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151 条记录 (耗时 0.121 秒)

    Antibodies that immunospecifically bind to TRAIL receptors
    141.
    发明申请
    Antibodies that immunospecifically bind to TRAIL receptors 有权
    免疫特异性结合TRAIL受体的抗体

    公开(公告)号：US20060270837A1

    公开(公告)日：2006-11-30

    申请号：US11391384

    申请日：2006-03-29

    申请人： Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

    发明人： Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

    IPC分类号： A61K39/395 ,  C07K16/30 ,  C07K16/46

    CPC分类号： C07K16/2878 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

    摘要翻译： 本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合TRAIL受体TR4的相关分子。

    Human secreted proteins
    145.
    发明申请
    Human secreted proteins 审中-公开
    人体分泌的蛋白质

    公开(公告)号：US20050176061A1

    公开(公告)日：2005-08-11

    申请号：US10472953

    申请日：2002-03-26

    申请人： Craig Rosen ,  Steven Ruben

    发明人： Craig Rosen ,  Steven Ruben

    IPC分类号： A61K38/00 ,  C07K14/47 ,  G01N33/53

    CPC分类号： C07K14/47 ,  A61K38/00 ,  Y02A50/393 ,  Y02A50/395

    摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diabetes mellitus and/or conditions related to diabetes. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

    摘要翻译： 本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与糖尿病相关的糖尿病和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

    Antibodies that specifically bind to neurokinin B
    146.
    发明申请
    Antibodies that specifically bind to neurokinin B 失效
    特异性结合神经激肽B的抗体

    公开(公告)号：US20050163777A1

    公开(公告)日：2005-07-28

    申请号：US10981692

    申请日：2004-11-05

    申请人： Craig Rosen ,  Steven Ruben

    发明人： Craig Rosen ,  Steven Ruben

    IPC分类号： C07K16/18 ,  A61K39/395

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S424/80 ,  Y10S424/804 ,  Y10S424/806 ,  Y10S424/809 ,  Y10S435/975

    摘要： The present invention relates to antibodies and related molecules that specifically bind to neurokinin B. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including pre-eclampsia, hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain. The invention also relates to nucleic acid molecules encoding anti-neurokinin B antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially pre-eclampsia, as well as hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to neurokinin B.

    摘要翻译： 本发明涉及与神经激肽B特异性结合的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及免疫系统疾病和病症，包括先兆子痫，高血压，炎症，哮喘， 胃肠道疾病，焦虑症，抑郁症，成瘾症或疼痛。 本发明还涉及编码抗神经激肽B抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是先兆子痫以及高血压，炎症，哮喘，胃肠道疾病，焦虑，抑郁，成瘾或疼痛的方法和组合物，其包括 向动物，优选人施用有效量的一种或多种特异性结合神经激肽B的抗体或其片段或变体或相关分子。

    Human tumor necrosis factor receptors TR21 and TR22
    148.
    发明申请
    Human tumor necrosis factor receptors TR21 and TR22 审中-公开
    人肿瘤坏死因子受体TR21和TR22

    公开(公告)号：US20050090436A1

    公开(公告)日：2005-04-28

    申请号：US10620562

    申请日：2003-07-17

    申请人： Zhizhen Zeng ,  Steven Ruben ,  Craig Rosen

    发明人： Zhizhen Zeng ,  Steven Ruben ,  Craig Rosen

    IPC分类号： A61K38/00 ,  A61K38/17 ,  A61P29/00 ,  C07K14/47 ,  C07K14/715 ,  C07K16/28 ,  C07H21/04

    CPC分类号： C07K14/7151 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2878 ,  C07K2317/622 ,  C07K2319/30 ,  G01N2333/70578

    摘要： The present invention relates to two novel proteins, TR21 and TR22, which are members of the tumor necrosis factor (TNF) receptor. In particular, isolated nucleic acid molecules are provided encoding the human TR21 and TR22 protein. TR21 and TR22 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR21 and TR22 activity; and methods of treating immune disorders by administering TR21 and TR22 polynucleotides, polypeptides, agonists, and antagonists.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体成员的两种新型蛋白质TR21和TR22。 特别地，提供编码人TR21和TR22蛋白的分离的核酸分子。 还提供TR21和TR22多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR21和TR22活性的激动剂和拮抗剂的筛选方法; 以及通过施用TR21和TR22多核苷酸，多肽，激动剂和拮抗剂来治疗免疫疾病的方法。

    Human prostate specific G-protein receptor HPRAJ70
    150.
    发明申请
    Human prostate specific G-protein receptor HPRAJ70 审中-公开
    人前列腺特异性G蛋白受体HPRAJ70

    公开(公告)号：US20050064499A1

    公开(公告)日：2005-03-24

    申请号：US10968294

    申请日：2004-10-20

    申请人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

    发明人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

    IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/705 ,  C07K16/28 ,  C12Q1/68 ,  A61K38/17 ,  C07H21/04 ,  C07K14/72 ,  G01N33/574

    CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K2317/622

    摘要： The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.

    摘要翻译： 本发明涉及PSGR，一种与在前列腺癌中过表达的G蛋白偶联受体具有同源性的新型前列腺特异性基因。 更具体地，本发明涉及PSGR多核苷酸和由这些多核苷酸编码的多肽，以及使用PSGR多核苷酸和多肽来检测生殖系统疾病，包括前列腺疾病，特别是癌症的存在。 本发明涉及PSGR多核苷酸和多肽以及载体，宿主细胞，针对PSGR多核苷酸和多肽的抗体以及用于制备它的重组和合成方法。 还提供了用于诊断，治疗，预防和/或预后与前列腺相关的疾病（包括癌症）的方法。 本发明还涉及用于鉴定本发明的PSGR多核苷酸和多肽的激动剂和拮抗剂的筛选方法以及用于抑制或增强本发明的PSGR多肽的产生和/或功能的方法和/或组合物。