公开(公告)号：US09359323B2

公开(公告)日：2016-06-07

申请号：US13879130

申请日：2011-10-13

Applicant: Donald Barton McPhail ,  Graeme James Cook ,  Richard Charles Hartley

Inventor： Donald Barton McPhail ,  Graeme James Cook ,  Richard Charles Hartley

IPC: C07D311/00 ,  C07D315/00 ,  C07D311/62 ,  C07D309/40 ,  C07D311/26

CPC classification number: C07D311/62 ,  C07D309/40 ,  C07D311/26

Abstract: The present invention provides compounds of the formula Formula I or a salt thereof: and the uses of such compounds for the treatment of a disease or disorder involving oxidative damage, for preventing UV damage to the skin of a mammal and for preventing or reversing the effects of ageing, or for treating or preventing dry skin.

公开(公告)号：US08795984B2

公开(公告)日：2014-08-05

申请号：US13530768

申请日：2012-06-22

Applicant: Piotr Bobrowicz ,  W. James Cook ,  Warren Kett

Inventor： Piotr Bobrowicz ,  W. James Cook ,  Warren Kett

IPC: C12P21/06 ,  C12N1/15 ,  C12N1/19 ,  A01N43/78 ,  C07D277/26

CPC classification number: C07K16/32 ,  C07K2317/41 ,  C12P21/005

Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.

Abstract translation: 描述了一种用于生产具有减少量的O-连接糖基化的蛋白质组合物的方法。 该方法包括在存在Pmt介导的O-连接糖基化的抑制剂和/或在一种或多种α-1,2-甘露糖苷酶的存在下培养的细胞中产生蛋白质。

公开(公告)号：US08468857B2

公开(公告)日：2013-06-25

申请号：US13549716

申请日：2012-07-16

Applicant: Jenn-Yeu Nieh ,  Bennett James Cook ,  James Andrew Oskins

Inventor： Jenn-Yeu Nieh ,  Bennett James Cook ,  James Andrew Oskins

IPC: D06F33/02

CPC classification number: D06F33/02 ,  D06F39/087 ,  D06F2202/085 ,  D06F2204/086

Abstract: A method for determining the laundry load size according to one embodiment of the invention in an automatic clothes washer comprising supplying water to a reference water level to define a first amount of water, supplying water from the reference water level to a second water level above the reference water level and sufficient to submerge the laundry load to define a second amount of water, and determining a load size for the laundry load based on the second amount of water such that errors associated with the first amount of water are not considered in the load size determination based on the second amount of water.

Abstract translation: 一种用于在自动洗衣机中根据本发明的一个实施例确定衣物负载大小的方法，包括向参考水位供水以限定第一量的水，将水从参考水位供应到第二水位以上 参考水位并足以淹没衣物负载以限定第二量的水，并且基于第二量的水确定衣物负载的负载大小，使得在负载中不考虑与第一量的水相关的误差 基于第二量的水的尺寸测定。

公开(公告)号：US20120276655A1

公开(公告)日：2012-11-01

申请号：US13395723

申请日：2010-09-14

Applicant: Neil James Cook

Inventor： Neil James Cook

IPC: G01N21/64 ,  C07K14/47

CPC classification number: G01N33/564 ,  G01N33/561

Abstract: The present invention relates to a method of detecting a target antibody, particularly a target autoantibody, in a sample, using a small molecule fluorophore-labelled target antigen, or a functional fragment, functional variant or functional derivative thereof that specifically binds to the target antibody. Detection is typically carried out using immunodiffusion or immunoelectrophoresis. The invention also relates to methods of diagnosing disease, particularly autoimmune disease, using small molecule fluorophore labelled target antigens and autoantigens. Small molecule fluorophore labelled target antigens, including autoantigens, are also disclosed, as are uses such.

