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    Spray-drying microcapsules using an aqueous liquid containing a volatile liquid
    132.
    发明授权
    Spray-drying microcapsules using an aqueous liquid containing a volatile liquid 失效
    使用含有挥发性液体的水性液体的喷雾干燥微胶囊

    公开(公告)号：US06623722B1

    公开(公告)日：2003-09-23

    申请号：US09023696

    申请日：1998-02-13

    Applicant: Nicholas Osborne ,  Andrew Derek Sutton ,  Richard Alan Johnson

    Inventor： Nicholas Osborne ,  Andrew Derek Sutton ,  Richard Alan Johnson

    IPC: A61B800

    CPC classification number: B01J13/043 ,  A61K49/223

    Abstract: A process for forming microcapsules comprising (i) providing a solution of a protein in an aqueous solvent and (ii) spraying the said solution into a gas such that the aqueous solvent evaporates, thereby forming hollow microcapsules, characterised in that the aqueous solution contains a liquid of greater volatility than water. The protein is preferably albumin and the volatile liquid is preferably ethanol. The microcapsules may be used as ultrasound echogenic contrast agents.

    Abstract translation: 一种形成微胶囊的方法，其包括（i）在水性溶剂中提供蛋白质溶液，和（ii）将所述溶液喷雾到气体中，使得水性溶剂蒸发，从而形成中空微胶囊，其特征在于，所述水溶液含有 液体比水更易挥发。蛋白质优选为白蛋白，挥发性液体优选为乙醇。微胶囊可用作超声回声造影剂。

    Preparing small microcapsules containing high concentration of cells or tissue
    135.
    发明授权
    Preparing small microcapsules containing high concentration of cells or tissue 有权
    制备含有高浓度细胞或组织的小微囊

    公开(公告)号：US06465226B1

    公开(公告)日：2002-10-15

    申请号：US08776969

    申请日：1998-10-19

    Applicant: Ulrich Zimmermann

    Inventor： Ulrich Zimmermann

    IPC: C12N1102

    CPC classification number: A61K9/5089 ,  A61K9/5036 ,  B01J13/043

    Abstract: Biologically active substances such as cells or tissue are microencapsulated by methods that provide a high proportion of microcapsules containing a core of the biologically active substance as compared to microcapsules not containing the biologically active substance. Microcapsules are obtained having a maximum diameter of 300 micrometers and a high concentration of biologically active substance. A solution of encapsulating material such as alginate containing dispersed biologically active substance is passed through an inner channel of a two-channel spray nozzle to form droplets containing a core of the biologically active substance. Air flow from an outer channel of the nozzle causes the droplets to break off from the nozzle. Conditions of air flow and flow rate of solution are selected to obtain droplets having a volume of 1.5 to 4 times the volume of the biologically active substance that forms the core. The droplets are passed to a precipitation bath containing polycations such as barium ions where the encapsulating material is gelled to form microcapsules containing a core of the biologically active substance and empty microcapsules not containing the biologically active substance. The microcapsules are passed to a density centrifugal separator where the empty microcapsules are separated to obtain the microcapsules containing the biologically active substance. In an alternative method, an electrostatic field is used to separate the droplets from the nozzle.

    Abstract translation: 与不含生物活性物质的微胶囊相比，生物活性物质如细胞或组织通过提供含有生物活性物质核心的高比例微胶囊的方法进行微胶囊化。 获得最大直径为300微米的微胶囊和高浓度的生物活性物质。 将包含分散的生物活性物质的海藻酸盐等包封材料的溶液通过双通道喷嘴的内部通道，形成含有生物活性物质核心的液滴。 来自喷嘴的外部通道的气流使得液滴从喷嘴脱落。 选择空气流动条件和溶液流速以获得体积为形成核心的生物活性物质体积的1.5至4倍的液滴。 将液滴送入包含诸如钡离子的聚阳离子的沉淀浴中，其中胶囊材料凝胶化以形成含有生物活性物质的核心的微胶囊和不含生物活性物质的空的微胶囊。 将微胶囊送至密度离心分离器，其中分离出空的微胶囊，得到含有生物活性物质的微胶囊。 在另一种方法中，使用静电场将液滴与喷嘴分开。

    Composite abrasive particles and method of manufacture
    136.
    发明申请
    Composite abrasive particles and method of manufacture 有权
    复合磨料颗粒及其制造方法

    公开(公告)号：US20020090891A1

    公开(公告)日：2002-07-11

    申请号：US09942007

    申请日：2001-08-29

    Inventor： Negus B. Adefris ,  William D. Joseph ,  Kathleen A. Wagle-Peterson

    IPC: B24B001/00 ,  B24B007/19 ,  B24B007/30 ,  B32B005/16 ,  B32B009/00 ,  B32B015/02 ,  B32B017/02 ,  B32B019/00 ,  B32B021/02 ,  B32B023/02 ,  B32B027/02 ,  B05D001/02

