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841 条记录 (耗时 0.022 秒)

    Process for preparing ruthenium-phosphine complex
    132.
    发明授权
    Process for preparing ruthenium-phosphine complex 失效
    制备钌膦配合物的方法

    公开(公告)号：US5919962A

    公开(公告)日：1999-07-06

    申请号：US933973

    申请日：1997-09-19

    申请人： Noboru Sayo ,  Kazushi Mashima ,  Kyoko Tamao ,  Tetsuo Ota

    发明人： Noboru Sayo ,  Kazushi Mashima ,  Kyoko Tamao ,  Tetsuo Ota

    IPC分类号： B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07F9/50 ,  C07F15/00 ,  C07F9/02

    CPC分类号： C07F15/0053

    摘要： Disclosed is a ruthenium-phosphine complex represented by formula (I):�{RuX(L)}.sub.2 (.mu.-X).sub.3 !.sup.- �R.sub.2 NH.sub.2 !.sup.+(I)wherein R is hydrogen, an alkyl group having 1 to 5 carbon atoms, a cycloalkyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted benzyl group; X is halogen; and L is an optically active or inactive tertiary phosphine. A process for preparing the complex (I) is also disclosed, which comprises (A) reacting a ruthenium complex represented by formula: �RuX(arene)(L)!X (wherein arene is a substituted or unsubstituted phenyl group) and an ammonium salt represented by formula (III): R.sub.2 NH.HX, or (B) reacting a ruthenium complex represented by formula: �RuX.sub.2 (arene)!.sub.2, a tertiary phosphine represented by L, and an ammonium salt (III). The complex (I) useful as a catalyst for general syntheses or asymmetric syntheses can be obtained easily in good yield.

    摘要翻译： 公开了由式（I）表示的钌膦配合物：[{RuX（L）} 2（mu -X）3] - [R 2 NH 2] +（I）其中R是氢，具有1至5个碳原子的烷基 原子，环烷基，取代或未取代的苯基或取代或未取代的苄基; X是卤素; L是光学活性或无活性的叔膦。 还公开了制备络合物（I）的方法，其包括（A）使由式[RuX（芳烃）（L）] X（其中芳烃为取代或未取代的苯基）和铵 由式（III）表示的盐：R2NH.HX，或（B）使由式[RuX2（芳烃）] 2表示的钌络合物，由L表示的叔膦和铵盐（III）反应。 可以容易地以良好的收率获得用作一般合成或不对称合成的催化剂的络合物（I）。

    Compounds for inhibiting immune response
    140.
    发明授权
    Compounds for inhibiting immune response 失效
    抑制免疫反应的化合物

    公开(公告)号：US5512687A

    公开(公告)日：1996-04-30

    申请号：US331388

    申请日：1994-10-28

    申请人： Cecilia M. Bastos

    发明人： Cecilia M. Bastos

    IPC分类号： A61K33/24 ,  C07F15/00 ,  C07F1/00

    CPC分类号： C07F15/0053 ,  A61K33/24

    摘要： Novel ruthenium complexes for use as immunosuppressive agents to prevent or significantly reduce graft rejection in organ and bone marrow transplantation are described. The ruthenium complexes can also be used as an immunosuppressant drug for T-lymphocyte mediated autoimmune diseases, such as diabetes, and may be useful in alleviating psoriasis and contact dermatitis.

    摘要翻译： 描述了用作免疫抑制剂以预防或显着降低器官和骨髓移植中的移植排斥的新型钌络合物。 钌络合物也可用作T淋巴细胞介导的自身免疫性疾病如糖尿病的免疫抑制药物，可用于缓解牛皮癣和接触性皮炎。