Abstract translation: 本发明涉及使用特异性结合靶抗体的小分子荧光团标记的靶抗原或其功能性片段，功能性变体或功能性衍生物来检测样品中的靶抗体，特别是靶自身抗体的方法 。 检测通常使用免疫扩散或免疫电泳进行。 本发明还涉及使用小分子荧光团标记的靶抗原和自身抗原来诊断疾病，特别是自身免疫性疾病的方法。 还公开了小分子荧光团标记的靶抗原，包括自身抗原，以及其用途。

公开(公告)号：US08245342B2

公开(公告)日：2012-08-21

申请号：US12182201

申请日：2008-07-30

Applicant: Jenn-Yeu Nieh ,  Bennett James Cook ,  James Andrew Oskins

Inventor： Jenn-Yeu Nieh ,  Bennett James Cook ,  James Andrew Oskins

IPC: D06F33/02

CPC classification number: D06F33/02 ,  D06F39/087 ,  D06F2202/085 ,  D06F2204/086

Abstract: A method for determining the laundry load size according to one embodiment of the invention in an automatic clothes washer comprising supplying water to a reference water level to define a first amount of water, supplying water from the reference water level to a second water level above the reference water level and sufficient to submerge the laundry load to define a second amount of water, and determining a load size for the laundry load based on the second amount of water such that errors associated with the first amount of water are not considered in the load size determination based on the second amount of water.

Abstract translation: 一种用于在自动洗衣机中根据本发明的一个实施例确定衣物负载大小的方法，包括向参考水位供水以限定第一量的水，将水从参考水位供应到第二水位以上 参考水位并足以淹没衣物负载以限定第二量的水，并且基于第二量的水确定衣物负载的负载大小，使得在负载中不考虑与第一量的水相关的误差 基于第二量的水的尺寸测定。

公开(公告)号：US20120135461A1

公开(公告)日：2012-05-31

申请号：US13191811

申请日：2011-07-27

Applicant: WILLIAM JAMES COOK ,  STEFAN WILDT

Inventor： WILLIAM JAMES COOK ,  STEFAN WILDT

IPC: C12P21/00

CPC classification number: C12P21/005 ,  C07K16/00 ,  C07K2317/41 ,  C12N9/2488 ,  C12N15/815 ,  C12N15/8257 ,  C12Y302/01113

Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of one or more α-1,2-mannosidases from Coccidiodes immitis, Coccidiodes posadasii, Penicillium citrinum, Magnaporthe grisea, Aspergillus saitoi, Aspergillus oryzae, and Chaetomiun globosum or a catalytically active fragment of said α-1,2-mannosidase.

Abstract translation: 描述了一种用于生产具有减少量的O-连接糖基化的蛋白质组合物的方法。 该方法包括在存在一种或多种来自椰子球菌，椰子球菌，青霉菌，稻瘟病菌，沙司酸曲霉，米曲霉和球孢白僵菌的一种或多种α-1,2-甘露糖苷酶的存在下培养的细胞中产生蛋白质，或催化活性片段 的所述α-1,2-甘露糖苷酶。

公开(公告)号：US20120095524A1

公开(公告)日：2012-04-19

申请号：US13381586

申请日：2010-06-29

Applicant: Timothy Scott Nelson ,  Mark James Cook ,  Anthony Neville Burkitt

Inventor： Timothy Scott Nelson ,  Mark James Cook ,  Anthony Neville Burkitt

IPC: A61N1/36

CPC classification number: A61N1/36082

Abstract: The present invention provides a method for counteracting seizure events in a mammalian brain, the method comprising applying an electrical stimulus to the brain, the electrical stimulus being pulsatile and comprising pulses forming a pulse train. In order to effectively “desynchronize” the neural activity patterns in the brain, the pulse train can be at a frequency greater than substantially 300 Hz and at a duty cycle greater than substantially 20%, the pulse train can have an inconstant inter pulse interval such that the pulse rate is not constant throughout the pulse train, and the pulses can have a pulse width greater than substantially 300 μsec. Apparatus for carrying out the method is also described.

