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公开(公告)号：US20200032201A1
公开(公告)日：2020-01-30
申请号：US16422155
申请日：2019-05-24
Inventor： Steven J. NORRIS , Diane G. EDMONSON
Abstract: Presented herein are compositions and methods for the long-term in vitro culturing of Treponema species such as T. pallidum. Culture media and systems for Treponema culture are also provided.
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公开(公告)号：US10519188B2
公开(公告)日：2019-12-31
申请号：US15953492
申请日：2018-04-15
Inventor： Boyu Zhong , Lijun Sun , Heping Shi , Qi Wei , Yuanwei Dai , Chuo Chen , Zhijian Chen
IPC: C07H21/04 , A61K31/7084 , C07H21/02 , A61K45/06
Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
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公开(公告)号：US20190384692A1
公开(公告)日：2019-12-19
申请号：US16442042
申请日：2019-06-14
Inventor： Tongping Liu , Hongyu Liu , Sam Albert Silvestro
Abstract: The techniques described herein may provide techniques for precise and fully-automatic on-site software failure diagnosis that overcomes issues of existing systems and general challenges of in-production software failure diagnosis. Embodiments of the present systems and methods may provide a tool capable of automatically pinpointing a fault propagation chain of program failures, with explicit symptoms. The combination of binary analysis, in-situ/identical replay, and debugging registers may be used together to simulate the debugging procedures of a programmer automatically. Overhead, privacy, transparency, convenience, and completeness challenges of in-production failure analysis are improved, making it suitable for deployment uses.
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公开(公告)号：US20190351046A1
公开(公告)日：2019-11-21
申请号：US16483103
申请日：2018-02-02
Inventor： Veljko VELJKOVIC , Slobodan PAESSLER
IPC: A61K39/145 , C07K14/005
Abstract: The present application generally relates to the development of a universal influenza vaccine, or production of antibodies, capable of providing broad protection against various strains of the flu, using an informational spectrum method (ISM) to identify the common structural characteristics of influenza antigens.
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145.发明申请公开(公告)号：US20190338311A1
公开(公告)日：2019-11-07
申请号：US16476137
申请日：2018-01-05
Inventor： Leonela AMOASII , Eric OLSON
Abstract: CRISPR/Cas9-mediated genome editing holds clinical potential for treating genetic diseases, such as Duchenne muscular dystrophy (DMD), which is caused by mutations in the dystrophin gene. Here, using three promoters to drive expression of the same DMD guide RNA, a more robust and safe form of genome editing was achieved in a humanized mouse model for DMD with a deletion 13 in exon 50, and in a ΔEx50-MD Dog.
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Patent Agency Ranking
146.发明申请公开(公告)号：US20190307107A1
公开(公告)日：2019-10-10
申请号：US16309026
申请日：2017-06-12
Inventor： Joseph A HILL , Gabriele G SCHIATTARELLA , Thomas G GILLETTE
IPC: A01K67/02 , A61N1/362 , A23K20/147 , A23K20/158 , A23K20/163 , A23K20/174 , A23K50/50 , A61K31/575
Abstract: Aspects of the disclosure relate to a composition comprising 20-60% w/w of fat combined with a nitric oxide synthase inhibitor. Method aspects of the disclosure relate to a method for inducing heart failure with preserved ejection fraction in an experimental laboratory animal, the method comprising administering a composition of the disclosure or a composition comprising 10-60% w/w of fat and a composition comprising a nitric oxide synthase inhibitor to the laboratory animal.
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公开(公告)号：US10431361B2
公开(公告)日：2019-10-01
申请号：US15134211
申请日：2016-04-20
Inventor： Zhiyue J. Wang , Yong Jong Park , Nancy K. Rollins
IPC: H01F7/02 , G01R33/3873 , A61B5/055 , G01R33/28 , A61C7/12 , A61B5/00 , A61B5/026 , G01R33/565
Abstract: This disclosure includes magnetic field correction devices and methods for using the same. In particular, some magnetic field corrections devices include an arch-shaped body configured to be worn outside of a user's mouth such that the arch-shaped body follows a contour of the user's face; and where the arch-shaped body comprises one or more sidewalls configured to be coupled to a plurality of members comprising magnetically permeable material. Other embodiments employ a forehead support, frame, and one or more straps coupled to an arch-shaped body. Other embodiments employ a hybrid of intraoral and external embodiments.
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公开(公告)号：US20190282173A1
公开(公告)日：2019-09-19
申请号：US16163661
申请日：2018-10-18
Inventor： Peter STARR , Steven BAILEY , Mauli AGRAWAL
IPC: A61B5/00 , G01L9/00 , A61B5/103 , A61F2/24 , B29C65/48 , A61B7/02 , A61B5/1473 , A61B5/0215
Abstract: A thin-film, diaphragm based device is disclosed which can be used to perform an array of sensing and actuating operations where a very thin profile is desired, such as in millimeter, micrometer, or nanometer tight spaces.
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公开(公告)号：US20190270705A1
公开(公告)日：2019-09-05
申请号：US16461793
申请日：2017-11-20
Inventor： Fernanda Laezza , Jia Zhou , Zhiqing Liu , Syed Ali
IPC: C07D207/16 , C07D417/12 , C07D413/12 , C07C237/52
Abstract: The present invention relates to novel small molecule modulators of Nav1.6 channels of the general formulae (I), (II), (III) and (IV), and the uses thereof.
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公开(公告)号：US10377986B2
公开(公告)日：2019-08-13
申请号：US15118539
申请日：2015-02-09
Inventor： Xiao-Dong Chen , Chih-ko Yeh , Joo L. Ong
Abstract: A cell culture system including a silk fibroid scaffold, culture media, and salivary gland cells. The salivary gland cells grown in the tissue culture system have physiological and morphological features like those of in vivo salivary gland cells. The cell culture system can be used to produce a salivary tissue-specific extracellular matrix capable of inducing differentiation of salivary gland cell precursors into salivary gland cells.
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