公开(公告)号：US07151599B2

公开(公告)日：2006-12-19

申请号：US11044421

申请日：2005-01-27

Applicant: M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

Inventor： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01N2201/0873

Abstract: Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed in a waveguide. The molecular analysis device also includes a wavelength demultiplexer and radiation sensors disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.

Abstract translation: 公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。 用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。 激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。 拉曼增强结构可以设置在波导中。 该分子分析装置还包括布置在基板上的波长解复用器和辐射传感器，并且被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射。

公开(公告)号：US20060275911A1

公开(公告)日：2006-12-07

申请号：US11145038

申请日：2005-06-03

Applicant: Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li

IPC: G01N33/00

CPC classification number: G01N21/658 ,  B01L3/5027 ,  B01L2200/0663 ,  B82Y15/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N33/48707 ,  Y10T436/17 ,  C12Q2565/632 ,  C12Q2565/631

Abstract: Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device includes a molecule sensor and a molecule guide. The molecule sensor comprises a nanostructure, which is configured for producing a nanostructure-enhanced Raman scattered radiation when an excitation radiation irradiates at least a portion of a molecule disposed near the NERS structure.

Abstract translation: 公开了用于检测生物聚合物的组成部分的装置和方法。 分子分析装置包括分子传感器和分子指导。 分子传感器包括纳米结构，其被配置为当激发辐射照射设置在NERS结构附近的分子的至少一部分时产生纳米结构增强的拉曼散射辐射。

公开(公告)号：US20060233481A1

公开(公告)日：2006-10-19

申请号：US11107098

申请日：2005-04-15

Applicant: Zhiyong Li

Inventor： Zhiyong Li

IPC: G02B6/00

CPC classification number: G02B6/1225 ,  B82Y20/00 ,  G02B2006/1215

Abstract: An apparatus for sensing at least one property of a fluid is described. A first photonic crystal structure and a second photonic crystal structure are defined in a dielectric slab. The first and second photonic crystal structures comprise differently patterned arrays of channels extending through the dielectric slab. The apparatus further comprises a fluid introduction device configured to introduce a common volume of the fluid into the channels of the first and second photonic crystal structures. The at least one property of the fluid can be sensed by measuring the propagation of radiation through the first and second photonic crystal structures.

Abstract translation: 描述了用于感测流体的至少一个性质的装置。 在介质板中限定第一光子晶体结构和第二光子晶体结构。 第一和第二光子晶体结构包括延伸穿过电介质板的不同图案的通道阵列。 该装置还包括流体引入装置，其构造成将共同体积的流体引入第一和第二光子晶体结构的通道中。 可以通过测量通过第一和第二光子晶体结构的辐射的传播来感测流体的至少一个性质。

公开(公告)号：US20060108322A1

公开(公告)日：2006-05-25

申请号：US10993451

申请日：2004-11-19

Applicant: Wei Wu ,  Zhiyong Li

Inventor： Wei Wu ,  Zhiyong Li

IPC: B44C1/22 ,  B32B27/00 ,  C08L33/00 ,  B32B3/00

CPC classification number: B81C1/0046 ,  B81B2207/07 ,  B81C2201/0153 ,  B82Y10/00 ,  B82Y30/00

Abstract: A lift-off material for use in fabricating a nanostructure. The lift-off material includes a first material adapted to, and present in an amount sufficient to provide a predetermined amount of mechanical strength to the nanostructure during fabrication; and a second material adapted to, and present in an amount sufficient to provide a predetermined solubility to the lift-off material.

Abstract translation: 用于制造纳米结构的剥离材料。 剥离材料包括第一材料，其适于并且以足以在制造期间向纳米结构提供预定量的机械强度的量存在; 以及第二材料，其适于并且以足以向剥离材料提供预定溶解度的量存在。

公开(公告)号：US20060056463A1

公开(公告)日：2006-03-16

申请号：US10942004

申请日：2004-09-14

Applicant: Shih-Yuan Wang ,  M. Islam ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  M. Islam ,  Zhiyong Li

IPC: H01S3/30

CPC classification number: G01N21/658 ,  G01J3/10 ,  G01N21/774 ,  H01S3/1086 ,  H01S3/169 ,  H01S5/026 ,  H01S5/1021 ,  H01S5/183 ,  H01S5/423

Abstract: Integrated radiation source/amplifying structures for use in surface enhanced Raman spectroscopy (SERS) and hyper-SERS are disclosed. The structures include a radiation source integrated with a SERS-active structure that is provided within a resonant cavity. SERS and hyper-SERS systems employing the integrated radiation source/amplifying structures are disclosed. Methods of performing SERS and hyper-SERS are also disclosed.

