公开(公告)号：US09884306B2

公开(公告)日：2018-02-06

申请号：US14324180

申请日：2014-07-05

Applicant: ACADEMIA SINICA

Inventor： Yeu-Kuang Hwu ,  Sheng-Feng Lai ,  Cheng-Liang Wang

IPC: B01J19/12 ,  B01J19/00 ,  B01J19/02 ,  B01J19/08 ,  B01J19/24 ,  B01J4/00

CPC classification number: B01J19/125 ,  B01J4/002 ,  B01J19/0093 ,  B01J19/02 ,  B01J19/082 ,  B01J19/2415 ,  B01J2219/00164 ,  B01J2219/00799 ,  B01J2219/00801 ,  B01J2219/00822 ,  B01J2219/00833 ,  B01J2219/00927 ,  B01J2219/00939 ,  B01J2219/00959 ,  B01J2219/0277 ,  B01J2219/0295 ,  B01J2219/0871 ,  B01J2219/0877

Abstract: A convection-free flow-type reactor includes a reactor body. The reactor body includes a reaction chamber to house a fluid. An inlet is in communication with the reaction chamber to allow input of a reactant fluid. An outlet is in communication with the reaction chamber to allow output of a product fluid. An energy beam source device provides an energy beam to irradiate the reactant fluid in the reaction chamber. The disclosure further provides a convection-free flow-type synthesis method.

公开(公告)号：US20140066762A1

公开(公告)日：2014-03-06

申请号：US14016060

申请日：2013-08-31

Applicant: ACADEMIA SINICA

Inventor： Yeu-Kuang Hwu ,  Chia-Chi Chien ,  Cheng-Liang Wang

IPC: A61B6/00

CPC classification number: A61B6/485 ,  A61B6/481 ,  A61B6/508 ,  A61K49/0065 ,  B82Y5/00 ,  B82Y15/00

Abstract: A method of tracking specific cells in vivo is disclosed. The method of the disclosure includes: providing fluorescent nanoparticles suitable for targeting of specific cells; administering the fluorescent nanoparticles to a subject; providing an X-ray source to irradiate the subject; and determining the distribution and growth of the specific cells by the fluorescent images from the fluorescent nanoparticles and X-ray images of the subject irradiated by the X-ray source.

Abstract translation: 公开了一种在体内追踪特定细胞的方法。 本公开的方法包括：提供适于靶向特定细胞的荧光纳米颗粒; 向受试者施用荧光纳米颗粒; 提供X射线源以照射受试者; 以及通过来自荧光纳米颗粒的荧光图像和由X射线源照射的被摄体的X射线图像确定特定细胞的分布和生长。

公开(公告)号：US09799479B2

公开(公告)日：2017-10-24

申请号：US14612393

申请日：2015-02-03

Applicant: Academia Sinica

Inventor： Yeu-Kuang Hwu ,  Tsung-Tse Li ,  Yu-Tai Ching

IPC: H01J35/08 ,  H01J35/30 ,  G06T11/00 ,  A61B6/00 ,  G01N23/04 ,  G01N23/20

CPC classification number: H01J35/08 ,  A61B6/40 ,  A61B6/5205 ,  G01N23/04 ,  G01N23/20075 ,  G06T11/006 ,  H01J35/30 ,  H01J2235/086

Abstract: The present invention relates to a method, a system, and a light source for penetrating radiation imaging, and more particularly, to a method, a system, and a light source for X-ray imaging. The system for X-ray phase contrast and high resolution imaging of the present invention comprises an X-ray source comprising a plurality of X-ray micro-light sources, an X-ray sensor configured to receive X-rays penetrating an object, and a computer configured to receive and compute raw image data from the X-ray sensor so as to obtain a clear image of the object.

公开(公告)号：US20150011818A1

公开(公告)日：2015-01-08

申请号：US14324183

申请日：2014-07-05

Applicant: ACADEMIA SINICA

Inventor： Yeu-Kuang Hwu ,  Chia-Chi Chien

IPC: A61K33/24 ,  A61N5/10 ,  A61K41/00

CPC classification number: A61K33/24 ,  A61K9/0019 ,  A61K9/5107 ,  A61K49/0423

Abstract: The present disclosure provides a tumor vessel embolizing agent, including: unmodified gold nanoparticles; and a pharmaceutically acceptable medium. The present disclosure also provides a method of embolizing tumor vessel, including administrating gold nanoparticles as a tumor vessel embolizing agent into a subject to accumulate the gold nanoparticles at a tumor in the subject and to embolize a vessel of the tumor.

Abstract translation: 本公开提供了一种肿瘤血管栓塞剂，其包括：未修饰的金纳米颗粒; 和药学上可接受的培养基。 本公开还提供了栓塞肿瘤血管的方法，包括将金纳米颗粒作为肿瘤血管栓塞剂施用于受试者以在受试者的肿瘤处积累金纳米颗粒并栓塞肿瘤的血管。

公开(公告)号：US09662080B2

公开(公告)日：2017-05-30

申请号：US14016060

申请日：2013-08-31

Applicant: ACADEMIA SINICA

Inventor： Yeu-Kuang Hwu ,  Chia-Chi Chien ,  Cheng-Liang Wang

IPC: A61B5/05 ,  A61B6/00 ,  A61K49/00 ,  B82Y5/00 ,  B82Y15/00

CPC classification number: A61B6/485 ,  A61B6/481 ,  A61B6/508 ,  A61K49/0065 ,  B82Y5/00 ,  B82Y15/00

Abstract: A method of tracking specific cells in vivo is disclosed. The method of the disclosure includes: providing fluorescent nanoparticles suitable for targeting of specific cells; administering the fluorescent nanoparticles to a subject; providing an X-ray source to irradiate the subject; and determining the distribution and growth of the specific cells by the fluorescent images from the fluorescent nanoparticles and X-ray images of the subject irradiated by the X-ray source.

公开(公告)号：US20140065074A1

公开(公告)日：2014-03-06

申请号：US14016061

申请日：2013-08-31

Applicant: ACADEMIA SINICA

Inventor： Yeu-Kuang Hwu ,  Chia-Chi Chien

IPC: A61K49/04

CPC classification number: A61K49/04 ,  A61K49/0008 ,  A61K49/0447

Abstract: A method of tracking growth and metastasis of specific cells in vivo is disclosed. The method of the disclosure includes culturing the specific cells in a medium containing 0.1 μM to 10 mM nanoparticles as a biomarker for X-rays, such that the specific cells carry the nanoparticles, administering the specific cells carrying the nanoparticles to a subject, irradiating the subject by an X-ray source, and determining the growth and metastasis of the specific cells by X-ray images of the nanoparticles in the subject.

Abstract translation: 公开了一种追踪体内特定细胞生长和转移的方法。 本公开的方法包括在含有0.1μM至10mM纳米颗粒的培养基中培养特定细胞作为X射线的生物标志物，使得特异性细胞携带纳米颗粒，将携带纳米颗粒的特定细胞给予受试者，照射 受X射线源的影响，并通过受试者中纳米颗粒的X射线图像确定特定细胞的生长和转移。