    CPC classification number: B01J13/043 ,  B24D11/00 ,  B24D13/18 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2998

    Abstract: The present application discloses an agglomerate. The agglomerate comprises a crystalline matrix. The agglomerate may additionally comprise abrasive particles. The agglomerate has a normalized bulk density of less than about 0.38. The present application additionally discloses a method of manufacturing the agglomerate. The agglomerate is manufactured by forming a mixture comprising an abrasive particle with a sol, the sol comprising an oxide and water and introducing the mixture into a spray dryer. The mixture is then dried in the spray dryer. The mixture is then fired, for example in an oven. The resulting agglomerates comprise abrasive particles retained within a crystalline matrix of the oxide. The present invention additionally discloses methods of using the agglomerates of the resent invention.

    Abstract translation: 本申请公开了一种附聚物。 附聚物包含结晶基质。 附聚物可另外包含磨料颗粒。 附聚物的标准化堆积密度小于约0.38。 本申请另外公开了一种制造附聚物的方法。 通过形成包含磨料颗粒与溶胶的混合物，所述溶胶包含氧化物和水，并将混合物引入喷雾干燥器来制造附聚物。 然后将混合物在喷雾干燥器中干燥。 然后将混合物烧制，例如在烘箱中。 所得到的附聚物包含保留在氧化物的晶体基质内的研磨颗粒。 本发明另外公开了使用本发明的附聚物的方法。

    Hollow silicone resin particles and method for the preparation thereof
    137.
    发明授权
    Hollow silicone resin particles and method for the preparation thereof 有权
    中空硅树脂颗粒及其制备方法

    公开(公告)号：US06180236B2

    公开(公告)日：2001-01-30

    申请号：US09235210

    申请日：1999-01-22

    Applicant: Mitsuo Hamada ,  Koichi Ozaki ,  Toyohiko Yamadera

    Inventor： Mitsuo Hamada ,  Koichi Ozaki ,  Toyohiko Yamadera

    IPC: B32B516

    CPC classification number: B01J13/043 ,  Y10T428/1372 ,  Y10T428/1386 ,  Y10T428/1397 ,  Y10T428/2982 ,  Y10T428/2985

    Abstract: Novel hollow silicone resin particles, having an average particle size of 0.1 to 100 &mgr;m are disclosed. The silicone resin particles comprise a skin formed from thermoplastic silicone resin configured in the shape of a hollow capsule. The hollow thermoplastic silicone resin particles are prepared by spraying a dispersion of water and thermoplastic silicone resin dissolved in solvent into hot gas. The hot gas evaporates the solvent and water and at the same time causes solidification of the thermoplastic silicone resin while it is in the spray state, so as to form a plurality of hollow particles therefrom.

    Abstract translation: 公开了平均粒径为0.1〜100μm的新型中空硅树脂颗粒。 有机硅树脂颗粒包括由中空胶囊形状的热塑性硅树脂形成的皮肤。 中空热塑性有机硅树脂颗粒通过将溶解在溶剂中的水和热塑性有机硅树脂的分散体喷雾到热气中来制备。 热气体蒸发溶剂和水，同时在热塑性硅树脂处于喷射状态时使其固化，从而形成多个中空颗粒。

    Method of preparing modified hollow, largely spherical particles by spray drying
    139.
    发明授权
    Method of preparing modified hollow, largely spherical particles by spray drying 失效
    通过喷雾干燥制备改性中空，大体积的球形颗粒的方法

    公开(公告)号：US3960583A

    公开(公告)日：1976-06-01

    申请号：US466326

    申请日：1974-05-02

    Applicant: David I. Netting ,  Elliot P. Hertzenberg

    Inventor： David I. Netting ,  Elliot P. Hertzenberg

    IPC: B01J13/04 ,  C08J9/16

    CPC classification number: B01J13/043

    Abstract: Products of a generally spherical nature with particulate matter embedded in the walls are prepared by forming a suspension of said particulate matter in a solution of a film-forming substance in a volatile solvent, spray drying said suspension-solution thereby forming the product which may be further dried if necessary to remove solvent and to "set" the walls. Such products can be used to provide pigmenting, reactive and/or fire retardant properties to organic systems to which they are added as fillers. The density of the product can also be controlled by this method for use as fillers in applications in which segregation of such fillers from the plastic matrix is normally a problem.

    Abstract translation: 通过在成膜物质溶于挥发性溶剂中形成所述颗粒状物质的悬浮液，喷雾干燥所述悬浮溶液从而形成可以是 如果需要，进一步干燥以除去溶剂并“设定”壁。 这些产品可以用于向作为填料添加的有机体系提供着色，反应性和/或阻燃性能。 通过这种方法也可以控制产品的密度，这种方法用作这种填料与塑料基质分离通常是问题的应用中的填料。

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