Abstract translation: 公开了用于表面增强拉曼光谱（SERS）和超SERS的集成放射源/放大结构。 该结构包括与设置在谐振腔内的SERS-活性结构集成的辐射源。 公开了采用集成放射源/放大结构的SERS和超SERS系统。 还公开了执行SERS和超SERS的方法。

公开(公告)号：US20060054881A1

公开(公告)日：2006-03-16

申请号：US10942693

申请日：2004-09-16

Applicant: Zhiyong Li ,  Shih-Yuan Wang

Inventor： Zhiyong Li ,  Shih-Yuan Wang

IPC: H01L29/06 ,  H01L31/0328

CPC classification number: G01N21/658 ,  B82Y30/00

Abstract: A SERS-active structure is disclosed that includes a substrate and at least one nanowire disposed on the substrate. The at least one nanowire includes a core including a first material and a coating including a SERS-active material. A SERS system is also disclosed that includes a SERS-active structure. Also disclosed are methods for forming a SERS-active structure and methods for performing SERS with SERS-active structures.

Abstract translation: 公开了一种SERS-活性结构，其包括衬底和设置在衬底上的至少一个纳米线。 所述至少一个纳米线包括包含第一材料和包含SERS-活性材料的涂层的芯。 还公开了包括SERS活性结构的SERS系统。 还公开了形成SERS活性结构的方法和用SERS活性结构进行SERS的方法。

公开(公告)号：US20050040417A1

公开(公告)日：2005-02-24

申请号：US10917751

申请日：2004-08-12

Applicant: Zhiyong Li ,  Yong Chen ,  Sean Zhang

Inventor： Zhiyong Li ,  Yong Chen ,  Sean Zhang

IPC: B82B1/00 ,  H01L29/22 ,  H01L31/0352 ,  H01L51/00 ,  H01L51/30

CPC classification number: H01L51/42 ,  H01L51/005 ,  H01L51/0071 ,  H01L51/0077 ,  H01L51/428 ,  Y02E10/549 ,  Y10S977/954

Abstract: An optical sensor is provided, comprising (a) a silicon nanowire of finite length having an electrical contact pad at each end thereof; and (b) a plurality of self-assembled molecules on a surface of the silicon nanowire, the molecules serving to modulate electrical conductivity of the silicon nanowire by either a reversible change in dipole moment of the molecules or by a reversible molecule-assisted electron/energy transfer from the molecules onto the silicon nanowire. Further, a method of making the optical sensor is provided. The concept of molecular self-assembly is applied in attaching functional molecules onto silicon nanowire surfaces, and the requirement of molecule modification (hydroxy group in molecules) is minimal from the point view of synthetic difficulty and compatibility. Self-assembly will produce well-ordered ultra-thin films with strong chemical bonding on a surface that cannot be easily achieved by other conventional methods.

Abstract translation: 提供了一种光学传感器，其包括（a）有限长度的硅纳米线，其每端具有电接触焊盘; 和（b）在硅纳米线的表面上的多个自组装分子，所述分子用于通过分子的偶极矩的可逆变化或通过可逆分子辅助电子/分子调制硅纳米线的导电性， 能量从分子转移到硅纳米线上。 此外，提供了制造光学传感器的方法。 分子自组装的概念应用于将功能分子附着在硅纳米线表面上，从合成难度和相容性的观点来看，分子修饰（分子中的羟基）的要求是最小的。 自组装将产生在表面上具有强化学键合的良好有序的超薄膜，其不能通过其它常规方法实现。