Abstract translation: 本发明提供了一种用于抵消哺乳动物脑中的发作事件的方法，所述方法包括对脑进行电刺激，电刺激是脉动的并且包括形成脉冲序列的脉冲。 为了有效地“同步”大脑中的神经活动模式，脉冲串可以处于大于基本上为300Hz的频率，并且在大于大致20％的占空比下，脉冲串可以具有不均匀的脉冲间隔 在整个脉冲串中脉冲频率不是恒定的，并且脉冲可以具有大于基本上300μsec的脉冲宽度。 还描述了用于执行该方法的装置。

公开(公告)号：US20100267132A1

公开(公告)日：2010-10-21

申请号：US12757717

申请日：2010-04-09

Applicant: Donald Barton McPhail ,  Graeme James Cook ,  Andrew Scott Johnstone

Inventor： Donald Barton McPhail ,  Graeme James Cook ,  Andrew Scott Johnstone

IPC: C12N5/0735 ,  C12N5/02 ,  C07D311/22

CPC classification number: C07D311/62 ,  A01N1/02 ,  A01N1/0226 ,  C07D207/36 ,  C07D215/22 ,  C07D307/58 ,  C07D311/30 ,  C07D333/32 ,  C07D335/06 ,  C12N5/0606 ,  C12N2501/999

Abstract: The invention is directed to compounds of Formula (I) or salts thereof. The invention is also directed to use of the compounds of formula (I) in the in vitro preservation of living animal cells. The living cells can be isolated cells, such as stem cells, or groups of cells such as tissue or an organ.

Abstract translation: 本发明涉及式（I）的化合物或其盐。 本发明还涉及式（I）化合物在活体动物细胞的体外保存中的用途。 活细胞可以是分离的细胞，例如干细胞或细胞组，例如组织或器官。

公开(公告)号：US20100256469A1

公开(公告)日：2010-10-07

申请号：US12678646

申请日：2008-09-19

Applicant: Richard James Cook ,  Timothy Watson ,  Frederic Festy

Inventor： Richard James Cook ,  Timothy Watson ,  Frederic Festy

IPC: A61B5/1455 ,  A61B6/00

CPC classification number: A61B5/14542 ,  A61B1/3137 ,  A61B5/1459

Abstract: The invention relates to an apparatus and a method for imaging the vascular structure and vascular blood flow of an organ or tissue and, in particular, relates to a selective wavelength epi-illumination endoscopic imaging apparatus to image vascular tissues and real time capillary blood flow in vivo. The invention also relates to determining the blood oxygen content of the organ or tissue.

Abstract translation: 本发明涉及一种用于对器官或组织的血管结构和血管血流进行成像的装置和方法，具体涉及用于对血管组织进行成像和实时毛细血管血流的选择性波长外照射内窥镜成像装置 体内。 本发明还涉及确定器官或组织的血氧含量。

公开(公告)号：US20100098713A1

公开(公告)日：2010-04-22

申请号：US12559673

申请日：2009-09-15

Applicant: Rachel E. Meyers ,  Joseph M. Carroll ,  William James Cook ,  Rosana Kapeller-Libermann ,  Nadine S. Welch ,  Rajasekhar Bandaru

Inventor： Rachel E. Meyers ,  Joseph M. Carroll ,  William James Cook ,  Rosana Kapeller-Libermann ,  Nadine S. Welch ,  Rajasekhar Bandaru

IPC: A61K39/395 ,  C07H21/00 ,  C12N1/00 ,  C12N5/00 ,  C07K14/00 ,  C07K16/00 ,  C12P21/00 ,  G01N33/53 ,  G01N33/48 ,  G01N33/68 ,  A61K38/02 ,  A61K38/16 ,  A61K31/7052 ,  A61P35/00 ,  A61P25/00 ,  A61P7/00 ,  A61P19/00 ,  A61P21/00 ,  A61P9/00

CPC classification number: A61K38/16 ,  A01K2217/05 ,  A61K38/4813 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/0008 ,  C12N9/12 ,  C12N9/16 ,  C12N9/20 ,  C12N9/6416 ,  C12N9/6424 ,  C12N9/6491 ,  C12N9/93 ,  C12Q1/25 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y603/02019 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/573 ,  G01N33/68 ,  G01N2500/10 ,  Y10T436/143333 ,  A61K2300/00

Abstract: The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract translation: 本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。 本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及 已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。 本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。 还提供了利用本发明组合物的诊断和治疗方法。