSING , Tobias SAWETZKI , Nicole EGGENHOFER
CPC classification number: B01L3/5085 , B01L9/523 , G01N21/59 , G01N21/6452 , B01L2200/06 , B01L2200/142 , B01L2300/0829
Abstract: An incubation cassette is disclosed for reducing liquid evaporation from wells of a microplate. A frame has a central first opening surrounded by an inner wall having dimensions designed for the placement of a microplate therein and an outer wall which extends substantially parallel to the inner wall. The outer wall adjoins the inner wall via an intermediate bottom such that a liquid reservoir is formed thereby. The liquid reservoir surrounds the first central opening. At least a portion of the incubation cassette that forms the liquid reservoir has a transparent portion. A microplate reader has a housing and a transport support which can be pulled out of the housing. The transport support has a bearing surface for placement of a microplate having a plurality of wells or such an incubation cassette, and a controller adapted to control a method for reducing liquid evaporation from wells of the microplate.
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公开(公告)号：US11565249B2
公开(公告)日：2023-01-31
申请号：US16954414
申请日：2018-12-12
Applicant: TECAN TRADING AG
Inventor： Philipp Ott
Abstract: A pipetting apparatus having a pipette tube with a first end provided with an opening for aspirating and/or dispensing of a sample fluid and a second end operationally connected to a pressure generating means. The pipetting apparatus has at least one measuring unit adapted to determine at least one measurement value of the sample fluid based on the aspirating and/or dispensing of the sample fluid and to provide a sample fluid measurement signal representative thereof to an output of the measuring unit. The pipetting apparatus also has a control circuit operationally coupled to the output of the measuring unit and the input of the pressure generating means, the control circuit is configured to control said pressure generating device based on the sample fluid measurement signal.
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公开(公告)号：US20220401958A1
公开(公告)日：2022-12-22
申请号：US17630037
申请日：2020-08-03
Applicant: TECAN TRADING AG
Inventor： Philipp OTT , Adrian SAGER , Lars Johan BRANDEN
Abstract: A cover for a fluid container having an essentially plane cover plate for closing at least one opening of at least one fluid container and at least two ports, and each port has a through channel extending through the entire thickness of the cover plate and a fluid impermeable first membrane is arranged over the entire cross section of the through channel of the first port and an at least gas permeable second membrane is arranged over the entire cross section of the through channel of the second port is disclosed.
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公开(公告)号：US11442260B2
公开(公告)日：2022-09-13
申请号：US16041922
申请日：2018-07-23
Applicant: TECAN TRADING AG
Inventor： Andreas Erlbacher , Markus Schürf , Josef Grassl , Alexander Kaser
Abstract: A system 100 and method are provided for imaging a sample in a sample holder. For providing autofocus, a 2D pattern is projected onto the sample holder 050 via an astigmatic optical element 120. Image data 172 of the sample is acquired by an image sensor 140 via magnification optics 150. A difference in sharpness of the two-dimensional pattern in the image data is measured along a first axis and a second axis. Based on the difference, a magnitude and direction of defocus of the camera subsystem is determined with respect to the sample holder. This enables the sample holder, and thereby the sample, to be brought into focus in a fast and reliable manner.
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