公开(公告)号：US09453793B2

公开(公告)日：2016-09-27

申请号：US13452218

申请日：2012-04-20

Applicant: Alexandre M Bratkovski ,  R Stanley Williams ,  Zhiyong Li

Inventor： Alexandre M Bratkovski ,  R Stanley Williams ,  Zhiyong Li

IPC: G01N21/00 ,  G01N21/01 ,  G01N21/65 ,  G01N21/64

CPC classification number: G01N21/01 ,  G01N21/648 ,  G01N21/658

Abstract: Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a flexible substrate, and an array of spaced apart sensing members formed on a surface of the flexible substrate. Each of the spaced apart sensing members includes a plurality of polygon assemblies. The polygon assemblies are arranged in a controlled pattern on the surface of the flexible substrate such that each of the plurality of polygon assemblies is a predetermined distance from each other of the plurality of polygon assemblies, and each of the plurality of polygon assemblies including collapsible signal amplifying structures controllably positioned in a predetermined geometric shape.

Abstract translation: 本文公开了集成传感器的示例。 集成传感器的示例包括柔性基板和形成在柔性基板的表面上的间隔开的感测部件阵列。 每个间隔开的感测构件包括多个多边形组件。 多边形组件以可控的图案布置在柔性基板的表面上，使得多个多边形组件中的每一个距离多个多边形组件中的彼此之间是预定距离，并且多个多边形组件中的每一个包括可折叠信号 放大结构可控地定位在预定的几何形状。

公开(公告)号：US09279767B2

公开(公告)日：2016-03-08

申请号：US13879255

申请日：2010-10-20

Applicant: Zhiyong Li ,  R. Stanley Williams

Inventor： Zhiyong Li ,  R. Stanley Williams

IPC: G01N21/00 ,  G01N21/64 ,  G01N21/65

CPC classification number: G01N21/6428 ,  G01N21/648 ,  G01N21/658 ,  G01N33/54373

Abstract: A chemical-analysis device integrated with a metallic-nanofinger device for chemical sensing. The chemical-analysis device includes a metallic-nanofinger device, and a platform. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with at least one analyte molecule. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A method for using, and a chemical-analysis apparatus including the chemical-analysis device are also provided.

Abstract translation: 与用于化学感测的金属纳米酮装置集成的化学分析装置。 化学分析装置包括金属纳米装置和平台。 金属纳米装置包括衬底和与衬底耦合的多个纳米器件。 多个纳米针板包括柔性柱和联接到柔性柱的顶点的金属帽。 至少纳米角蛋白和多个纳米针的第二纳米角键将与至少一个分析物分子自组织成紧密堆积的构型。 金属盖的形态是产生与来自分析物分子的放大发光相关的移位等离子体共振峰。 还提供了一种使用方法和包括该化学分析装置的化学分析装置。

公开(公告)号：US09274058B2

公开(公告)日：2016-03-01

申请号：US13879245

申请日：2010-10-20

Applicant: Zhiyong Li ,  R. Stanley Williams

Inventor： Zhiyong Li ,  R. Stanley Williams

IPC: G01N21/65 ,  G01N21/64

CPC classification number: G01N21/658 ,  G01N21/648

Abstract: A metallic-nanofinger device for chemical sensing. The device includes a substrate, and a plurality of nanofingers. A nanofinger includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least the metallic cap and a second metallic cap of respective nanofinger and second nanofinger. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A coating encapsulating the metallic cap to respond upon exposure to a liquid, and a chemical-sensing chip including the metallic-nanofinger device are also provided.

Abstract translation: 用于化学感应的金属纳米膜装置。 该装置包括基板和多个纳米装置。 纳米针框包括柔性柱和与柔性柱的顶点相连的金属帽。 至少纳米酮和第二纳米酮将自排列成紧密堆积的构型，其中至少一个分析物分子设置在至少金属盖和相应的纳芬酮和第二纳米酮之间的第二金属盖之间。 金属帽的形态是产生与来自分析物分子的放大发光相关的移位等离子体共振峰。 还提供了包封金属盖以在暴露于液体时响应的涂层，以及包括金属纳米酮装置的化学感测芯片。