公开(公告)号：US20150201611A1

公开(公告)日：2015-07-23

申请号：US14600651

申请日：2015-01-20

Applicant: MERIAL INC.

Inventor： James Pate ,  Natalya Shub

IPC: A01N25/10 ,  A01N53/00 ,  A01N43/56

CPC classification number: A01N25/10 ,  A01N43/56 ,  A01N53/00 ,  A61K9/0014

Abstract: The invention is a pour-on antiparasitic formulation having superior water resistant properties. The pour-on formulation utilizes one or more polymers (water insoluble with or without water soluble) in the range of about 5 to about 40% w/w, one or more solvents in the range of about 50 to about 94% w/w, with or without additive (e.g., isopropanol or ethanol) in the range of about 5 to about 30% w/w, and optionally a plasticizer in the range of about 0.5 to about 25% w/w. The pour-on antiparasitic formulation features limited spreading when applied to animals (cattle, sheep, dogs and the like). The pour-on antiparasitic formulation further partially evaporates, leaving a water resistant polymer matrix that diffuses at least one active ingredient to the animal's skin.

Abstract translation: 本发明是具有优异防水性能的浇注抗寄生虫制剂。 倾注配方使用一种或多种聚合物（水溶性或不含水溶性）在约5至约40％w / w的范围内，一种或多种在约50至约94％w / w范围内的溶剂 ，含或不含有约5至约30％w / w范围内的添加剂（例如异丙醇或乙醇），以及任选的增塑剂在约0.5至约25％w / w范围内。 灌注抗寄生虫制剂在施用于动物（牛，绵羊，狗等）时具有有限的扩散。 浇注抗寄生虫制剂进一步部分蒸发，留下将至少一种活性成分扩散至动物皮肤的防水聚合物基质。

公开(公告)号：US11497802B2

公开(公告)日：2022-11-15

申请号：US15763892

申请日：2016-10-05

Applicant: MERIAL INC. ,  VETAGRO-SUP ,  INSTITUT PASTEUR

Inventor： Natalia Ines Bomchil ,  Lionel Pierre Cupillard ,  Celia Fontana ,  Pierre-Michel Guigal ,  Jerome Bouvet ,  Mathieu Picardeau ,  Angeli Kodjo

IPC: A61K39/02 ,  C07K14/20 ,  A61K39/00

Abstract: The present invention provides compositions or vaccines that contain a recombinant or an attenuated Leptospira interrogans that elicit an immune response in animals against Leptospira infection, including compositions comprising said recombinant or attenuated L. interrogans, methods of vaccination against Leptospira, and kits for use with such methods and compositions.

公开(公告)号：US20190216784A1

公开(公告)日：2019-07-18

申请号：US16247359

申请日：2019-01-14

Applicant: MERIAL, INC.

Inventor： Mark D. Soll ,  Joseph K. Rosentel, JR. ,  James Pate ,  Natalya Shub ,  Monica Tejwani-Motwani ,  Carol Belansky

IPC: A61K31/42 ,  A61K38/15 ,  A61K45/06 ,  A61K31/4745 ,  A61K31/4402 ,  A61K31/44 ,  A61K31/415 ,  A61K31/366 ,  A61K31/231 ,  A61K31/22 ,  A61K31/215 ,  A61K9/06 ,  A61K9/00 ,  A01N49/00 ,  A01N43/80 ,  A01N43/40 ,  A61K47/26 ,  A61K47/22 ,  A61K47/14 ,  A61K47/10 ,  A61K47/08 ,  A61K31/7048

Abstract: This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

公开(公告)号：US10251863B2

公开(公告)日：2019-04-09

申请号：US15632705

申请日：2017-06-26

Applicant: MERIAL, INC.

Inventor： Charles Meng ,  Loïc Le Hir de Fallois

IPC: C07D209/08 ,  A61K31/404 ,  C07D209/10 ,  C07D401/04 ,  C07D401/12 ,  H03K5/04 ,  H03K7/00

Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

公开(公告)号：US10188734B2

公开(公告)日：2019-01-29

申请号：US14880145

申请日：2015-10-09

Applicant: Merial Inc.

