公开(公告)号：US20140065074A1

公开(公告)日：2014-03-06

申请号：US14016061

申请日：2013-08-31

Applicant: ACADEMIA SINICA

Inventor： Yeu-Kuang Hwu ,  Chia-Chi Chien

IPC: A61K49/04

CPC classification number: A61K49/04 ,  A61K49/0008 ,  A61K49/0447

Abstract: A method of tracking growth and metastasis of specific cells in vivo is disclosed. The method of the disclosure includes culturing the specific cells in a medium containing 0.1 μM to 10 mM nanoparticles as a biomarker for X-rays, such that the specific cells carry the nanoparticles, administering the specific cells carrying the nanoparticles to a subject, irradiating the subject by an X-ray source, and determining the growth and metastasis of the specific cells by X-ray images of the nanoparticles in the subject.

Abstract translation: 公开了一种追踪体内特定细胞生长和转移的方法。 本公开的方法包括在含有0.1μM至10mM纳米颗粒的培养基中培养特定细胞作为X射线的生物标志物，使得特异性细胞携带纳米颗粒，将携带纳米颗粒的特定细胞给予受试者，照射 受X射线源的影响，并通过受试者中纳米颗粒的X射线图像确定特定细胞的生长和转移。

公开(公告)号：US20140033374A1

公开(公告)日：2014-01-30

申请号：US13948991

申请日：2013-07-23

Applicant: ACADEMIA SINICA

Inventor： WEI-TSE CHANG ,  ING-SHOUH HWANG

IPC: G01Q70/10 ,  G01Q70/16

CPC classification number: G01Q70/10 ,  B82Y35/00 ,  G01Q70/16

Abstract: Disclosed is a method for fabricating a nanoscale probe. A first conductor and a second conductor are immersed into an electrolyte contained in an electrolytic tank. The first conductor and the second conductor are connected to a power source respectively. An electrolytic reaction is established when an electrical circuit is established between the first conductor and the second conductor. The second conductor is configured to output electrons. The first conductor is configured to receive electrons. Therefore, the first conductor is etched when the electrical circuit is established between the first conductor and the second conductor. A necking portion is created at the first conductor approximately near the surface of the electrolyte. A nanoscale probe is fabricated when first conductor breaks at the necking portion.

Abstract translation: 公开了一种制造纳米级探针的方法。 将第一导体和第二导体浸入包含在电解槽中的电解质中。 第一导体和第二导体分别连接到电源。 当在第一导体和第二导体之间建立电路时，建立电解反应。 第二导体被配置为输出电子。 第一导体被配置为接收电子。 因此，当在第一导体和第二导体之间建立电路时，第一导体被蚀刻。 在第一导体处产生大致接近电解质表面的颈缩部分。 当第一导体在颈缩部分断裂时，制造纳米级探针。

公开(公告)号：US08637814B2

公开(公告)日：2014-01-28

申请号：US13691785

申请日：2012-12-01

Applicant: Academia Sinica

Inventor： Chung-Hsuan Chen ,  Jung-Lee Lin ,  Nien-Yeen Hsu ,  Yi-Sheng Wang

IPC: H01J49/26 ,  H01J49/40

CPC classification number: H05H5/047 ,  H01J49/06 ,  H01J49/40 ,  H01J49/403

Abstract: A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte.

Abstract translation: 提供了一种用于加速分析物的新系统和方法，包括但不限于分子离子，生物分子，聚合物，纳米和微粒。 本发明可用于在诸如质谱法，进行碰撞诱导的解离分子结构分析和使用加速分析物的探测表面和样品等应用中提高检测灵敏度。

公开(公告)号：US20130256540A1

公开(公告)日：2013-10-03

申请号：US13850853

申请日：2013-03-26

Applicant: ACADEMIA SINICA ,  NATIONAL CENTRAL UNIVERSITY ,  NATIONAL UNITED UNIVERSITY

Inventor： PING-KUN TENG ,  AUGUSTINE EI-FANG CHEN ,  MING-LEE CHU ,  CHIH-HSUN LIN ,  CHUNG-HSIANG WANG

IPC: H01J47/00

CPC classification number: H01J47/001 ,  G01T1/17

Abstract: The present invention provides a readout device of an accelerator beam monitoring detector, comprising: a transimpedance amplifier receiving a charge signal from a particle detector and converting the charge signal into an analog voltage signal; and a data acquisition system comprising an analog-to-digital converter (ADC) to covert the analog voltage signal into digital data.

