利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

166 条记录 (耗时 0.035 秒)

    Compounds, compositions and use
    131.
    发明授权
    Compounds, compositions and use 有权
    化合物，组合物和用途

    公开(公告)号：US08710008B2

    公开(公告)日：2014-04-29

    申请号：US13141465

    申请日：2009-12-22

    申请人： Oyvind Jacobsen ,  Jo Klaveness ,  Pal Rongved ,  Mahmood Amiry-Moghaddam ,  Ole Petter Ottersen

    发明人： Oyvind Jacobsen ,  Jo Klaveness ,  Pal Rongved ,  Mahmood Amiry-Moghaddam ,  Ole Petter Ottersen

    IPC分类号： A61K38/00 ,  C07K14/00 ,  A61P25/00 ,  A61K38/16 ,  C07K14/705

    CPC分类号： A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  C07K14/705

    摘要： A peptide comprising a unit of formula (I) and having a molecular weight of less than 2000 wherein each X is independently an organic group, e.g. a C1-6 alkyl or C1-6 alkenyl group, preferably —CH2—CH═CH2, or the two X groups taken together can form a covalent or non-covalent link between the two O groups, preferably a C1-10 saturated or unsaturated carbon chain optionally interrupted by one or more heteroatoms selected from O, S, N, P, or Si, especially a C3-10 carbon chain or one X represents an azido group and the other an C2-6-alkynyl group; both Z's are the same and are O or S; each Y is independently C, CH, CH2, N or NH; R1 is H or C1-6 alkyl; R2 is H or C1-6 alkyl; R5 is a C1-6 alkyl group, preferably isopropyl; or a salt, ester or prodrug thereof.

    摘要翻译： 一种包含式（I）单元并且分子量小于2000的肽，其中每个X独立地是有机基团，例如， C 1-6烷基或C 1-6烯基，优选-CH 2 -CH 2 CH 2或两个X基团可以在两个O基之间形成共价或非共价键，优选为C1-10饱和或不饱和的 碳链，任选地被一个或多个选自O，S，N，P或Si的杂原子中断，特别是C3-10碳链或一个X代表叠氮基，另一个是C 2-6炔基; 两个Z都是相同的，是O或S; 每个Y独立地为C，CH，CH 2，N或NH; R1是H或C1-6烷基; R2是H或C1-6烷基; R5是C1-6烷基，优选是异丙基; 或其盐，酯或前药。

    OMEGA 3
    136.
    发明申请
    OMEGA 3 审中-公开
    欧米加3

    公开(公告)号：US20090221705A1

    公开(公告)日：2009-09-03

    申请号：US12278687

    申请日：2007-02-07

    申请人： Pal Rongved ,  Jo Klaveness

    发明人： Pal Rongved ,  Jo Klaveness

    IPC分类号： A61K31/202 ,  C11B1/10 ,  C11C3/00 ,  A61P3/02

    CPC分类号： C11C3/00 ,  C07C51/48 ,  C07C51/487 ,  C07C51/50 ,  C07C215/10 ,  C08B37/003 ,  C08L5/08 ,  C08L5/16 ,  C07C53/126 ,  C07C57/03

    摘要： A process for the preparation of a water soluble unsaturated fatty acid salt from a crude composition comprising at least one non-water soluble or sparingly water soluble unsaturated fatty acid or salt thereof, said process comprising: adding to said crude composition in the presence of water at least one amino alcohol compound so as to form a water soluble amino alcohol salt of said acid or salt; separating an aqueous phase; and optionally isolating said salt from said aqueous phase.

    摘要翻译： 一种从粗制组合物制备水溶性不饱和脂肪酸盐的方法，其包含至少一种非水溶性或微溶于水的不饱和脂肪酸或其盐，所述方法包括：在水存在下向所述粗制组合物中加入 至少一种氨基醇化合物，以形成所述酸或盐的水溶性氨基醇盐; 分离水相; 并任选地从所述水相中分离所述盐。

    USE OF PARTICULATE CONTRAST AGENTS IN DIAGNOSTIC IMAGING FOR STUDYING PHYSIOLOGICAL PARAMATERS
    137.
    发明申请
    USE OF PARTICULATE CONTRAST AGENTS IN DIAGNOSTIC IMAGING FOR STUDYING PHYSIOLOGICAL PARAMATERS 审中-公开
    用于研究生理参数的诊断成像中的粒子对比剂

    公开(公告)号：US20090191131A1

    公开(公告)日：2009-07-30

    申请号：US12354275

    申请日：2009-01-15

    申请人： Sigrid Lise Fossheim ,  Jo Klaveness ,  Atle Bjornerud ,  Pal Rongved ,  Klaes Golman ,  Roald Skurtveit

    发明人： Sigrid Lise Fossheim ,  Jo Klaveness ,  Atle Bjornerud ,  Pal Rongved ,  Klaes Golman ,  Roald Skurtveit

    IPC分类号： A61K49/18 ,  A61K49/12

    CPC分类号： A61B5/01 ,  A61B5/055 ,  A61B5/416 ,  A61B5/4519 ,  A61B8/481 ,  A61K49/1812 ,  A61K49/223

    摘要： The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameter; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physiological parameter.

    摘要翻译： 本发明涉及一种对人或非动物体动物进行成像的方法，该方法包括：向所述身体肠胃外给予包含基质或膜材料和至少一种对比生成物质的颗粒材料，所述物质或基质或膜 材料响应于预先选择的生理参数，从而响应于所述参数的值的变化来改变所述物种的对比效能; 生成存在所述物种的所述身体的至少一部分的图像数据; 以及由此生成指示所述身体的所述部分中的所述参数的值或变化的信号。 本发明还涉及用于对生理参数进行成像的造影剂。

    Omega 3
    140.
    发明申请
    Omega 3 审中-公开
    欧米加3

    公开(公告)号：US20070213298A1

    公开(公告)日：2007-09-13

    申请号：US11672249

    申请日：2007-02-07

    申请人： Pal Rongved ,  Jo Klaveness

    发明人： Pal Rongved ,  Jo Klaveness

    IPC分类号： A61K31/70

    CPC分类号： C11C3/00 ,  C07C51/48 ,  C07C51/487 ,  C07C51/50 ,  C07C215/10 ,  C08B37/003 ,  C08L5/08 ,  C08L5/16 ,  C07C53/126 ,  C07C57/03

    摘要： A process for the preparation of a water soluble unsaturated fatty acid salt from a crude composition comprising at least one non-water soluble or sparingly water soluble unsaturated fatty acid or salt thereof, said process comprising: adding to said crude composition in the presence of water at least one amino alcohol compound so as to form a water soluble amino alcohol salt of said acid or salt; separating an aqueous phase; and optionally isolating said salt from said aqueous phase.

    摘要翻译： 一种从粗制组合物制备水溶性不饱和脂肪酸盐的方法，其包含至少一种非水溶性或微溶于水的不饱和脂肪酸或其盐，所述方法包括：在水存在下向所述粗制组合物中加入 至少一种氨基醇化合物，以形成所述酸或盐的水溶性氨基醇盐; 分离水相; 并任选地从所述水相中分离所述盐。