Inventor： Noel Yves Henri Jean Genin

IPC: A61K47/26 ,  A61K39/00 ,  A61K39/12 ,  A61K39/17 ,  A61K39/215 ,  A61K39/255 ,  A61K39/275 ,  A61K9/20 ,  A61K9/46 ,  A61K9/00

Abstract: The present invention relates to novel stable compressed vaccine composition comprising at least one anhydrous antigenic component comprising a stabilizer susceptible to foaming when the composition is mixed with liquid diluent; and an effective amount of a sugar alcohol.

公开(公告)号：US10073072B2

公开(公告)日：2018-09-11

申请号：US14872639

申请日：2015-10-01

Applicant: MERIAL, INC.

Inventor： Abu M. Rustum ,  Satish Kumar ,  Andrew L. McAdoo

IPC: G01N33/15 ,  C09K3/00 ,  G01N30/06 ,  G01N13/00

CPC classification number: G01N33/15 ,  C09K3/00 ,  G01N30/06 ,  G01N2013/006

Abstract: This disclosure describes the results of the studies conducted to develop a dissolution method to monitor release profiles of hydrophobic active pharmaceutical ingredients such as ivermectin with or without pyrantel pamoate from a drug product made of complex matrix that includes, but is not limited to beef, tallow, corn cob and soy protein.

公开(公告)号：US10058601B2

公开(公告)日：2018-08-28

申请号：US15594451

申请日：2017-05-12

Applicant: MERIAL, INC.

Inventor： Russell F. Bey ,  Paulraj Kirubakaran Lawrence ,  Randy R. Simonson

IPC: A61K39/02 ,  A61K49/00 ,  A61K39/00 ,  A61K39/102 ,  C07K14/285 ,  C12N1/36

CPC classification number: A61K39/102 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/285 ,  C12N1/36

Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.

公开(公告)号：US10010499B2

公开(公告)日：2018-07-03

申请号：US14930831

申请日：2015-11-03

Applicant: MERIAL, INC. ,  Georgia Tech Research Corporation

Inventor： Yu-Wei Chiang ,  Mark R. Prausnitz ,  Kristopher Daniel DeWitt ,  Jaya Arya

IPC: C12N7/00 ,  A61K9/00 ,  A61K39/205 ,  A61K39/12 ,  A61M37/00 ,  A61K39/00 ,  A61B5/15 ,  A61B17/20

CPC classification number: A61K9/0021 ,  A61B5/150984 ,  A61B17/20 ,  A61B17/205 ,  A61K39/12 ,  A61K39/205 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0061 ,  C12N7/00 ,  C12N2760/20034 ,  C12N2760/20134

Abstract: The present invention relates to microneedle vaccine formulations, as well as methods of use thereof to provide animals, including canines, protective immunity against infection and disease caused by rabies viruses. Once placed onto the skin of the animals, the microneedle formulations dissolve quickly into the surrounding skin, where the antigens then elicit in the animals high and protective levels of rabies virus neutralizing antibodies.

公开(公告)号：US20180147276A1

公开(公告)日：2018-05-31

申请号：US15828067

申请日：2017-11-30

Applicant: MERIAL INC.

Inventor： Teshome Mebatsion ,  Taejoong Kim ,  Paul Michael Dorr ,  Martin Leonardo Liebstein-Bellia ,  Alton Timothy Leard

IPC: A61K39/145 ,  C12N15/85 ,  C12N7/00

Abstract: This disclosure provides attenuated swine influenza strains, particularly those produced via a reverse genetics approach, compositions comprising same, and methods of production and use thereof.

公开(公告)号：US09913896B2

公开(公告)日：2018-03-13

申请号：US15378147

申请日：2016-12-14

Applicant: Merial, Inc.

Inventor： Francois Xavier Le Gros

IPC: A61K39/23 ,  C12N7/00 ,  C07K14/005 ,  A61K39/00

CPC classification number: A61K39/23 ,  A61K2039/5254 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14122 ,  C12N2750/14134 ,  C12N2750/14322 ,  C12N2750/14334

Abstract: This disclosure provides an attenuated palmiped parvovirus that affords heterologous protection for both Muscovy duck parvovirus and goose parvovirus (i.e., Derzsy's Disease). The disclosure further provides compositions comprising the same, and methods of production and use thereof.