Abstract translation: 本发明提供一种加速器监视检测器的读出装置，包括：跨阻抗放大器，接收来自粒子检测器的电荷信号，并将该充电信号转换为模拟电压信号; 以及包括模拟 - 数字转换器（ADC）以将模拟电压信号转换成数字数据的数据采集系统。

公开(公告)号：US20130187042A1

公开(公告)日：2013-07-25

申请号：US13713792

申请日：2012-12-13

Applicant: Academia Sinica

Inventor： Kent J. Gillig ,  Chung-Hsuan Chen

IPC: H01J49/26 ,  H01J49/00

CPC classification number: H01J49/26 ,  G01N27/624 ,  H01J49/0031 ,  H01J49/22

Abstract: A periodic field differential mobility analyzer apparatus for separating and identifying ionic analytes employs a series of elongated parallel channels, a pump, a first voltage providing an electric field Ex in a direction opposing the gas flow, a second voltage providing an electric field Ey in a direction perpendicular to the gas flow, an ion source, and a detector. The periodic field differential mobility analyzer provides high resolution and sensitivity.

Abstract translation: 用于分离和鉴定离子分析物的周期性场差分迁移率分析仪装置采用一系列细长的平行通道，泵，在与气流相反的方向上提供电场Ex的第一电压，在第一电压中提供电场Ey 垂直于气流的方向，离子源和检测器。 周期场差分迁移率分析仪提供高分辨率和灵敏度。

公开(公告)号：US20130126834A1

公开(公告)日：2013-05-23

申请号：US13677317

申请日：2012-11-15

Applicant: Au Optronics Corporation ,  Academia Sinica

Inventor： Chin-Ti Chen ,  Yi-Ting Lee ,  Meng-Ting Lee ,  Po-Hsuan Chiang ,  Chieh-Wei Chen ,  Chung-Chun Lee

IPC: H01L51/00

CPC classification number: H01L51/0061 ,  C07D209/86 ,  C09B57/00 ,  C09B57/008 ,  C09B57/10 ,  C09B69/008 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1022 ,  C09K2211/1029 ,  C09K2211/185 ,  H01L51/0067 ,  H01L51/0068 ,  H01L51/0072 ,  H01L51/0081 ,  H01L51/0085 ,  H01L51/5016 ,  H01L2251/308

Abstract: An organic luminescent material includes a host luminescent material and a guest luminescent material. The host luminescent material includes a compound represented by formula (1), where n is 0˜8; R2 and R3 respectively represent H, CF3, CN, CH3 or C5H11; R1 is CH3 or one of substituents shown as follows:

Abstract translation: 有机发光材料包括主发光材料和客体发光材料。 主体发光材料包括由式（1）表示的化合物，其中n为0〜8; R2和R3分别表示H，CF3，CN，CH3或C5H11; R 1是CH 3或如下所示的取代基之一：

公开(公告)号：US20130123183A1

公开(公告)日：2013-05-16

申请号：US13738856

申请日：2013-01-10

Applicant: Academia Sinica

Inventor： Shu-Mei Liang ,  Chi-Ming Liang

IPC: A61K38/38

CPC classification number: A61K38/385 ,  A61K38/162 ,  A61K38/38 ,  A61K45/06 ,  A61K47/643 ,  A61N5/10 ,  C07K14/765 ,  C12N7/00 ,  C12N2770/32133

Abstract: Fibrillar human serum albumin was shown to be effective in the treatment of various types of cancers. Methods and compositions are disclosed for using fibrillar human serum albumin as a medicament to treat subjects having cancer.

Abstract translation: 纤维素人血清白蛋白显示有效治疗各种类型的癌症。 公开了使用原纤维人血清白蛋白作为治疗患有癌症的受试者的药物的方法和组合物。

公开(公告)号：US20040254347A1

公开(公告)日：2004-12-16

申请号：US10307562

申请日：2002-11-25

Applicant: Academia Sinica

Inventor： Han-Jia Lin ,  Yee-Hsiung Chen

IPC: C12P021/06 ,  C07K014/00

CPC classification number: C12N9/104 ,  C07K1/1075 ,  C12P21/00

Abstract: A method of cross-linking a peptide to form a homopolymer of the peptide, to immobilize the peptide on a solid phase and to enhance antigenicity of the peptide is disclosed. The method comprises the steps of preparing a fusion peptide by incorporating a cross-linking segment including a tetrapeptide sequence QXK(S/T) into the peptide and cross-linking the peptide by a glutaminase.

