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公开(公告)号：US07282562B2
公开(公告)日：2007-10-16
申请号：US10213145
申请日：2002-08-05
申请人： Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , Daniel Tumas , Colin K. Watanabe , William I. Wood
发明人： Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , Daniel Tumas , Colin K. Watanabe , William I. Wood
CPC分类号： C07K14/4702
摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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公开(公告)号：US07442772B2
公开(公告)日：2008-10-28
申请号：US10735014
申请日：2003-12-12
申请人： Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Daniel Tumas , William I. Wood
发明人： Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Daniel Tumas , William I. Wood
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , C07K14/705 , C07K16/18
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07741056B2
公开(公告)日：2010-06-22
申请号：US11725063
申请日：2007-03-15
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎性疾病和/或癌症相关的抗原的存在。
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公开(公告)号：US07419663B2
公开(公告)日：2008-09-02
申请号：US10964263
申请日：2004-10-12
申请人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, Jr. , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, Jr. , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K14/70503 , A61K2039/505 , C07K16/2803 , C07K2317/76 , C07K2319/30 , Y10S424/809 , Y10S424/81
摘要： The present invention concerns a recently discovered macrophage specific receptor, STIgMA, and its use in the treatment of complement-associated disorders.
摘要翻译： 本发明涉及最近发现的巨噬细胞特异性受体STIgMA及其在补体相关疾病的治疗中的应用。
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145.发明授权Nucleic acids encoding proteins that stimulate the proliferation of t-lymphocytes 有权编码刺激T淋巴细胞增殖的蛋白质的核酸公开(公告)号：US06838554B2
公开(公告)日：2005-01-04
申请号：US09953499
申请日：2001-09-14
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , William I. Wood
CPC分类号： C07K14/705 , C07K16/28 , C07K2317/24 , C07K2319/30
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing such antigens PRO301, PRO362 or PRO245.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于存在与炎性疾病和/或癌症相关的抗原，以及核苷酸序列，包括表达的序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞 表达这种抗原PRO301，PRO362或PRO245。
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公开(公告)号：US06410708B1
公开(公告)日：2002-06-25
申请号：US09254465
申请日：1999-03-05
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , William I. Wood
IPC分类号： C07H2104
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , C07K16/28 , C07K2317/24 , C07K2319/00 , C07K2319/30 , G01N33/5008 , G01N33/5011 , G01N33/5017 , G01N33/5047 , G01N33/505 , G01N33/5064 , G01N33/5091 , G01N33/57484 , G01N33/68 , G01N33/6845
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing such antigens PRO301, PRO362 or PRO245.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于存在与炎性疾病和/或癌症相关的抗原，以及核苷酸序列，包括表达的序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞 表达这种抗原PRO301，PRO362或PRO245。
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公开(公告)号：US20090275738A1
公开(公告)日：2009-11-05
申请号：US11725063
申请日：2007-03-15
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
IPC分类号： C07K19/00 , C07K14/435
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎性疾病和/或癌症相关的抗原的存在。
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公开(公告)号：US20080312421A1
公开(公告)日：2008-12-18
申请号：US11725027
申请日：2007-03-15
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎症性疾病和/或癌症相关的抗原的存在。
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公开(公告)号：US20090291097A1
公开(公告)日：2009-11-26
申请号：US11802794
申请日：2007-05-25
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC分类号： A61K39/395 , C07K16/18 , A61P37/00
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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150.发明申请NUCLEIC ACIDS ENCODING RECEPTOR FOR IL-17 HOMOLOGOUS POLYPEPTIDES AND USES THEREOF 审中-公开IL-17同种异体多核苷酸编码受体的核酸及其用途公开(公告)号：US20090227017A1
公开(公告)日：2009-09-10
申请号：US12417097
申请日：2009-04-02
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
CPC分类号： C07K14/705 , A61K38/00 , C07K14/54 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/04
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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