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公开(公告)号:US20070015908A1
公开(公告)日:2007-01-18
申请号:US10866878
申请日:2004-06-15
申请人: Carrie Fischer , Craig Rosen , Daniel Soppet , Steven Ruben , Hla Kyaw , Yi Li , Zhizhen Zeng , David LaFleur , Paul Moore , Yanggu Shi , Henrik Olsen , Reinhard Ebner , Charles Birse
发明人: Carrie Fischer , Craig Rosen , Daniel Soppet , Steven Ruben , Hla Kyaw , Yi Li , Zhizhen Zeng , David LaFleur , Paul Moore , Yanggu Shi , Henrik Olsen , Reinhard Ebner , Charles Birse
CPC分类号: A01C23/024 , A61K38/00 , C07K14/47 , C12N9/00 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/5091 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20050037467A1
公开(公告)日:2005-02-17
申请号:US10936773
申请日:2004-09-09
申请人: Steven Ruben , Ping Feng , David LaFleur , Paul Moore , Yanggu Shi , Hla Kyaw , Yi Li , ZhiZhen Zeng , Kenneth Carter , Gregory Endress , Ying-Fei Wei , Ping Fan , Craig Rosen
发明人: Steven Ruben , Ping Feng , David LaFleur , Paul Moore , Yanggu Shi , Hla Kyaw , Yi Li , ZhiZhen Zeng , Kenneth Carter , Gregory Endress , Ying-Fei Wei , Ping Fan , Craig Rosen
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20060084082A1
公开(公告)日:2006-04-20
申请号:US11144947
申请日:2005-06-06
申请人: Steven Ruben , Craig Rosen , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Carrie Fischer , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Yi Li , ZhiZhen Zeng , Hla Kyaw
发明人: Steven Ruben , Craig Rosen , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Carrie Fischer , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Yi Li , ZhiZhen Zeng , Hla Kyaw
CPC分类号: C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号:US20070203070A1
公开(公告)日:2007-08-30
申请号:US11744695
申请日:2007-05-04
申请人: Craig Rosen , Steven Ruben , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie Fischer , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
发明人: Craig Rosen , Steven Ruben , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie Fischer , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
IPC分类号: A61K38/17 , C07H21/04 , C07K16/00 , C07K4/00 , C12N15/00 , C12N15/09 , C12N5/00 , C12N5/08 , C12Q1/00 , C12Q1/68
CPC分类号: C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20060223077A1
公开(公告)日:2006-10-05
申请号:US11229770
申请日:2005-09-20
申请人: Jian Ni , Reinhard Ebner , David LaFleur , Paul Moore , Henrik Olsen , Craig Rosen , Steven Ruben , Daniel Soppet , Paul Young , Yanggu Shi , Kimberly Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie Fischer , Ann Ferrie , Ping Fan , Ping Feng , Gregory Endress , Patrick Dillon , Kenneth Carter , Laurie Brewer , Guo-Liang Yu , Zhizhen Zeng , John Greene
发明人: Jian Ni , Reinhard Ebner , David LaFleur , Paul Moore , Henrik Olsen , Craig Rosen , Steven Ruben , Daniel Soppet , Paul Young , Yanggu Shi , Kimberly Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie Fischer , Ann Ferrie , Ping Fan , Ping Feng , Gregory Endress , Patrick Dillon , Kenneth Carter , Laurie Brewer , Guo-Liang Yu , Zhizhen Zeng , John Greene
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号:US20050208621A1
公开(公告)日:2005-09-22
申请号:US10951993
申请日:2004-09-29
申请人: Craig Rosen , Steven Ruben , Yi Li , ZhiZhen Zeng , Hla Kyaw , Carrie Fishcher , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
发明人: Craig Rosen , Steven Ruben , Yi Li , ZhiZhen Zeng , Hla Kyaw , Carrie Fishcher , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
CPC分类号: C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20050090436A1
公开(公告)日:2005-04-28
申请号:US10620562
申请日:2003-07-17
申请人: Zhizhen Zeng , Steven Ruben , Craig Rosen
发明人: Zhizhen Zeng , Steven Ruben , Craig Rosen
CPC分类号: C07K14/7151 , A61K38/00 , A61K2039/505 , C07K16/2878 , C07K2317/622 , C07K2319/30 , G01N2333/70578
摘要: The present invention relates to two novel proteins, TR21 and TR22, which are members of the tumor necrosis factor (TNF) receptor. In particular, isolated nucleic acid molecules are provided encoding the human TR21 and TR22 protein. TR21 and TR22 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR21 and TR22 activity; and methods of treating immune disorders by administering TR21 and TR22 polynucleotides, polypeptides, agonists, and antagonists.
摘要翻译: 本发明涉及作为肿瘤坏死因子(TNF)受体成员的两种新型蛋白质TR21和TR22。 特别地,提供编码人TR21和TR22蛋白的分离的核酸分子。 还提供TR21和TR22多肽,载体,宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR21和TR22活性的激动剂和拮抗剂的筛选方法; 以及通过施用TR21和TR22多核苷酸,多肽,激动剂和拮抗剂来治疗免疫疾病的方法。
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公开(公告)号:US20070048818A1
公开(公告)日:2007-03-01
申请号:US10868184
申请日:2004-06-16
申请人: Craig Rosen , Steven Ruben , George Komatsoulis
发明人: Craig Rosen , Steven Ruben , George Komatsoulis
CPC分类号: C07K14/47
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20070015162A1
公开(公告)日:2007-01-18
申请号:US10670185
申请日:2003-09-25
申请人: Craig Rosen , Steven Ruben
发明人: Craig Rosen , Steven Ruben
CPC分类号: C12Q1/6883 , C07K14/47 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2500/04 , G01N2800/24
摘要: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译: 本发明涉及人分泌多肽,以及编码所述多肽的分离的核酸分子,其可用于诊断和治疗过敏性和哮喘性疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体,宿主细胞以及用于产生所述多核苷酸,多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。
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公开(公告)号:US20060246483A1
公开(公告)日:2006-11-02
申请号:US11366486
申请日:2006-03-03
申请人: Craig Rosen , Steven Ruben
发明人: Craig Rosen , Steven Ruben
CPC分类号: C07K14/47
摘要: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译: 本发明涉及人分泌的多肽,以及编码所述多肽的分离的核酸分子,其可用于诊断和治疗与之有关的心血管疾病,病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体,宿主细胞,以及用于产生所述多核苷酸,多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。
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