Abstract translation: 公开了将肽交联以形成肽的均聚物的方法，以将肽固定在固相上并增强肽的抗原性。 该方法包括以下步骤：通过将包含四肽序列QXK（S / T）的交联链段并入肽中并通过谷氨酰胺酶交联而制备融合肽。

公开(公告)号：US20040155910A1

公开(公告)日：2004-08-12

申请号：US10361500

申请日：2003-02-11

Applicant: ACADEMIA SINICA

Inventor： Shin-Hung Chang ,  Shao-Ting Lee ,  Jan-Ming Ho

IPC: G09G005/00 ,  G09G001/14

CPC classification number: G06F3/1462

Abstract: A real-time screen recording system is disclosed. Under the design of the real-time screen recording system of this invention, the Event Inspector records updated regions of the screen when a windows update event is generated, the Periodical Extractor records the screen updates periodically. This mechanism ensures that all updates will be recorded. The Event Filter inspects the update events to identify events relating to updates of screen to ensure correct recording of the updated regions. The Sporadic Controller adjusts the working frequency of the Periodical Extractor, so that the Periodical Extractor operates in an efficient manner. The Update Region Filter filters out unnecessary updated regions to avoid heavy workload of the computer system. As a result, an efficient and correct screen recording system may be achieved.

Abstract translation: 公开了一种实时屏幕录制系统。 在本发明的实时屏幕录制系统的设计下，当生成Windows更新事件时，事件检查器记录屏幕的更新区域，周期性提取器周期性地记录屏幕更新。 该机制可确保所有更新都将被记录。 事件过滤器检查更新事件以识别与更新屏幕相关的事件，以确保正确记录更新的区域。 零星控制器调整定期提取器的工作频率，以便定期提取器以有效的方式运行。 更新区域过滤器过滤掉不必要的更新区域，以避免计算机系统的繁重工作量。 结果，可以实现有效且正确的屏幕记录系统。

公开(公告)号：US20040077621A1

公开(公告)日：2004-04-22

申请号：US10637770

申请日：2003-08-08

Applicant: Academia Sinica

Inventor： Chi-Ming Yang

IPC: A61K031/555 ,  A61K031/409

CPC classification number: A61K31/409 ,  A61K31/555

Abstract: This invention features a method for eliciting an antioxidative effect. The method includes administering to a subject (e.g., an animal or human) in need thereof an effective amount of a tetrapyrrole compound of formula (I): 1 Each of Ra, Rb, Rc, Rd, Re, Rf, Rg, and Rh, independently, is H or alkyl; R1 is alkyl or CHO; R2 is alkyl; R3 and R4 taken together are part of a cyclyl or heterocyclyl ring, and R5 is (CH2)mCOOR, in which R is H, and m is 1, 2, or 3; or R3 is (CH2), COORnull, C(O)(CH2)nCOORnull, CH(OH)(CH2)nCOORnull, and R4 and R5 taken together are part of a cyclyl or heterocyclyl ring, in which Rnull is H or alkyl, and n is 0, 1, 2, or 3; and R6 is alkenyl or CHO; the tetrapyrrole compound optionally being chelated with Mg2null, Mn2null, Cu2null, Fe2null, Co2null, Ni2null, or Zn2null through the nitrogen atoms on the four pyrrole rings.

Abstract translation: 本发明的特征在于引发抗氧化作用的方法。 该方法包括向有需要的受试者（例如，动物或人）施用有效量的式（I）的四吡咯化合物：R a，R b，R c，R c， R“，R”，R“，R”和R“独立地是H或烷基; R1是烷基或CHO; R2是烷基; R 3和R 4一起是环基或杂环基的一部分，R 5是（CH 2）m COOR，其中R是H，m是1,2或3; 或R 3是（CH 2），COOR'，C（O）（CH 2）n COOR'，CH（OH）（CH 2）n COOR'，并且R 4和R 5一起是环基或杂环基环的一部分，其中R' H或烷基，n为0,1,2或3; R6是烯基或CHO; 四吡咯化合物任选与Mg 2+，Mn 2+，Cu 2+，Fe 2+，Co 2+，Ni 2+或Zn 2+螯合而通过 四个吡咯环上的氮原子。